79 research outputs found
Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis
© 2010 Cascão et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by sustained
synovitis. Recently, several studies have proposed neutrophils and Th17 cells as key players in the onset and
perpetuation of this disease. The main goal of this work was to determine whether cytokines driving neutrophil
and Th17 activation are dysregulated in very early rheumatoid arthritis patients with less than 6 weeks of disease
duration and before treatment (VERA).
Methods: Cytokines related to neutrophil and Th17 activation were quantified in the serum of VERA and
established RA patients and compared with other very early arthritis (VEA) and healthy controls. Synovial fluid (SF)
from RA and osteoarthritis (OA) patients was also analyzed.
Results: VERA patients had increased serum levels of cytokines promoting Th17 polarization (IL-1b and IL-6), as
well as IL-8 and Th17-derived cytokines (IL-17A and IL-22) known to induce neutrophil-mediated inflammation. In
established RA this pattern is more evident within the SF. Early treatment with methotrexate or corticosteroids led
to clinical improvement but without an impact on the cytokine pattern.
Conclusions: VERA patients already display increased levels of cytokines related with Th17 polarization and
neutrophil recruitment and activation, a dysregulation also found in SF of established RA. 0 Thus, our data suggest
that a cytokine-milieu favoring Th17 and neutrophil activity is an early event in RA pathogenesis.This work was supported by a grant from Sociedade Portuguesa de Reumatologia/Schering-Plough 2005. RAM and RC were funded by Fundação para a Ciência e a Tecnologia (FCT) SFRH/BD/30247/2006 and
SFRH/BD/40513/2007, respectively. MMS-C was funded by Marie Curie Intra-European Fellowship PERG-2008-239422 and a EULAR Young Investigator Award
Estimating the Effect of Student Aid on College Enrollment: Evidence from a Government Grant Policy Reform
Improving the functionality and performance of AA2024 corrosion sensing coatings with nanocontainers
The compatibility between nanocontainers and coating formulations is perhaps the last frontier in the quest for
functional coatings. Sensing coatings for early metallic corrosion detection is an urgently needed technology
by aeronautical companies to mitigate the costs of corrosion through continuous monitoring. In this work, we
revisit phenolphthalein encapsulated silica nanocapsules, which were incorporated into a water-based lacquer,
resulting in a novel corrosion sensing coating for aluminum alloy 2024 with improved functionality and standard
performance. The ability of the coatings to detect corrosion by color change was investigated by immersion
and salt-spray tests. During these tests, it was clearly demonstrated that encapsulation of the active compound
is essential to obtain a functional coating, since the shell of the silica nanocapsules minimizes the detrimental
interaction of the active compound with the coating formulation. The compatibility between nanostructured additives
and coatings is almost never taken into consideration in the literature. Herein this aspect evidences the
positive effects of active agent encapsulation, which is explored in terms of reactivity, viscoelastic properties,
curing, thermal stability, release and leaching studies, hardness, mechanical properties and corrosion resistance.
Computer simulations based on the density functional theory and periodic structural models were performed to
unveil the interaction mode of phenolphthalein with the metallic surface.This work was developed in the scope of the project CICECO – Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (Ref. FCT UID/CTM/50011/2013), financed by national funds through the FCT/ MEC and when applicable co-financed by FEDER under the PT2020 Partnership Agreement. This work has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie SkĹ‚odowska-Curie grant agreements No 645662. It was also financed in the framework of the project reference PTDC/QEQQFI/ 4719/2014, Project 3599 – Promover a Produção CientĂfica e Desenvolvimento TecnolĂłgico e a Constituição de Redes Temáticas (3599-PPCDT) and FEDER funds through COMPETE 2020, Programa Operacional Competitividade e Internacionalização (POCI). The authors also thank financial support from FCT and COMPETE (Programa Investigador FCT). JT thanks FCT for the research grant IF/00347/ 2013.publishe
O Serviço de documentação textual e iconografia do Museu Paulista
The essay compares the curatorship's works realized during the decade of 1990 by the actual Department of Textual and Iconographical Documentation of Museu Paulista, responsible for the MP Fund / Permanent File (Fundo MP/Arquivo Permanente), hundreds of collections and textual funds and 50.000 iconography pieces, great part of which are gathered in photographic collections. It shows how the documentation work extrapolates the limits of SVDHICO in order to integrate itself with the group activities of the museum and with other research groups. It also points towards new work methodologies which allow to perform the curatorship in an integrated way with the interdisciplinary research and the culture diffusion.O artigo faz um balanço dos trabalhos de curadoria realizados durante a década de 1990 pelo atual Serviço de Documentação Textual e Iconografia do Museu Paulista, responsável pelo Fundo MP/Arquivo Permanente, centenas de coleções e fundos textuais e 50.000 peças de iconografia, grande parte delas reunidas em coleções fotográficas. Mostra como o trabalho de documentação extrapola os limites do SVDHICO para integrar-se com as atividades de conjunto do Museu e com outros grupos de pesquisa. Aponta também para novas metodologias de trabalho com imagens que permitem realizar a curadoria de forma integrada à pesquisa interdisciplinar e à difusão cultural
Epidemiology of the viral hepatitis B and C in female prisoners of Metropolitan Regional Prison Complex in the State of Goiás, Central Brazil
Pollen and seed flow patterns of Carapa guianensis Aublet. (Meliaceae) in two types of Amazonian forest
Avaliação de laboratĂłrios brasileiros na determinação de alguns parâmetros de qualidade de biocombustĂveis
This work shows the results of a Proficiency Testing performed by a partnership between INMETRO and ANP. The performance of 49 Brazilian laboratories (using the z-score statistical test) in determining 10 quality parameters of ethanol fuel and biodiesel was evaluated. The certified reference values were provided by INMETRO, allowing a more rigorous assessment of the laboratories. For hydrous ethanol, the acidity parameter showed the lowest number of laboratories with satisfactory results (48%), while 85% of the laboratories presented satisfactory results for ethanol content. For biodiesel, the percentage of laboratories with satisfactory results ranged from 46% (kinematic viscosity) to 92% (acid number)
Serological, epidemiological and molecular aspects of hepatitis C virus infection in a population from Londrina, PR, Brazil, 2001-2002
Early Clinical Manifestations Associated with Death from Visceral Leishmaniasis
The visceral leishmaniasis (VL) is a disease potentially fatal if not diagnosed and treated opportunely. This article presents the results of the study on the manifestations identified at the time of the clinical suspicion of the VL cases. This study was conducted in Belo Horizonte, the capital of the State of Minas Gerais, located in southeastern Brazil. This study is both timely and substantive because the Belo Horizonte is an area of transmission of VL, with one of the highest VL-death proportions of Brazil. The patients with higher risk of death had at least one of the following characteristics: ≥60 years, weakness, HIV co-infection, bleeding, jaundice and other associated infections. During the period 2002–2009, 8% to 22% of the patients with VL progressed to death in Belo Horizonte, whilst the proportion in the country was much lower and varied between 5% and 9%. This study has identified vulnerable patients who are at higher risk of death from VL and who would benefit from early predictive evaluation of the prognostic. Hence, the knowledge regarding the factors associated with death may contribute for clinical management and for reduction of deaths from VL
Redes de subcontratação e trabalho a domicĂlio na indĂşstria de confecção: um estudo na regiĂŁo de Campinas
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