Numerical simulations of the flow and sediment transport regimes surrounding a short cylinder

Author Posting. © IEEE, 2007. This article is posted here by permission of IEEE for personal use, not for redistribution. The definitive version was published in IEEE Journal of Oceanic Engineering 32 (2007): 249-259, doi:10.1109/JOE.2007.890986.The 3-D flow field and bed stress surrounding a short cylinder in response to combined wave and mean-flow forcing events is examined. Model simulations are performed with a 3-D nonhydrostatic computational fluid dynamics model, FLOW-3D. The model is forced with a range of characteristic tidal and wave velocities as observed in 12–15 m of water at the Martha's Vineyard Coastal Observatory (MVCO, Edgartown, MA). The 2.4-m-long and 0.5-m diameter cylinder is buried 10% of the diameter on a flat, fixed bed. Regions of incipient motion are identified through local estimates of the Shields parameter exceeding the critical value. Potential areas of sediment deposition are identified with local estimates of the Rouse parameter exceeding ten. The model predictions of sediment response are in general in agreement with field observations of seabed morphology obtained over a one-week period during the 2003–2004 MVCO mine burial experiment. Both observations and simulations show potential transport occurring at the ends of the mine in wave-dominated events. Mean flows greater than 10 cm/s lead to the formation of larger scour pits upstream of the cylinder. Deposition in both cases tends to occur along the sides, near the center of mass of the mine. However, the fixed-bed assumption prohibits the prediction of full perimeter scour as is observed in nature. Predicted scour and burial regimes for a range of wave and mean-flow combinations are established.This work was supported in part by the U.S. Office of Naval Research under the mine burial project N00014-00-1-0570. The work of K. A. Hatton was supported by the National Science Foundation Graduate Research Fellowship

How to Create Videos for Extension Education: An Innovative Five-Step Procedure

Although the benefits of using video as a learning tool in Extension programs are well known, less is understood about effective methods for creating videos. We present a five-step procedure for developing educational videos that focus on evidence-based practices, and we provide practical examples from our use of the five steps in creating a video series for an Extension program. Through the effective development of videos, Extension professionals can organize and present information in a meaningful way. Using video media can be a successful way to demonstrate best practices, but there has been limited guidance for how to develop such media. The five-step procedure described in this article can be adapted in a variety of Extension areas to develop educational videos that effectively illustrate evidence-based practices

SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection

COVID-19 causes severe disease with poor outcomes. We tested the hypothesis that early SARS-CoV-2 viral infection disrupts innate immune responses. These changes may be important for understanding subsequent clinical outcomes. We obtained residual nasopharyngeal swab samples from individuals who requested COVID-19 testing for symptoms at drive-through COVID-19 clinical testing sites operated by the University of Utah. We applied multiplex immunoassays, real-time polymerase chain reaction assays and quantitative proteomics to 20 virus-positive and 20 virus-negative samples. ACE-2 transcripts increased with infection (OR =17.4, 95% CI [CI] =4.78-63.8) and increasing viral N1 protein transcript load (OR =1.16, CI =1.10-1.23). Transcripts for two interferons (IFN) were elevated, IFN-λ1 (OR =71, CI =7.07-713) and IFN-λ2 (OR =40.2, CI =3.86-419), and closely associated with viral N1 transcripts (OR =1.35, CI =1.23-1.49 and OR =1.33 CI =1.20-1.47, respectively). Only transcripts for IP-10 were increased among systemic inflammatory cytokines that we examined (OR =131, CI =1.01-2620). We found widespread discrepancies between transcription and translation. IFN proteins were unchanged or decreased in infected samples (IFN-γ OR =0.90 CI =0.33-0.79, IFN-λ2,3 OR =0.60 CI =0.48-0.74) suggesting viral-induced shut-off of host antiviral protein responses. However, proteins for IP-10 (OR =3.74 CI =2.07-6.77) and several interferon-stimulated genes (ISG) increased with viral load (BST-1 OR =25.1, CI =3.33-188; IFIT1 OR =19.5, CI =4.25-89.2; IFIT3 OR =245, CI =15-4020; MX-1 OR =3.33, CI =1.44-7.70). Older age was associated with substantial modifications of some effects. Ambulatory symptomatic patients had an innate immune response with SARS-CoV-2 infection characterized by elevated IFN, proinflammatory cytokine and ISG transcripts, but there is evidence of a viral-induced host shut-off of antiviral responses. Our findings may characterize the disrupted immune landscape common in patients with early disease