Quantitative evaluation of multiband photographic techniques Final report

Quantitative evaluation of multiband photographic techniques using combination of black and white and color photo

The Role of Physical and Numerical Modeling in Design Development of the Priest Rapids Fish Bypass

This paper describes a number of years of physical and numerical modelling that were instrumental in the development of the final fish bypass design at Priest Rapids Dam. Three physical models and multiple numerical models were used to guide the design of the fish bypass including its location on the dam, impact on forebay and tailrace flow patterns, intake configuration, design flow rates, flow control scheme, tailrace egress, potential for scour near the dam, potential impacts on total dissolved gas (TDG), impacts on spillway and powerhouse operation, and overall fish friendliness of the bypass. Throughout those years of design work, results from actively tagged salmonid smolt studies were used to guide and validate each step of the design process. In 2011, a construction contract was awarded and the Priest Rapids Fish Bypass facility was completed in the early spring of 2014. Final validation of this newly constructed facility came in the spring of 2014 with a survival and behavior study conducted using acoustic tagged yearling Chinook and juvenile steelhead smolts to evaluate the salmonid smolt survival rate through the bypass along with the fish passage efficiency (FPE) of the bypass facility. This paper discusses the physical models plus CFD models used to support the design development of a non-turbine fish bypass and presents the results of the survival and behaviour studies conducted after the fish bypass was installed at Priest Rapids Dam

Testing Einstein's time dilation under acceleration using M\"ossbauer spectroscopy

The Einstein time dilation formula was tested in several experiments. Many trials have been made to measure the transverse second order Doppler shift by M\"{o}ssbauer spectroscopy using a rotating absorber, to test the validity of this formula. Such experiments are also able to test if the time dilation depends only on the velocity of the absorber, as assumed by Einstein's clock hypothesis, or the present centripetal acceleration contributes to the time dilation. We show here that the fact that the experiment requires $\gamma$-ray emission and detection slits of finite size, the absorption line is broadened; by geometric longitudinal first order Doppler shifts immensely. Moreover, the absorption line is non-Lorenzian. We obtain an explicit expression for the absorption line for any angular velocity of the absorber. The analysis of the experimental results, in all previous experiments which did not observe the full absorption line itself, were wrong and the conclusions doubtful. The only proper experiment was done by K\"{u}ndig (Phys. Rev. 129 (1963) 2371), who observed the broadening, but associated it to random vibrations of the absorber. We establish necessary conditions for the successful measurement of a transverse second order Doppler shift by M\"{o}ssbauer spectroscopy. We indicate how the results of such an experiment can be used to verify the existence of a Doppler shift due to acceleration and to test the validity of Einstein's clock hypothesis.Comment: 11 pages, 4 figure

Over-the-counter analgesics during pregnancy : a comprehensive review of global prevalence and offspring safety

Funding This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC)/EASTBIO studentship to A.Z. (Grant Number: 1942576). RTM is supported by UKRI Future Leaders Fellowship (MR/S017151/1). The MRC Centre for Reproductive Health is supported by MRC Centre Grant (MR/N022556/1).Peer reviewedPostprin

Risk factors for bovine respiratory disease in Australian feedlot cattle: use of a causal diagram-informed approach to estimate effects of animal mixing and movements before feedlot entry

A nationwide longitudinal study was conducted to investigate risk factors for bovine respiratory disease (BRD) in cattle in Australian feedlots. After induction (processing), cattle were placed in feedlot pens (cohorts) and monitored for occurrence of BRD over the first 50 days on feed. Data from a national cattle movement database were used to derive variables describing mixing of animals with cattle from other farms, numbers of animals in groups before arrival at the feedlot, exposure of animals to saleyards before arrival at the feedlot, and the timing and duration of the animal's move to the vicinity of the feedlot. Total and direct effects for each risk factor were estimated using a causal diagram-informed process to determine covariates to include in four-level Bayesian logistic regression models. Mixing, group size and timing of the animal's move to the feedlot were important predictors of BRD. Animals not mixed with cattle from other farms prior to 12 days before induction and then exposed to a high level of mixing (≥4 groups of animals mixed) had the highest risk of developing BRD (OR 3.7) compared to animals mixed at least 4 weeks before induction with less than 4 groups forming the cohort. Animals in groups formed at least 13 days before induction comprising 100 or more (OR 0.5) or 50-99 (OR 0.8) were at reduced risk compared to those in groups of less than 50 cattle. Animals moved to the vicinity of the feedlot at least 27 days before induction were at reduced risk (OR 0.4) compared to cattle undergoing short-haul transportation

