Two results from Morita theory of stable model categories

We prove two results from Morita theory of stable model categories. Both can be regarded as topological versions of recent algebraic theorems. One is on recollements of triangulated categories, which have been studied in the algebraic case by Jørgensen. We give a criterion which answers the following question: When is there a recollement for the derived category of a given symmetric ring spectrum in terms of two other symmetric ring spectra? The other result is on well generated triangulated categories in the sense of Neeman. Porta characterizes the algebraic well generated categories as localizations of derived categories of DG categories. We prove a topological analogon: a topological triangulated category is well generated if and only if it is triangulated equivalent to a localization of the derived category of a symmetric ring spectrum with several objects. Here `topological' means triangulated equivalent to the homotopy category of a spectral model category. Moreover, we show that every well generated spectral model category is Quillen equivalent to a Bousfield localization of a category of modules via a single Quillen functor

Towards understanding crossover for Cartesian Genetic Programming

Unlike in traditional Genetic Programming, Cartesian Genetic Programming (CGP) does not commonly feature a recombination/crossover operator, although recombination plays an important role in other evolutionary techniques, including Genetic Programming from which CGP originates. Instead, CGP mainly depends on mutation and selection operators in their evolutionary search. To this day, it is still unclear as to why CGP’s performance does not generally improve with the addition of crossover. In this work, we argue that CGP’s positional bias might be a reason for this phenomenon. This bias describes a skewed distribution of active and inactive nodes, which might lead to destructive behaviour of standard recombination operators. We provide a first assessment with preliminary results. No final conclusion to this hypothesis can be drawn yet, as more thorough evaluations must be done first. However, our first results show promising trends and may lay the foundationf or future work

Process Stabilization at welding Copper by Laser Power Modulation

AbstractDue to their material properties such as high electrical and thermal conductivity, copper materials are more and more demanded for industrial applications. The same material properties make laser welding of copper a challenging task. Laser welds often suffer from defective weld seams with ejections, pores and a large fluctuation in the penetration depth. In this paper the influence of laser power modulation during copper welding on weld imperfections is discussed. It is shown that a sinusoidal power modulation leads to a strong reduction of melt ejections and also to an increase in penetration depth

Characterization of an Aldehyde Oxidoreductase From the Mesophilic Bacterium Aromatoleum aromaticum EbN1, a Member of a New Subfamily of Tungsten-Containing Enzymes

The biochemical properties of a new tungsten-containing aldehyde oxidoreductase from the mesophilic betaproteobacterium Aromatoleum aromaticum EbN1 (AORAa) are presented in this study. The enzyme was purified from phenylalanine-grown cells of an overexpressing mutant lacking the gene for an aldehyde dehydrogenase normally involved in anaerobic phenylalanine degradation. AORAa catalyzes the oxidation of a broad variety of aldehydes to the respective acids with either viologen dyes or NAD+ as electron acceptors. In contrast to previously known AORs, AORAa is a heterohexameric protein consisting of three different subunits, a large subunit containing the W-cofactor and an Fe-S cluster, a small subunit containing four Fe-S clusters, and a medium subunit containing an FAD cofactor. The presence of the expected cofactors have been confirmed by elemental analysis and spectrophotometric methods. AORAa has a pH optimum of 8.0, a temperature optimum of 40°C and is completely inactive at 50°C. Compared to archaeal AORs, AORAa is remarkably resistant against exposure to air, exhibiting a half-life time of 1 h as purified enzyme and being completely unaffected in cell extracts. Kinetic parameters of AORAa have been obtained for the oxidation of one aliphatic and two aromatic aldehydes, resulting in about twofold higher kcat values with benzyl viologen than with NAD+ as electron acceptor. Finally, we obtained evidence that AORAa is also catalyzing the reverse reaction, reduction of benzoate to benzaldehyde, albeit at very low rates and under conditions strongly favoring acid reduction, e.g., low pH and using Ti(III) citrate as electron donor of very low redox potential. AORAa appears to be a prototype of a new subfamily of bacterial AOR-like tungsten-enzymes, which differ from the previously known archaeal AORs mostly by their multi-subunit composition, their low sensitivity against oxygen, and the ability to use NAD+ as electron acceptor

Why we fail: mechanisms and co-factors of unsuccessful thrombectomy in acute ischemic stroke

Purpose Mechanical thrombectomy (MT) is an effective treatment for patients suffering from acute ischemic stroke. However, recanalization fails in about 16.5% of interventions. We report our experience with unsuccessful MT and analyze technical reasons plus patient-related parameters for failure. Methods Five hundred ninety-six patients with acute ischemic stroke in the anterior circulation and intention to perform MT with an aspiration catheter and/or stent retriever were analyzed. Failure was defined as 0, 1, or 2a on the mTICI scale. Patients with failing MT were analyzed for interventional progress and compared to patients with successful intervention, whereby parameters included demographics, medical history, stroke presentation, and treatment. Results One hundred of the 596 (16.8%) interventions failed. In 20 cases, thrombus could not be accessed or passed with the device. Peripheral arterial occlusive disease is common in those patients. In 80 patients, true stent retriever failure occurred. In this group, coagulation disorders are associated with poor results, whereas atrial fibrillation is associated with success. The administration of intravenous thrombolysis and intake of nitric oxide donors are associated with recanalization success. Intervention duration was significantly longer in the failing group. Conclusion In 20% of failing MT, thrombus cannot be reached/passed. Direct carotid puncture or surgical arterial access could be considered in these cases. In 80% of failing interventions, thrombus can be passed with the device, but the occluded vessel cannot be recanalized. Rescue techniques can be an option. Development of new devices and techniques is necessary to improve recanalization rates. Assessment of pre-existing illness could sensitize for occurring complications

