361 research outputs found
Preliminary investigation of the parameterisation of surface fluxes from heterogeneous land cover for the EFEDA area
Micro-climate influence on reference evapotranspiration estimates in wetlands
Temperature and relative humidity measurements were made within and outside a lowland fen in eastern England during 2009 and 2010. Summer temperatures were found to be on average 0.24°C lower within the fen than outside, whilst summer vapour pressures were found to be on average 0.074 kPa higher within the fen. In contrast, winter temperatures were found to be higher within the fen by an average of 0.03°C. These differences may be expected to influence evapotranspiration estimates derived using data from each of the sites. The influence of the location of meteorological measurements on evapotranspiration estimates was therefore evaluated. The existence of a wetland microclimate results in up to a 7% reduction in annual reference evapotranspiration compared to a site surrounded by arable farmland only 5.5 km away
A Search for Ultra-High Energy Counterparts to Gamma-Ray Bursts
A small air shower array operating over many years has been used to search
for ultra-high energy (UHE) gamma radiation ( TeV) associated with
gamma-ray bursts (GRBs) detected by the BATSE instrument on the Compton
Gamma-Ray Observatory (CGRO). Upper limits for a one minute interval after each
burst are presented for seven GRBs located with zenith angles . A excess over background was observed between 10 and
20 minutes following the onset of a GRB on 11 May 1991. The confidence level
that this is due to a real effect and not a background fluctuation is 99.8\%.
If this effect is real then cosmological models are excluded for this burst
because of absorption of UHE gamma rays by the intergalactic radiation fields.Comment: 4 pages LaTeX with one postscript figure. This version does not use
kluwer.sty and will allow automatic postscript generatio
Contribution of nuclei accelerated by gamma-ray pulsars to cosmic rays in the Galaxy
We consider the galactic population of gamma-ray pulsars as possible sources
of cosmic rays at and just above the ``knee'' in the observed cosmic ray
spectrum at -- eV. We suggest that iron nuclei may be
accelerated in the outer gaps of pulsars, and then suffer partial
photo-disintegration in the non-thermal radiation fields of the outer gaps. As
a result, protons, neutrons, and surviving heavier nuclei are injected into the
expanding supernova remnant. We compute the spectra of nuclei escaping from
supernova remnants into the interstellar medium, taking into account the
observed population of radio pulsars.
Our calculations, which include a realistic model for acceleration and
propagation of nuclei in pulsar magnetospheres and supernova remnants, predict
that heavy nuclei accelerated directly by gamma-ray pulsars could contribute
about 20% of the observed cosmic rays in the knee region. Such a contribution
of heavy nuclei to the cosmic ray spectrum at the knee can significantly
increase the average value of with increasing energy as is suggested
by recent observations.Comment: 21 pages, 5 figures, accepted for publication in Astroparticle
Physic
Type-Decomposition of a Pseudo-Effect Algebra
The theory of direct decomposition of a centrally orthocomplete effect
algebra into direct summands of various types utilizes the notion of a
type-determining (TD) set. A pseudo-effect algebra (PEA) is a (possibly)
noncommutative version of an effect algebra. In this article we develop the
basic theory of centrally orthocomplete PEAs, generalize the notion of a TD set
to PEAs, and show that TD sets induce decompositions of centrally orthocomplete
PEAs into direct summands.Comment: 18 page
QCD Corrections to QED Vacuum Polarization
We compute QCD corrections to QED calculations for vacuum polarization in
background magnetic fields. Formally, the diagram for virtual loops
is identical to the one for virtual loops. However due to
confinement, or to the growth of as decreases, a direct
calculation of the diagram is not allowed. At large we consider the
virtual diagram, in the intermediate region we discuss the role of
the contribution of quark condensates \left and at the
low-energy limit we consider the , as well as charged pion
loops. Although these effects seem to be out of the measurement accuracy of
photon-photon laboratory experiments they may be relevant for -ray
burst propagation. In particular, for emissions from the center of the galaxy
(8.5 kpc), we show that the mixing between the neutral pseudo-scalar pion
and photons renders a deviation from the power-law spectrum in the
range. As for scalar quark condensates \left and
virtual loops are relevant only for very high radiation density
and very strong magnetic fields of order .Comment: 15 pages, 4 figures; Final versio
Clinical activity of ipilimumab for metastatic uveal melanoma: a retrospective review of the Dana-Farber Cancer Institute, Massachusetts General Hospital, Memorial Sloan-Kettering Cancer Center, and University Hospital of Lausanne experience.
