4,375 research outputs found
Some Abnormal Reactions of Organomagnesium Halides
Nitro and nitroso groups react with methylmagnesium halides (and other RMgX compounds) to give methane and some ethane. The gases so evolved make it necessary to correct for the ordinary determination of active hydrogen by means of the Zerewitinoff method. Accordingly, the new hydroxy structure proposed for o-nitrobenzaladehyde finds no support on the basis of gas evolved when treated with alkylmagnesium halides
High Consequence Scenarios for North Korean Atmospheric Nuclear Tests with Policy Recommendations for the U.S. Government
The government of North Korea has declared high-altitude EMP-capability to be a “strategic goal” and has also threatened an atmospheric test of a hydrogen bomb. Atmospheric nuclear tests have the potential to cripple satellites and the undersea cable networks critical to communication, and navigation necessary for trans-Pacific trade among the U.S., China, and other nations. When a nuclear warhead is detonated at high altitude, a series of electromagnetic pulses radiate downward within the line of sight of the blast. These pulses can disable equipment with miniature electronics and long conductors. Electric grid controls and transmission systems are especially vulnerable. Intense X-rays and free electrons caused by high-altitude nuclear tests can also disable satellites over large regions of space. After the 1962 Starfish Prime test of EMP effects by the U.S, numerous satellites failed. Based on past missile tests, calculated delivery ranges, EMP coverage areas, and geography, Resilient Societies developed five scenarios for North Korean atmospheric tests. Possible sites for EMP tests include the South Pacific Ocean northeast of French Polynesia, Johnson Atoll southwest of Hawaii, and vicinity of the U.S. territory of Guam. Missile trajectories for all three of these EMP test scenarios overfly populated areas. Missile navigation or nuclear device fuzing errors could place the populations of Japan, Guam, and Hawaii are at risk. All potential EMP test locations could cause disruption to international satellite and undersea cable communications networks. North Korea should not be permitted to conduct an atmospheric nuclear tests since EMP effects on large networks necessary for electric power and international data sharing could have serious worldwide consequences due to the importance of Asia and the Pacific region to the global economy. In the regrettable event that North Korea chooses to conduct atmospheric nuclear tests, U.S. and allied monitoring of EMP effects will be helpful
Chandra detection of the intracluster medium around 3C294 at z=1.786
We present a Chandra observation of the powerful radio galaxy 3C294 showing
clear evidence for a surrounding intracluster medium. At a redshift of 1.786
this is the most distant cluster of galaxies yet detected in X-rays. The radio
core is detected as a point source, which has a spectrum consistent with a
heavily-absorbed power law implying an intrinsic 2-10 keV luminosity of ~10^45
erg/s. A small excess of emission is associated with the southern radio
hotspots. The soft, diffuse emission from the intracluster medium is centred on
the radio source. It has an hour-glass shape in the N-S direction, extending to
radii of at least 100 kpc, well beyond the radio source. The X-ray spectrum of
this extended component is fit by a thermal model with temperature ~5 keV, or
by gas cooling from above 7 keV at rates of ~400-700 Msolar/yr. The rest-frame
0.3-10 keV luminosity of the cluster is ~4.5x10^44 erg/s. The existence of such
a cluster is consistent with a low density universe.Comment: 5 pages, 6 figures, accepted by MNRA
The Extended Star Formation History of the Andromeda Spheroid at 35 Kpc on the Minor Axis
Using the HST ACS, we have obtained deep optical images reaching well below
the oldest main sequence turnoff in fields on the southeast minor-axis of the
Andromeda Galaxy, 35 kpc from the nucleus. These data probe the star formation
history in the extended halo of Andromeda -- that region beyond 30 kpc that
appears both chemically and morphologically distinct from the metal-rich,
highly-disturbed inner spheroid. The present data, together with our previous
data for fields at 11 and 21 kpc, do not show a simple trend toward older ages
and lower metallicities, as one might expect for populations further removed
from the obvious disturbances of the inner spheroid. Specifically, the mean
ages and [Fe/H] values at 11 kpc, 21 kpc, and 35 kpc are 9.7 Gyr and -0.65,
11.0 Gyr and -0.87, and 10.5 Gyr and -0.98, respectively. In the best-fit model
of the 35 kpc population, one third of the stars are younger than 10 Gyr, while
only ~10% of the stars are truly ancient and metal-poor. The extended halo thus
exhibits clear evidence of its hierarchical assembly, and the contribution from
any classical halo formed via early monolithic collapse must be small.Comment: Accepted for publication in The Astrophysical Journal Letters. 4
pages, latex, 2 color figure
Chandra study of an overdensity of X-ray sources around two distant (z~0.5) clusters
We present results from a Chandra X-ray Observatory study of the field X-ray
source populations in 4 different observations: two high-redshift (z~0.5)
clusters of galaxies 3C295 and RXJ003033.2+261819; and two non-cluster fields
with similar exposure time. Surprisingly, the 0.5-2 keV source surface
densities (~900-1200 sources deg**-2 at a flux limit of 1.5x10**-15 erg
cm**-2s**-1) measured in an ~8'x8' area surrounding each cluster exceed by a
factor of ~2 the value expected on the basis of the ROSAT and Chandra
logN-logS, with a significance of ~2 sigma each, or ~3.5 sigma when the 2
