Fühl die Stadt – Methoden zur Erfassung subjektiver Wahrnehmung

Wie der Mensch urbane Räume wahrnimmt, ist vor allem im Hinblick auf die Akzeptanz der gebauten Umwelt durch BewohnerInnen eine grundlegende Forschungsfrage der Stadtplanung. Im Zeitalter digitaler Technologien, welche eine Vielzahl an Möglichkeiten zur Erfassung unterschiedlichster Messgrößen bieten, können nun die subjektiven Wahrnehmungen bzw. Emotionen von Menschen erfasst werden. Die Verschneidung der Disziplinen Raumplanung, Geoinformatik und Computerlinguistik forciert ein besseres Verständnis, wie Menschen den (urbanen) Raum wahrnehmen und auf Umwelteinflüsse reagieren. „Multi-Methoden-Ansätze“ gewinnen in diesem Zusammenhang an Relevanz; insbesondere dann, wenn im Sinne der Methodentriangulation sowohl technische Sensoren als objektive Methoden mit subjektiven Befragungen kombiniert werden. Im Rahmen von studentischen Projektarbeiten wurden die verschiedenen Methoden zur Erhebung der subjektiven Wahrnehmung mit Hilfe von Sensoren bzw. Wearables angewandt, getestet und anschließend analysiert sowie bezüglich ihrer Anwendbarkeit verglichen. Zielstellung dieser Arbeiten war es, geeignete Methodensets zu entwickeln. Das Hauptaugenmerk lag auf der Analyse, welches Methodenset geeignet ist und wie die erhobenen Daten anschließend in eine (virtuelle) Karte übertragen werden können. Darüber hinaus wurde auch die Frage behandelt, wie diese Methoden in Planungsprozesse miteinbezogen werden können. Ein Fallbeispiel betrachtete die gefühlte Sicherheit im Radverkehr in Abhängigkeit unterschiedlicher radinfrastrukturellen Gegebenheiten mittels verschiedener Sensoren. Zum anderen untersuchten die Studierenden, wie der Wiener Donaukanals von den NutzerInnen wahrgenommen wird, der in den letzten Jahren sowohl zum kommerzfreien Erholungsraum avancierte als auch kommerziell durch Gastronomie genutzt wird und unterschiedliche Teilräume mit verschiedenen stadträumlichen Qualitäten aufweis

Randomized Controlled Clinical Trial of Blood Glucose Awareness Training (BGAT III) in Switzerland and Germany

Although both diabetes and the efficacy of medical management are international issues, psycho-educational interventions might be culturally bound. Blood Glucose Awareness Training (BGAT) is a psycho-educational program for patients with type 1 diabetes mellitus. It is focused on improving recognition and management of extreme blood glucose levels, and is the best documented American psycho-educational program for this purpose. A randomized controlled clinical trial of BGAT's long-term benefits in a non-American setting has been lacking. One hundred and eleven adults with type 1 diabetes mellitus from Switzerland and Germany participated. After a 6 months baseline assessment, subjects were randomly assigned to receive either 2 months of BGAT (n = 56) or a physician-guided self-help control intervention (n = 55). BGAT improved recognition of low (p = 0.008), high (p = .03), and overall blood glucose (p = 0.001), and reduced frequency of severe hypoglycemia (p = 0.04), without compromising metabolic control. BGAT reduced both the external locus of control (p < 0.02) and fear of hypoglycemia (p < 0.02). BGAT was efficacious in reducing adverse clinical events and achieving clinically desirable goals in a European, as well as American settin

The New Generation of the KIT 3D USCT

The first clinical studies with our current prototype, 3D USCT II, enabled us to identify the necessary improvements for transition of our method to clinical practice. The main goals are to improve the contrast of reflection and transmission tomography, and to optimize the coverage of the imaged breast by a new geometry of the transducer distribution. Furthermore, for cost-effective industrial mass production, a self-calibration method allows us to relax the precision of the positioning of the transducers to 0.1 mm. The readout of the transducer arrays is now carried out by an ASIC, developed for a more cost-effective design. The coupling of the measuring device to the patient was optimized to cover the full size of the breast up to the pectoral muscles. Finally, the data acquisition and readout time were reduced to 1.5 minutes each by new micro-TCA electronics and larger FPGAs

Subglottic MALT Lymphoma of the Larynx - More Attention to the Glottis

Abstract. Background: Mucosa-associated Since the first description of lymphoma arising from mucosaassociated lymphoid tissue (MALT) as an entity by Isaacson and Wright in 1983 (1), several cases of laryngeal MALT were reported in a more or less anecdotal form, starting with Diebold and colleagues in 1990 (2). The case reported by Case Report A 62-year-old male with adipositas was admitted and complained of a dry cough, increasing exertional dyspnea, and stridor for one year. Blood work and clinical examination were uneventful. In order to prevent edema due to mechanical manipulation, 250 mg cortisone were administered intravenously one hour prior to flexible bronchoscopy. The bronchoscopy revealed a circumferential subglottic lesio

Früherkennung von Fruchtbarkeitsstörungen

Zur Früherkennung von Fruchtbarkeitsstörungen und Eutererkrankungen beim Milchrind wurden Modelle erarbeitet, um Zwischentragezeiten bzw. Mastitiserkrankungen vorhersagen zu können. Die Früherkennung basierte auf den anfallenden Informationen rund um das Management einer sächsischen Milchviehherde. Im Fruchtbarkeitsmodell konnten hohe Sensitivitäten bei Fehlerraten um 20 Prozent erreicht werden. Im Eutererkrankungsmodell lagen die Fehlerraten bei über 50 Prozent. Daher sind die Frühwarnsysteme noch nicht praxisreif

MONOPOL - A traveling-wave magnetic neutron spin resonator for tailoring polarized neutron beams

We report on first experimental tests of a neutron magnetic spin resonator at a very cold neutron beam port of the high flux reactor at the ILL Grenoble. When placed between two supermirror neutron polarizers and operated in a pulsed traveling-wave mode it allows to decouple its time- and wavelength-resolution and can therefore be used simultaneously as electronically tunable monochromator and fast beam chopper. As a first ‘real’ scientific application we intend its implementation in the PERC (p roton and e lectron r adiation c hannel) project related to high-precision experiments in neutron beta decay

Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles

SummaryMutations in the juxtamembrane and kinase domains of FLT3 are common in AML, but it is not known whether alterations outside these regions contribute to leukemogenesis. We used a high-throughput platform to interrogate the entire FLT3 coding sequence in AML patients without known FLT3 mutations and experimentally tested the consequences of each candidate leukemogenic allele. This approach identified gain-of-function mutations that activated downstream signaling and conferred sensitivity to FLT3 inhibition and alleles that were not associated with kinase activation, including mutations in the catalytic domain. These findings support the concept that acquired mutations in cancer may not contribute to malignant transformation and underscore the importance of functional studies to distinguish “driver” mutations underlying tumorigenesis from biologically neutral “passenger” alterations

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN