8,575 research outputs found
Modeling of intrinsic electron and hole trapping in crystalline and amorphous ZnO
Recent advances in ultrafast liquid quenching and deposition of thin films on cold substrates make growing amorphous (a)‐ZnO films increasingly feasible. The electronic structure and electron and hole trapping properties of amorphous ZnO are predicted using density functional theory (DFT) simulations with a hybrid density functional (h‐DFT). An ensemble of fifty 324‐atom structures is employed to obtain the distribution of structural and electronic properties of a‐ZnO. The results demonstrate that electrons do not localize in a‐ZnO, but holes form deep localized states with average trapping energy of about 0.9 eV. It is also shown that dispersion at the conduction band minimum (CBM) is not affected upon amorphization, suggesting that high electron mobility should be retained. An average value of a‐ZnO band gap of 3.36 eV is calculated with no states splitting into the band gap, which accounts for no substantial detrimental effect on the optical transparency upon amorphization. These findings may have important implications for future applications of a‐ZnO as a transparent conductor and photocatalyst
Two-Stream Instability of Counter-Rotating Galaxies
The present study of the two-stream instability in stellar disks with
counter-rotating components of stars and/or gas is stimulated by recently
discovered counter-rotating spiral and S0 galaxies. Strong linear two-stream
instability of tightly-wrapped spiral waves is found for one and two-armed
waves with the pattern angular speed of the unstable waves always intermediate
between the angular speed of the co-rotating matter () and that of the
counter-rotating matter (). The instability arises from the
interaction of positive and negative energy modes in the co- and
counter-rotating components. The unstable waves are in general convective -
they move in radius and radial wavenumber space - with the result that
amplification of the advected wave is more important than the local growth
rate. For a galaxy of co-rotating stars and counter-rotating stars of
mass-fraction , or of counter-rotating gas of mass-fraction
, the largest amplification is usually for the one-armed
leading waves (with respect to the co-rotating stars). For the case of both
counter-rotating stars and gas, the largest amplifications are for , also for one-armed leading waves. The two-armed trailing
waves usually have smaller amplifications. The growth rates and amplifications
all decrease as the velocity spreads of the stars and/or gas increase. It is
suggested that the spiral waves can provide an effective viscosity for the gas
causing its accretion.Comment: 14 pages, submitted to ApJ. One table and 17 figures can be obtained
by sending address to R. Lovelace at [email protected]
The frequency and properties of young tidal dwarf galaxies in nearby gas-rich groups
We present high-resolution Giant Metrewave Radio Telescope (GMRT) HI
observations and deep Canada-France-Hawaii Telescope (CFHT) optical imaging of
two galaxy groups: NGC 4725/47 and NGC 3166/9. These data are part of a
multi-wavelength unbiased survey of the gas-rich dwarf galaxy populations in
three nearby interacting galaxy groups. The NGC 4725/47 group hosts two tidal
knots and one dIrr. Both tidal knots are located within a prominent HI tidal
tail, appear to have sufficient mass (M_gas~10^8 M_sol) to evolve into
long-lived tidal dwarf galaxies (TDGs) and are fairly young in age. The NGC
3166/9 group contains a TDG candidate, AGC 208457, at least three dIrrs and
four HI knots. Deep CFHT imaging confirms that the optical component of AGC
208457 is bluer -- with a 0.28 mag g-r colour -- and a few Gyr younger than its
purported parent galaxies. Combining the results for these groups with those
from the NGC 871/6/7 group reported earlier, we find that the HI properties,
estimated stellar ages and baryonic content of the gas-rich dwarfs clearly
distinguish tidal features from their classical counterparts. We optimistically
identify four potentially long-lived tidal objects associated to three separate
pairs of interacting galaxies, implying that TDGs are not readily produced
during interaction events as suggested by some recent simulations. The tidal
objects examined in this survey also appear to have a wider variety of
properties than TDGs of similar mass formed in current simulations of
interacting galaxies, which could be the result of pre- or post-formation
environmental influences.Comment: 18 pages, 14 figures, accepted for publication in MNRA
The representation of abstract task rules in the human prefrontal cortex
