Structural heterogeneity in the megathrust zone and mechanism of the 2011 Tohoku-oki earthquake (Mw 9.0)

The great 2011 Tohoku-oki earthquake (Mw 9.0) and its 339 foreshocks and 5,609 aftershocks (9–27 March 2011) were relocated using a three-dimensional seismic velocity model and local P and S wave arrival times. The distribution of relocated hypocenters was compared with a tomographic image of the Northeast Japan forearc. The comparison indicates that the rupture nucleation of the largest events in the Tohoku-oki sequence, including the mainshock, was controlled by structural heterogeneities in the megathrust zone

Deep structure of Japan subduction zone as derived from local, regional, and teleseismic events

We have determined a detailed three-dimensional P wave velocity structure of the Japan subduction zone to 500-km depth by inverting local, regional, and teleseismic data simultaneously. We used 45,318 P wave arrivals from 1241 shallow and deep earthquakes which occurred in and around the Japan Islands. The arrival times are recorded by the Japan University Seismic Network which covers the entire Japan Islands densely and uniformly. We also used 4211 travel time residuals from 100 teleseismic events which are read from seismograms recorded by seismic stations in northeastern Japan. In comparison with the previous results obtained from only local and regional events, the present result for the area around the lower plate boundary and the mantle below the plate is determined more reliably because of the addition of 7035 data from 100 teleseismic events and 41 very deep earthquakes. In the crust and uppermost mantle, low-velocity zones are clearly visible beneath active volcanoes. In the mantle wedge the low-velocity zones generally parallel with the slab and exist continuously to a depth of about 200-km, which is consistent with the petrological, geochemical and geodynamic studies. We consider that the existence of volcanism-related low-velocity anomalies in the mantle wedge is a general Seismological characteristic of subduction zones, in light of all the available tomographic results for many subduction zones in the world. The Pacific slab beneath Japan is imaged more clearly than in previous studies as a high-velocity zone with a thickness of 80–90 km and a P wave velocity 4–6% higher than the normal mantle. Lower velocity anomalies are found in the mantle below the slab

Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cells

<p>Abstract</p> <p>Background</p> <p>HTLV-1 causes adult T-cell leukemia (ATL). Although there have been many studies on the oncogenesis of the viral protein Tax, the precise oncogenic mechanism remains to be elucidated. Recently, a new viral factor, HTLV-1 basic Zip factor (HBZ), encoded from the minus strand mRNA was discovered and the current models of Tax-centered ATL cell pathogenesis are in conflict with this discovery. HBZs consisting of non-spliced and spliced isoforms (HBZ-SI) are thought to be implicated in viral replication and T-cell proliferation but there is little evidence on the HBZ expression profile on a large scale.</p> <p>Results</p> <p>To investigate the role of HBZ-SI in HTLV-1 provirus-positive cells, the HBZ-SI and Tax mRNA loads in samples with a mixture of infected and non-infected cells were measured and then adjusted by dividing by the HTLV-I proviral load. We show here that the HBZ-SI mRNA level is 4-fold higher than non-spliced HBZ and is expressed by almost all cells harboring HTLV-1 provirus with variable intensity. The proviral-adjusted HBZ-SI and Tax quantification revealed a characteristic imbalanced expression feature of high HBZ and low Tax expression levels in primary ATL cells or high HBZ and very high Tax levels in HTLV-1-related cell lines (cell lines) compared with a standard expression profile of low HBZ and low Tax in infected cells. Interestingly, according to the mutual Tax and HBZ expression status, HTLV-1-related cell lines were subcategorized into two groups, an ATL cell type with high HBZ and low Tax levels and another type with high Tax and either high or low HBZ, which was closely related to its cell origin.</p> <p>Conclusion</p> <p>This is the first comprehensive study to evaluate the mutual expression profile of HBZ and Tax in provirus-positive cells, revealing that there are quantitative and relative characteristic features among infected cells, primary ATL cells, and cell lines.</p

Absence of spontaneous action anticipation by false belief attribution in children with autism spectrum disorder

