Pregna-1,4,20-trien-3-one, a cytotoxic marine steroid from the marine soft coral Nephthea sp.

The title compound, C21H28O, was isolated from the cytotoxic lipid extract of the Fidjian soft coral Nephthea sp. The steroid showed inhibitory activity to human colon adenocarcinoma SW480 cells (IC50 = 2.5 µg ml−1). The mol­ecular structure indicates that the A ring is almost planar (r.m.s. deviation = 0.032 Å), the B and C rings adopt chair conformations and the five-membered D ring is a half-chair. The B/C and C/D ring junctions are trans-fused

Noncommutative SU(N) and Gauge Invariant Baryon Operator

We propose a constraint on the noncommutative gauge theory with U(N) gauge group which gives rise to a noncommutative version of the SU(N) gauge group. The baryon operator is also constructed.Comment: 10 page

On the eve of the 100th anniversary of IAU Commission 19/A2 “Rotation of the Earth”

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.IAU Commission 19 began in 1919 with the birth of the IAU at the Brussels Conference, where Standing Committee 19 on Latitude Variations was established as one of 32 standing committees. At the first IAU General Assembly in 1922, Standing Committee 19 became Commission 19 “Variation of Latitude”. In the beginning, the main topic of the Commission was the investigation of polar motion. Later, its activities included observations and theory of Earth rotation and connections between Earth orientation variations and geophysical phenomena. As a result, in 1964 at the XII IAU General Assembly, the Commission was renamed “Rotation of the Earth”. The investigation of Earth orientation variations is primarily based on observations of natural and artificial celestial objects. Therefore, maintenance of the international terrestrial and celestial reference frames, as well as the coordinate transformation between the frames and the improvement of the model of precession/nutation, have always been among the primary Commission topics. In 1987, the IAU through Commissions 19 and 31 “Time” established, jointly with the International Union of Geodesy and Geophysics, what is now known as the International Earth Rotation and Reference Systems Service. Commission 19 continued to work to develop methods to improve the accuracy and understanding of Earth orientation variations and related reference systems and frames as well as theoretical studies of Earth rotation. In 2015, Commission 19 was renewed as Commission A2 “Rotation of the Earth” continuing Commission 19’s functions and linking the astronomical community to other scientific organizations such as the International Association of Geodesy, International VLBI Service for Geodesy and Astrometry, International GNSS Service, International Laser Ranging Service and International DORIS Service. During its entire history, IAU Commission 19/A2 has always worked in close cooperation with these and other related services to improve the accuracy and consistency of the Earth orientation parameters and celestial and terrestrial reference frames

Semiclassical Analysis of String/Gauge Duality on Non-commutative Space

We use semiclassical method to study closed strings in the modified AdS_5*S^5 background with constant B-fields. The point-like closed strings and the streched closed strings rotating around the big circle of S^5 are considered. Quantization of these closed string leads to a time-dependent string spectrum, which we argue to correspond to the RG-flow of the dual noncommutative Yang Mills theory.Comment: 19 pages, 1 figure, revtex4. minor corrections. references adde

Isolation, Structure Elucidation and Total Synthesis of Lajollamide A from the Marine Fungus Asteromyces cruciatus

The marine-derived filamentous fungus Asteromyces cruciatus 763, obtained off the coast of La Jolla, San Diego, USA, yielded the new pentapeptide lajollamide A (1), along with the known compounds regiolone (2), hyalodendrin (3), gliovictin (4), 1N-norgliovicitin (5), and bis-N-norgliovictin (6). The planar structure of lajollamide A (1) was determined by Nuclear Magnetic Resonance (NMR) spectroscopy in combination with mass spectrometry. The absolute configuration of lajollamide A (1) was unambiguously solved by total synthesis which provided three additional diastereomers of 1 and also revealed that an unexpected acid-mediated partial racemization (2:1) of the l-leucine and l-N-Me-leucine residues occurred during the chemical degradation process. The biological activities of the isolated metabolites, in particular their antimicrobial properties, were investigated in a series of assay systems

Experimental Comparison of Efficient Tomography Schemes for a Six-Qubit State

Quantum state tomography suffers from the measurement effort increasing exponentially with the number of qubits. Here, we demonstrate permutationally invariant tomography for which, contrary to conventional tomography, all resources scale polynomially with the number of qubits both in terms of the measurement effort as well as the computational power needed to process and store the recorded data. We demonstrate the benefits of combining permutationally invariant tomography with compressed sensing by studying the influence of the pump power on the noise present in a six-qubit symmetric Dicke state, a case where full tomography is possible only for very high pump powers.Comment: 7 pages, 7 figure

Dynamics of Wilson Observables in Non-Commutative Gauge Theory

An equation for the quantum average of the gauge invariant Wilson loop in non-commutative Yang-Mills theory with gauge group U(N) is obtained. In the 't Hooft limit, the equation reduces to the loop equation of ordinary Yang-Mills theory. At finite $N$, the equation involves the quantum averages of the additional gauge invariant observables of the non-commutative theory associated with open contours in space-time. We also derive equations for correlators of several gauge invariant (open or closed) Wilson lines. Finally, we discuss a perturbative check of our results.Comment: 12 pages, typo in formula (32) correcte

Draft Genome Sequence of Micromonospora sp. Strain MW-13, a Bacterial Strain with Antibacterial Properties and Plant Growth Promotion Potential Isolated from the Rhizosphere of Wheat in Iran.

Jahanshah G, Miess H, Busche T, et al. Draft Genome Sequence of Micromonospora sp. Strain MW-13, a Bacterial Strain with Antibacterial Properties and Plant Growth Promotion Potential Isolated from the Rhizosphere of Wheat in Iran. Microbiology resource announcements. 2019;8(2): e01375-18

Anomalous C-violating Three Photon Decay of the Neutral Pion in Noncommutative Quantum Electrodynamics

We show that a simple and reasonable generalization of the anomalous interaction between the neutral pion and two photons can induce the C-violating three photon decay of the neutral pion in noncommutative quantum electrodynamics. We find that it is mandatory for consistency reasons to include simultaneously the normal neutral pion and photon interaction in which the neutral pion transforms under U(1) in a similar way as in the adjoint representation of a non-Abelian gauge theory. We demonstrate that the decay has a characteristic distribution although its rate still seems too small to be experimentally reachable in the near future. We also describe how to manipulate phase space integration correctly when Lorentz invariance is lost.Comment: 12 pages, 1 figure using axodraw; minor revisions in the abstract and in the paragraph following eq (32); update refs and add two old ref

Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase

Baulig A, Helmle I, Bader M, et al. Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase. CHEMICAL SCIENCE. 2019;10(16):4486-4490.Phosphoramidon is a potent metalloprotease inhibitor and a widespread tool in cell biology research. It contains a dipeptide backbone that is uniquely linked to a 6-deoxysugar via a phosphoramidate bridge. Herein, we report the identification of a gene cluster for the formation of phosphoramidon and its detailed characterization. In vitro reconstitution of the biosynthesis established TalE as a phosphoramidate-forming kinase and TalC as the glycosyltransferase which installs the L-rhamnose moiety by phosphoester linkage