The accuracy of chromosomal microarray testing for identification of embryonic mosaicism in human blastocysts

A dança é uma forma ancestral de magia, invenção dos deuses que a ensinaram aos homens, diz-nos a mitologia hindu. Envolvido no mistério e movimento da dança, o dançarino pode encantar; porém, antes de tudo é preciso que encante a si mesmo. Não seria este também o caminho do professor? Fazer para si para poder fazer ou propor aos educandos, encantar-se para poder encantar; criar para poder seguir com as crianças a aventura da criação; ousar para poder encorajar? Nesta direção, a pergunta que percorre o presente artigo é assim formulada: como contribuir com o processo de encantamento dos professores, como alimentar a sensibilidade, nos percursos da formação universitária? Buscando respostas no processo de pesquisa, identifica-se na experiência com as danças circulares, tradição de diferentes povos, um profícuo caminho pelo qual aquele espaço de encantamento, de inteireza, de educação estética, igualmente, pode ser provocado

DLCQ of Fivebranes, Large N Screening, and L^2 Harmonic Forms on Calabi Manifolds

We find one explicit L^2 harmonic form for every Calabi manifold. Calabi manifolds are known to arise in low energy dynamics of solitons in Yang-Mills theories, and the L^2 harmonic form corresponds to the supersymmetric ground state. As the normalizable ground state of a single U(N) instanton, it is related to the bound state of a single D0 to multiple coincident D4's in the non-commutative setting, or equivalently a unit Kaluza-Klein mode in DLCQ of fivebrane worldvolume theory. As the ground state of nonabelian massless monopoles realized around a monopole-``anti''-monopole pair, it shows how the long range force between the pair is screened in a manner reminiscent of large N behavior of quark-anti-quark potential found in AdS/CFT correspondence.Comment: LaTeX, 23 page

Rape, inequality and the criminal justice response in England: The importance of age and gender

© The Author(s) 2019. This article draws upon quantitative and content analysis of 585 reports of rape recorded within two police force areas in England in 2010 and in 2014 tracking individual incidents to eventual outcome to examine the impact, if any, of intersecting inequalities on trajectories of rape cases reported to police. The data were collected as part of the wider Economic and Social Research Council funded Justice, Inequality and Gender-Based Violence research project which examined victim-survivor experiences and perspectives on justice. Building on existing distinctions between types of rape case based on the relationship between victim-survivor and accused, the results suggest age and gender are significant factors in how sexual violence, and the criminal justice system, is experienced. While younger women and girls were disproportionately affected by certain types of sexual violence case and more likely to come into contact with the criminal justice system compared to men and older women, they were not necessarily more likely to achieve a conviction. The findings also confirm that some of the most vulnerable victims-survivors of sexual violence, especially those with poor mental health, are still not achieving criminal justice. Victims-survivors from Black and minority ethnic group or lesbian, gay, bisexual, transgender, transsexual, queer groups are underrepresented within the criminal justice system, implying these groups are not seeking a criminal justice response in the same way as ‘white’ heterosexual victims-survivors

The smart grid as commons: exploring alternatives to infrastructure financialisation

This paper explores a tension between financialisation of electricity infrastructures and efforts to bring critical urban systems into common ownership. Focusing on the emerging landscape of electricity regulation and e-mobility in the United Kingdom (UK), it examines how electricity grid ownership has become financialised, and why the economic assumptions that enabled this financialisation are being called into question. New technologies, such as smart electricity meters and electric vehicles, provide cities with new tools to tackle poor air quality and greenhouse gas emissions. Electricity grids are key enabling infrastructures but the companies that run them do not get rewarded for improving air quality or tackling climate change. UK government regulation of electricity grids both enables financialisation and forecloses opportunities to manage the infrastructure for wider environmental and public benefit. Nonetheless, the addition of smart devices to this network - the ‘smart grid’ – opens up an opportunity for common ownership of the infrastructure. Transforming the smart grid into commons necessitates deep structural reform to the entire architecture of infrastructure regulation in the UK

