Bidirectional ventricular tachycardia in cardiac sarcoidosis.

A 73-year-old man with history of pulmonary sarcoidosis was found to have runs of non-sustained bidirectional ventricular tachycardia (BVT) with two different QRS morphologies on a Holter monitor. Cardiac magnetic resonance delayed gadolinium imaging revealed a region of patchy mid-myocardial enhancement within the left ventricular basal inferolateral myocardium. An 18-fluorodeoxyglucose positron emission tomography (FDG-PET) showed increased uptake in the same area, consistent with active sarcoid, with no septal involvement. Follow-up FDG-PET one year later showed disease progression with new septal involvement. Cardiac sarcoidosis, characterized by myocardial inflammation and interstitial fibrosis that can lead to conduction system disturbance and macro re-entrant arrhythmias, should be considered in differential diagnosis of BVT. BVT may indicate septal involvement with sarcoidosis before the lesions are large enough to be detected radiologically

Exoplanetary atmosphere target selection in the era of comparative planetology

The large number of new planets expected from wide-area transit surveys means that follow-up transmission spectroscopy studies of their atmospheres will be limited by the availability of telescope assets. We argue that telescopes covering a broad range of apertures will be required, with even 1m-class instruments providing a potentially important contribution. Survey strategies that employ automated target selection will enable robust population studies. As part of such a strategy, we propose a decision metric to pair the best target to the most suitable telescope, and demonstrate its effectiveness even when only primary transit observables are available. Transmission spectroscopy target selection need not therefore be impeded by the bottle-neck of requiring prior follow-up observations to determine the planet mass. The decision metric can be easily deployed within a distributed heterogeneous network of telescopes equipped to undertake either broadband photometry or spectroscopy. We show how the metric can be used either to optimise the observing strategy for a given telescope (e.g. choice of filter) or to enable the selection of the best telescope to optimise the overall sample size. Our decision metric can also provide the basis for a selection function to help evaluate the statistical completeness of follow-up transmission spectroscopy datasets. Finally, we validate our metric by comparing its ranked set of targets against lists of planets that have had their atmospheres successfully probed, and against some existing prioritised exoplanet lists.Comment: 20 pages, 16 figures, 3 tables. Revision 3, accepted by MNRAS. Improvements include always using planetary masses where available and reliable, treatment for sky backgrounds and out-of-transit noise and a use case for defocused photometr

Advanced magneto-optical microscopy: Imaging from picoseconds to centimeters - imaging spin waves and temperature distributions (invited)

© 2016 Author(s).Recent developments in the observation of magnetic domains and domain walls by wide-field optical microscopy based on the magneto-optical Kerr, Faraday, Voigt, and Gradient effect are reviewed. Emphasis is given to the existence of higher order magneto-optical effects for advanced magnetic imaging. Fundamental concepts and advances in methodology are discussed that allow for imaging of magnetic domains on various length and time scales. Time-resolved imaging of electric field induced domain wall rotation is shown. Visualization of magnetization dynamics down to picosecond temporal resolution for the imaging of spin-waves and magneto-optical multi-effect domain imaging techniques for obtaining vectorial information are demonstrated. Beyond conventional domain imaging, the use of a magneto-optical indicator technique for local temperature sensing is shown

A statistical model with a standard Gamma distribution

We study a statistical model consisting of $N$ basic units which interact with each other by exchanging a physical entity, according to a given microscopic random law, depending on a parameter $\lambda$. We focus on the equilibrium or stationary distribution of the entity exchanged and verify through numerical fitting of the simulation data that the final form of the equilibrium distribution is that of a standard Gamma distribution. The model can be interpreted as a simple closed economy in which economic agents trade money and a saving criterion is fixed by the saving propensity $\lambda$. Alternatively, from the nature of the equilibrium distribution, we show that the model can also be interpreted as a perfect gas at an effective temperature $T(\lambda)$, where particles exchange energy in a space with an effective dimension $D(\lambda)$.Comment: 5 pages, including 4 figures. Uses REVTeX styl

Aqueous-Based Extrusion Fabrication of Ceramics on Demand

Aqueous-Based Extrusion Fabrication is an additive manufacturing technique that extrudes ceramic slurries of high solids loading layer by layer for part fabrication. The material reservoir in a previously developed system has been modified to allow for starting and stopping of the extrusion process on demand. Design pros and cons are examined and a comparison between two material reservoir designs is made. Tests are conducted to determine the optimal deposition parameters for starting and stopping the extrudate on demand. The collected test data is used for the development of a deposition strategy that improves material deposition consistency, including reduced material buildup at sharp corners. Example parts are fabricated using the deposition strategy and hardware design.Mechanical Engineerin

