568 research outputs found
Adherence to individualized recall intervals for oral health examinations
Objectives: The aim of this follow-up study was to investigate whether adults attend an oral health examination (OHE) based on their individual recall interval (IRI) without a reminder recall system.Methods: The study population included adults who were attending an OHE recommended by their dentists based on their IRI in public oral healthcare clinics of Helsinki City January 1, 2009-December 31, 2009. The inclusion criteria were as follows: alive until the end of IRI, length of the IRI of 12-60 months, and study participants had not been treated successfully by a dental specialist during the IRI period (n = 41,255). We used a multinomial model to identify the factors associated with the timing of OHE. The following predictors were included: oral health indices such as Decayed Teeth and the Community Periodontal Index, the length of the IRI based on an OHE in 2009, age, gender, socioeconomic status, presence of chronic diseases, and emergency appointment. Results were presented as odds ratios with 95% confidence intervals.Results: The OHE based on IRI occurred for 7505 individuals (18.2%) and the OHE was late for 9159 individuals (22.2%). A total of 24,591 (59.6%) adults did not undergo follow-up OHE based on the IRI period of on time or late. Those who came on time for follow-up OHE experienced less caries than those who came later. There was not much difference in periodontal health between the groups. The models indicated that having an emergency appointment was associated with a higher probability of having an OHE. A long IRI (37-60 months) was associated with a higher probability of not participating in OHE even late.Conclusions: It would be beneficial for patients to take appointments based on the recall interval. The results of this study indicated that more needs to be done to increase awareness in the adult population of the benefits and availability of follow-up OHEs based on their IRI in oral healthcare.Peer reviewe
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Winning and losing in the creative industries: an analysis of creative graduates' career opportunities across creative disciplines
Following earlier work looking at overall career difficulties and low economic rewards faced by graduates in creative disciplines, the paper takes a closer look into the different career patterns and economic performance of βBohemianβ graduates across different creative disciplines. While it is widely acknowledged in the literature that careers in the creative field tend to be unstructured, often relying on part-time work and low wages, our knowledge of how these characteristics differ across the creative industries and occupational sectors is very limited. The paper explores the different trajectory and career patterns experienced by graduates in different creative disciplinary fields and their ability to enter creative occupations. Data from the Higher Education Statistical Agency (HESA) are presented, articulating a complex picture of the reality of finding a creative occupation for creative graduates. While students of some disciplines struggle to find full-time work in the creative economy, for others full-time occupation is the norm. Geography plays a crucial role also in offering graduates opportunities in creative occupations and higher salaries. The findings are contextualised in the New Labour cultural policy framework and conclusions are drawn on whether the creative industries policy construct has hidden a very problematic reality of winners and losers in the creative economy
Mortality of midlife women with surgically verified endometriosis-a cohort study including 2.5 million person-years of observation
