Basins of Attraction, Commitment Sets and Phenotypes of Boolean Networks

The attractors of Boolean networks and their basins have been shown to be highly relevant for model validation and predictive modelling, e.g., in systems biology. Yet there are currently very few tools available that are able to compute and visualise not only attractors but also their basins. In the realm of asynchronous, non-deterministic modeling not only is the repertoire of software even more limited, but also the formal notions for basins of attraction are often lacking. In this setting, the difficulty both for theory and computation arises from the fact that states may be ele- ments of several distinct basins. In this paper we address this topic by partitioning the state space into sets that are committed to the same attractors. These commitment sets can easily be generalised to sets that are equivalent w.r.t. the long-term behaviours of pre-selected nodes which leads us to the notions of markers and phenotypes which we illustrate in a case study on bladder tumorigenesis. For every concept we propose equivalent CTL model checking queries and an extension of the state of the art model checking software NuSMV is made available that is capa- ble of computing the respective sets. All notions are fully integrated as three new modules in our Python package PyBoolNet, including functions for visualising the basins, commitment sets and phenotypes as quotient graphs and pie charts

XMM-Newton observation of the Galactic supernova remnant W51C (G49.1-0.1)

The supernova remnant (SNR) W51C is a Galactic object located in a strongly inhomogeneous interstellar medium with signs of an interaction of the SNR blast wave with dense molecular gas. Diffuse X-ray emission from the interior of the SNR can reveal element abundances in the different emission regions and shed light on the type of supernova (SN) explosion and its progenitor. The hard X-ray emission helps to identify possible candidates for a pulsar formed in the SN explosion and for its pulsar wind nebula (PWN). We have analysed X-ray data obtained with XMM-Newton. Spectral analyses in selected regions were performed. Ejecta emission in the bright western part of the SNR, located next to a complex of dense molecular gas, was confirmed. The Ne and Mg abundances suggest a massive progenitor with a mass of > 20 M_sun. Two extended regions emitting hard X-rays were identified (corresponding to the known sources [KLS2002] HX3 west and CXO J192318.5+140305 discovered with ASCA and Chandra, respectively), each of which has an additional point source inside and shows a power-law spectrum with Gamma ~ 1.8. Based on their X-ray emission, both sources can be classified as PWN candidates.Comment: 6 pages, 4 figures, accepted for publication in Astronomy and Astrophysic

Eschatology in the Teachings of Jesus

A study of biblical language about kingdom and life reveals that both terms are eschatological and that both emphasize the quality of Christian living rather than presenting a timetable for the advent of the Parousia. Jesus brings both and calls men to decision. Kingdom and life are present possessions of believers, and the day of judgment will bring their culmination. When Jesus spoke of the signs of His Parousia, He was speaking of the signs that point to the coming of the Son of Man rather than to the actual coming itself. Eschatological hope characterizes all that the Christian does

Parietal Dwellings

My work is inspired by the mysterious qualities of our earth, and the beings that inhabit it. I reference nature, biology, architecture, and popular culture to make works which encourage contemplation. I am creating my own personal history through the making, as well as inviting the communal connection. This body of work aims to create a space filled with juxtapositions, optical illusions, and familiar materials. Inspired by lucid dreaming, the work puts a twist on assumed normalcy in our environment

The Return of the Rachel- A Critique of Melville\u27s Moby-Dick

This critique is to clarify the relation of the ship Rachel to the rest of the story. The Rachel carries with it certain symbolical implications that have been neglected in in interpretations and criticisms of Moby-Dick. In chapter CXXVIII, “The Pequod Meets the Rachel,” the symbolic meaning suggest Jacob’s wife Rachel crying in the wilderness because her sons are not, Jeremiah 31:15. The continuation of this symbolism in the epilogue would include a more definite recognition of the influence of Christianity on Melville then some critics would admit, namely, that Ishmael’s rescue by the Rachel symbolically is Christian brotherly love effecting it universal significance in answer to Melville’s problem

Occupational Strengths and Job Interests of Individuals with Asperger's Syndrome

Rooted in the neurodiversity approach, this study provides an overview of the strengths and interests of individuals with Asperger's Syndrome. We interviewed136 individuals with Asperger's Syndrome and 155 neurotypical individuals via an online survey with regards to (a) demography, (b) occupational strengths, (c) general self-efficacy, (d) occupational self- efficacy, and (e) the job interest profile according to Holland. The vocational and educational fields of the individuals with Asperger's in the sample are more diverse than and surpass those classical fields stated in research and biographical literature. The comparison of both groups in cross- tables showed that the indicated strengths differ in several areas (ΦCramer = .02–.47), which means that a specific strength profile can be derived, and this profile goes beyond the clinical view of the diagnostic criteria. Individuals with Asperger's indicate lower self-efficacy, both general and occupational. Furthermore, a high concentration of individuals with Asperger's can be found in the areas I (Investigative) and C (Conventional) of Holland's RIASEC model

The Common Good Balance Sheet and Employees’ Perceptions, Attitudes and Behaviors

The Common Good Balance Sheet (CGB) is an instrument to measure a company’s contribution to the common good. In our study, we investigate whether employees from companies with higher CBG scores perceive more corporate social responsibility than employees from companies with lower CBG scores and whether relationships can be found between the achieved CGB scores and employees’ job-related attitudes and behaviors. We conducted an online survey of 332 employees from eight German companies with published CGBs. According to results from multiple linear regression analyses, employees from companies with higher CGB scores perceive more CSR and are more satisfied with their jobs and payments. In addition, they report less job demands, more organizational support, more work meaningfulness and more organizational citizenship behaviors towards their company. Employees identify more with their company if high transparency and co-determination is practiced. However, the value and social impact of the companies’ products is not related to employees’ organizational identification. Moreover, employees from companies with high CGB scores do not report more organizational citizenship behaviors towards their colleagues. Our results indicate that the CGB is a tool that measures aspects concerning job-related attitudes and behaviors and allows comparability between companies. However, aspects relevant to job satisfaction may still be missing in the CGB scoring