We have previously reported sustained activation in the ventral
prefrontal cortex while participants prepared to perform 1 of 2 tasks
as instructed. But there are studies that have reported activation
reflecting task rules elsewhere in prefrontal cortex, and this is true in
particular when it was left to the participants to decide which rule to
obey. The aim of the present experiment was to use functional
magnetic resonance imaging (fMRI) to find whether there was
activation in common, irrespective of the way that the task rules
were established. On each trial, we presented a word after a variable
delay, and participants had to decide either whether the word was
abstract or concrete or whether it had 2 syllables. The participants
either decided before the delay which task they would perform or
were instructed by written cues. Comparing the self-generated with
the instructed trials, there was early task set activation during the
delay in the middle frontal gyrus. On the other hand, a conjunction
analysis revealed sustained activation in the ventral prefrontal and
polar cortex for both conditions. We argue that the ventral prefrontal
cortex is specialized for handling conditional rules regardless of how
the task rules were established
Galleria mellonella as a host model to study Candida glabrata virulence and antifungal efficacy
This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this record.This work was supported in part by the Wellcome Trust Strategic
Award for Medical Mycology and Fungal Immunology 097377/Z/11/
Multiple prebiotic metals mediate translation.
Today, Mg2+ is an essential cofactor with diverse structural and functional roles in life's oldest macromolecular machine, the translation system. We tested whether ancient Earth conditions (low O2, high Fe2+, and high Mn2+) can revert the ribosome to a functional ancestral state. First, SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension) was used to compare the effect of Mg2+, Fe2+, and Mn2+ on the tertiary structure of rRNA. Then, we used in vitro translation reactions to test whether Fe2+ or Mn2+ could mediate protein production, and quantified ribosomal metal content. We found that (i) Mg2+, Fe2+, and Mn2+ had strikingly similar effects on rRNA folding; (ii) Fe2+ and Mn2+ can replace Mg2+ as the dominant divalent cation during translation of mRNA to functional protein; and (iii) Fe and Mn associate extensively with the ribosome. Given that the translation system originated and matured when Fe2+ and Mn2+ were abundant, these findings suggest that Fe2+ and Mn2+ played a role in early ribosomal evolution
Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis
Particularly interesting new cysteine-histidine-rich protein (PINCH) protein is part of the ternary complex known as the IPP (integrin linked kinase (ILK)-PINCH-Parvin-α) complex. PINCH itself binds to ILK and to another protein known as Rsu-1 (Ras suppressor 1). We generated PINCH 1 and PINCH 2 Double knockout mice (referred as PINCH DKO mice). PINCH2 elimination was systemic whereas PINCH1 elimination was targeted to hepatocytes. The genetically modified mice were born normal. The mice were sacrificed at different ages after birth. Soon after birth, they developed abnormal hepatic histology characterized by disorderly hepatic plates, increased proliferation of hepatocytes and biliary cells and increased deposition of extracellular matrix. After a sustained and prolonged proliferation of all epithelial components, proliferation subsided and final liver weight by the end of 30 weeks in livers with PINCH DKO deficient hepatocytes was 40% larger than the control mice. The livers of the PINCH DKO mice were also very stiff due to increased ECM deposition throughout the liver, with no observed nodularity. Mice developed liver cancer by one year. These mice regenerated normally when subjected to 70% partial hepatectomy and did not show any termination defect. Ras suppressor 1 (Rsu-1) protein, the binding partner of PINCH is frequently deleted in human liver cancers. Rsu-1 expression is dramatically decreased in PINCH DKO mouse livers. Increased expression of Rsu-1 suppressed cell proliferation and migration in HCC cell lines. These changes were brought about not by affecting activation of Ras (as its name suggests) but by suppression of Ras downstream signaling via RhoGTPase proteins. In conclusion, our studies suggest that removal of PINCH results in enlargement of liver and tumorigenesis. Decreased levels of Rsu-1, a partner for PINCH and a protein often deleted in human liver cancer, may play an important role in the development of the observed phenotype. © 2013 Donthamsetty et al
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