Water activity and freezing points in aqueous solutions of manganese nitrate: experimental and modeling

The water activities of manganese nitrate solutions were measured using a humidity sensor instrument up to almost the saturation molality at 298.15 K; the thermodynamic properties of the system were described by the Pitzer model and specific interaction theory (SIT). The evaluation of the ion interaction parameters for the Pitzer model and SIT were carried out using experimental freezing points and osmotic coefficients of manganese nitrate aqueous solutions, collected from the open literature, and the water activity data measured in this work. A set of Pitzer and SIT parameters were estimated using a temperature dependency, that enables us to cover wider temperature ranges, and consequently calculate system properties to higher molalities. Both approaches represent very satisfactorily, and with similar accuracy, the experimental data and the calculated manganese nitrate molal activity coefficients are comparable to those already published for analogous systems. Additionally, the Pitzer model was also able to calculate the ice curve and the solubility branch of manganese nitrate hexahydrate up to a salt solution 6.5 mol-kg-1.This work was developed in the scope of the projects POCI-01-0145-FEDER- 006984—Associate Laboratory LSRE-LCM both funded by European Regional Development Fund (ERDF) through COMPETE2020—Programa Operacional Competitividade e Internacionalização (POCI)—and by national funds through FCT—Fundação para a Ciência e a Tecnologia. This work is also a result of project ‘‘AIProcMat@N2020—Advanced Industrial Processes and Materials for a Sustainable Northern Region of Portugal 2020’’, with the reference NORTE-01-0145-FEDER-000006, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through ERDF.info:eu-repo/semantics/publishedVersio

Tekstien uudelleenkäyttö suomalaisessa sanoma- ja aikakauslehdistössä 1771–1920. Digitaalisten ihmistieteiden näkökulma

Artikkelissa tutkitaan suomalaista sanoma- ja aikakauslehdistöä tekstin uudelleenkäytön näkökulmasta.Saman tekstin julkaiseminen uudelleen eri yhteyksissä on sinänsä vanha ja tunnettu ilmiö, mutta ennen sanoma- ja aikakauslehtien digitoimista tätä lehdistön piirrettä ei ole voitu tutkia systemaattisesti. Tutkimuksen lähdeaineistona on Suomen Kansalliskirjaston julkaisema sanoma- ja aikakauslehtien digitoitu OCR-korpus, josta on COMHIS-hankkeessa kehitetyn, tekstin uudelleenkäytön tunnistavan BLAST-menetelmän avulla etsitty lehdistössä esiintyvää kopiointia ja toisteisuutta. Aikavälillä 1771–1920 toistoa sisältäviä tekstejä tai tekstikatkelmia on löytynyt noin 13,8 miljoonan klusterin eli pidemmän merkkijonon verran. Artikkelissa esitellään sekä itse uudelleenkäytön tunnistukseen käytettyä BLAST-menetelmää että tämän tunnistuksen tuloksia. Tutkimus osoittaa, että tekstien kopioiminen ja uudelleenkäyttö on merkittävä osa suomalaista lehdistöä. Menetelmänä tekstien uudelleenkäytön tunnistus tarjoaa uuden keinon tutkia informaation liikkeitä ja reittejä.This article explores Finnish newspapers and periodicals produced between 1771 and 1920, with a focus on the reuse of texts. While the reprinting of particular texts in a range of different locations can be regarded as an old and well-acknowledged practice in the press, a systematic examination was not possible until the digitization of these historical documents. This primary research material derives from the digitized OCR corpus of newspapers and periodicals published by the National Library of Finland. In the COMHIS project, we have developed a text-mining software, based on NCBI BLAST, which effectively recognizes and enables the location of textual repetitions. We have found approximately 13.8 million clusters of text reuse. As well as an introduction to the methods and uses of BLAST, the article will also explore the results gained through these and what they reveal about the nature of the circulation of information in the Finnish press during this period. This article shows that the copying and reuse of texts was a remarkable part of the process.</p

Cost analysis of antibiotic therapy versus appendectomy for treatment of uncomplicated acute appendicitis: 5-year results of the APPAC randomized clinical trial

