Pengaruh Main Entrance Terhadap Aksesibilitas Pengunjung Rumah Sakit Studi Kasus: Koridor Jl. Dr. Soetomo Dan Jl. Kariadi Semarang

. RSUP1 Dr. Kariadi Semarang serves as a general hospital for the regional of Jawa Tengah. The hospital environment, as public facility, provides health care and intensive care for society. Kariadi Street and Dr.Soetomo Street are the major road that can access RSUP1 Dr.Kariadi environment. In year 2010, there was an increase volume of health services and function program that carried out by hospital. Therefore, main entrance is designed based on the bay system that could accommodate 2-3 cars. By the existence of main entrance on Kariadi Street, it could attract the street vendors to set up a tent on the pedestrian ways. On the otherhand, at Dr.Soetomo corridor, there are taxi stands around the main entrance to accomodate the passengers.Main entrance has been predicted has an influence the accessibility of visitors to the hospital environment. The result of this research is there are some influences and relations between main entrance to the hospital visitors' accessibility. There are no significant differences between the visitors' accessibility of main entrance group on Dr. Soetomo Street and Kariadi Street. There is an additional of health service function which will increase the number of visitors of Dr. Kariadi Hospital either in or out at the main entrance

Peranan Pembayangan pada Courtyard terhadap Pengendalian Suhu Permukaan (Studi Kasus Gedung Widya Puraya Universitas Diponegoro Semarang)

Courtyard merupakan komponen bangunan sejak lampau yang memiliki fungsi sebagai elemen estetika di dalam bangunan juga berperan dalam usaha menciptakan sistem pengkondisian udara dan pencahayaan alami. Sebagai bukaan tentunya penetrasi radiasi matahari langsung ke dalam bangunan tidak dapat di hindari akan tetapi dengan bentuk struktur yang khas dari courtyard ditambah dengan ketersediaan elemen vegetasi akan membentuk bidang-bidang bayangan. Tulisan ini bertujuan untuk memberikan pemaparan hasil penelitian mengenai sejauh mana peranan pembayangan pada courtyard dalam mereduksi peningkatan suhu permukaan akibat dari penetrasi radiasi matahari. Metode yang digunakan pada penilitan ini adalah analisis secara kualitatif terhadap data kuantitatif hasil observasi dan pengukuran langsung terhadap obyek studi.  Dari hasil analisis dapat diketahui bahwa variasi bidang pembayangan dan durasi pembayangan pada area courtyard gedung Widya Puraya Universitas Diponego dapat mengendalikan peningkatan suhu permukaan yang dipengaruhi oleh durasi puncak peningkatan suhu permukaan.   Kata Kunci : Pembayangan, Courtyard, Suhu Permukaa

Clinical and pathological outcomes of induction chemotherapy before neoadjuvant radiotherapy in locally‐advanced rectal cancer

Background and ObjectivesIn North America, preoperative combination chemoradiation is the most commonly recommended and utilized approach to locally advanced rectal cancer. There is increasing interest in the use of induction chemotherapy (IC) before radiation and surgery in locally advanced rectal cancer. How widely IC is being used and whether it improves pathologic and oncologic outcomes is unknown.MethodsWe evaluated clinical stage 2 or 3 rectal cancer patients in the National Cancer Database between 2006 and 2015. We identified predictors of use of IC with multivariable logistic regression and compared survival between groups using Cox proportional hazards regression.ResultsAmong 36 268 patients, IC use increased significantly over time from 5.5% in 2006 to 15.9% in 2015 (P < 0.001). Treatment at a hospital with a high IC rate was an independent predictor of receipt of IC. IC and traditional therapy yielded similar pathologic complete response rates (32.2% vs 30.5%, P = 0.2) and similar 5‐year survival (82.4% vs 81.4%, 0.71).ConclusionsUse of IC for locally advanced rectal cancer has increased significantly. The choice of IC seems to be driven more by institutional and regional practice patterns than clinical characteristics and is not associated with improved pathologic or oncologic outcomes.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/150518/1/jso25474.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/150518/2/jso25474_am.pd

Molecular analysis of endocrine disruption in hornyhead turbot at wastewater outfalls in southern california using a second generation multi-species microarray.

