Sideshow Sounds: Black Bandleaders Respond to Exoticism

Everyone knows P. G. Lowery, broadcaster of African-American music. Less known are those whose sideshow leadership predates that of Lowery. The pioneering entrepreneurial-entertainment legacy of bandleaders like Solomon P. White, J. 0. McNutt, and James Wolfscale set the stage for Lowery\u27s phenomenal success. This presentation investigates their personal histories in the context of mainstream and circus cultures; their indispensable contribution to the success of the circus and the popularization of African-American music; and their role as the sinew of African-American communities through newspaper distribution and correspondence. Black sideshow bands-first documented in 1881 within Milner Library\u27s Circus Route Books Digital Collection, were relegated to the circus annex, constrained by compounding layers of liminality. Sideshows housed those performers labeled as exotic, and musicians were expected to perform as such. This presentation details how Black musicians responded to their forced otherness, highlighting their agency within a confined stage. Through ingenious spectacles, they deployed the marketing of exoticism onto the audience\u27s desire for the novel and the authentic. Possessing both musical and managerial skills, they utilized their market share to transform themselves from employees to autonomous business owners. This research was conducted for the digital humanities exhibit, Agency through Otherness: Portraits of Performers in Circus Route Books 1875-1925. The exhibit is the final segment of the Council on Library and Information Resources grant project, Step Right Up: Digitizing Over 100 Years of Circus Route Books with collaborating institutions the Circus World Museum and The Ringling Archives

The Multitude of Molecular Hydrogen Knots in the Helix Nebula

We present HST/NICMOS imaging of the H_2 2.12 \mu m emission in 5 fields in the Helix Nebula ranging in radial distance from 250-450" from the central star. The images reveal arcuate structures with their apexes pointing towards the central star. Comparison of these images with comparable resolution ground based images reveals that the molecular gas is more highly clumped than the ionized gas line tracers. From our images, we determine an average number density of knots in the molecular gas ranging from 162 knots/arcmin^2 in the denser regions to 18 knots/arcmin^2 in the lower density outer regions. Using this new number density, we estimate that the total number of knots in the Helix to be ~23,000 which is a factor of 6.5 larger than previous estimates. The total neutral gas mass in the Helix is 0.35 M_\odot assuming a mass of \~1.5x10^{-5} M_\odot for the individual knots. The H_2 intensity, 5-9x10^{-5} erg s^{-1} cm^{-2} sr^{-1}, remains relatively constant with projected distance from the central star suggesting a heating mechanism for the molecular gas that is distributed almost uniformly in the knots throughout the nebula. The temperature and H_2 2.12 \mu m intensity of the knots can be approximately explained by photodissociation regions (PDRs) in the individual knots; however, theoretical PDR models of PN under-predict the intensities of some knots by a factor of 10.Comment: 26 pages, 3 tables, 10 figures; AJ accepte

Neutralino annihilation gamma-rays from clumps and the LMC

We discuss the detectability of dark matter clumps in the Milky Way halo due to neutralino annihilation. We then focus on a known ``clump'', the Large Magellanic Cloud.Comment: 4 pages, 4 figures; to appear in New Astronomy Reviews, Proceedings of 2nd VERITAS symposiu

Learning from Engineers to Develop a Model of Disciplinary Literacy in Engineering (Year 3)

Purpose This paper will the describe the overall project goals, activities, preliminary findings, and future work on this project. The purpose of this project is to develop a model of Disciplinary Literacy Instruction (DLI) in engineering that can be used in both K-12 and undergraduate engineering settings. This model of DLI will be informed by knowledge about the ways practicing engineers across four disciplines of engineering (i.e., electrical/computer, mechanical/aerospace, civil/environmental, and chemical/biological) read, interpret, evaluate, and generate texts in the context of their work environment. This information will be translated into a model of DLI in engineering to teach students how to use authentic engineering literacy practices as they learn discipline specific engineering content. Project Activities During the first year of this project, we conducted on-site observations with two electrical engineers and two mechanical engineers. In addition, we held interviews and conducted think-aloud protocols that were informed by the observations with each engineer. From these data sources, we developed a codebook describing the types of texts that the engineers interpreted, evaluated, and generated at the workplace. worked with both mechanical and electrical engineering consultants to help refine and revise the codes and code definitions to enhance their authenticity to each discipline. To further ensure the quality of our data analysis procedures, we sought feedback on our codes from three advisory board consultants having expertise in disciplinary literacy, engineering, and K-12 engineering education. During the second year of this project, we analyzed the interview and think-aloud protocol transcripts from the electrical and mechanical engineers to generate themes that described the interpretive and evaluative frameworks the engineers used as they solved a technical problem or generated a solution for a client or customer. Similarly, we developed themes that described the socially situated activities in which the previously defined genres were embedded. Taken together, these frameworks and activities inform the development of the DLI model in engineering. We also began collecting observation, interview, and think aloud data with one civil and one environmental engineer during this year. Currently, in the third year of this project, we are analyzing the observation field notes and the interview and think-aloud protocol transcripts from the civil and environmental engineers. Simultaneously, we are generating data with the final pair of engineers: one biological and one chemical engineer. We continue to refine our codebook by adding new genres as they appear and merging any similar, existing genres to capture the range of texts with which the engineers engaged. Engineering consultants from both the civil and environmental disciplines will provide feedback on our codes. Combined data from this phase with previous phases will be used develop disciplinary specific curricular materials for K-12 and undergraduate engineering education. Future Activities The data collected and analyzed throughout the project will inform the development of a model for DLI in engineering that can be used by teachers in both undergraduate and K-12 educational settings. This model will provide a framework for teachers to instruct students on how to use the authentic reading and writing strategies that practicing engineers use while solving problems. By providing a diverse set of students with exposure to these literacy practices in school at a young age, a model of DLI in engineering has the potential to remove literacy-based barriers that may deter students from pursuing engineering pathways

