943 research outputs found
Tooth Decay in Alcohol Abusers Compared to Alcohol and Drug Abusers
Alcohol and drug abuse are detrimental to general and oral health. Though we know the effects of these harmful habits on oral mucosa, their independent and combined effect on the dental caries experience is unknown and worthy of investigation. We compared 363 âalcohol onlyâ abusers to 300 âalcohol and drugâ abusers to test the hypothesis that various components of their dental caries experience are significantly different due to plausible sociobiological explanations. After controlling for the potential confounders, we observe that the âalcohol and drugâ group had a 38% higher risk of having decayed teeth compared to the âalcohol onlyâ group (P < .05). As expected, those who belonged to a higher social class (OR = 1.98; 95%ââCI = 1.43â2.75) and drank wine (OR = 1.85; 95%ââCI = 1.16â2.96) had a higher risk of having more filled teeth. We conclude that the risk of tooth decay among âalcohol onlyâ abusers is significantly lower compared to âalcohol and drugâ abusers
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Changes in biomass allocation buffer low CO2 effects on tree growth during the last glaciation
Isotopic measurements on junipers growing in southern California during the last glacial, when the ambient atmospheric [CO2] (ca) was ~180 ppm, show the leaf-internal [CO2] (ci) was approaching the modern CO2 compensation point for C3 plants. Despite this, stem growth rates were similar to today. Using a coupled light-use efficiency and tree growth model, we show that it is possible to maintain a stable ci/ca ratio because both vapor pressure deficit and temperature were decreased under glacial conditions at La Brea, and these have compensating effects on the ci/ca ratio. Reduced photorespiration at lower temperatures would partly mitigate the effect of low ci on gross primary production, but maintenance of present-day radial growth also requires a ~27% reduction in the ratio of fine root mass to leaf area. Such a shift was possible due to reduced drought stress under glacial conditions at La Brea. The necessity for changes in allocation in response to changes in [CO2] is consistent with increased below-ground allocation, and the apparent homoeostasis of radial growth, as ca increases today
Probing the origin of VHE emission from M 87 with MWL observations in 2010
The large majority of extragalactic very high energy (VHE; E>100 GeV) sources
belongs to the class of active galactic nuclei (AGN), in particular the BL Lac
sub-class. AGNs are characterized by an extremely bright and compact emission
region, powered by a super-massive black hole (SMBH) and an accretion disk, and
relativistic outflows (jets) detected all across the electro-magnetic spectrum.
In BL Lac sources the jet axis is oriented close to the line of sight, giving
rise to a relativistic boosting of the emission. In radio galaxies, on the
other hand, the jet makes a larger angle to the line of sight allowing to
resolve the central core and the jet in great details. The giant radio galaxy M
87 with its proximity (1 6Mpc) and its very massive black hole ((3-6) x 10^9
M_solar) provides a unique laboratory to investigate VHE emission in such
objects and thereby probe particle acceleration to relativistic energies near
SMBH and in jets. M 87 has been established as a VHE emitter since 2005. The
VHE emission displays strong variability on time-scales as short as a day. It
has been subject of a large joint VHE and multi-wavelength (MWL) monitoring
campaign in 2008, where a rise in the 43 GHz VLBA radio emission of the
innermost region (core) was found to coincide with a flaring activity at VHE.
