An Observational Limit on the Dwarf Galaxy Population of the Local Group

We present the results of an all-sky, deep optical survey for faint Local Group dwarf galaxies. Candidate objects were selected from the second Palomar survey (POSS-II) and ESO/SRC survey plates and follow-up observations performed to determine whether they were indeed overlooked members of the Local Group. Only two galaxies (Antlia and Cetus) were discovered this way out of 206 candidates. Based on internal and external comparisons, we estimate that our visual survey is more than 77% complete for objects larger than one arc minute in size and with a surface brightness greater than an extremely faint limit over the 72% of the sky not obstructed by the Milky Way. Our limit of sensitivity cannot be calculated exactly, but is certainly fainter than 25 magnitudes per square arc second in R, probably 25.5 and possibly approaching 26. We conclude that there are at most one or two Local Group dwarf galaxies fitting our observational criteria still undiscovered in the clear part of the sky, and a roughly a dozen hidden behind the Milky Way. Our work places the "missing satellite problem" on a firm quantitative observational basis. We present detailed data on all our candidates, including surface brightness measurements.Comment: 58 pages in AJ manuscript format; some figures at slightly reduced quality; accepted by the Astronomical Journa

Concurrent Magnetic and Metal-Insulator Transitions in (Eu,Sm)B_6 Single Crystals

The effects of magnetic doping on a EuB_6 single crystal were investigated based on magnetic and transport measurements. A modest 5% Sm substitution for Eu changes the magnetic and transport properties dramatically and gives rise to concurrent antiferromagnetic and metal-insulator transitions (MIT) from ferromagnetic MIT for EuB6. Magnetic doping simultaneously changes the itinerant carrier density and the magnetic interactions. We discuss the origin of the concurrent magnetic MIT in (Eu,Sm)B_6.Comment: 13 pages, 3 figures, final version to appear in Appl. Phys. Lett

Echinostoma caprom' infection in non-pregnant female BALB/c and Swiss T.O. mice: effect on feed intake, liveweight, and serum pregnancy-associated murine protein-l and corticosterone

The effect of experimental infection with the intestinal ti'einatode. Echinosloma caprani, on feed intake, liyeweight and serum pregnaney-associated murine protein-l (PAMP-1) and corticosteronc was investigated in non-pregnant female BALB/cand Swiss T.O. mice. Twenty-five metacereariae were given by oral gavage on day 0 of which 19.6 % were recovered at post monem on day 46 in the BALB/c mice and 22.0 % in the Swiss T.O. mice. Oral praziquantel treatment (50 mg/kg) on day 39 reduced the recovery of tlnkes from previously-infected mice by 85.4% and 100% in BALB/e and Swiss T 0 mice respectively. The food consumption in the infected Swiss T.0. mice was significantly increased compared to the infected-treated and the controls. In the BALB/c mice the food intake in the infected and infectedtreated animals was significantly increased compared with the controls, The liveweight gain during the experiment in the BALB/e control mice was significantly higher than in the infectedtreated groups. In the Swiss T.0. mice the infected animals gained more weight than the controls and the infected- treated animals. E. caproni was associated with a significant reduction in PAMP-l concentrations in both strains of mice, even in animals from which the majority of flukes had been removed by praziquantel-treatment. There was no significant correlation between the magnitude of the parasite burden and serum PAMP~1 values. Corticosterone values were unaffected by either mouse strain, E. capromi infection or anthelmintie treatment. These results suggest that the previously reported adverse effect of E. capromi on early pregnancy in mice may be caused by parasiteiinduced effects occurring prior to fertilisation

Repeated stressors in adulthood increase the rate of biological ageing

Background Individuals of the same age can differ substantially in the degree to which they have accumulated tissue damage, akin to bodily wear and tear, from past experiences. This accumulated tissue damage reflects the individual’s biological age and may better predict physiological and behavioural performance than the individual‘s chronological age. However, at present it remains unclear how to reliably assess biological age in individual wild vertebrates. Methods We exposed hand-raised adult Eurasian blackbirds (Turdus merula) to a combination of repeated immune and disturbance stressors for over one year to determine the effects of chronic stress on potential biomarkers of biological ageing including telomere shortening, oxidative stress load, and glucocorticoid hormones. We also assessed general measures of individual condition including body mass and locomotor activity. Results By the end of the experiment, stress-exposed birds showed greater decreases in telomere lengths. Stress-exposed birds also maintained higher circulating levels of oxidative damage compared with control birds. Other potential biomarkers such as concentrations of antioxidants and glucocorticoid hormone traits showed greater resilience and did not differ significantly between treatment groups. Conclusions The current data demonstrate that repeated exposure to experimental stressors affects the rate of biological ageing in adult Eurasian blackbirds. Both telomeres and oxidative damage were affected by repeated stress exposure and thus can serve as blood-derived biomarkers of biological ageing.</p

SPEDEN: Reconstructing single particles from their diffraction patterns

Speden is a computer program that reconstructs the electron density of single particles from their x-ray diffraction patterns, using a single-particle adaptation of the Holographic Method in crystallography. (Szoke, A., Szoke, H., and Somoza, J.R., 1997. Acta Cryst. A53, 291-313.) The method, like its parent, is unique that it does not rely on ``back'' transformation from the diffraction pattern into real space and on interpolation within measured data. It is designed to deal successfully with sparse, irregular, incomplete and noisy data. It is also designed to use prior information for ensuring sensible results and for reliable convergence. This article describes the theoretical basis for the reconstruction algorithm, its implementation and quantitative results of tests on synthetic and experimentally obtained data. The program could be used for determining the structure of radiation tolerant samples and, eventually, of large biological molecular structures without the need for crystallization.Comment: 12 pages, 10 figure

