SJÖGREN SENDROMLU HASTANIN ORAL BULGULARI VE DENTAL TEDAVİ YAKLAŞIMI: OLGU SUNUMU [Oral Findings and Dental Treatment Approach of the Patient with Sjögren’s Syndrome: A Case Report ]

ÖZET Sjögren sendromu endokrin bezlerin, özellikle de lakrimal ve tükürük bezlerinin, bağışıklık sistemi ile yıkıma uğraması nedeniyle oluşan, göz kuruluğu (kseroftalmi) ve ağız kuruluğu (kserestomi) ile tanımlanan bir sendromdur. Hastalığın oral belirtileri olarak, yarıklı dil, mantar enfeksiyonları başta olmak üzere sık oral enfeksiyonlar ve özellikle kök yüzeylerinde olmak üzere özellikle köklerde ve kesicilerde yaygın çürükler görülmektedir. Bu çalışmanın amacı Primer Sjögren sendromlu bir hastada hastalığın oral bulgularını ve dental tedavi yaklaşımını sunmaktır. Anahtar kelimeler: Sjögren Sendromu, Ağız kuruluğu, Oral Sağlık ABSTRACT Public demand for tooth whitening has increased in recent Sjogren’s syndrome is defined as a syndrome of dry eyes (xerophthalmia) and dry mouth (xerostomia) due to immune destruction of endocrine glands, especially of the lacrimal and salivary glands. Oral manifestations of this disease include tongue fissures, frequent mouth infections including fungal infections, and rampant dental caries, especially at root and incisors. The aim of this study is to present oral findings and dental treatment of a patient with Primer Sjögren Syndrome. Keywords: Sjögren Syndrome, Xerostomia, Oral Healt

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C

Unusual treatment of symptomatic condensing osteitis related to mandibular premolar teeth: a case report

<p><strong>Objectives:</strong> Condensing osteitis is defined as pathologic sclerosis of maxillo-mandibular bones characterized by mild clinical symptoms. This case report presented a different approach to a patient with symptomatic condensing osteitis.</p> <p><strong>Materials and Methods:</strong> A twenty one years old male patient was referred to our department because of pain in his left mandibular region during chewing. Intraoral examination revealed pain in the lower left first premolar tooth during percussion and it was seen that this tooth was associated with an apical sclerotic lesion approximately 1cm wide in radiographic examination. Root canal treatment was performed to the tooth. As complaints of pain during chewing exceeded, both biopsy and apical root resection were performed.</p> <p><strong>Results:</strong> The lesion was diagnosed as symptomatic condensing osteitis after clinical, radiological and pathological examinations. A month after the operation, the patient’s symptoms completely disappeared. In 6, and 12 months radiographic controls, beginning of new bone formation in region of resection and also regression of lesion were observed.</p> <p><strong>Conclusions:</strong> The conventional treatment of condensing osteitis is extraction of related tooth and curetting of that region or root treatment of related the tooth. In this type of lesion, in condition of failed root canal treatment, instead of the tooth extraction, as a different treatment option, apical root resection can cut the relationship between the root and the lesion.</p&gt

Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children

International audienceMultisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1 , OAS2 , or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)–sensing OAS1 and OAS2 generate 2′-5′-linked oligoadenylates (2-5A) that activate the single-stranded RNA–degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L–deficient cells. Cytokine production in RNase L–deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS–RNase L deficiencies in these patients unleash the production of SARS-CoV-2–triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C