This had been interpreted as a strong indication that the VHE emission is
produced in the direct vicinity of the SMBH black hole. In 2010 again a flare
at VHE was detected triggering further MWL observations with the VLBA, Chandra,
and other instruments. At the same time M 87 was also observed with the
Fermi-LAT telescope at GeV energies and the European VLBI Network (EVN). In
this contribution preliminary results from the campaign will be presented.Comment: 5 pages, 2 figures, in the proceedings of the "International Workshop
on Beamed and Unbeamed Gamma-Rays from Galaxies" 11-15 April 2011, Lapland
Hotel Olos, Muonio, Finland, Journal of Physics: Conference Series Volume
355, 201
Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth Restriction
Placental dysfunction is the underlying cause of pregnancy complications such as fetal growth restriction (FGR) and pre-eclampsia. No therapies are available to treat a poorly functioning placenta, primarily due to the risks of adverse side effects in both the mother and the fetus resulting from systemic drug delivery. The use of targeted liposomes to selectively deliver payloads to the placenta has the potential to overcome these issues. In this study, we assessed the safety and efficacy of epidermal growth factor (EGF)-loaded, peptide-decorated liposomes to improve different aspects of placental function, using tissue from healthy control pregnancies at term, and pregnancies complicated by FGR. Phage screening identified a peptide sequence, CGPSARAPC (GPS), which selectively homed to mouse placentas in vivo, and bound to the outer syncytiotrophoblast layer of human placental explants ex vivo. GPS-decorated liposomes were prepared containing PBS or EGF (50â100 ng/mL), and placental explants were cultured with liposomes for up to 48 h. Undecorated and GPS-decorated liposomes containing PBS did not affect the basal rate of amino acid transport, human chorionic gonadotropin (hCG) release or cell turnover in placental explants from healthy controls. GPS-decorated liposomes containing EGF significantly increased amino acid transporter activity in healthy control explants, but not in placental explants from women with FGR. hCG secretion and cell turnover were unaffected by EGF delivery; however, differential activation of downstream protein kinases was observed when EGF was delivered via GPS-decorated vs. undecorated liposomes. These data indicate that targeted liposomes represent a safe and useful tool for the development of new therapies for placental dysfunction, recapitulating the effects of free EGF
Ultrafast control of donor-bound electron spins with single detuned optical pulses
The ability to control spins in semiconductors is important in a variety of
fields including spintronics and quantum information processing. Due to the
potentially fast dephasing times of spins in the solid state [1-3], spin
control operating on the picosecond or faster timescale may be necessary. Such
speeds, which are not possible to attain with standard electron spin resonance
(ESR) techniques based on microwave sources, can be attained with broadband
optical pulses. One promising ultrafast technique utilizes single broadband
pulses detuned from resonance in a three-level Lambda system [4]. This
attractive technique is robust against optical pulse imperfections and does not
require a fixed optical reference phase. Here we demonstrate the principle of
coherent manipulation of spins theoretically and experimentally. Using this
technique, donor-bound electron spin rotations with single-pulse areas
exceeding pi/4 and two-pulses areas exceeding pi/2 are demonstrated. We believe
the maximum pulse areas attained do not reflect a fundamental limit of the
technique and larger pulse areas could be achieved in other material systems.
This technique has applications from basic solid-state ESR spectroscopy to
arbitrary single-qubit rotations [4, 5] and bang-bang control[6] for quantum
computation.Comment: 15 pages, 4 figures, submitted 12/2008. Since the submission of this
work we have become aware of related work: J. Berezovsky, M. H. Mikkelsen, N.
G. Stoltz, L. A. Coldren, and D. D. Awschalom, Science 320: 349-352 (2008
Mass equidistribution of Hilbert modular eigenforms
Let F be a totally real number field, and let f traverse a sequence of
non-dihedral holomorphic eigencuspforms on GL(2)/F of weight (k_1,...,k_n),
trivial central character and full level. We show that the mass of f
equidistributes on the Hilbert modular variety as max(k_1,...,k_n) tends to
infinity.
Our result answers affirmatively a natural analogue of a conjecture of
Rudnick and Sarnak (1994). Our proof generalizes the argument of
Holowinsky-Soundararajan (2008) who established the case F = Q. The essential
difficulty in doing so is to adapt Holowinsky's bounds for the Weyl periods of
the equidistribution problem in terms of manageable shifted convolution sums of
Fourier coefficients to the case of a number field with nontrivial unit group.Comment: 40 pages; typos corrected, nearly accepted for
Gas morphology and energetics at the surface of PDRs: new insights with Herschel observations of NGC 7023
We investigate the physics and chemistry of the gas and dust in dense
photon-dominated regions (PDRs), along with their dependence on the
illuminating UV field. Using Herschel-HIFI observations, we study the gas
energetics in NGC 7023 in relation to the morphology of this nebula. NGC 7023
is the prototype of a PDR illuminated by a B2V star and is one of the key
targets of Herschel. Our approach consists in determining the energetics of the
region by combining the information carried by the mid-IR spectrum (extinction
by classical grains, emission from very small dust particles) with that of the
main gas coolant lines. In this letter, we discuss more specifically the
intensity and line profile of the 158 micron (1901 GHz) [CII] line measured by
HIFI and provide information on the emitting gas. We show that both the [CII]
emission and the mid-IR emission from polycyclic aromatic hydrocarbons (PAHs)
arise from the regions located in the transition zone between atomic and
molecular gas. Using the Meudon PDR code and a simple transfer model, we find
good agreement between the calculated and observed [CII] intensities. HIFI
observations of NGC 7023 provide the opportunity to constrain the energetics at
the surface of PDRs. Future work will include analysis of the main coolant line
[OI] and use of a new PDR model that includes PAH-related species.Comment: Accepted for publication in Astronomy and Astrophysics Letters
(Herschel HIFI special issue), 5 pages, 5 figure
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