STUDY QUESTION Is all-cause and cause-specific mortality increased among women with surgically verified endometriosis? SUMMARY ANSWER The all-cause and cause-specific mortality in midlife was lower throughout the follow-up among women with surgically verified endometriosis compared to the reference cohort. WHAT IS KNOWN ALREADY Endometriosis has been associated with an increased risk of comorbidities such as certain cancers and cardiovascular diseases. These diseases are also common causes of death; however, little is known about the mortality of women with endometriosis. STUDY DESIGN, SIZE, DURATION A nationwide retrospective cohort study of women with surgically verified diagnosis of endometriosis was compared to the reference cohort in Finland (1987-2012). Follow-up ended at death or 31 December 2014. During the median follow-up of 17years, 2.5 million person-years accumulated. PARTICIPANTS/MATERIALS, SETTING, METHODS Forty-nine thousand nine hundred and fifty-six women with at least one record of surgically verified diagnosis of endometriosis in the Finnish Hospital Discharge Register between 1987 and 2012 were compared to a reference cohort of 98824 age- and municipality-matched women. The age (meanstandard deviation) of the endometriosis cohort was 36.49.0 and 53.612.1years at the beginning and at the end of the follow-up, respectively. By using the Poisson regression models the crude and adjusted all-cause and cause-specific mortality rate ratios (MRR) and 95% confidence intervals (CI) were assessed. Calendar time, age, time since the start of follow-up, educational level, and parity adjusted were considered in the multivariate analyses. MAIN RESULTS AND THE ROLE OF CHANCE A total of 1656 and 4291 deaths occurred in the endometriosis and reference cohorts, respectively. A lower all-cause mortality was observed for the endometriosis cohort (adjusted MRR, 0.73 [95% CI 0.69 to 0.77])-there were four deaths less per 1000 women over 10years. A lower cause-specific mortality contributed to this: the adjusted MRR was 0.88 (95% CI 0.81 to 0.96) for any cancer and 0.55 (95% CI 0.47 to 0.65) for cardiovascular diseases, including 0.52 (95% CI 0.42 to 0.64) for ischemic heart disease and 0.60 (95% CI 0.47 to 0.76) for cerebrovascular disease. Mortality due to alcohol, accidents and violence, respiratory, and digestive disease-related causes was also decreased. LIMITATIONS, REASONS FOR CAUSATION These results are limited to women with endometriosis diagnosed by surgery. In addition, the study does not extend into the oldest age groups. The results might be explained by the characteristics and factors related to women's lifestyle, and/or increased medical attention and care received, rather than the disease itself. WIDER IMPLICATIONS OF THE FINDINGS These reassuring data are valuable to women with endometriosis and to their health care providers. Nonetheless, more studies are needed to address the causality. STUDY FUNDING/COMPETING INTEREST This research was funded by the Hospital District of Helsinki and Uusimaa and The Finnish Medical Foundation. None of the authors report any competing interest in relation to the present work; all the authors have completed the disclosure form.Peer reviewe
ΠΠΠΠΠΠΠΠ‘Π« Π‘ΠΠ ΠΠΠ Π, Π‘ΠΠΠΠ¦Π, ΠΠΠΠ¬Π¦ΠΠ― Π‘ ΠΠΠ‘Π€ΠΠ‘Π€ΠΠΠΠΠ«ΠΠ ΠΠΠΠΠΠΠΠΠ
It is interesting in chemical terms and promising in the applied production of new complexes of metals with bisphosphonic ligands with a popular set of consumer properties. To date, little has been studied chemistry of bisphosphonic acid complexes with the basic structure of 1-hydroxymethylene-bisphosphonic acid with a side chain containing 11 carbon atoms and ending with an amino group. The main objective is to obtain new bisphosphonates of s-, p -, d - and f-elements, their characterization by a complex of physical and chemical research methods (NMR and IR spectrometry, RSA, DTA, optical microscopy, laser diffraction) and to identify new applications of bisphosphonic acids and their salts. In the course of the work, complexes of Ag, Pb, Ca, with 1-hydroxymethylene-bisphosphonic acid (H2N(CH2)xC(OH)(H2PO3)2) and its derivatives, the side chain ends with an amino group, its length is 11 carbon atoms. Crystal structures of metal-bisphosphonate complexes with the general formula H2N(CH2)10C(OH)(HPO3)xM (M = Ag, Pb, Ca) were determined. The complexes were characterized by IR spectroscopy and 31P solid-state NMR spectroscopy, RSA. The areas of practical use of the complexes are outlined. It is shown, by the example of wastewater in Kuopio, Finland, that bisphosphonic acids can be used for wastewater treatment of enterprises from heavy metals (M =Pb, Zn, Cd, etc.).ΠΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠ½ΡΠΌ Π² Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΏΠ»Π°Π½Π΅ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ - Π² ΠΏΡΠΈΠΊΠ»Π°Π΄Π½ΠΎΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² Ρ Π±ΠΈΡΡΠΎΡΡΠΎΠ½ΠΎΠ²ΡΠΌΠΈ Π»ΠΈΠ³Π°Π½Π΄Π°ΠΌΠΈ, ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΡ
Π²ΠΎΡΡΡΠ΅Π±ΠΎΠ²Π°Π½Π½ΡΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠΌ ΠΏΠΎΡΡΠ΅Π±ΠΈΡΠ΅Π»ΡΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ². Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΌΡ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΠΌΠ°Π»ΠΎ ΠΈΠ·ΡΡΠ΅Π½Π° Ρ
ΠΈΠΌΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² Π±ΠΈΡΡΠΎΡΡΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ, ΠΈΠΌΠ΅ΡΡΠΈΡ
Π±Π°Π·ΠΎΠ²ΡΡ ΡΡΡΡΠΊΡΡΡΡ 1-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΌΠ΅ΡΠΈΠ»Π΅Π½-Π±ΠΈΡΡΠΎΡΡΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ Ρ Π±ΠΎΠΊΠΎΠ²ΠΎΠΉ ΡΠ΅ΠΏΡΡ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅ΠΉ 11 Π°ΡΠΎΠΌΠΎΠ² ΡΠ³Π»Π΅ΡΠΎΠ΄Π° ΠΈ ΠΎΠΊΠ°Π½ΡΠΈΠ²Π°ΡΡΠ΅ΠΉΡΡ Π°ΠΌΠΈΠ½ΠΎΠ³ΡΡΠΏΠΏΠΎΠΉ. ΠΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ
Π±ΠΈΡΡΠΎΡΡΠΎΠ½Π°ΡΠΎΠ² s-, p-, d- ΠΈ f- ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ², ΠΈΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·Π°ΡΠΈΡ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ (Π―ΠΠ - ΠΈ ΠΠ-ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΡ, ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΡΡΡΡΠΊΡΡΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ·, Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ·, ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡ, Π»Π°Π·Π΅ΡΠ½Π°Ρ Π΄ΠΈΡΡΠ°ΠΊΡΠΈΡ) ΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ
ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π±ΠΈΡΡΠΎΡΡΠΎΠ½ΠΎΠ²ΡΡ
ΠΊΠΈΡΠ»ΠΎΡ ΠΈ ΠΈΡ
ΡΠΎΠ»Π΅ΠΉ. Π Ρ
ΠΎΠ΄Π΅ ΡΠ°Π±ΠΎΡΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ Ag, Pb, Ca, Ρ 1-Π³ΠΈΠ΄ΡΠΎΠΊΡΠΈΠΌΠ΅ΡΠΈΠ»Π΅Π½-Π±ΠΈΡΡΠΎΡΡΠΎΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΠΎΠΉ (H2N(CH2)xC(OH)(H2PO3)2) ΠΈ Π΅Π΅ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΡΠΌΠΈ, Π±ΠΎΠΊΠΎΠ²Π°Ρ ΡΠ΅ΠΏΠΎΡΠΊΠ° ΠΎΠΊΠ°Π½ΡΠΈΠ²Π°Π΅ΡΡΡ Π°ΠΌΠΈΠ½ΠΎΠ³ΡΡΠΏΠΏΠΎΠΉ, Π° Π΄Π»ΠΈΠ½Π° ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 11 Π°ΡΠΎΠΌΠΎΠ² ΡΠ³Π»Π΅ΡΠΎΠ΄Π°. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΡΠΈΡΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΡΡΡΠΊΡΡΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² ΡΠΎΡΡΠ°Π²Π° H2N(CH2)10C(OH)(HPO3)xM (Π = Ag, Pb, Ca). ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ ΠΎΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½Ρ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΠ-ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ, ΡΠ²Π΅ΡΠ΄ΠΎΡΠ°Π·Π½ΠΎΠΉ 31P-Π―ΠΠ -ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΡΡΡΡΠΊΡΡΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΎΠ±ΡΠ°Π·ΡΠΎΠ². ΠΠ°ΠΌΠ΅ΡΠ΅Π½Ρ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ². ΠΠ° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΡΡΠΎΡΠ½ΡΡ
Π²ΠΎΠ΄ Π² Π³. ΠΡΠΎΠΏΠΈΠΎ, Π€ΠΈΠ½Π»ΡΠ½Π΄ΠΈΡ, ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π±ΠΈΡΡΠΎΡΡΠΎΠ½ΠΎΠ²ΡΠ΅ ΠΊΠΈΡΠ»ΠΎΡΡ ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡΠΈΠΌΠ΅Π½ΡΡΡ Π΄Π»Ρ ΠΎΡΠΈΡΡΠΊΠΈ ΡΡΠΎΡΠ½ΡΡ
Π²ΠΎΠ΄ ΠΏΡΠ΅Π΄ΠΏΡΠΈΡΡΠΈΠΉ ΠΎΡ ΡΡΠΆΠ΅Π»ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² (Π=Pb, Zn, Cd ΠΈ Π΄Ρ.)