A self-referenced in-situ arrival time monitor for X-ray free-electron lasers

We present a novel, highly versatile, and self-referenced arrival time monitor for measuring the femtosecond time delay between a hard X-ray pulse from a free-electron laser and an optical laser pulse, measured directly on the same sample used for pump-probe experiments. Two chirped and picosecond long optical supercontinuum pulses traverse the sample with a mutually fixed time delay of 970 fs, while a femtosecond X-ray pulse arrives at an instant in between both pulses. Behind the sample the supercontinuum pulses are temporally overlapped to yield near-perfect destructive interference in the absence of the X-ray pulse. Stimulation of the sample with an X-ray pulse delivers non-zero contributions at certain optical wavelengths, which serve as a measure of the relative arrival time of the X-ray pulse with an accuracy of better than 25 fs. We find an excellent agreement of our monitor with the existing timing diagnostics at the SACLA XFEL with a Pearson correlation value of 0.98. We demonstrate a high sensitivity to measure X-ray pulses with pulse energies as low as 30 $\mu$J. Using a free-flowing liquid jet as interaction sample ensures the full replacement of the sample volume for each X-ray/optical event, thus enabling its utility even at MHz repetition rate XFEL sources

AI-based multi-PRS models outperform classical single-PRS models

Polygenic risk scores (PRS) calculate the risk for a specific disease based on the weighted sum of associated alleles from different genetic loci in the germline estimated by regression models. Recent advances in genetics made it possible to create polygenic predictors of complex human traits, including risks for many important complex diseases, such as cancer, diabetes, or cardiovascular diseases, typically influenced by many genetic variants, each of which has a negligible effect on overall risk. In the current study, we analyzed whether adding additional PRS from other diseases to the prediction models and replacing the regressions with machine learning models can improve overall predictive performance. Results showed that multi-PRS models outperform single-PRS models significantly on different diseases. Moreover, replacing regression models with machine learning models, i.e., deep learning, can also improve overall accuracy

Recommendations for the Visibility of Open Access Publications in the Search Engine of the Austrian Library Network: Report of the OBV Working Group “Repositories in the Network”

Im vorliegenden Beitrag werden die Ergebnisse der OBV-Arbeitsgruppe „Repositorien im Verbund“ präsentiert. Die AG verfolgte das Ziel, einen Leitfaden für die Erfassung von Metadaten für Objekte in Repositorien, der dazu beiträgt, einheitliche Standards in dieser Hinsicht zu entwickeln, mit dessen Hilfe es in weiterer Folge ermöglicht werden soll, Repositorienbestände ohne Erzeugung von Dubletten in Alma bzw. im Verbundkatalog nachzuweisen. Weitere Ziele waren die Erarbeitung von Empfehlungen für eine zentrale Bereitstellung von Metadaten von Open Access-Publikationen zur Vereinfachung der lokalen Workflows (analog zum DFG-geförderten Projekt DeepGreen) mittels Teilautomatisierung sowie von Empfehlungen für eine Etablierung eines Reiters für Open Access-Materialien in der Suchmaschine des Österreichischen Bibliothekenverbundes (analog zu den Reitern „Fachliteratur“, „Hochschulschriften“ und „Nachlässe / Handschriften“).This paper presents the results of the OBV working group “Repositories in the Austrian Library Network”. The aim of the working group was to develop a guideline for the registration of metadata for objects in repositories, which would contribute to the development of uniform standards in this regard, and with the help of which it should subsequently be possible to identify repository holdings in Alma or in the Austrian Union Catalogue without creating duplicates. Further goals were the development of recommendations for a central provision of metadata of open access publications to simplify local workflows (analogous to the DFG-funded project DeepGreen) by means of partial automation, as well as recommendations for establishing a tab for open access materials in the search engine of the Austrian Library Network (analogous to the tabs “Literature”, “Theses and Dissertations” and “Bequests / Autographs”)

Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study

IntroductionCommunity-acquired pneumonia (CAP) and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in high morbidity, mortality, and socio-economic burden. The usage of easily accessible biomarkers informing on disease entity, severity, prognosis, and pathophysiological endotypes is limited in clinical practice. Here, we have analyzed selected plasma markers for their value in differential diagnosis and severity grading in a clinical cohort.MethodsA pilot cohort of hospitalized patients suffering from CAP (n = 27), AECOPD (n = 10), and healthy subjects (n = 22) were characterized clinically. Clinical scores (PSI, CURB, CRB65, GOLD I-IV, and GOLD ABCD) were obtained, and interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-2-receptor (IL-2R), lipopolysaccharide-binding protein (LBP), resistin, thrombospondin-1 (TSP-1), lactotransferrin (LTF), neutrophil gelatinase-associated lipocalin (NGAL), neutrophil-elastase-2 (ELA2), hepatocyte growth factor (HGF), soluble Fas (sFas), as well as TNF-related apoptosis-inducing ligand (TRAIL) were measured in plasma.ResultsIn CAP patients and healthy volunteers, we found significantly different levels of ELA2, HGF, IL-2R, IL-6, IL-8, LBP, resistin, LTF, and TRAIL. The panel of LBP, sFas, and TRAIL could discriminate between uncomplicated and severe CAP. AECOPD patients showed significantly different levels of LTF and TRAIL compared to healthy subjects. Ensemble feature selection revealed that CAP and AECOPD can be discriminated by IL-6, resistin, together with IL-2R. These factors even allow the differentiation between COPD patients suffering from an exacerbation or pneumonia.DiscussionTaken together, we identified immune mediators in patient plasma that provide information on differential diagnosis and disease severity and can therefore serve as biomarkers. Further studies are required for validation in bigger cohorts