110 research outputs found

    Measuring procedures for surface evaluation of additively manufactured powder bed-based polymer and metal parts

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    AbstractPowder bed-based additive manufacturing has become increasingly important for industrial applications. In the light of this, qualitative considerations such as the geometrical accuracy, the resulting mechanical properties, and the surface quality of additively manufactured parts must be taken into account. Optical measuring techniques such as confocal laser scanning microscopy, fringe projection and focus variation as well as profilometers are evaluated here, to determine the surface quality of powder bed-based manufactured parts. Even though these surface evaluation methods are established commercially, no standardized measuring procedure has yet been established. Within an experimental study the validity and accuracy of surface measurement methods are evaluated below, taking the limitations of each measurement system and the comparability of areal surface textures into account. The examinations are carried out with the powder materials EN-AW2024, Ti-6V-4Al and PA12, which are processed by electron beam melting, and laser beam melting of metals and polymers. Guidance for a consistent and comparable surface evaluation is thereby provided

    Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures

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    The bone ingrowth potential of biomimetic hydroxyapatite and brushite coatings applied on porous E-beam structure was examined in goats and compared to a similar uncoated porous structure and a conventional titanium plasma spray coating. Specimens were implanted in the iliac crest of goats for a period of 3 (4 goats) or 15 weeks (8 goats). Mechanical implant fixation generated by bone ingrowth was analyzed by a push out test. Histomorphometry was performed to assess the bone ingrowth depth and bone implant contact. The uncoated and hydroxyapatite-coated cubic structure had significantly higher mechanical strength at the interface compared to the Ti plasma spray coating at 15 weeks of implantation. Bone ingrowth depth was significantly larger for the hydroxyapatite- and brushite-coated structures compared to the uncoated structure. In conclusion, the porous E-beam surface structure showed higher bone ingrowth potential compared to a conventional implant surface after 15 weeks of implantation. Addition of a calcium phosphate coating to the E-beam structure enhanced bone ingrowth significantly. Furthermore, the calcium phosphate coating appears to work as an accelerator for bone ingrowth

    Report from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)

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    This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23–24 April 2015 (HOME IV). The aim of the meeting was to achieve consensus over the preferred outcome instruments for measuring patient-reported symptoms and quality of life for the HOME core outcome set for atopic eczema (AE). Following presentations, which included data from systematic reviews, consensus discussions were held in a mixture of whole group and small group discussions. Small groups were allocated a priori to ensure representation of different stakeholders and countries. Decisions were voted on using electronic keypads. For the patient-reported symptoms, the group agreed by vote that itch, sleep loss, dryness, redness/inflamed skin and irritated skin were all considered essential aspects of AE symptoms. Many instruments for capturing patient-reported symptoms were discussed [including the Patient-Oriented SCOring Atopic Dermatitis index, Patient-Oriented Eczema Measure (POEM), Self-Administered Eczema Area and Severity Index, Itch Severity Scale, Atopic Dermatitis Quickscore and the Nottingham Eczema Severity Score] and, by consensus, POEM was selected as the preferred instrument to measure patient-reported symptoms. Further work is needed to determine the reliability and measurement error of POEM. Further work is also required to establish the importance of pain/soreness and the importance of collecting information regarding the intensity of symptoms in addition to their frequency. Much of the discussion on quality of life concerned the Dermatology Life Quality Index and Quality of Life Index for Atopic Dermatitis; however, consensus on a preferred instrument for measuring this domain could not be reached. In summary, POEM is recommended as the HOME core outcome instrument for measuring AE symptoms

    Effects of eight neuropsychiatric copy number variants on human brain structure

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    Impact of food processing and detoxification treatments on mycotoxin contamination

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