Unidentified EGRET Sources and the Extragalactic Gamma-Ray Background

The large majority of EGRET point sources remain to this day without an identified low-energy counterpart. Whatever the nature of the EGRET unidentified sources, faint unresolved objects of the same class must have a contribution to the diffuse gamma-ray background: if most unidentified objects are extragalactic, faint unresolved sources of the same class contribute to the background, as a distinct extragalactic population; on the other hand, if most unidentified sources are Galactic, their counterparts in external galaxies will contribute to the unresolved emission from these systems. Understanding this component of the gamma-ray background, along with other guaranteed contributions from known sources, is essential in any attempt to use gamma-ray observations to constrain exotic high-energy physics. Here, we follow an empirical approach to estimate whether a potential contribution of unidentified sources to the extragalactic gamma-ray background is likely to be important, and we find that it is. Additionally, we comment on how the anticipated GLAST measurement of the diffuse gamma-ray background will change, depending on the nature of the majority of these sources.Comment: 6 pages, 3 figures, to appear in proceedings of "The Multi-Messenger Approach to High Energy Gamma-Ray Sources", Barcelona, 4-7 July 2006; comments welcom

Gamma-ray and synchrotron emission from neutralino annihilation in the Large Magellanic Cloud

We calculate the expected flux of gamma-ray and radio emission from the LMC due to neutralino annihilation. Using rotation curve data to probe the density profile and assuming a minimum disk, we describe the dark matter halo of the LMC using models predicted by N-body simulations. We consider a range of density profiles including the NFW profile, a modified NFW profile proposed by Hayashi et al.(2003) to account for the effects of tidal stripping, and an isothermal sphere with a core. We find that the gamma-ray flux expected from these models may be detectable by GLAST for a significant part of the neutralino parameter space. The prospects for existing and upcoming Atmospheric Cherenkov Telescopes are less optimistic, as unrealistically long exposures are required for detection. However, the effects of adiabatic compression due to the baryonic component may improve the chances for detection by ACTs. The maximum flux we predict is well below EGRET's measurements and thus EGRET does not constrain the parameter space. The expected synchrotron emission generally lies below the observed radio emission from the LMC in the frequency range of 19.7 to 8550 MHz. As long as <2x 10^-26 cm^3 s^-1 for a neutralino mass of 50 GeV, the observed radio emission is not primarily due to neutralinos and is consistent with the assumption that the main source is cosmic rays. We find that the predicted fluxes, obtained by integrating over the entire LMC, are not very strongly dependent on the inner slope of the halo profile, varying by less than an order of magnitude for the range of profiles we considered.Comment: 24 pages, 5 figures; detailed discussion of how the neutralino induced signals compare with the cosmic-ray induced ones was added. Main conclusions unchanged. Matches accepted version, to appear in Astroparticle Physic

Incidence and survival for oropharynx and non-oropharynx head and neck cancers among veterans living with HIV

BACKGROUND: People living with HIV/AIDS (PLWH) have an excess risk for head and neck squamous cell carcinoma (HNSCC) compared to the general U.S. population, but little is known about HIV-specific risk factors associated with the incidence and outcomes HNSCC. We aim to identify clinical and HIV-specific risk factors associated with oropharyngeal and non-oropharyngeal HNSCC incidence and outcomes separately. METHODS: We constructed a retrospective cohort study of 45,052 PLWH aged 18 or above from the national Veteran Affairs (VA) Corporate Data from 1999 to 2015. We extracted demographic data and risk factor information, including history of alcohol abuse, smoking, CD4 count (cells/μl), and percent of follow-up time with undetectable HIV viral load as time-updated variables. We calculated the age-standardized incidence rates of oropharyngeal and non-oropharyngeal HNSCC and estimated adjusted hazard ratios (HR). We also examined overall survival using Kaplan-Meier curves and adjusted HR. RESULTS: The standardized incidence rate of oropharyngeal and non-oropharyngeal HNSCC in this veteran cohort of PLWH is 23.0 (95% confidence intervals (CIs): 17.1-28.9) and 55.4 (95% CI: 46.5-64.3) per 100,000 person-years, respectively. Nadir CD4 count ≤200 was associated with an increased risk of non-oropharyngeal HNSCC (HR: 1.78; 95% CI: 1.31-2.30 vs \u3e200). Five-year overall survival of OPSCC (37.0%) was significantly lower than non-oropharyngeal HNSCC (49.1%). CONCLUSIONS: PLWH who receive care in the VA had higher age-adjusted HNSCC incidence rates than reported in the general population, suggesting that HIV and immunosuppression play a role. Additional studies should be conducted to study the interaction between HPV and HIV

