The Benefits of Breastfeeding

It is important to educate women of childbearing age, their families, and society of the benefits that breastfeeding has over bottle-feeding and formula-feeding. The benefits of breastfeeding are in three main categories. First, the developmental, physical, emotional, and spiritual benefits of the baby will be discussed. Then the physical, emotional, and spiritual benefits for the mother will be talked about along with possible contraindications or difficulties. Finally, the financial benefits of breastfeeding over feeding an infant from the bottle will be discussed as it relates to the family and government. The goal is to persuade that breastfeeding is a superior nutritional resource and has numerous physiological, psychological and financial benefits for all members of society

You and Your Neighbor

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Reversed papilledema in an MPS VI patient with galsulfase (Naglazyme®) therapy

MPS VI (mucopolysaccharidosis VI, known as Maroteaux–Lamy syndrome) is a multi-systemic inherited disease, resulting from a deficiency of N-acetylgalactosamine-4-sulfatase, causing accumulation of the glycosaminoglycan (GAG) dermatan sulfate in all tissues. It is one of almost 50 lysosomal storage disorders. Ocular pathology is common in patients with MPS VI, with complications including ocular hypertension, progressive corneal clouding, optic nerve swelling (or papilledema) often associated with communicating hydrocephalus (Ashworth et al., Eye 20(5), 553–563, 2006; Goldberg et al., AJO 69(6), 969–975), and raised intracranial pressure (ICP) progressing to atrophy with loss of vision (Goodrich et al., Loss of vision in MPS VI is a consequence of increased intracranial pressure, 2002). This is the first case report of reversed papilledema and improved visual acuity in an 11-year-old MPS VI patient receiving galsulfase (Naglazyme®), an enzyme-replacement therapy (ERT) of recombinant human arylsulfatase B (rhASB) (Harmatz et al., J Pediatr 148(4), 533–539, 2006)

The impact of classroom design on collaborative learning

This paper discusses a trial of a recently opened Collaborative Learning Centre at the University of Queensland. The aim of the trial was to see how the space could be used with science students in a first-year introductory statistics course, and what kinds of collaborations the space might encourage. The Centre has a number of spaces designed for collaborative learning, but only one of these was completed at the time of the trial. This space was the largest, accommodating around 100 students in five ‘pods’, each with a main computer and data projector as well as six to eight other computers. It is clear that the space is not just a computer laboratory, with computers to support collaboration rather than being the focus. The trial attempted to use a learning task that would meet such characteristics of the space

The Advanced Study Program in Science: challenging, motivating and inspiring our best science students

The Advanced Study Program in Science is an enrichment program for science students at The University of Queensland (UQ) which targets highly motivated, high achieving students with an interest in research and a career in science. The program is coordinated across the full three years of the degree with the core aims of: • providing a cohort experience with a group of like-minded individuals which becomes a closely bonded learning community throughout the undergraduate experience and beyond; • exposing motivated and interested students to the research culture of the university and the myriad of career opportunities in science; • allowing these students to gain genuine research laboratory experience earlier and more intensely than in a regular undergraduate degree program; and • challenging these students to develop complex problem solving skills. The program has an enrolment of approximately 40 students per year and these students participate in a number of cohort building exercises including science camps, team assignments and social activities. The students gain academic credit for three specific courses, one in each year, which consist of seminar attendance, research projects, discussion groups and advanced laboratory exercises. The results of the research projects completed in second and third year are presented within an authentic science context at an Annual Undergraduate Research Symposium as either oral or poster presentations. The Advanced Study Program has been very successful in providing immediate and accessible links between the science research occurring at UQ and the undergraduate learning environment

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn

<p>Abstract</p> <p>Background</p> <p>Tau protein is the principal component of the neurofibrillary tangles found in Alzheimer's disease, where it is hyperphosphorylated on serine and threonine residues, and recently phosphotyrosine has been demonstrated. The Src-family kinase Fyn has been linked circumstantially to the pathology of Alzheimer's disease, and shown to phosphorylate Tyr18. Recently another Src-family kinase, Lck, has been identified as a genetic risk factor for this disease.</p> <p>Results</p> <p>In this study we show that Lck is a tau kinase. <it>In vitro</it>, comparison of Lck and Fyn showed that while both kinases phosphorylated Tyr18 preferentially, Lck phosphorylated other tyrosines somewhat better than Fyn. In co-transfected COS-7 cells, mutating any one of the five tyrosines in tau to phenylalanine reduced the apparent level of tau tyrosine phosphorylation to 25-40% of that given by wild-type tau. Consistent with this, tau mutants with only one remaining tyrosine gave poor phosphorylation; however, Tyr18 was phosphorylated better than the others.</p> <p>Conclusions</p> <p>Fyn and Lck have subtle differences in their properties as tau kinases, and the phosphorylation of tau is one mechanism by which the genetic risk associated with Lck might be expressed pathogenically.</p

Causal associations between depression symptoms and cognition in a community-based cohort of older adults.

OBJECTIVE: To evaluate the temporal association between depression symptoms and cognitive function in older adults over a 4-year period. METHODS: Using a longitudinal, cross-lagged, population-based design, we studied depression symptoms and cognitive domains (including processing speed, verbal fluency, face and word recognition, episodic memory, and simple and choice reaction time) in 896 community-dwelling adults aged 70-97 years. RESULTS: Cross-lagged structural equation models suggested that initial depression symptoms affected subsequent processing speed and simple and choice reaction time but that cognition did not predict depression symptoms over time. The associations between depression and cognitive variables were attenuated when the models were adjusted for sensory impairment, physical health, and locus of control. CONCLUSION: The findings suggest that, causally, depression precedes cognitive impairment in this age group and that the association is related to physical health and perceptions of a lack of control

Testing Cost Containment of Future Healthcare with Maintained or Improved Quality—The COSTCARES Project

Increasing healthcare costs need to be contained in order to maintain equality of access to care for all EU citizens. A cross-disciplinary consortium of experts was supported by the EU FP7 research programme, to produce a roadmap on cost containment, while maintaining or improving the quality of healthcare. The roadmap comprises two drivers: person-centred care and health promotion; five critical enablers also need to be addressed: information technology, quality measures, infrastructure, incentive systems, and contracting strategies

Mapping midwifery and obstetric units in England

Objective: to describe the configuration of midwifery units, both alongside&free-standing, and obstetric units in England.Design: national survey amongst Heads of Midwifery in English Maternity ServicesSetting: National Health Service (NHS) in EnglandParticipants: English Maternity ServicesMeasurements: descriptive statistics of Alongside Midwifery Units and Free-standing Midwifery Units and Obstetric Units and their annual births/year in English Maternity ServicesFindings: alongside midwifery units have nearly doubled since 2010 (n = 53–97); free-standing midwifery units have increased slightly (n = 58–61). There has been a significant reduction in maternity services without either an alongside or free-standing midwifery unit (75–32). The percentage of all births in midwifery units has trebled, now representing 14% of all births in England. This masks significant differences in percentage of all births in midwifery units between different maternity services with a spread of 4% to 31%.Key conclusions: In some areas of England, women have no access to a local midwifery unit, despite the National Institute for Health&Clinical Excellence (NICE) recommending them as an important place of birth option for low risk women. The numbers of midwifery units have increased significantly in England since 2010 but this growth is almost exclusively in alongside midwifery units. The percentage of women giving birth in midwifery units varies significantly between maternity services suggesting that many midwifery units are underutilised.Implications for practice: Both the availability and utilisation of midwifery units in England could be improved