Sentinel fish hornyhead turbot (Pleuronichthysverticalis) captured near wastewater outfalls are used for monitoring exposure to industrial and agricultural chemicals of ~ 20 million people living in coastal Southern California. Although analyses of hormones in blood and organ morphology and histology are useful for assessing contaminant exposure, there is a need for quantitative and sensitive molecular measurements, since contaminants of emerging concern are known to produce subtle effects. We developed a second generation multi-species microarray with expanded content and sensitivity to investigate endocrine disruption in turbot captured near wastewater outfalls in San Diego, Orange County and Los Angeles California. Analysis of expression of genes involved in hormone [e.g., estrogen, androgen, thyroid] responses and xenobiotic metabolism in turbot livers was correlated with a series of phenotypic end points. Molecular analyses of turbot livers uncovered altered expression of vitellogenin and zona pellucida protein, indicating exposure to one or more estrogenic chemicals, as well as, alterations in cytochrome P450 (CYP) 1A, CYP3A and glutathione S-transferase-α indicating induction of the detoxification response. Molecular responses indicative of exposure to endocrine disruptors were observed in field-caught hornyhead turbot captured in Southern California demonstrating the utility of molecular methods for monitoring environmental chemicals in wastewater outfalls. Moreover, this approach can be adapted to monitor other sites for contaminants of emerging concern in other fish species for which there are few available gene sequences

Prolactin and hostility in hospitalised patients and healthy women: A systematic review and meta-analysis.

The aim of this systematic review and meta-analysis was to assess any difference in the self-ratings of hostility in mentally healthy women with different levels of prolactin (PRL). Electronic databases (PubMed, MEDLINE, EMBASE and the Cochrane Library) were searched up to 2nd July 2012 for published literature comparing hostility levels in women with different levels of PRL. Keyword pairs ('prolactin' and 'aggression', 'prolactin' and 'hostil*', 'prolactin' and 'anger', and 'prolactin' and 'angry') were entered simultaneously. From 1065 resulting titles, and one unpublished study, 214 articles underwent full-text review by authors JB and EM. Studies were selected based on clinical relevance. Eight comparative studies consisting of 242 female patients with high PRL levels, 207 female patients with normal PRL levels and 127 healthy controls with normal PRL levels were included. Data were analysed using the inverse variance method with a random-effects model. Analysis revealed significantly higher hostility in patients with high PRL compared with that in healthy control women (Z = 1.94, p < 0.05; Hedges' g = 0.72; 95% confidence interval [CI]: -0.01-1.45), significantly higher hostility in patient controls compared with that in healthy controls (Z = 1.94, p < 0.05; Hedges' g = 0.47; 95% CI: 0.00-0.94) and non-significantly higher hostility levels in patients with high PRL compared with that in patients with normal PRL levels (Z = 1.45, p < 0.15; Hedges' g = 0.38; 95% CI: -0.13-0.89). In this meta-analysis, hostility appears to be accounted for partly by PRL levels and also partly by patient status, perhaps due to the stress of being a patient. Methodological considerations and implications for patient care are discussed

Youth sport during the COVID-19 pandemic: The influence of race and affluence on parents’ perspectives of youth participation

COVID-19 restrictions led to a nearly 50% decline in youth sport participation across the United States (Dorsch et al., 2021). Today, communities and sport organizations have resumed sport. However, research has yet to fully elucidate how COVID-19 restrictions impacted youth participation across different sociodemographic groups during the pandemic. The present study explored the association between race and affluence and their relationship with parents' attitudes toward children's youth sport participation before, during, and after the COVID-19 pandemic. Online questionnaires were completed by a nationally representative sample of 3706 parents (Mage = 39.57 ± 9.03 years) who had a child regularly participating in youth sport before COVID-19. Multivariate Analyses of Variance using Tukey post-hoc tests were conducted to examine the main effect differences by race and affluence and the interactive effects of race and affluence. Results suggest that race and affluence -- independently and in combination -- were salient categorical variables of children's weekly hours of sport participation during the COVID-19 pandemic. Findings highlight that White*high affluent groups had the highest rates of sport participation during the COVID-19 pandemic and that these families desire to invest more time and money at greater rates upon returning. Theoretically, designed intersectionality research is recommended to explore further effects of race and affluence in youth sport