Bump start needed: linking guidelines, policy and practice in promoting physical activity during and beyond pregnancy

First paragraph: There is compelling evidence that regular physical activity (PA) during pregnancy benefits both mother and baby.1 2 Notably, physical and psychological benefits are evident in the literature, such as marked reductions in the development of gestational diabetes and hypertensive disorders, alongside improvements in depressive symptoms and cardiorespiratory fitness.1 2 The evidence base has been reflected by recent policy initiatives, for example, in 2017 (relaunched in 2019), the UK‘s chief medical officers (CMOs) published PA guidelines for pregnant women, which made substantial strides in unifying and translating the evidence into recommendations.1 The CMO guidelines are aimed at supporting health professionals to provide consistent, evidence-based PA messages to women throughout pregnancy.1 Recently, the Chartered Institute for the Management of Sport and Physical Activity have updated their professional standards for working with antenatal and postnatal clients to align with these CMO guidelines.3 However, not all women have access to professionals with this level of expertise and training, potentially limiting the impact of the CMO guidelines

Probing gas and dust in the tidal tail of NGC 5221 with the type Ia supernova iPTF16abc

Context. Type Ia supernovae (SNe Ia) can be used to address numerous questions in astrophysics and cosmology. Due to their well known spectral and photometric properties, SNe Ia are well suited to study gas and dust along the lines-of-sight to the explosions. For example, narrow Na I D and Ca II H&K absorption lines can be studied easily, because of the well-defined spectral continuum of SNe Ia around these features. Aims. We study the gas and dust along the line-of-sight to iPTF16abc, which occurred in an unusual location, in a tidal arm, 80 kpc from centre of the galaxy NGC 5221. Methods. Using a time-series of high-resolution spectra, we examine narrow Na I D and Ca II H&K absorption features for variations in time, which would be indicative for circumstellar (CS) matter. Furthermore, we take advantage of the well known photometric properties of SNe Ia to determine reddening due to dust along the line-of-sight. Results. From the lack of variations in Na I D and Ca II H&K, we determine that none of the detected absorption features originate from the CS medium of iPTF16abc. While the Na I D and Ca II H&K absorption is found to be optically thick, a negligible amount of reddening points to a small column of interstellar dust. Conclusions. We find that the gas along the line-of-sight to iPTF16abc is typical of what might be found in the interstellar medium (ISM) within a galaxy. It suggests that we are observing gas that has been tidally stripped during an interaction of NGC 5221 with one of its neighbouring galaxies in the past $\sim10^9$ years. In the future, the gas clouds could become the locations of star formation. On a longer time scale, the clouds might diffuse, enriching the circum-galactic medium (CGM) with metals. The gas profile along the line-of-sight should be useful for future studies of the dynamics of the galaxy group containing NGC 5221.Comment: 8 pages, 6 figure

Psychological Flexibility, ACT, and Organizational Behavior

This paper offers organizational behavior management (OBM) a behavior analytically consistent way to expand its analysis of, and methods for changing, organizational behavior. It shows how Relational Frame Theory (RFT) suggests that common, problematic, psychological processes emerge from language itself, and they produce psychological inflexibility. Research suggests that an applied extension of RFT, Acceptance and Commitment Therapy, has led to new interventions that increase psychological flexibility and, thereby enhance, organizational behavior and health

A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation

Using a novel molecular design approach, we have prepared a thermo-responsive supramolecular polyurethane as a matrix material for use in drug eluting implants. The dynamic supramolecular polyurethane (SPU) is able to self-assemble through hydrogen bonding and π-π stacking interactions, resulting in an addressable polymer network with a relatively low processing temperature. The mechanical properties of the SPU demonstrated the material was self-supporting, stiff, yet flexible thus making it suitable for hot-melt extrusion processing, inclusive of related 3D printing approaches. Cell-based toxicity assays revealed the SPU to be non-toxic and therefore a viable candidate as a biocompatible polymer for implant applications. To this end, the SPU was formulated with paracetamol (16 %w/w) and 4 wt% or 8 wt% poly(ethylene glycol) (PEG) as an excipient and hot melt extruded at 100 °C to afford a 3D printed prototype implant to explore the extended drug release required for an implant and the potential manipulation of the release profile. Furthermore, rheological, infra-red spectroscopy, powder X-ray diffraction and scanning electron microscopy studies revealed the chemical and physical properties and compatibility of the formulation components. Successful release of paracetamol was achieved from in vitro dissolution studies and it was predicted that the drug would be released over a period of up to 8.5 months with hydrophilic PEG being able to influence the release rate. This extended release time is consistent with applications of this novel dynamic polymer as a drug eluting implant matrix