Ferrocene-quinoxaline Y-shaped chromophores as fascinating second-order NLO building blocks for long lasting highly active SHG polymeric films
The first example of a Y-shaped ferrocene quinoxaline derivative with a surprisingly high and stable second harmonic generation (SHG) response in composite polymeric films is reported. The interesting quadratic hyperpolarizability values of different substituted Y-shaped chromophores are also investigated in solution by the EFISH technique
Multisite musculoskeletal pain predicts medically certified disability retirement among Finns
BackgroundMusculoskeletal pain at several sites (multisite pain) is more common than single-site pain. Little is known on its effects on disability pension (DP) retirement. MethodsA nationally representative sample comprised 4071 Finns in the workforce aged 30 to 63. Data (questionnaire, interview, clinical examination) were gathered in 2000-2001 and linked with national DP registers for 2000-2011. Pain during the preceding month in 18 locations was combined into four sites (neck, upper limbs, low back, lower limbs). Hazard ratios (HR) of DP were estimated by Cox regression. ResultsThe HR of any DP (n=477) was 1.6 (95% confidence interval 1.2-2.1) for one, 2.5 (1.9-3.3) for two, 3.1 (2.3-4.3) for three and 5.6 (4.0-7.8) for four pain sites, when adjusted for age and gender. When additionally adjusted for clinically assessed chronic diseases, the HRs varied from 1.4 (1.0-1.8) to 3.5 (2.5-4.9), respectively. When further adjusted for physical and psychosocial workload, education, body mass index, smoking, exercise and sleep disorders, the HRs were 1.3 (0.9-1.7), 1.6 (1.2-2.2), 1.8 (1.3-2.5) and 2.5 (1.8-3.6). The number of pain sites was especially strong in predicting DPs due to musculoskeletal diseases (HRs in the full model; 3.1 to 4.3), but it also predicted DPs due to other somatic diseases (respective HRs 1.3 to 2.3); pain in all four sites was also predictive of DPs due to mental disorders (full model HR 2.2). ConclusionsThe number of pain sites independently predicted DP retirement. Employees with multisite pain may need specific support to maintain their work ability.Peer reviewe
Synthesis, structure and antimicrobial activity of new Co(II) complex with bis-morpholino/benzoimidazole -s-triazine Ligand
Funding: The authors would like to extend their sincere appreciation to the Researchers Supporting Project (RSP2023R64), King Saud University, Riyadh, Saudi Arabia.A new Co(II) perchlorate complex of the bis-morpholino/benzoimidazole-s-triazine ligand, 4,4β²-(6-(1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine ( BMBIT ), was synthesized and characterized. The structure of the new Co(II) complex was approved to be [Co(BMBIT)2(H2O)4](ClO4)2*H2O using single-crystal X-ray diffraction. The Co(II) complex was found crystallized in the monoclinic crystal system and P21/c space group. The unit cell parameters are a = 22.21971(11) Γ
, b = 8.86743(4) Γ
, c = 24.38673(12) Γ
and Ξ² = 113.4401(6)Β°. This heteroleptic complex has distorted octahedral coordination geometry with two monodenatate BMBIT ligand units via the benzoimidazole N-atom and four water molecules as monodentate ligands. The hydration water and perchlorate ions participated significantly in the supramolecular structure of the [Co( BMBIT )2(H2O)4](ClO4)2*H2O complex. Analysis of dnorm map and a fingerprint plot indicated the importance of OΒ·Β·Β·H, NΒ·Β·Β·H, CΒ·Β·Β·H, CΒ·Β·Β·O, CΒ·Β·Β·N and HΒ·Β·Β·H contacts. Their percentages are 27.5, 7.9, 14.0, 0.9, 2.8 and 43.5%, respectively. The sensitivity of some harmful microbes towards the studied compounds was investigated. The Co(II) complex has good antifungal activity compared to the free BMBIT which has no antifungal activity. The Co(II) complex has good activity against B. subtilis, S. aureus, P. vulgaris and E. coli while the free BMBIT ligand has limited activity only towards B. subtilis and P. vulgaris. Hence, the [Co( BMBIT )2(H2O)4](ClO4)2*H2O complex has broad spectrum antimicrobial action compared to the free BMBIT ligand.Publisher PDFPeer reviewe
