Administration error of benzathine penicillin G in a Saudi male

Background Benzathine penicillin G is indicated for intramuscular (IM ) administration. There have been reports of unintentional intravenous (IV ) administration, which has been associated with cardiorespiratory arrest and death. This article reports on a case of inadvertent IV administration of benzathine penicillin G instead of IM injection. Clinical details A 29‐year‐old Saudi army male with no history of any chronic illness visited the Security Forces Hospital in Makkah because of injuries to his left hand and left ear as a result of a bomb blast. The patient underwent surgery, and was conscious, oriented and vitally stable after the operation. He was prescribed benzathine penicillin G to prevent wound infection, but the injection was incorrectly administered IV instead of IM . Outcomes The patient did not exhibit any visible clinical symptoms after receiving the drug via the wrong route. The patient's vital signs were fine and he did not have a fever. The full complete blood count was normal, except for a mild elevation in the neutrophil count (84%) and a mild decrease in lymphocytes (8.8%). Random blood glucose was 149 mg/dL and the activated partial thromboplastin time was 39.3 s. All other laboratory investigations were within the normal range. The creatinine concentration fluctuated between 0.8 and 1 mg/dL. Conclusion This was an obvious case of a drug‐related problem categorised as a ‘wrong route error’. The role of clinical pharmacists in preventing such errors is important to ensure patient safety.Scopu

Co-crystallization of a neutral molecule and its zwitterionic tautomer: structure and Hirshfeld surface analysis of 5-methyl-4-(5-methyl-1H-pyrazol-3-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-one 5-methyl-4-(5-methyl-1H-pyrazol-2-ium-3-yl)-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-1-ide monohydrate

The title compound, 2C14H14N4OH2O, comprises a neutral molecule containing a central pyrazol-3-one ring flanked by an N-bound phenyl group and a C-bound 5-methyl-1H-pyrazol-3-yl group (at positions adjacent to the carbonyl substituent), its zwitterionic tautomer, whereby the N-bound proton of the central ring is now resident on the pendant ring, and a water molecule of crystallization. Besides systematic variations in geometric parameters, the two independent organic molecules have broadly similar conformations, as seen in the dihedral angle between the five-membered rings [9.72 (9) for the neutral molecule and 3.32 (9) for the zwitterionic tautomer] and in the dihedral angles between the central and pendant five-membered rings [28.19 (8) and 20.96 (8) (neutral molecule); 11.33 (9) and 11.81 (9)]. In the crystal, pyrazolyl-N—HO(carbonyl) and pyrazolium-N—HN(pyrazolyl) hydrogen bonds between the independent organic molecules give rise to non-symmetric ninemembered {HNNHNC3O} and {HNNHNC3O} synthons, which differ in the positions of the N-bound H atoms. These aggregates are connected into a supramolecular layer in the bc plane by water-O—HN(pyrazolide), waterO—HO(carbonyl) and pyrazolyl-N—HO(water) hydrogen bonding. The layers are linked into a three-dimensional architecture by methyl-C—H(phenyl) interactions. The different interactions, in particular the weaker contacts, formed by the organic molecules are clearly evident in the calculated Hirshfeld surfaces, and the calculated electrostatic potentials differentiate the tautomers

An Overview Of Brucellosis Epidemiology, Management Approaches, And Public Health Concern

The zoonotic disease known as brucellosis is caused by a number of different species of the genus Brucella. Not only does it primarily impact cattle and wildlife, but it also poses serious hazards to public health, particularly in areas where hygiene, food safety, and veterinary care standards are not as high as they should be. It is possible for humans to get the disease by consuming contaminated animal products or by interacting with animals that are afflicted. It can be concluded that brucellosis is a significant zoonotic disease that has ramifications for the health of the general populace. It is imperative that efforts be directed toward the development and implementation of efficient animal immunization programs, as well as the improvement of diagnostic tools, antibiotic stewardship, and in the fight against antibiotic resistance. When it comes to addressing the adverse effects that brucellosis has on global health, interdisciplinary collaboration and continued research are absolutely necessary

An Overview Healthcare Management Roles with the Physicians, Nurses, Medical Laboratory and Pharmacist to Promote Patient Saftey and Care

Through interactions with healthcare administration in community settings, nurse-pharmacists, clinical laboratories, and physicians were able to enhance disease management, prevent adverse medication events, and minimize the number of patients who required hospitalization. In the end, they led to the early detection and rectification of medication safety-related difficulties, a reduction in wait times to see general practitioners, and an improvement in the ability of individuals living in the community to manage chronic diseases on their own. For the purpose of maintaining such cooperation, particularly in community settings, it is necessary to do research in order to enhance the existing policies and organizational structures. Through interaction with both the patient and the physician, the clinical pharmacist becomes an essential member of the healthcare team and contributes to the improvement of patient care

Performance of Healthcare workers regarding Infection Control Precautions in Primary Health Care Centers

