388 research outputs found

    Fisgando oportunidades.

    Get PDF
    bitstream/item/128287/1/EDUFA-FISGANDO.pdf1. ed.Projeto Minibibliotecas

    Esta é uma outra história.

    Get PDF
    bitstream/item/128292/1/EDUFA-HISTORIA.pdfProjeto Minibibliotecas

    Influence diagnostics in exponentiated-Weibull regression models with censored data.

    Get PDF
    Diagnostic methods have been an important tool in regression analysis to detect anomalies, such as departures from the error assumptions and the presence of outliers and influential observations with the fitted models. The literature provides plenty of approaches for detecting outlying or influential observations in data sets. In this paper, we follow the local influence approach (Cook 1986) in detecting influential observations with exponentiated-Weibull regression models. The relevance of the approach is illustrated with a real data set, where it is shown that by removing the most influential observations, there is a change in the decision about which model fits the data better.Peer Reviewe

    Influence diagnostics in exponentiated-Weibull regression models with censored data

    Get PDF
    Diagnostic methods have been an important tool in regression analysis to detect anomalies, such as departures from the error assumptions and the presence of outliers and influential observations with the fitted models. The literature provides plenty of approaches for detecting outlying or influential observations in data sets. In this paper, we follow the local influence approach (Cook 1986) in detecting influential observations with exponentiated-Weibull regression models. The relevance of the approach is illustrated with a real data set, where it is shown that by removing the most influential observations, there is a change in the decision about which model fits the data better

    The Role of Gut Microbiota in the Etiopathogenesis of Multiple Chronic Diseases

    Get PDF
    Chronic diseases (CD) may result from a combination of genetic factors, lifestyle and social behaviours, healthcare system influences, community factors, and environmental determinants of health. These risk factors frequently coexist and interact with one another. Ongoing research and a focus on personalized interventions are pivotal strategies for preventing and managing chronic disease outcomes. A wealth of literature suggests the potential involvement of gut microbiota in influencing host metabolism, thereby impacting various risk factors associated with chronic diseases. Dysbiosis, the perturbation of the composition and activity of the gut microbiota, is crucial in the etiopathogenesis of multiple CD. Recent studies indicate that specific microorganism-derived metabolites, including trimethylamine N-oxide, lipopolysaccharide and uremic toxins, contribute to subclinical inflammatory processes implicated in CD. Various factors, including diet, lifestyle, and medications, can alter the taxonomic species or abundance of gut microbiota. Researchers are currently dedicating efforts to understanding how the natural progression of microbiome development in humans affects health outcomes. Simultaneously, there is a focus on enhancing the understanding of microbiome-host molecular interactions. These endeavours ultimately aim to devise practical approaches for rehabilitating dysregulated human microbial ecosystems, intending to restore health and prevent diseases. This review investigates how the gut microbiome contributes to CD and explains ways to modulate it for managing or preventing chronic conditions.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support by national funds FCT/MCTES CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020); national funding by FCT, P.I., through the institutional scientific employment program-contract for S.Heleno and R. Calhelha contracts.info:eu-repo/semantics/publishedVersio

    Development of natural preservatives for the food industry: an integrated strategy focused on the use of sustainable, low cost and efficient processes

    Get PDF
    The demand for natural foods is increasing, since the concern about the use of artificial additives is increasing too. In the search for alternatives to the synthetic ones, natural preservatives obtained from plants appears as a viable option, ensuring consumer´s safety. The aim of the present work was to evaluate the preservative capacity of natural matrices such as rosemary (Rosmarinus officinalis L.), basil (Ocimum basilicum L.) and sage (Salvia officinalis L.) and compare their behavior with an artificial one (potassium sorbate). These preservatives were incorporated in yogurts and the physical parameters and nutritional profile were accessed.To the Foundation for Science and Technology (FCT) and FEDER, under program PT2020 for financial support to CIMO (UD/AGR/00690/2019). M. Carocho and S. Heleno thank FCT for their individual research program-contract (CEECIND/00831/2018; CEECIND/03040/2017), while L. Barros thanks FCT for her institutional scientific employment program contract.info:eu-repo/semantics/publishedVersio

    In-band network monitoring technique to support SDN-based wireless networks

    Get PDF
    Most industrial applications demand determinism in terms of latency, reliability, and throughput. This goes hand in hand with the increased complexity of real-time network programability possibilities. To ensure network performance low-overhead, high-granularity, and timely network verification techniques need to be deployed. The first cornerstone of network verification ability is to enable end-to-end network monitoring, including end devices too. To achieve this, this article shows a novel and low overhead in-band network telemetry and monitoring technique for wireless networks focusing on IEEE 802.11 networks. A design of in-band network telemetry enabled node architecture is proposed and its proof of concept implementation is realized. The PoC realization is used to monitor a real-life SDN-based wireless network, enabling on-the-fly (re)configuration capabilities based on monitoring data. In addition, the proposed monitoring technique is validated in terms of monitoring accuracy, monitoring overhead, and network (re)configuration accuracy. It is shown that the proposed in-band monitoring technique has 6 times lower overhead than other active monitoring techniques on a single-hop link. Besides this, it is demonstrated that (re)configuration decisions taken based on monitored data fulfill targeted application requirements, validating the suitability of the proposed monitoring technique

    Efficacy, sustainability and safety of natural food preservatives: a study on muffins preserved with plant extracts

    Get PDF
    The natural preservatives do not show deep changes on the nutritional profile, and, pending their efficacy on antioxidant activity, should be encouraged as alternatives to synthetic preservatives. The natural additives should be encouraged to be used as alternatives to synthetic ones. They did not impact the colour of muffins.Foundation for Science and Technology (FCT) and FEDER, under program PT2020 for financial support to CIMO (UD/AGR/00690/2019). S. Heleno and M. Carocho thank FCT for their individual research program-contract (CEECIND/00831/2018; CEECIND/03040/2017), while L. Barros thanks FCT for her institutional scientific employment program-contract.info:eu-repo/semantics/publishedVersio

    Bioactive properties of Clitocybe alexandri

    Get PDF
    Some mushrooms are known to have strong antioxidant capacity [1]. There is an accepted relationship between the physiopathology of several chronic diseases and oxidative stress. Therefore, the use of foods such as those mushrooms with antioxidant capacity, as phytochemical protectors, may be relevant for the prevention of oxidative stress related diseases such as cancer. Additionally, mushrooms have been described as a source of potential antitumour molecules, making them attractive candidates for drug discovery [2,3]. However, there are no such studies on the Portuguese wild mushroom Clitocybe alexandri
    • …
    corecore