Area Deprivation index and Segregation On the Risk of Hiv: a Us Veteran Case-Control Study

BACKGROUND: Preventing HIV infection remains a critically important tool in the continuing fight against HIV/AIDS. The primary aim is to evaluate the effect and interactions between a composite area-level social determinants of health measure and an area-level measure of residential segregation on the risk of HIV/AIDS in U.S. Veterans. METHODS: Using the individual-level patient data from the U.S. Department of Veterans Affairs, we constructed a case-control study of veterans living with HIV/AIDS (VLWH) and age-, sex assigned at birth- and index date-matched controls. We geocoded patient\u27s residential address to ascertain their neighborhood and linked their information to two measures of neighborhood-level disadvantage: area deprivation index (ADI) and isolation index (ISOL). We used logistic regression to estimate the odds ratio (OR) and 95% confidence interval (CI) for comparing VLWH with matched controls. We performed analyses for the entire U.S. and separately for each U.S. Census division. FINDINGS: Overall, living in minority-segregated neighborhoods was associated with a higher risk of HIV (OR: 1.88 (95% CI: 1.79-1.97) while living in higher ADI neighborhoods was associated with a lower risk of HIV (OR: 0.88; 95% CI: 0.84-0.92). The association between living in a higher ADI neighborhood and HIV was inconsistent across divisions, while living in minority-segregated neighborhoods was consistently associated with increased risk across all divisions. In the interaction model, individuals from low ADI and high ISOL neighborhoods had a higher risk of HIV in three divisions: East South Central; West South Central, and Pacific. INTERPRETATION: Our results suggest that residential segregation may prevent people in disadvantaged neighborhoods from protecting themselves from HIV independent from access to health care. There is the need to advance knowledge about the neighborhood-level social-structural factors that influence HIV vulnerability toward developing interventions needed to achieve the goal of ending the HIV epidemic. FUNDING: US National Cancer Institute

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions is mediated by a high-affinity interaction between the capsid hexon protein and blood coagulation factor X (FX), whilst penton-α(v)integrin interactions are thought to contribute to the induction of anti-Ad5 inflammatory and innate immune responses. To overcome these limitations, we sought to develop and characterise for the first time novel Ad5 vectors possessing mutations ablating both hexon:FX and penton:integrin interactions. As expected, intravascular administration of the FX binding-ablated Ad5HVR5*HVR7*E451Q vector (AdT*) resulted in significantly reduced liver transduction in vivo compared to Ad5. In macrophage-depleted mice, increased spleen uptake of AdT* was accompanied by an elevation in the levels of several inflammatory mediators. However ablation of the penton RGD motif in the AdT* vector background (AdT*RGE) resulted in a significant 5-fold reduction in spleen uptake and attenuated the antiviral inflammatory response. A reduction in spleen uptake and inflammatory activation was also observed in animals after intravascular administration of Ad5RGE compared to the parental Ad5 vector, with reduced co-localisation of the viral beta-galactosidase transgene with MAdCAM-1+ sinus-lining endothelial cells. Our detailed assessment of these novel adenoviruses indicates that penton base RGE mutation in combination with FX binding-ablation may be a viable strategy to attenuate the undesired liver uptake and pro-inflammatory responses to Ad5 vectors after intravascular deliver

Prospectus, September 13, 1978

ELECTION DAYS ARE HERE!; Students get refund from hungry Canteen machines; Recipes for college students; CPR saves lives; Advertising Policy; PC band formed; \u27Lost in a masquerade\u27 Benson creates ecstasy; Creative writers receive assistance; Health issues program new WPCD addition; Operetta to begin tomorrow; Shaker photograph exhibition; Student Elections -- Today!; Cadaver lab is added; Apathetic turnout; Poet contest sponsored; Volleyball clinic held Sept. 9; Meeting Sept. 26 for cheerleaders; WPCD\u27s Top 15 For The Week Of Sept. 11; German club to begin activities; Classifieds; Cimmeron review \u27mediocre\u27; Thought food offered for older adults; Student Activities-\u2778; Doehring keeps on truckin\u27; Coach Jim Reed gets many players; Klems wins first Freddy contest; Cooper recruits well; Williams has busy year ahead of him; Fast Freddy Contest; Cross Country Schedulehttps://spark.parkland.edu/prospectus_1978/1012/thumbnail.jp