Basins of Attraction, Commitment Sets and Phenotypes of Boolean Networks

The attractors of Boolean networks and their basins have been shown to be highly relevant for model validation and predictive modelling, e.g., in systems biology. Yet there are currently very few tools available that are able to compute and visualise not only attractors but also their basins. In the realm of asynchronous, non-deterministic modeling not only is the repertoire of software even more limited, but also the formal notions for basins of attraction are often lacking. In this setting, the difficulty both for theory and computation arises from the fact that states may be ele- ments of several distinct basins. In this paper we address this topic by partitioning the state space into sets that are committed to the same attractors. These commitment sets can easily be generalised to sets that are equivalent w.r.t. the long-term behaviours of pre-selected nodes which leads us to the notions of markers and phenotypes which we illustrate in a case study on bladder tumorigenesis. For every concept we propose equivalent CTL model checking queries and an extension of the state of the art model checking software NuSMV is made available that is capa- ble of computing the respective sets. All notions are fully integrated as three new modules in our Python package PyBoolNet, including functions for visualising the basins, commitment sets and phenotypes as quotient graphs and pie charts

XMM-Newton observation of the Galactic supernova remnant W51C (G49.1-0.1)

The supernova remnant (SNR) W51C is a Galactic object located in a strongly inhomogeneous interstellar medium with signs of an interaction of the SNR blast wave with dense molecular gas. Diffuse X-ray emission from the interior of the SNR can reveal element abundances in the different emission regions and shed light on the type of supernova (SN) explosion and its progenitor. The hard X-ray emission helps to identify possible candidates for a pulsar formed in the SN explosion and for its pulsar wind nebula (PWN). We have analysed X-ray data obtained with XMM-Newton. Spectral analyses in selected regions were performed. Ejecta emission in the bright western part of the SNR, located next to a complex of dense molecular gas, was confirmed. The Ne and Mg abundances suggest a massive progenitor with a mass of > 20 M_sun. Two extended regions emitting hard X-rays were identified (corresponding to the known sources [KLS2002] HX3 west and CXO J192318.5+140305 discovered with ASCA and Chandra, respectively), each of which has an additional point source inside and shows a power-law spectrum with Gamma ~ 1.8. Based on their X-ray emission, both sources can be classified as PWN candidates.Comment: 6 pages, 4 figures, accepted for publication in Astronomy and Astrophysic

Validity and invariance of Turker’s corporate social responsibility scale in five cross-cultural samples

As organizational research turned its focus to Corporate Social Responsibility (CSR), interest also grew in the individual’s perspective on CSR. When looking for cross-cultural comparisons of the effects of CSR, measurement invariance is of utter importance as a questionnaire might not be equivalent in all investigated samples and thus bias results. We examined a previously published questionnaire assessing different aspects of personal CSR ratings. Factorial validity and measurement invariance was tested by means of confirmatory factor analysis and Bayesian structural equation modeling in five samples (total N = 1120): 2 US-American, 2 German, and 1 English-speaking Indian sample. In an exploratory-confirmatory approach, the originally proposed factor structure was altered to finally comprise four facets of CSR: employee-related CSR, environmental CSR, philanthropy and customer-related CSR. Measurement invariance tests showed evidence for small differences of the English and German version as well as significant divergences of the measurement model in the Indian sample. In conclusion, we show the validity of the questionnaire for a circumscribed Western context but are hesitant about further transfers. Future research on perception of CSR in non-western contexts might depend on new and tailored questionnaires