Immunospecific Antibody Concentration in Egg Yolk of Chickens Orally Immunised with Varying Doses of Bovine Serum Albumin and the Mucosal Adjuvant, RhinoVax®, using Different Immunization Regimes

Antibody harvested from eggs of immunised chickens, IgY, has proven to be a non-invasive alternative to  antibodies purified from serum of mammals. Taking the non-invasive concept further, the development of  oral immunization techniques combined with IgY harvest from chicken eggs may subsequently eliminate  all regulated procedures from polyclonal antibody production. In the present study, we report the effects of  varying the temporal administration mode of the antigen (immunogen) comparing dosing on three consecutive  days with dosing on five consecutive days, and of incorporating a mucosal adjuvant. Two antigen  doses were compared: 30 mg bovine serum albumin (BSA) and 300 mg BSA, with and without the mucosal  adjuvant, RhinoVax®, administered to laying chickens. The egg yolk of chickens dosed with BSA in combination  with 20% RhinoVax®, contained significantly higher concentrations of immunospecific IgY than  did egg yolks of chickens fed with BSA without adjuvant. The most efficient dose in the RhinoVax®-treated  groups was 300 mg BSA regardless of whether the chickens were initially immunised daily for three or  five days. A 3-day dosing regime with BSA alone also induced immunospecific IgY production. This study  confirms that RhinoVax® is an efficient oral adjuvant. It also demonstrates the efficacy of daily immunizations  on three or five consecutive days on immunospecific IgY production. The chickens received oral  booster immunizations one and two months after the initial immunization. No real effect could be recorded  after the second and third immunization, although the study did provide some evidence of memory  based on an optimum IgY concentration recorded after the 2nd immunization.

Financial Transaction Tax: Small is Beautiful

The case for taxing financial transactions merely to raise more revenues from the financial sector is not particularly strong. Better alternatives to tax the financial sector are likely to be available. However, a tax on financial transactions could be justified in order to limit socially undesirable transactions when more direct means of doing so are unavailable for political or practical reasons. Some financial transactions are indeed likely to do more harm than good, especially when they contribute to the systemic risk of the financial system. However, such a financial transaction tax should be very small, much smaller than the negative externalities in question, because it is a blunt instrument that also drives out socially useful transactions. There is a case for taxing over-the-counter derivative transactions at a somewhat higher rate than exchange-based derivative transactions. More targeted remedies to drive out socially undesirable transactions should be sought in parallel, which would allow, after their implementation, to reduce or even phase out financialtransaction taxes

Atom capture by nanotube and scaling anomaly

The existence of bound state of the polarizable neutral atom in the inverse square potential created by the electric field of single walled charged carbon nanotube (SWNT) is shown to be theoretically possible. The consideration of inequivalent boundary conditions due to self-adjoint extensions lead to this nontrivial bound state solution. It is also shown that the scaling anomaly is responsible for the existence of bound state. Binding of the polarizable atoms in the coupling constant interval \eta^2\in[0,1) may be responsible for the smearing of the edge of steps in quantized conductance, which has not been considered so far in literature.Comment: Accepted in Int.J.Theor.Phy

Progress in Three-Dimensional Coherent X-Ray Diffraction Imaging

The Fourier inversion of phased coherent diffraction patterns offers images without the resolution and depth-of-focus limitations of lens-based tomographic systems. We report on our recent experimental images inverted using recent developments in phase retrieval algorithms, and summarize efforts that led to these accomplishments. These include ab-initio reconstruction of a two-dimensional test pattern, infinite depth of focus image of a thick object, and its high-resolution (~10 nm resolution) three-dimensional image. Developments on the structural imaging of low density aerogel samples are discussed.Comment: 5 pages, X-Ray Microscopy 2005, Himeji, Japa

New Consequences of Induced Transparency in a Double-Lambda scheme: Destructive Interference In Four-wave Mixing

We investigate a four-state system interacting with long and short laser pulses in a weak probe beam approximation. We show that when all lasers are tuned to the exact unperturbed resonances, part of the four-wave mixing (FWM) field is strongly absorbed. The part which is not absorbed has the exact intensity required to destructively interfere with the excitation pathway involved in producing the FWM state. We show that with this three-photon destructive interference, the conversion efficiency can still be as high as 25%. Contrary to common belief,our calculation shows that this process, where an ideal one-photon electromagnetically induced transparency is established, is not most suitable for high efficiency conversion. With appropriate phase-matching and propagation distance, and when the three-photon destructive interference does not occur, we show that the photon flux conversion efficiency is independent of probe intensity and can be close to 100%. In addition, we show clearly that the conversion efficiency is not determined by the maximum atomic coherence between two lower excited states, as commonly believed. It is the combination of phase-matching and constructive interference involving the two terms arising in producing the mixing wave that is the key element for the optimized FWM generation. Indeed, in this scheme no appreciable excited state is produced, so that the atomic coherence between states |0> and |2> is always very small.Comment: Submitted to Phys. Rev. A, 7 pages, 4 figure