Application of palladium complexes bearing acyclic amino(hydrazido)carbene ligands as catalysts for copper-free Sonogashira cross-coupling
Metal-mediated coupling of one isocyanide in cis-[PdCl2(CNR1)2] (R1 = C6H11 (Cy) 1, tBu 2, 2,6-Me2C6H3 (Xyl) 3, 2-Cl-6-MeC6H34) and various carbohydrazides R2CONHNH2 [R2 = Ph 5, 4-ClC6H46, 3-NO2C6H47, 4-NO2C6H48, 4-CH3C6H49, 3,4-(MeO)2C6H310, naphth-1-yl 11, fur-2-yl 12, 4-NO2C6H4CH213, Cy 14, 1-(4-fluorophenyl)-5-oxopyrrolidine-3-yl 15, (pyrrolidin-1-yl)C(O) 16, 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propane-1-yl 17, EtNHC(O) 18] or sulfohydrazides R3SO2NHNH2 [R3 = Ph 19, 4-MeC6H420] led to a series of (hydrazido)(amino)carbene complexes cis-[PdCl2{C(NHNHX)double bond; length as m-dashN(H)R1}(CNR1)]; X = COR2, SO2R3 (21β48, isolated yields 60β96%). All prepared species were characterized by elemental analyses (C, H, N), HR ESI+-MS, IR, 1H and 13C{1H} NMR spectroscopy, and by a single-crystal X-ray diffraction for 38. Complexes 21β48 demonstrated excellent activity as catalysts in copper-free Sonogashira coupling of aryl iodides and a variety of aromatic terminal alkynes. Catalytic system runs in environmentally benign EtOH ensuring product yields of up to 75β96% and TONs of up to 104. Mechanism of the copper-free Sonogashira catalytic cycle involving 21β48 as catalysts was proposed upon identification of key intermediates using HRESI-mass
Bis 4,5-diazafluoren-9-one silver(I) nitrate: synthesis, X-ray structures, solution chemistry, hydrogel loading, DNA coupling and anti-bacterial screening
Synthesis of bis-4,5-diazafluoren-9-one silver(I) nitrate I (dafone = 4,5-diazafluoren-9-one) and the low temperature X-ray single crystal structure of [Ag(4,5-diazafluoren-9-one)<sub>2</sub>NO<sub>3</sub>], crystal form 1, and a re-determination of [Ag(4,5-diazafluoren-9-one)<sub>2</sub>]NO<sub>3</sub> . H<sub>2</sub>O, crystal form 2 are presented. Crystal form 1 has a distorted trigonal planar coordination geometry around Ag(I) with an N-Ag-N bond angle of 123.45(7)<sup>o</sup>. Crystal form 2 has a perfect linear coordination around Ag, with N-Ag-N 180.0<sup>o</sup>. Compound I was characterized by <sup>1</sup>H-NMR, biological activity and ESI-MS in DMSO at room temperature. The biological activity was determined against 6 different resistant clinical isolates; two Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and four Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis, and Salmonella sp.) in comparison with 15 known antibiotics used in the treatment of diabetic foot infections. Compound I showed broad spectrum activity against all the test organisms. P. mirabilis and S. aureus and K. pneumoniae were the most sensitive clinical isolates (MIC = 4, 6 and 4 μg ml<sup>-1</sup>, respectively). Three different hydrogels containing I or Ag<sub>2</sub>SO<sub>4</sub> were prepared and the antimicrobial activity against Ps. aeruginosa (ATCC 15442) compared, showing more or less equal activity on a weight basis, but I seems to have a significant better performance per silver ion. The Ag(I) complex also binds more effectively to calf thymus DNA than the dafone ligand itself
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