Links of personality traits to media multitasking: Conscientiousness predicts mobile phone use in the college classroom

The present study investigated the relation among mobile phone use in the college classroom and Big Five personality traits, which had not been addressed in previous research. Undergraduate students (83 males and 92 females) whose average age was 20 (SD = 5.1) completed questionnaires on demographic characteristics, mobile phone use, impulse control, and Big Five personality traits. Hierarchical regression analyses were conducted to examine whether each personality trait made a unique contribution in predicting mobile phone use in the classroom after taking into consideration the contribution of impulse control in this prediction. The results show that impulse control and conscientiousness are significant, independent predictors of in-class mobile phone use over and above each other after controlling for demographic characteristics and general mobile phone use. These results suggest that some aspects of conscientiousness unexplained by impulse control may also be related to media multitasking in the college classroom, and the present study sheds light on the importance of continued research on the relation between conscientiousness and in-class media multitasking

Emergence of macroscopic simplicity from the Tumor Necrosis Factor-alpha signaling dynamics

The Tumor Necrosis Factor-α (TNF-α), a cytokine produced during the innate immune response to invading pathogens, is involved in numerous fundamental cellular processes. Here, to understand the temporal activation profiles of the TNF-α regulated signaling network, we developed a dynamic computational model based on the perturbation-response approach and the law of information (signaling flux) conservation. Our simulations show that the temporal average population response of the TNF-α stimulated transcription factors NF-κB and AP-1, and 3 groups of 180 downstream gene expressions follow first-order equations. Using the model, in contrast to a well-known previous study, our model suggests that the continuous activation of the third group of genes is not mainly due to the poor rate of mRNA decay process, rather, the law of signaling flux conservation stipulates the presence of secondary signaling, such as feedback mechanism or autocrine signaling, is crucial. Although the living system is perceived as sophisticated and complex, notably, our work reveals the presence of simple governing principles in cell population dynamics

On Local Symmetric Order Parameters of Vortex Lattice States

This paper gives a new refined definition of local symmetric order parameters (OPs)(s-wave, d-wave and p-wave order parameters) of vortex lattice states for singlet superconductivity. s-wave, d-wave and p-wave OPs at a site (m,n) are defined as A, B and E representations of the four fold rotation C_4 at the site (m,n) of nearest neighbor OPs etc. The new OPs have a well defined nature such that an OP(e.g. d-wave) at the site obtained under translation by a lattice vector (of the vortex lattice) from a site (m,n) is expressed by the corresponding OP (e.g. d-wave) at the site (m,n) times a phase factor. The winding numbers of s-wave and d-wave OPs are given.Comment: RevTeX v3.1, 5 pages with 3 figures, uses epsf.sty. to appear in Prog. Theor. Phys. Vol.101 No.3. (1999

Kinematics of SiO J=8-7 Emission towards the HH 212 Jet

We present SiO J=8-7 (347.3 GHz) observations towards HH 212 using the ASTE telescope. Our observations with a 22''-diameter beam show that the SiO emission is highly concentrated within 1' of the driving source. We carefully compare the SiO observations with archival H_2 1-0 S(1) images and published H_2 echelle spectra. We find that, although the SiO velocities closely match the radial velocities seen in H_2, the distribution of H_2 and SiO emission differ markedly. We attribute the latter to the different excitation conditions required for H_2 and SiO emission, particularly the higher critical density (n_H2 ~10^8 cm^-3) of the SiO J=8-7 emission. The kinematic similarities imply that the H_2 and SiO are associated with the same internal working surfaces. We conclude that the SiO J=8-7 emission has a potential to probe the jet/wind launching region through interferometric observations in the future, particularly for the youngest, most deeply embedded protostars where IR observations are not possible.Comment: 6 pages, 4 figures, accepted to PAS

Electrostatic Barrier against Dust Growth in Protoplanetary Disks. I. Classifying the Evolution of Size Distribution