BackgroundThe efficacy and safety of antibiotic treatment for uncomplicated acute appendicitis hasbeen established at long-term follow-up with the majority of recurrences shown to occurwithin the first year. Overall costs of antibiotics are significantly lower compared with appendectomyat short-term follow-up, but long-term durability of these cost savings is unclear.The study objective was to compare the long-term overall costs of antibiotic therapy versusappendectomy in the treatment of uncomplicated acute appendicitis in the APPAC (APPendicitisACuta) trial at 5 years.Methods and findingsThis multicentre, non-inferiority randomized clinical trial randomly assigned 530 adultpatients with CT-confirmed uncomplicated acute appendicitis to appendectomy or antibiotictreatment at six Finnish hospitals. All major costs during the 5-year follow-up were recorded,whether generated by the initial visit and subsequent treatment or possible recurrent appendicitis.Between November 2009 and June 2012, 273 patients were randomized to appendectomyand 257 to antibiotics. The overall costs of appendectomy were 1.4 times higher(pCI: €3879 to €4463) resulting in cost savings of €1545 per patient (95% CI: €1193 to €1899;ppatients did not undergo appendectomy.ConclusionsAt 5-year follow-up antibiotic treatment resulted in significantly lower overall costs comparedwith appendectomy. As the majority of appendicitis recurrences occur within the first yearafter the initial antibiotic treatment, these results suggest that treating uncomplicated acuteappendicitis with antibiotics instead of appendectomy results in lower overall costs even atlonger-term follow-up.</p

Monitoring of ticks and tick-borne pathogens through a nationwide research station network in Finland

In 2015 a long-term, nationwide tick and tick-borne pathogen (TBP) monitoring project was started by the Finnish Tick Project and the Finnish Research Station network (RESTAT), with the goal of producing temporally and geographically extensive data regarding exophilic ticks in Finland. In the current study, we present results from the first four years of this collaboration. Ticks were collected by cloth dragging from 11 research stations across Finland in May September 2015-2018 (2012-2018 in Seili). Collected ticks were screened for twelve different pathogens by qPCR: Borrelia afzelii, Borrelia garinii, Borrelia valaisiana, Borrelia burgdorferi sensu stricto, Borrelia miyamotoi, Babesia spp., Anaplasma phagocytophilum, Rickettsia spp., Candidatus Neoehrlichia mikurensis, Francisella tularensis, Bartonella spp. and tick-borne encephalitis virus (TBEV). Altogether 15 067 Ixodes ricinus and 46 Ixodes persulcatus were collected during 68 km of dragging. Field collections revealed different seasonal activity patterns for the two species. The activity of I. persulcatus adults (only one nymph detected) was unimodal, with activity only in May July, whereas Ixodes ricinus was active from May to September, with activity peaks in September (nymphs) or July August (adults). Overall, tick densities were higher during the latter years of the study. Borrelia burgdorferi sensu lato were the most common pathogens detected, with 48.9 +/- 8.4% (95% Cl) of adults and 25.3 +/- 4.4% of nymphs carrying the bacteria. No samples positive for F. tularensis, Bartonella or TBEV were detected. This collaboration project involving the extensive Finnish Research Station network has ensured enduring and spatially extensive, long-term tick data collection to the foreseeable future.Peer reviewe

Monitoring of ticks and tick-borne pathogens through a nationwide research station network in Finland

In 2015 a long-term, nationwide tick and tick-borne pathogen (TBP) monitoring project was started by the Finnish Tick Project and the Finnish Research Station network (RESTAT), with the goal of producing temporally and geographically extensive data regarding exophilic ticks in Finland. In the current study, we present results from the first four years of this collaboration. Ticks were collected by cloth dragging from 11 research stations across Finland in May–September 2015–2018 (2012–2018 in Seili). Collected ticks were screened for twelve different pathogens by qPCR: Borrelia afzelii, Borrelia garinii, Borrelia valaisiana, Borrelia burgdorferi sensu stricto, Borrelia miyamotoi, Babesia spp., Anaplasma phagocytophilum, Rickettsia spp., Candidatus Neoehrlichia mikurensis, Francisella tularensis, Bartonella spp. and tick-borne encephalitis virus (TBEV). Altogether 15 067 Ixodes ricinus and 46 Ixodes persulcatus were collected during 68 km of dragging. Field collections revealed different seasonal activity patterns for the two species. The activity of I. persulcatus adults (only one nymph detected) was unimodal, with activity only in May–July, whereas Ixodes ricinus was active from May to September, with activity peaks in September (nymphs) or July–August (adults). Overall, tick densities were higher during the latter years of the study. Borrelia burgdorferi sensu lato were the most common pathogens detected, with 48.9 ± 8.4% (95% Cl) of adults and 25.3 ± 4.4% of nymphs carrying the bacteria. No samples positive for F. tularensis, Bartonella or TBEV were detected. This collaboration project involving the extensive Finnish Research Station network has ensured enduring and spatially extensive, long-term tick data collection to the foreseeable future