[Wallace-Hardeman correspondence, May 19, 1945-October 3, 1945]

https://digitalcommons.acu.edu/crs_books/1424/thumbnail.jp

John Nelson Armstrong folder of correspondence

The folder of correspondence labeled John Nelson Armstrong has been digitized and the original order maintained. The correspondence between J. N. Armstrong, N. B. Hardeman, Foy E. Wallace, and J. W. Shepherd is discussing the premillennialism teaching of R. H. Boll and others

Drug-induced sleep endoscopy while administering CPAP therapy in patients with CPAP failure

Study objectives: To study the pattern of upper airway collapse in patients with CPAP failure by performing DISE while administering CPAP therapy and to determine the reason for CPAP failure accordingly. Methods: This observational retrospective study comprised 30 patients diagnosed with OSA and CPAP failure, who underwent DISE while administering CPAP therapy. During DISE, the upper airway was assessed with and without CPAP therapy using the VOTE classification. Additionally, a jaw thrust maneuver was performed, in order to mimic the effect of an additional mandibular advancement device (MAD) in combination with CPAP therapy. Consequently, the outcome of DISE was translated into a clinically relevant categorization. Results: Eleven patients (37%) had a persistent anteroposterior (AP) collapse, including a collapse at velum, tongue base, or epiglottis level and multilevel collapse. Eight patients (27%) had a floppy epiglottis. Five patients (17%) had a persistent complete concentric collapse (CCC) and three patients had a persistent laryngeal collapse (10%). In three patients (10%), no airway collapse was found after CPAP administration. Conclusions: Based on the results of the reported study, in most cases, the potential cause of CPAP failure can be determined by this new diagnostic method. Consequently, suggestions can be made for additional therapy

Communication of behaviour change interventions: Can they be recognised from written descriptions?

Objective: Communication of the content of a behaviour change intervention (BCI) involves clear description followed by appropriate recognition and interpretation. We investigated accuracy of recognition of BCI descriptions and the effects of training in the behaviour change taxonomy BCTTv1. Methods: Materials were 166 written descriptions of two BCIs previously written by 166 separate writers after viewing a video of the BCI. Each of the current participants (12 naïve and 12 trained in BCTTv1) was presented with a random sample of the written descriptions and asked to form groups of descriptions they judged to be describing the same intervention. For each participant, we assessed the number of groupings of BCI descriptions, their purity (containing only one BCI) and their differentiation (having a dominant BCI). Results: All except one participant classified the descriptions into more than two groupings. Naïve participants created significantly more groupings, fewer ‘pure’ groupings and less differentiated groupings (all Mann–Whitney p  <  .05). Conclusions: Written communications of BCI contents may not be recognised and interpreted adequately to support implementation. BCT taxonomy training may lead to some progress in interpreting the active content of interventions but, based on this limited study, further progress is needed if BCIs for accurate implementation

Applying the behaviour change technique (BCT) taxonomy v1: a study of coder training.

Behaviour Change Technique Taxonomy v1 (BCTTv1) has been used to detect active ingredients of interventions. The purpose of this study was to evaluate effectiveness of user training in improving reliable, valid and confident application of BCTTv1 to code BCTs in intervention descriptions. One hundred sixty-one trainees (109 in workshops and 52 in group tutorials) were trained to code frequent BCTs. The following measures were taken before and after training: (i) inter-coder agreement, (ii) trainee agreement with expert consensus, (iii) confidence ratings and (iv) coding competence. Coding was assessed for 12 BCTs (workshops) and for 17 BCTs (tutorials). Trainees completed a course evaluation. Methods improved agreement with expert consensus (p < .05) but not inter-coder agreement (p = .08, p = .57, respectively) and increased confidence for BCTs assessed (both p < .05). Methods were as effective as one another at improving coding competence (p = .55). Training was evaluated positively. The training improved agreement with expert consensus, confidence for BCTs assessed, coding competence but not inter-coder agreement. This varied according to BCT.This work was carried out as part of the Behavior Change Technique Taxonomy project funded by the Medical Research Council via its Methodology panel [G0901474/1].This is the accepted manuscript version. The final publication is available from Springer at http://link.springer.com/article/10.1007%2Fs13142-014-0290-

Systematic review of reviews of intervention components associated with increased effectiveness in dietary and physical activity interventions.

BACKGROUND: To develop more efficient programmes for promoting dietary and/or physical activity change (in order to prevent type 2 diabetes) it is critical to ensure that the intervention components and characteristics most strongly associated with effectiveness are included. The aim of this systematic review of reviews was to identify intervention components that are associated with increased change in diet and/or physical activity in individuals at risk of type 2 diabetes. METHODS: MEDLINE, EMBASE, CINAHL, PsycInfo, and the Cochrane Library were searched for systematic reviews of interventions targeting diet and/or physical activity in adults at risk of developing type 2 diabetes from 1998 to 2008. Two reviewers independently selected reviews and rated methodological quality. Individual analyses from reviews relating effectiveness to intervention components were extracted, graded for evidence quality and summarised. RESULTS: Of 3856 identified articles, 30 met the inclusion criteria and 129 analyses related intervention components to effectiveness. These included causal analyses (based on randomisation of participants to different intervention conditions) and associative analyses (e.g. meta-regression). Overall, interventions produced clinically meaningful weight loss (3-5 kg at 12 months; 2-3 kg at 36 months) and increased physical activity (30-60 mins/week of moderate activity at 12-18 months). Based on causal analyses, intervention effectiveness was increased by engaging social support, targeting both diet and physical activity, and using well-defined/established behaviour change techniques. Increased effectiveness was also associated with increased contact frequency and using a specific cluster of "self-regulatory" behaviour change techniques (e.g. goal-setting, self-monitoring). No clear relationships were found between effectiveness and intervention setting, delivery mode, study population or delivery provider. Evidence on long-term effectiveness suggested the need for greater consideration of behaviour maintenance strategies. CONCLUSIONS: This comprehensive review of reviews identifies specific components which are associated with increased effectiveness in interventions to promote change in diet and/or physical activity. To maximise the efficiency of programmes for diabetes prevention, practitioners and commissioning organisations should consider including these components.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Tropomyosin Promotes Lamellipodial Persistence by Collaborating with Arp2/3 at the Leading Edge