fields are combined (i.e. a probability to be a statistical fluctuation of <1%
and <0.04%, respectively). The same analysis performed on the non-cluster
fields and on the outer chips of the cluster fields does NOT show evidence of
such an excess. In both cluster fields, the summed 0.5-10 keV spectrum of the
detected objects is well fitted by a power-law with Gamma~1.7 similar to AGNs
and shows no sign of intrinsic absorption. The few (~10 out of 35) optical
identifications available to date confirm that most of them are, as expected,
AGNs but the number of redshifts available is too small to allow conclusions on
their nature. We discuss possible interpretations of the overdensity in terms
of: a statistical variation of Cosmic Background sources; a concentration of
AGNs and/or powerful starburst galaxies associated with the clusters; and g
ravitational lensing of background QSO's by the galaxy clusters. All
explanations are however difficult to reconcile with the large number of excess
sources detected. Deeper X-ray observations and more redshifts measurements are
clearly required to settle the issue.Comment: 22 LateX pages (including Tables and Figures), uses psfig.sty and
emulateapj.sty. Accepted for publication in Astrophysical Journa
Metabolomics and pharmacogenetics based 5-fluorouracil monitoring in colorectal cancer patients
Objective: To provide quick and accurate clinical diagnostic tools those are currently not available leading to improper management of colorectal cancer (CRC) patients. Methods: The metabolomic profiles of 10 CRC patients treated with 5-fluorouracil and 24 healthy volunteers were analysed. The subjects were genotyped for UGT1A1*28, DPYD 1896 T>C and DPYD*5. Results: Our results show alterations in the metabolism of bile acid, glycolysis and fatty acid in patients. The distinctive metabolite profiles established using PLSDA identify several biomarkers for diagnostic use in clinical settings. The predictive PLSDA model revealed 100% accuracy of metabolites differentiating CRC patients and healthy volunteers. In addition, the metabolic profiles associated with different genotypes of DPYD and UGT1A1 explains the impact of genetic variation on differential drug responses. Conclusion: Pharmacogenetics and metabolomics profiles are potential platforms for more comprehensive monitoring of patient's disease progress and drug response. Further study is however needed to validate the use of biomarkers identified
Improving Student Engagement in Veterinary Business Studies
In a densely packed veterinary curriculum, students may find it particularly challenging to engage in the less overtly clinical subjects, yet pressure from industry and an increasingly competitive employment market necessitate improved veterinary student education in business and management skills. We describe a curriculum intervention (formative reflective assignment) that optimizes workplace learning opportunities and aims to provide better student scaffolding for their in-context business learning. Students were asked to analyze a business practice they experienced during a period of extra-mural studies (external work placement). Following return to the college, they were then instructed to discuss their findings in their study group, and produce a group reflection on their learning. To better understand student engagement in this area, we analyzed individual and group components of the assignment. Thematic analysis revealed evidence of various depths of student engagement, and provided indications of the behaviors they used when engaging at different levels. Interactive and social practices (discussing business strategies with veterinary employees and student peers) appeared to facilitate student engagement, assist the perception of relevance of these skills, and encourage integration with other curriculum elements such as communication skills and clinical problem solving
Pain outcomes in patients with bone metastases from advanced cancer: assessment and management with bone-targeting agents
Bone metastases in advanced cancer frequently cause painful complications that impair patient physical activity and negatively affect quality of life. Pain is often underreported and poorly managed in these patients. The most commonly used pain assessment instruments are visual analogue scales, a single-item measure, and the Brief Pain Inventory Questionnaire-Short Form. The World Health Organization analgesic ladder and the Analgesic Quantification Algorithm are used to evaluate analgesic use. Bone-targeting agents, such as denosumab or bisphosphonates, prevent skeletal complications (i.e., radiation to bone, pathologic fractures, surgery to bone, and spinal cord compression) and can also improve pain outcomes in patients with metastatic bone disease. We have reviewed pain outcomes and analgesic use and reported pain data from an integrated analysis of randomized controlled studies of denosumab versus the bisphosphonate zoledronic acid (ZA) in patients with bone metastases from advanced solid tumors. Intravenous bisphosphonates improved pain outcomes in patients with bone metastases from solid tumors. Compared with ZA, denosumab further prevented pain worsening and delayed the need for treatment with strong opioids. In patients with no or mild pain at baseline, denosumab reduced the risk of increasing pain severity and delayed pain worsening along with the time to increased pain interference compared with ZA, suggesting that use of denosumab (with appropriate calcium and vitamin D supplementation) before patients develop bone pain may improve outcomes. These data also support the use of validated pain assessments to optimize treatment and reduce the burden of pain associated with metastatic bone disease
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