The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.

We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC – IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC

Le Muséum au premier siècle de son histoire

1793. En pleine Terreur, la Convention nationale crée le Muséum national d’Histoire naturelle. Le décret du 10 juin confie, à ce qui fut le Jardin du roi, la tâche d’enseigner les sciences naturelles au peuple. Le présent ouvrage retrace les grandes étapes du développement du Muséum en tant qu’Institution, en tant qu’organisme de recherches et en tant que modèle pour l’Europe et le monde. Sur un siècle d’histoire, défilent les difficultés de sa construction administrative dans un contexte politique mouvementé, l’organisation et le développement du travail scientifique de ses savants, la participation de l’établissement aux grandes missions de découvertes comme aux débats scientifiques qui agitent le monde de cette époque. Un siècle, trois générations c’est beaucoup et c’est peu, de la période cruciale de sa fondation, à l’« âge d’or » jusqu’en 1850, jusqu’à la période incertaine précédant la 1ère Guerre mondiale. Ce livre, qui se présente sous forme de contributions d’éminents spécialistes d’histoire des sciences, aborde dans une langue claire et accessible l’histoire des idées et l’histoire d’une institution prestigieuse. À cet égard, son public est aussi vaste que celui qui fréquente le Muséum : chercheurs du monde entier, connaisseurs du patrimoine, amoureux du Jardin des Plantes

Primum non nocere: a call for balance when reporting on CTE.

No abstract available