Report on the 2nd International Summer School on Network and Service Management (ISSNSM'08)

This report summarizes the 2nd International Summer School on Network and Service Management (ISSNSM'08), which was held at the Communication Systems Group (CSG) of the Department of Informatics (IFI), University of Zurich, Switzerland, on 2-6 June 2008. Supported by the European FP6 Network of Excellence for the Management of Internet Technologies and Complex Services (EMANICS), the ISSNSM presented within 5 days eight different topics, covering the areas of (1) security, (2) virtualization and simulations, and (3) network monitoring and management. All of these run for a full or half day, including a short theoretical introduction and larger practical lab course components, respectivel

Report on the 2nd International Summer School on Network and Service Management (ISSNSM'08)

This report summarizes the 2nd International Summer School on Network and Service Management (ISSNSM’08), which was held at the Communication Systems Group (CSG) of the Department of Informatics (IFI), University of Zurich, Switzerland, on 2–6 June 2008. Supported by the European FP6 Network of Excellence for the Management of Internet Technologies and Complex Services (EMANICS), the ISSNSM presented within 5 days eight different topics, covering the areas of (1) security, (2) virtualization and simulations, and (3) network monitoring and management. All of these run for a full or half day, including a short theoretical introduction and larger practical lab course components, respectively

Solving a Slick Problem; Morally Preferable; Objectors by Conscience

News release announces a UD biologist\u27s solutions for cleaning up the massive oil spill in the Persian golf, a senior research scientist\u27s comments on the use of smart weapons in the Persian Gulf, and counseling concerning the selective service law and legal option for members of the UD community will be offered

Co-Inventor of Jet Engine to Donate Draper Prize Medal to UD

News release announces that Hans von Ohain will present the Charles Stark Draper medal to the University of Dayton

LiveShift: mesh-pull P2P live and time-shifted video streaming

The popularity of video sharing over the Internet has increased significantly. High traffic generated by such applications at the source can be better distributed using a peer-to-peer overlay. LiveShift combines both live and on-demand video streaming -- while video is transmitted through the peer-to-peer network in a live fashion, all peers participate in distributed storage. This adds the ability to replay time-shifted streams from other peers in a distributed and scalable manner. This technical report describes an architecture, a mesh-pull protocol, and a set of policies that support the envisioned use case enable. User-focused evaluation results show its effectiveness and limits in terms of quality of experience

LiveShift: Mesh-pull live and time-shifted P2P video streaming

The popularity of video sharing over the Internet has increased significantly. High traffic generated by such applications at the source can be better distributed using a peer-to-peer (P2P) overlay. Unlike most P2P systems, LiveShift combines both live and on-demand video streaming while video is transmitted through the peer-to-peer network in a live fashion, all peers participate in distributed storage. This adds the ability to replay time-shifted streams from other peers in a distributed and scalable manner. This paper describes an adaptive fully-distributed mesh-pull protocol that supports the envisioned use case and a set of policies that enable efficient usage of resources, discussing interesting trade-offs encountered. User-focused evaluation results, including both channel switching and time shifting behavior, show that the proposed system provides good quality of experience for most users, in terms of infrequent stalling, low playback lag, and a small proportion of skipped blocks in all the scenarios studied, even in presence of churn

Mitoxantrone pleurodesis to palliate malignant pleural effusion secondary to ovarian cancer

BACKGROUND: Advanced ovarian cancer is the leading non-breast gynaecologic cause of malignant pleural effusion. Aim of this study was to assess the efficacy of mitoxantrone sclerotherapy as a palliative treatment of malignant pleural effusions due to ovarian cancer. METHODS: Sixty women with known ovarian cancer and malignant recurrent symptomatic pleural effusion were treated with chest tube drainage followed by intrapleural mitoxantrone sclerotherapy. Survival, complications and response to pleurodesis were recorded. The data are expressed as the mean ± SEM and the median. RESULTS: The mean age of the entire group was 64 ± 11,24 years. The mean interval between diagnosis of ovarian cancer and presentation of the effusion was 10 ± 2,1 months. Eighteen patients (30%) had pleural effusion as the first evidence of recurrence. The mean volume of effusion drained was 1050 ± 105 ml and chest tube was removed within 4 days in 75% of patients. There were no deaths related to the procedure. Side effects of chemical pleurodesis included fever (37–38,5°C) chest pain, nausea and vomiting. At 30 days among 60 treated effusions, there was an 88% overall response rate, including 41 complete responses and 12 partial responses. At 60 days the overall response was 80% (38 complete responses and 10 partial responses). The mean survival of the entire population was 7,5 ± 1,2 months. CONCLUSIONS: Mitoxantrone is effective in the treatment of malignant pleural effusion secondary to ovarian cancer without causing significant local or systemic toxicity

Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study

<p>Abstract</p> <p>Background</p> <p>To assess the impact of polymorphisms in Glutathione S-transferase (GST) -P1, -M1, and -T1 on self-reported chemotherapy-induced long-term toxicities in testicular cancer survivors (TCSs).</p> <p>Methods</p> <p>A total of 238 TCSs, who had received cisplatin-based chemotherapy at median twelve years earlier, had participated in a long-term follow-up survey which assessed the prevalence of self-reported paresthesias in fingers/toes, Raynaud-like phenomena in fingers/toes, tinnitus, and hearing impairment. From all TCSs lymphocyte-derived DNA was analyzed for the functional A→G polymorphism at bp 304 in <it>GSTP1</it>, and deletions in <it>GST-M1 </it>and <it>GST-T1</it>. Evaluation of associations between GST polymorphisms and self-reported toxicities included adjustment for prior treatment.</p> <p>Results</p> <p>All six evaluated toxicities were significantly associated with the cumulative dose of cisplatin and/or bleomycin. Compared to TCSs with either <it>GSTP1-AG </it>or <it>GSTP1</it>-<it>AA</it>, the 37 TCSs with the genotype <it>GSTP1-GG</it>, were significantly less bothered by paresthesias in fingers and toes (p = 0.039, OR 0.46 [0.22–0.96] and p = 0.023, OR 0.42 [0.20–0.88], respectively), and tinnitus (p = 0.008, OR 0.33 [0.14–0.74]). Furthermore, absence of functional GSTM1 protected against hearing impairment (p = 0.025, OR 1.81 [1.08–3.03]).</p> <p>Conclusion</p> <p>In TCSs long-term self-reported chemotherapy-induced toxicities are associated with functional polymorphisms in <it>GSTP1 </it>and <it>GSTM1</it>. Hypothetically, absence of GST-M1 leaves more glutathione as substrate for the co-expressed GST-P1. Also intracellular inactivation of pro-apoptotic mediators represents a possible explanation of our findings. Genotyping of these GSTs might be a welcomed step towards a more individualized treatment of patients with metastatic testicular cancer.</p