Weighing the Milky Way

We describe an experiment to measure the mass of the Milky Way galaxy. The experiment is based on calculated light travel times along orthogonal directions in the Schwarzschild metric of the Galactic center. We show that the difference is proportional to the Galactic mass. We apply the result to light travel times in a 10cm Michelson type interferometer located on Earth. The mass of the Galactic center is shown to contribute 10^-6 to the flat space component of the metric. An experiment is proposed to measure the effect.Comment: 10 pages, 1 figur

Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle

Placental insufficiency causes intrauterine growth restriction (IUGR) and disturbances in glucose homeostasis with associated β adrenergic receptor (ADRβ) desensitization. Our objectives were to measure insulin-sensitive glucose metabolism in neonatal lambs with IUGR and to determine whether daily treatment with ADRβ2 agonist and ADRβ1/β3 antagonists for 1 month normalizes their glucose metabolism. Growth, glucose-stimulated insulin secretion (GSIS) and glucose utilization rates (GURs) were measured in control lambs, IUGR lambs and IUGR lambs treated with adrenergic receptor modifiers: clenbuterol atenolol and SR59230A (IUGR-AR). In IUGR lambs, islet insulin content and GSIS were less than in controls; however, insulin sensitivity and whole-bodyGUR were not different from controls.Of importance, ADRβ2 stimulation with β1/β3 inhibition increases both insulin sensitivity and whole-body glucose utilization in IUGR lambs. In IUGR and IUGR-AR lambs, hindlimb GURs were greater but fractional glucose oxidation rates and ex vivo skeletal muscle glucose oxidation rates were lower than controls. Glucose transporter 4 (GLUT4) was lower in IUGR and IUGR-AR skeletal muscle than in controls but GLUT1 was greater in IUGR-AR. ADRβ2, insulin receptor, glycogen content and citrate synthase activity were similar among groups. In IUGR and IUGR-AR lambs heart rates were greater, which was independent of cardiac ADRβ1 activation. We conclude that targeted ADRβ2 stimulation improved whole-body insulin sensitivity but minimally affected defects in GSIS and skeletal muscle glucose oxidation. We show that risk factors for developing diabetes are independent of postnatal catch-up growth in IUGR lambs as early as 1 month of age and are inherent to the islets and myocytes

Inclusive growth: the challenges of multidimensionality and multilateralism

The two decades either side of the global financial crisis have seen a remarkable surge and an equally remarkable reaction to global inequalities. This has played some part in fuelling the recent populist backlash against globalisation. In response, many global institutions and some national governments have embraced the concept of inclusive growth – proposing a policy agenda designed to share the benefits of economic growth and development more equitably. This paper argues that the current debate about inclusivity suffers from two major misspecifications that weaken the concept and undermine the prospect of the economic and political goals it stands for being achieved. For inclusivity to be meaningful and sustainable it must be understood in multidimensional terms, but attaching it to orthodox thinking on growth continually draws the debate back to narrow economic considerations. The concept has also been hampered by ‘methodological nationalism’, whereby policies for inclusivity are considered predominantly at the national level without adequate attention being given to the multilateral dimensions of inclusivity in a world of global interdependence. To be coherent and applicable, inclusive growth must be (re)conceived multilaterally and embrace a more multidimensional notion of inclusive development that hinges around a meaningful conception of human wellbeing

A novel systematic approach for analysing exploratory design ideation

Two kinds of design ideation process may be distinguished in terms of the problems addressed: (i) solution-focused, i.e. generating solutions to address a fixed problem specifying a desired output; and (ii) exploratory, i.e. considering different interpretations of an open-ended problem and generating associated solutions. Existing systematic analysis approaches focus on the former; the literature is lacking such an approach for the latter. In this paper, we provide a means to systematically analyse exploratory ideation for the first time through a new approach: Analysis of Exploratory Design Ideation (AEDI). AEDI involves: (1) open-ended ideation tasks; (2) coding of explored problems and solutions from sketches; and (3) evaluating ideation performance based on coding. We applied AEDI to 812 concept sketches from 19 open-ended tasks completed during a neuroimaging study of 30 professional product design engineers. Results demonstrate that the approach provides: (i) consistent tasks that stimulate problem exploration; (ii) a reliable means of coding explored problems and solutions; and (iii) an appropriate way to rank/compare designers’ performance. AEDI enables the benefits of systematic analysis (e.g. greater comparability, replicability, and efficiency) to be realised in exploratory ideation research, and studies using open-ended problems more generally. Future improvements include increasing coding validity and reliability