Occupational Strengths and Job Interests of Individuals with Asperger's Syndrome

Rooted in the neurodiversity approach, this study provides an overview of the strengths and interests of individuals with Asperger's Syndrome. We interviewed136 individuals with Asperger's Syndrome and 155 neurotypical individuals via an online survey with regards to (a) demography, (b) occupational strengths, (c) general self-efficacy, (d) occupational self- efficacy, and (e) the job interest profile according to Holland. The vocational and educational fields of the individuals with Asperger's in the sample are more diverse than and surpass those classical fields stated in research and biographical literature. The comparison of both groups in cross- tables showed that the indicated strengths differ in several areas (ΦCramer = .02–.47), which means that a specific strength profile can be derived, and this profile goes beyond the clinical view of the diagnostic criteria. Individuals with Asperger's indicate lower self-efficacy, both general and occupational. Furthermore, a high concentration of individuals with Asperger's can be found in the areas I (Investigative) and C (Conventional) of Holland's RIASEC model

Comparing Job-Related Barriers and Possible Solutions in and outside of Autism-Specific Employment

The aim of this study was to discover how individuals with autism succeed in entering the job market. We therefore sought to identify expected and occurred barriers, keeping them from taking up and staying in employment as well as to identify the solutions used to overcome these barriers. Sixty-six employed individuals with autism–17 of them with autism-specific employment–participated in an online survey. Results showed a variety of possible barriers. Individuals in autism-specific employment named formality problems–problems with organizational and practical process-related aspects of the job entry–most frequently while individuals in non-autism-specific employment mentioned social problems–obstacles concerning communication and human interaction–most. In terms of solutions, both groups used their own resources as much as external help, but differed in their specific strategies. In addition, correlations of an autism-specific employment with general and occupational self-efficacy as well as life and job satisfaction were examined. Possible implications of the results are discussed with regard to problem solving behavior and the use of strengths

Construction and Validation of the Compound PsyCap Scale (CPC-12)

With the Psychological Capital Questionnaire (PCQ) being the standard measure to assess psychological capital (PsyCap) in the context of organizations, this paper aims to broaden this domain-specific approach by introducing a measure with universal claim. Two studies were conducted to create and validate a German self-report scale (CPC-12) measuring PsyCap. We performed confirmatory factor analyses and correlations with other positive psychological constructs on the data of two German samples (N1 = 321; N2 = 202). The twelve-item CPC-12 exhibits the anticipated factorial structure with a very good model fit and associations to other constructs concur with previous findings with other measures of PsyCap

Eschatology in the Teachings of Jesus

A study of biblical language about kingdom and life reveals that both terms are eschatological and that both emphasize the quality of Christian living rather than presenting a timetable for the advent of the Parousia. Jesus brings both and calls men to decision. Kingdom and life are present possessions of believers, and the day of judgment will bring their culmination. When Jesus spoke of the signs of His Parousia, He was speaking of the signs that point to the coming of the Son of Man rather than to the actual coming itself. Eschatological hope characterizes all that the Christian does

Measurement of the 70Ge(n,γ) cross section up to 300 keV at the CERN n_TOF facility

Neutron capture data on intermediate mass nuclei are of key importance to nucleosynthesis in the weak component of the slow neutron capture processes, which occurs in massive stars. The (n,γ) cross section on 70Ge, which is mainly produced in the s process, was measured at the neutron time-of-flight facility n_TOF at CERN. Resonance capture kernels were determined up to 40 keV neutron energy and average cross sections up to 300 keV. Stellar cross sections were calculated from kT =5 keV tokT =100 keV and are in very good agreement with a previous measurement by Walter and Beer (1985) and recent evaluations. Average cross sectionsareinagreementwithWalterandBeer(1985)overmostoftheneutronenergyrangecovered,whilethey aresystematicallysmallerforneutronenergiesabove150keV.Wehavecalculatedisotopicabundancesproduced in s-process environments in a 25 solar mass star for two initial metallicities (below solar and close to solar). While the low metallicity model reproduces best the solar system germanium isotopic abundances, the close to solar model shows a good global match to solar system abundances in the range of mass numbers A=60–80.Austrian Science Fund J3503Adolf Messer Foundation ST/M006085/1European Research Council ERC2015-StGCroatian Science Foundation IP-2018-01-857