Gravity and gravity gradient from spherical harmonics, case 310

Explicit and recursive formulas for acceleration and gravity gradient derived from spherical harmonic

Relationships between geographic and inertial coordinates of position

Relationships between geographic and inertial coordinates of positio

Unnormalized associated Legendre functions: A compendium of graphs, expansions, properties, and integrals

Compendium of graphs, expansions, propertites, and integrals for unnormalized associated Legendre function

Decline in HIV Prevalence among Young Women in Zambia: National-Level Estimates of Trends Mask Geographical and Socio-Demographic Differences

Background: A decline in HIV incidence has been reported in Zambia and a number of other sub-Saharan countries. The trend of HIV prevalence among young people is a good marker of HIV incidence. In this study, different data sources are used to examine geographical and sub-population group differentials in HIV prevalence trends among men and women aged 15–24 years in Zambia. Design and Methods: We analysed ANC data for women aged 15–24 years from 22 sentinel sites consistently covered in the period 1994–2008, and HIV data for young men and women aged 15–24 years from the ZDHS 2001/2 and 2007. In addition, we systematically reviewed peer-reviewed articles that have reported findings on HIV prevalence and incidence among young people. Findings: Overall trends of the ANC surveillance data indicated a substantial HIV prevalence decline among young women in both urban and rural areas. However, provincial declines differed substantially, i.e. between 10 % and 68 % among urban women, and from stability to 86 % among rural women. Prevalence declines were steeper among those with the highest educational attainments than among the least educated. The ZDHS data indicated a significant reduction in prevalence between the two survey rounds among young women only. Provincial-level ZDHS changes were difficult to assess because the sample sizes were small. ANC-based trend patterns were consistent with those observed in PMTCT-based data (2002

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood [1, 2]. Using a metabolomics approach with isotope labeling, we found that in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase (PHGDH). An analysis of human cancers showed that PHGDH is recurrently amplified in a genomic region of focal copy number gain most commonly found in melanoma. Decreasing PHGDH expression impaired proliferation in amplified cell lines. Increased expression was also associated with breast cancer subtypes, and ectopic expression of PHGDH in mammary epithelial cells disrupted acinar morphogenesis and induced other phenotypic alterations that may predispose cells to transformation. Our findings show that the diversion of glycolytic flux into a specific alternate pathway can be selected during tumor development and may contribute to the pathogenesis of human cancer.National Institutes of Health (U.S.)National Cancer Institute (U.S.)Smith Family FoundationDamon Runyon Cancer Research FoundationBurroughs Wellcome Fun

Understanding the Impacts of Outdoor Air Pollution on Social Inequality: Advancing a Just Transition Framework

Outdoor air pollution is a major environmental risk that caused over 4.2 million premature deaths worldwide in 2016. In this article, we investigate how groups with lower social-economic status are disproportionally affected by outdoor air pollution. Based on a comparative case study of two heavily polluted urban areas around Beijing and Delhi, we find that people's economic welfare and political rights are affected disproportionally not only by toxic air pollutants, but also through various policy interventions, market activities, and social practices designed to reduce or adapt to air pollution. Drawing on the concepts of environmental justice and just transitions, we present an analytical framework for investigating the links between outdoor air pollution and social inequalities. The framework enables a better understanding of structural constraints, political constraints and protective constraints in the context of outdoor air pollution and their impacts on social vulnerabilities with particular relevance to fast industrialising countries. We also provide recommendations on how to design and implement air pollution policies and social interventions in a socially inclusive manner