Background: Standard precautions are designed to protect healthcare staff from risks resulting from exposure to blood and body fluids and to protect patients from potential cross-infection. Knowledge of clinical infection control practices is continually growing and changing. The study aimed to assess healthcare workers’ performance regarding infection control precautions in primary healthcare centers. Research design: a descriptive-analytical design was used. Subjects: a simple random sample of a total of 379 healthcare workers was recruited from January to March 2022, at selected primary healthcare centers, in Jeddah, KSA according to a large number of healthcare workers. Tools of data collection: three tools were used to collect data: a structured self-administered healthcare workers\u27 questionnaire, an observational checklist, and an environmental assessment checklist. Results: The results revealed that 44.6% of the studied participants had an average level of total knowledge, whereas 58.6% of them had incompetent practice regarding infection control precautions. Moreover, there was a highly statistically significant positive linear correlation between total healthcare workers\u27 knowledge about infection control precautions in primary healthcare centers and their practice at (r = 0.317, and p =0.000). In conclusion, Based on the findings of this study, it can be concluded that more than one-third of healthcare workers in the current study had average overall knowledge scores, while more than one-half of them had incompetent practice regarding infection control precautions. A highly statistically significant positive linear correlation between total healthcare workers\u27 knowledge about infection control precautions in primary healthcare centers and their practice was pointed up. Recommendations: A mandatory regular base educational program must be planned to overcome the weak level of knowledge and update the practice regarding infection control standard precautions

Prevalence, Recognition, And Management Of Mental Disorders In Primary Care

According to latest figures, 50% of individuals will have a minimum of one mental health issue in their lifetime, with at least 25% experiencing a mental condition in the previous year. primary care doctors are overwhelmingly responsible for recognition, evaluation, therapy, and referral, with at least one-third of their consultations containing a direct and obvious mental aspect Primary care physicians are the foundation of the majority of medical care programs that involve recognizing, diagnosing, treating, and referring patients to specialists for every kind of diseases, whether physical, mental, or both. Over the last two decades, there has been a greater emphasis on this position, notably in the treatment of mental problems in primary care

Review: Healthcare Informatics , Nurses And Assistant, And Healthcare Management Responsibilities In Facilitating Obstacles Facing Patients Centred Care

Healthcare systems, organizations, and providers, including healthcare informatics, nurses, assistants, and healthcare administration, face the challenge of arranging patient care within limited resources. In order to effectively implement patient-centred care (PCC), it is necessary to remove any obstacles or hindrances that may arise. Thus far, there has been a dearth of thorough examinations on potential factors influencing patient-centered care (PCC) in diverse health and social care organizations (HSCOs). The findings underscored the patient\u27s uniqueness, cultural beliefs, comprehensive care, the significance of robust healthcare provider-patient connections, and a patient-focused setting. The nursing, administrative, and informatics staff regarded PCC as having a good impact on the quality of nursing care and the job satisfaction of nurses. The findings provide detailed insights into the viewpoints of nurse managers regarding patient-centeredness and identify specific areas that require improvement

Review: Medical Equipment Engineering and the Role of Health Adminstration and Nurses in Promoting the Proper Collaboration

By taking on expanded roles in collaboration with administrative and medical equipment engineering, to working in new settings in innovative ways, and to partnering with communities and other sectors, nurses have the potential to be key contributors to making substantial progress toward health care equity in the world in the decade that lies ahead. However, the potential for nurses to assist individuals and communities in leading healthier lives can only be fulfilled if the obstacles that prevent them from working to the full extent of their education and training are addressed

Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas

Recently, two cases of complete remission of classical Hodgkin lymphoma (cHL) and follicular lymphoma (FL) after SARS-CoV-2 infection were reported. However, the precise molecular mechanism of this rare event is yet to be understood. Here, we hypothesize a potential anti-tumor immune response of SARS-CoV-2 and based on a computational approach show that: (i) SARS-CoV-2 Spike-RBD may bind to the extracellular domains of CD15, CD27, CD45, and CD152 receptors of cHL or FL and may directly inhibit cell proliferation. (ii) Alternately, upon internalization after binding to these CD molecules, the SARS-CoV-2 membrane (M) protein and ORF3a may bind to gamma-tubulin complex component 3 (GCP3) at its tubulin gamma-1 chain (TUBG1) binding site. (iii) The M protein may also interact with TUBG1, blocking its binding to GCP3. (iv) Both the M and ORF3a proteins may render the GCP2-GCP3 lateral binding where the M protein possibly interacts with GCP2 at its GCP3 binding site and the ORF3a protein to GCP3 at its GCP2 interacting residues. (v) Interactions of the M and ORF3a proteins with these gamma-tubulin ring complex components potentially block the initial process of microtubule nucleation, leading to cell-cycle arrest and apoptosis. (vi) The Spike-RBD may also interact with and block PD-1 signaling similar to pembrolizumab and nivolumab- like monoclonal antibodies and may induce B-cell apoptosis and remission. (vii) Finally, the TRADD interacting “PVQLSY” motif of Epstein-Barr virus LMP-1, that is responsible for NF-kB mediated oncogenesis, potentially interacts with SARS-CoV-2 M(pro), NSP7, NSP10, and spike (S) proteins, and may inhibit the LMP-1 mediated cell proliferation. Taken together, our results suggest a possible therapeutic potential of SARS-CoV-2 in lymphoproliferative disorders

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ПОДРОСТКИМОЛОЧНЫЕ ЖЕЛЕЗЫ ЧЕЛОВЕКА /АНОМАЛБОЛЕЗНИ РЕДКИЕМАКРОМАСТИЯГИПЕРТРОФИЯМОЛОЧНОЙ ЖЕЛЕЗЫ ПЛАСТИКАХИРУРГИЧЕСКИЕ ОПЕРАЦИИ ВОССТАНОВИТЕЛЬНЫЕМОЛОЧНОЙ ЖЕЛЕЗЫ БОЛЕЗНИ /ТЕР /ХИ