Mystify me: Coke, terror and the symbolic immortality boost

A panel on “Marketing as Mystification” convened at the 2011 Academy of Marketing conference in Liverpool. Ideas from the Liverpool event were supplemented by commentaries from selected other authors. Each commentary explores the aspects of “mystification” observable in marketing discourses and practices. In what follows, Laufer interprets marketing mystification as modern form of sophism, Dholakia and Firat discuss mystifying ways that inequality is marketed, Varman analyzes the perversion and mystification of “development” via neoliberal marketing of “social entrepreneurship,” Mikkonen explores mystifying marketing representations of gays and lesbians, and Freund and Jacobi present a fascinating interpretation of how Coca-Cola advertising mystically reassures us that our difficult, dangerous lifeworld is actually quite hunky-dory. </jats:p

The effectiveness of flow cytometric sorting of human sperm (MicroSort) for influencing a child’s sex

Abstract Background: Flow cytometric sorting can be used to separate sperm based on sex chromosome content. Differential fluorescence emitted by stained X-vs. Y-chromosome-bearing sperm enables sorting and collection of samples enriched in either X-or Y-bearing sperm for use to influence the likelihood that the offspring will be a particular sex. Herein we report the effectiveness of flow cytometric sorting of human sperm and its use in human ART procedures

Taking stock of gene therapy for cystic fibrosis

The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal models in vivo has been followed by numerous clinical studies using both viral and non-viral vectors to transfer normal copies of the gene to the lungs and noses of CF patients. A wealth of data have emerged from these studies, reflecting enormous progress and also helping to focus and define key difficulties that remain unresolved. Gene therapy for CF remains the most promising possibility for curative rather than symptomatic therapy

A Spitzer Survey of Young Stellar Clusters within One Kiloparsec of the Sun: Cluster Core Extraction and Basic Structural Analysis

We present a uniform mid-infrared imaging and photometric survey of 36 young, nearby, star-forming clusters and groups using {\it Spitzer} IRAC and MIPS. We have confidently identified and classified 2548 young stellar objects using recently established mid-infrared color-based methods. We have devised and applied a new algorithm for the isolation of local surface density enhancements from point source distributions, enabling us to extract the overdense cores of the observed star forming regions for further analysis. We have compiled several basic structural measurements of these cluster cores from the data, such as mean surface densities of sources, cluster core radii, and aspect ratios, in order to characterize the ranges for these quantities. We find that a typical cluster core is 0.39 pc in radius, has 26 members with infrared excess in a ratio of Class II to Class I sources of 3.7, is embedded in a $A_K$=0.8 mag cloud clump, and has a surface density of 60 pc$^{-2}$. We examine the nearest neighbor distances among the YSOs in several ways, demonstrating similarity in the spacings between Class II and Class I sources but large member clusters appear more dense than smaller clusters. We demonstrate that near-uniform source spacings in cluster cores are common, suggesting that simple Jeans fragmentation of parsec-scale cloud clumps may be the dominant process governing star formation in nearby clusters and groups. Finally, we compare our results to other similar surveys in the literature and discuss potential biases in the data to guide further interpretation.Comment: 207 pages, 54 figures, 44 tables. Accepted to ApJ Supplements. Full resolution version at http://www.cfa.harvard.edu/~rgutermuth/preprints/gutermuth_clusters_survey.pd

Open Wilson Lines and Generalized Star Product in Noncommutative Scalar Field Theories

Open Wilson line operators and generalized star product have been studied extensively in noncommutative gauge theories. We show that they also show up in noncommutative scalar field theories as universal structures. We first point out that dipole picture of noncommutative geometry provides an intuitive argument for robustness of the open Wilson lines and generalized star products therein. We calculate one-loop effective action of noncommutative scalar field theory with cubic self-interaction and show explicitly that the generalized star products arise in the nonplanar part. It is shown that, at low-energy, large noncommutativity limit, the nonplanar part is expressible solely in terms of the {\sl scalar} open Wilson line operator and descendants.Comment: 13 pages, Latex, 1 .eps figure, v2. typos corrected, v3. combinatorics correcte