At the leading edge of migrating cells, protrusion of the lamellipodium is driven by Arp2/3-mediated polymerization of actin filaments [1]. This dense, branched actin network is promoted and stabilized by cortactin [2, 3]. In order to drive filament turnover, Arp2/3 networks are remodeled by proteins such as GMF, which blocks the actin-Arp2/3 interaction [4, 5], and coronin 1B, which acts by directing SSH1L to the lamellipodium where it activates the actin-severing protein cofilin [6, 7]. It has been shown in vitro that cofilin-mediated severing of Arp2/3 actin networks results in the generation of new pointed ends to which the actin-stabilizing protein tropomyosin (Tpm) can bind [8]. The presence of Tpm in lamellipodia, however, is disputed in the literature [9-19]. Here, we report that the Tpm isoforms 1.8/9 are enriched in the lamellipodium of fibroblasts as detected with a novel isoform-specific monoclonal antibody. RNAi-mediated silencing of Tpm1.8/9 led to an increase of Arp2/3 accumulation at the cell periphery and a decrease in the persistence of lamellipodia and cell motility, a phenotype consistent with cortactin- and coronin 1B-deficient cells [2, 7]. In the absence of coronin 1B or cofilin, Tpm1.8/9 protein levels are reduced while, conversely, inhibition of Arp2/3 with CK666 leads to an increase in Tpm1.8/9 protein. These findings establish a novel regulatory mechanism within the lamellipodium whereby Tpm collaborates with Arp2/3 to promote lamellipodial-based cell migration

Efecto del desarrollo económico en la mortalidad relacionada con el transporte, entre diferentes tipos de usuarios de las vías: un estudio transversal internacional.

Este artículo presenta un análisis de regresión transversal con datos recientes de mortalidad en 44 países, utilizando datos de certificados de defunción provenientes de la Organización Mundial de la Salud

Efecto del desarrollo económico en la mortalidad relacionada con el transporte, entre diferentes tipos de usuarios de las vías: un estudio transversal internacional

Introducción: La relación entre el estado de desarrollo económico de un país y su tasa de mortalidad por colisiones de vehículos de motor (CVM) no ha sido definida para los diferentes tipos de usuarios de las vías. Métodos: Este artículo presenta un análisis de regresión transversal con datos recientes de mortalidad en 44 países, utilizando datos de certificados de defunción provenientes de la Organización Mundial de la Salud. Resultados: Para cinco tipos de usuarios de las vías, la mortalidad por CVM es expresada como muertes por 100.000 habitantes, y muertes por 1.000 vehículos de motor. El desarrollo económico es medido como el Producto Interno Bruto (PIB) per cápitaen dólares de Estados Unidos, y como vehículos de motor por 1.000 habitantes. Los resultados mostraron que la mortalidad total por CVM en los países con bajos ingresos presentó un pico a un PIB alrededor de US $2.000 per cápita, y cerca de 100 vehículospor 1.000habitantes.Conclusiones: La mortalidad total disminuyó con el incremento del ingreso nacional alrededor de US$24.000. La mayoría de los cambios en la mortalidad por CVM asociados con el desarrollo económico fueron explicados por cambios en las tasas de usuarios nomotorizados, especialmente de peatones. Las tasas totales de CVM fueron más bajas cuando la exposición de los peatones fue menor o porque hubo pocos vehículos de motor o peatones; y fueron más altas durante un periodo crítico de transición hacia transporte motorizado, cuando gran cantidad de peatones y otros usuarios vulnerables compitieron por el uso de las vías con vehículos de motor.AbstractIntroduction: The relationship between a country’s economic development and its fatality rate from motor vehicle accidents (MVA) has not been studied according to the different types of users of public thoroughfares. Methodology: This article presents a cross analysis of recent mortality data from 44 countries through the use of information found in the death certifications supplied by the World Health Organization. Results: For five types of users of public roadways the mortality rate by MVA is presented as deaths per 100,000 inhabitants and deaths per 1000 motor vehicles. Economic development is measured by the per capita GDP (Gross Domestic Product) in US dollars and the number of motor vehicles per 1000 inhabitants. The results showed that the total mortality rate by MVA in low income countries reached a peak at a GDP of around US $2000 per capita and around 100 motor vehicles per 1000 inhabitants. Conclusions: The overall mortality rate diminished with the increase of national incomeat around US$24,000. The majority of the changes in fatality by MVA in association with economic development were explained by changes in the number of nonmotorized users of public ways, especially pedestrians. The total number of MVA was reduced when the exposure of pedestrians to motorized traffic was lower either because there were fewer motor vehicles or because there were fewer pedestrians. The rate was higher during critical periods of transition towards more motorized transportation when many pedestrians and other non-motorized users of public thoroughfares were competing for space with increased numbers of motorized vehicles. Key words: Transit accidents, fatalities, economic developmen