Recently, a series of studies demonstrated false belief understanding in young children through completely nonverbal measures. These studies have revealed that children younger than 3 years of age, who consistently fail the standard verbal false belief test, can anticipate others' actions based on their attributed false beliefs. The current study examined whether children with autism spectrum disorder (ASD), who are known to have difficulties in the verbal false belief test, may also show such action anticipation in a nonverbal false belief test. We presented video stimuli of an actor watching an object being hidden in a box. The object was then displaced while the actor was looking away. We recorded children's eye movements and coded whether they spontaneously anticipated the actor's subsequent behavior, which could only have been predicted if they had attributed a false belief to her. Although typically developing children correctly anticipated the action, children with ASD failed to show such action anticipation. The results suggest that children with ASD have an impairment in false belief attribution, which is independent of their verbal ability

Subcutaneous Nodule on the Right Palm of a Young Boy : A Quiz

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Molecular epidemiology of Clostridioides difficile and risk factors for the detection of toxin gene-positive strains

In this study, we investigated all Clostridioides difficile strains isolated from stool samples in Nagasaki University Hospital between January 2012 and December 2014. Toxin genes (tcdA, tcdB and cdtA/cdtB) were analyzed for multiplex PCR in a total of 213 strains. In the toxin gene-positive strain, PCR ribotyping was conducted using capillary gel electrophoresis-based PCR and the Webribo database. Patients’ backgrounds were analyzed by departments, disorders, antimicrobials, and clinical dates. The positive rates of tcdA, tcdB, and cdtA/cdtB genes were 62.9%, 63.4%, and 2.8%, respectively. The most frequent PCR ribotype was 047 (14.1%), followed by 014/0 (11.1%) and 002/0 (8.2%). In univariate analysis, the risk factors for the detection of toxin gene-positive strains in patients were older age (p = 0.0036), over ≥ 65 years old (p = 0.0175), the patients hospitalized at Department of Digestive Surgery (P = 0.0059), higher CRP level (P = 0.0395), and lower albumin level (p = 0.0014). In the multivariate analysis, the risk factor for detection of toxin gene-positive strains was the patients hospitalized at Department of Digestive Surgery (OR; 4.62, 95% CI; 1.18–18.0, p = 0.0274). In this study, the percentage of toxin gene-positive and cdtA/cdtB gene-positive strains was almost the same as that reported in previous studies, but the ribotype was different. In addition, we revealed that the risk factor associated with the detection of toxin gene-positive strains was the patients hospitalized at Department of digestive surgery

Extracting proficiency differences and individual characteristics in golfers' swing using single-video markerless motion analysis

In this study, we analyzed golfers' swing movement to extract differences in proficiency and individual characteristics using two-dimensional video data from a single camera. We conducted an experiment with 27 golfers who had a wide range of skill levels, using a 7-iron; we acquired video data with a camera on the sagittal plane. For data extraction, we used pose estimation (using HRNet) and object detection (using DeepLabCut) methods to extract human-joint and club-head data. We examined the relationship between proficiency and individual characteristics vis-à-vis forward tilt angle and club trajectory. The results showed that the stability and reproducibility of the forward tilt angle are characteristics of proficiency. Highly skilled golfers showed low variability and high reproducibility between trials in forward tilt angle. However, we found that club trajectory may not be a characteristic of proficiency but rather an individual characteristic. Club trajectory was divided roughly into clockwise rotation and counterclockwise rotation. Thus, the analysis based on video data from a single markerless camera enabled the extraction of the differences in proficiency and individual characteristics of golf swing. This suggests the usefulness of our system for simply evaluating golf swings and applying it to motor learning and coaching situations

Landslide basal friction as measured by seismic waves

Dynamical predictions of landslide runout require measurements of the basal friction. Here we present the first seismically determined bounds on the frictional coefficients for three large volcanic landslides. The three landslides (Bezymianny, Russia 1956, Sheveluch, Russia 1964 and Mount St. Helens, USA 1980) have masses that vary by a factor of 5 and were all followed immediately by eruptions. We use teleseismic and regional seismic data to show that all three landslides are consistent with an apparent coefficient of friction of 0.2 which corresponds to an actual areally-averaged frictional coefficient of 0.2–0.6. The apparent friction is independent of the quantity of hot gas subsequently released

Detection of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae using the MALDI Biotyper Selective Testing of Antibiotic Resistance?β-Lactamase (MBT STAR-BL) assay

The MALDI Biotyper Selective Testing of Antibiotic Resistance?β-Lactamase (MBT STAR-BL) assay, which analyzes bacterial induced hydrolysis of cefotaxime using MALDI-TOF MS, correctly identified 100.0% of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae as positive and 94.7% of non-ESBL producers as negative in 80 strains tested