Exploding lakes in Vanuatu - "Surtseyan-style" eruptions witnessed on Ambae Island

After a long silence, Lake Vui on Ambae Island burst into spectacular life on the 28th of November 2005, disrupting the lives of 10 000 inhabitants on this sleepy tropical island in the SW Pacific. "Surtseyan- style" explosions burst through the Island's summit lake waters forming a new tuff-cone and threatening to form deadly lahars or volcanic floods. Such eruptions are rarely well observed, and these fleeting opportunities provide a chance to match volcanic processes with rock-sequences found commonly in the geologic recor

Measuring cyber wisdom: preliminary validation of a new four-component measure

Cyber-wisdom is the ability to know and do the right thing at the right time, when using digital technologies, and is a concept that is gaining attention from educators. Whilst the theory and practice of cyber-wisdom education is established, to date there has been no attempt to investigate how the virtue of cyber-wisdom might be measured. This is a lacuna as it limits future research in the area, including, in particular, proximal evaluations of cyber-wisdom interventions. This article introduces a new four-component measure of cyber-wisdom, which is relevant to how the virtue may be cultivated in practice via formal education and the teaching of what is generally referred to as digital citizenship education. The measure was piloted with 1,331 13-16 year-olds. The findings provide initial evidence that cyber-wisdom literacy, reasoning, reflection, and motivation can be measured. This study provides preliminary validation of cyber-wisdom sub-measures that might be used in evaluations of educational interventions that seek to help children and adolescents live with wisdom in the digital age

Tracking Ontogenetic Changes of Ionocyte Distribution and Morphology in Larval White Seabass (Atractoscion nobilis)

Teleost fishes maintain homeostasis through the action of ionocytes, epithelial cells specialized for osmoregulation, acid-base regulation, and ammonia excretion, among other functions. While studied extensively in adult fishes, much less is known about ionocytes and their function in marine teleost larvae. The goal of this thesis is to track the ontogenetic changes in number, size, distribution, and morphology of ionocytes in skin and gills of larval White Seabass (Atractoscion nobilis) ranging from 1-32 days post-hatch (2.6 to 16.4 mm body length). Immunostaining of ionocytes revealed a stark increase in ionocyte number and density, and a decrease in ionocyte size throughout the sample period. Relative ionocyte area, a proxy for ion excretion across the skin, was calculated revealing a decrease in cutaneous ion excretion prior to the timing of notochord flexion. During this period, the branchial structures became increasingly developed and were highly abundant in ionocytes, suggesting they are taking on a large portion of the ionoregulatory role. Scanning electron microscopy revealed several different apical morphologies in a 32 DPH larva, and confocal scanning laser microscopy revealed the presence of ionocyte in the skin of a juvenile White Seabass. This is the first study to provide high temporal resolution tracking of the ontogenetic changes of ionocytes in larval White Seabass, who were selected due to their high socio-economic value and for the increasing demand for research to aid in the wild stock enhancement aquaculture program operated by Hubbs SeaWorld Research Institute (San Diego)

Community Emergency Management During the 2005 Ambae Eruption, Vanuatu, SW Pacific.

No abstract availabl

Evidence That Nasal Insulin Induces Immune Tolerance to Insulin in Adults With Autoimmune Diabetes

OBJECTIVE: Insulin in pancreatic β-cells is a target of autoimmunity in type 1 diabetes. In the NOD mouse model of type 1 diabetes, oral or nasal administration of insulin induces immune tolerance to insulin and protects against autoimmune diabetes. Evidence for tolerance to mucosally administered insulin or other autoantigens is poorly documented in humans. Adults with recent-onset type 1 diabetes in whom the disease process is subacute afford an opportunity to determine whether mucosal insulin induces tolerance to insulin subsequently injected for treatment. RESEARCH DESIGN AND METHODS: We randomized 52 adults with recent-onset, noninsulin-requiring type 1 diabetes to nasal insulin or placebo for 12 months. Fasting blood glucose and serum C-peptide, glucagon-stimulated serum C-peptide, and serum antibodies to islet antigens were monitored three times monthly for 24 months. An enhanced ELISpot assay was used to measure the T-cell response to human proinsulin. RESULTS: β-Cell function declined by 35% overall, and 23 of 52 participants (44%) progressed to insulin treatment. Metabolic parameters remained similar between nasal insulin and placebo groups, but the insulin antibody response to injected insulin was significantly blunted in a sustained manner in those who had received nasal insulin. In a small cohort, the interferon-γ response of blood T-cells to proinsulin was suppressed after nasal insulin. CONCLUSIONS: Although nasal insulin did not retard loss of residual β-cell function in adults with established type 1 diabetes, evidence that it induced immune tolerance to insulin provides a rationale for its application to prevent diabetes in at-risk individuals

WashU Epigenome Browser update 2022

WashU Epigenome Browser (https://epigenomegateway.wustl.edu/browser/) is a web-based genomic data exploration tool that provides visualization, integration, and analysis of epigenomic datasets. The newly renovated user interface and functions have enabled researchers to engage with the browser and genomic data more efficiently and effectively since 2018. Here, we introduce a new integrated panel design in the browser that allows users to interact with 1D (genomic features), 2D (such as Hi-C), 3D (genome structure), and 4D (time series) data in a single web page. The browser can display three-dimensional chromatin structures with the 3D viewer module. The 4D tracks, called \u27Dynamic\u27 tracks, animatedly display time-series data, allowing for a more striking visual impact to identify the gene or genomic region candidates as a function of time. Genomic data, such as annotation features, numerical values, and chromatin interaction data can all be viewed in the dynamic track mode. Imaging data from microscopy experiments can also be displayed in the browser. In addition to software development, we continue to service and expand the data hubs we host for large consortia including 4DN, Roadmap Epigenomics, TaRGET and ENCODE, among others. Our growing user/developer community developed additional track types as plugins, such as qBed and dynseq tracks, which extend the utility of the browser. The browser serves as a foundation for additional genomics platforms including the WashU Virus Genome Browser (for COVID-19 research) and the Comparative Genome Browser. The WashU Epigenome Browser can also be accessed freely through Amazon Web Services at https://epigenomegateway.org/

Be Patient When Measuring Hyperbolic Discounting: Stationarity, Time Consistency and Time Invariance in a Field Experiment

Most evidence of hyperbolic discounting is based on violations of either stationarity or time consistency as observed in choice experiments. These choice reversals may however also result from time-varying discount rates. Hyperbolic discounting is a plausible explanation for choice reversals only if violations of stationarity and time consistency overlap. Our field experiment examines the extent to which this is the case. At different points in time, the same participants allocated a future gift over sooner-smaller and later-larger rewards with varying front-end delays. We find that most violations of time consistency do not coincide with violations of stationarity. This is surprisingly similar to what an earlier experiment on stationarity, time invariance and time consistency finds using a different design among a different type of participants (Halevy, Econometrica , 2015). Random noise in decision-making alone does not explain this finding, given that we find a significant association between changes in household wealth and violations of stationarity and time consistency. We conclude that when incomes fluctuate, one can only identify hyperbolic discounting by eliciting violations of both stationarity and time consistency through a longitudinal design for the same subject pool

Формирование здорового образа жизни студентов

В статье рассматривается формирование здорового образа жизни студенто