BACKGROUND: Uveal melanoma exhibits a high incidence of metastases; and, to date, there is no systemic therapy that clearly improves outcomes. The anticytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4) antibody ipilimumab is a standard of care for metastatic melanoma; however, the clinical activity of CTLA-4 inhibition in patients with metastatic uveal melanoma is poorly defined.
METHODS: To assess ipilimumab in this setting, the authors performed a multicenter, retrospective analysis of 4 hospitals in the United States and Europe. Clinical characteristics, toxicities, and radiographic disease burden, as determined by central, blinded radiology review, were evaluated.
RESULTS: Thirty-nine patients with uveal melanoma were identified, including 34 patients who received 3 mg/kg ipilimumab and 5 who received 10 mg/kg ipilimumab. Immune-related response criteria and modified World Health Organization criteria were used to assess the response rate (RR) and the combined response plus stable disease (SD) rate after 12 weeks, after 23 weeks, and overall (median follow-up, 50.4 weeks [12.6 months]). At week 12, the RR was 2.6%, and the response plus SD rate was 46.%; at week 23, the RR was 2.6%, and the response plus SD rate was 28.2%. There was 1 complete response and 1 late partial response (at 100 weeks after initial SD) for an immune-related RR of 5.1%. Immune-related adverse events were observed in 28 patients (71.8%) and included 7 (17.9%) grade 3 and 4 events. Immune-related adverse events were more frequent in patients who received 10 mg/kg ipilimumab than in those who received 3 mg/kg ipilimumab. The median overall survival from the first dose of ipilimumab was 9.6 months (95% confidence interval, 6.3-13.4 months; range, 1.6-41.6 months). Performance status, lactate dehydrogenase level, and an absolute lymphocyte count ≥ 1000 cells/μL at week 7 were associated significantly with survival.
CONCLUSIONS: In this multicenter, retrospective analysis of 4 hospitals in the United States and Europe of patients with uveal melanoma, durable responses to ipilimumab and manageable toxicity were observed
Stomatal responses of Eucalyptus species to elevated CO2 concentration and drought stress
Five species of Eucalyptus (E. grandis, E. urophylla, E. camaldulensis, E. torelliana, and E. phaeotrica), among the ten species most commonly used in large scale plantations, were selected for studies on the effects of elevated CO2 concentration [CO2] and drought stress on stomatal responses of 2.5-month old seedlings. The first three species belong to the subgenus Smphyomyrtus, whereas the fourth species belongs to the subgenus Corymbia and E. phaeotrica is from the subgenus Monocalyptus. Seedlings were grown in four pairs of open-top chambers, arranged to have 2 plants of each species in each chamber, with four replications in each of two CO2 concentrations: 350 ± 30 mumol mol-1 and 700 ± 30 mumol mol-1. After 100 days in the chambers, a series of gas exchange measurements were made. Half the plants in each chamber, one plant per species per chamber, were drought-stressed by withholding irrigation, while the remaining plants continued to be watered daily. Drought stress decreased stomatal conductance, photosynthesis and transpiration rates in all the species. The effect of drought stress on stomatal closure was similar in both [CO2]. The positive effects of elevated [CO2] on photosynthesis and water use efficiency were maintained longer during the stress period than under well-watered conditions. The photosynthetic rate of E. phaeotrica was higher even in the fourth day of the drought stress. Drought stress increased photoinhibition of photosynthesis, as measured by chlorophyll fluorescence, which varied among the species, as well as in relation to [CO2]. The results are in agreement with observed differences in stomatal responses between some eucalyptus species of the subgenera Symphyomyrtus and Monocalyptus
- …