Collisional growth of submicron-sized dust grains into macroscopic aggregates is the first step of planet formation in protoplanetary disks. These grains are expected to carry nonzero negative charges in the weakly ionized disks, but its effect on their collisional growth has not been fully understood so far. In this paper, we investigate how the charging affects the evolution of the dust size distribution properly taking into account the charging mechanism in a weakly ionized gas as well as porosity evolution through low-energy collisions. To clarify the role of the size distribution, we divide our analysis into two steps. First, we analyze the collisional growth of charged aggregates assuming a monodisperse (i.e., narrow) size distribution. We show that the monodisperse growth stalls due to the electrostatic repulsion when a certain condition is met, as is already expected in the previous work. Second, we numerically simulate dust coagulation using Smoluchowski's method to see how the outcome changes when the size distribution is allowed to freely evolve. We find that, under certain conditions, the dust undergoes bimodal growth where only a limited number of aggregates continue to grow carrying the major part of the dust mass in the system. This occurs because remaining small aggregates efficiently sweep up free electrons to prevent the larger aggregates from being strongly charged. We obtain a set of simple criteria that allows us to predict how the size distribution evolves for a given condition. In Paper II (arXiv:1009.3101), we apply these criteria to dust growth in protoplanetary disks.Comment: 20 pages, 22 figures, accepted for publication in Ap

Polymorphic ventricular tachycardia in a patient with hypertrophic cardiomyopathy and digitalis intoxication

SummaryWe report the case of a 74-year-old woman who presented with recurrent episodes of polymorphic ventricular tachycardia (PVT) with a normal QT interval due to digitalis intoxication (serum digoxin concentration, 5.0 ng/mL) and severe hyperkalemia (serum potassium level, 8.3 mEq/L). In addition, laboratory data showed elevated levels of blood urea nitrogen (54 mg/dL) and serum creatinine (1.57 mg/dL), suggesting dehydration. She had been treated with a combination of digoxin and eplerenone for atrial fibrillation and heart failure. The PVT resolved after treatment for hyperkalemia. Cardiac magnetic resonance imaging and left ventriculography showed left ventricular hypertrophy predominantly in the apex, suggesting apical hypertrophic cardiomyopathy (HCM). We presume that the presence of HCM was related to the occurrence of PVT in this patient with digitalis intoxication and hyperkalemia.<Learning objective: PVT with a normal QT interval caused by digitalis intoxication with hyperkalemia was observed in a patient with HCM treated with digoxin and eplerenone for atrial fibrillation and heart failure. The presence of HCM may be related to the occurrence of PVT. Combination therapy with digoxin and aldosterone receptor antagonist may predispose severe hyperkalemia, and monitoring of serum digitalis concentration and potassium level should be done strictly.

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases

Aims The genetic cause of cardiac conduction system disease (CCSD) has not been fully elucidated. Whole-exome sequencing (WES) can detect various genetic variants; however, the identification of pathogenic variants remains a challenge. We aimed to identify pathogenic or likely pathogenic variants in CCSD patients by using WES and 2015 American College of Medical Genetics and Genomics (ACMG) standards and guidelines as well as evaluating the usefulness of functional studies for determining them. Methods and Results We performed WES of 23 probands diagnosed with early-onset (&amp;lt;65 years) CCSD and analyzed 117 genes linked to arrhythmogenic diseases or cardiomyopathies. We focused on rare variants (minor allele frequency &amp;lt; 0.1%) that were absent from population databases. Five probands had protein truncating variants in EMD and LMNA which were classified as “pathogenic” by 2015 ACMG standards and guidelines. To evaluate the functional changes brought about by these variants, we generated a knock-out zebrafish with CRISPR-mediated insertions or deletions of the EMD or LMNA homologs in zebrafish. The mean heart rate and conduction velocities in the CRISPR/Cas9-injected embryos and F2 generation embryos with homozygous deletions were significantly decreased. Twenty-one variants of uncertain significance were identified in 11 probands. Cellular electrophysiological study and in vivo zebrafish cardiac assay showed that 2 variants in KCNH2 and SCN5A, 4 variants in SCN10A, and 1 variant in MYH6 damaged each gene, which resulted in the change of the clinical significance of them from “Uncertain significance” to “Likely pathogenic” in 6 probands. Conclusions Of 23 CCSD probands, we successfully identified pathogenic or likely pathogenic variants in 11 probands (48%). Functional analyses of a cellular electrophysiological study and in vivo zebrafish cardiac assay might be useful for determining the pathogenicity of rare variants in patients with CCSD. SCN10A may be one of the major genes responsible for CCSD. Translational Perspective Whole-exome sequencing (WES) may be helpful in determining the causes of cardiac conduction system disease (CCSD), however, the identification of pathogenic variants remains a challenge. We performed WES of 23 probands diagnosed with early-onset CCSD, and identified 12 pathogenic or likely pathogenic variants in 11 of these probands (48%) according to the 2015 ACMG standards and guidelines. In this context, functional analyses of a cellular electrophysiological study and in vivo zebrafish cardiac assay might be useful for determining the pathogenicity of rare variants, and SCN10A may be one of the major development factors in CCSD