Artificial intelligence insights into hippocampal processing

Advances in artificial intelligence, machine learning, and deep neural networks have led to new discoveries in human and animal learning and intelligence. A recent artificial intelligence agent in the DeepMind family, muZero, can complete a variety of tasks with limited information about the world in which it is operating and with high uncertainty about features of current and future space. To perform, muZero uses only three functions that are general yet specific enough to allow learning across a variety of tasks without overgeneralization across different contexts. Similarly, humans and animals are able to learn and improve in complex environments while transferring learning from other contexts and without overgeneralizing. In particular, the mammalian extrahippocampal system (eHPCS) can guide spatial decision making while simultaneously encoding and processing spatial and contextual information. Like muZero, the eHPCS is also able to adjust contextual representations depending on the degree and significance of environmental changes and environmental cues. In this opinion, we will argue that the muZero functions parallel those of the hippocampal system. We will show that the different components of the muZero model provide a framework for thinking about generalizable learning in the eHPCS, and that the evaluation of how transitions in cell representations occur between similar and distinct contexts can be informed by advances in artificial intelligence agents such as muZero. We additionally explain how advances in AI agents will provide frameworks and predictions by which to investigate the expected link between state changes and neuronal firing. Specifically, we will discuss testable predictions about the eHPCS, including the functions of replay and remapping, informed by the mechanisms behind muZero learning. We conclude with additional ways in which agents such as muZero can aid in illuminating prospective questions about neural functioning, as well as how these agents may shed light on potential expected answers.</jats:p

Differences in reward biased spatial representations in the lateral septum and hippocampus

© 2020, eLife Sciences Publications Ltd. All rights reserved. The lateral septum (LS), which is innervated by the hippocampus, is known to represent spatial information. However, the details of place representation in the LS, and whether this place information is combined with reward signaling, remains unknown. We simultaneously recorded from rat CA1 and caudodorsal lateral septum in rat during a rewarded navigation task and compared spatial firing in the two areas. While LS place cells are less numerous than in hippocampus, they are similar to the hippocampus in field size and number of fields per cell, but with field shape and center distributions that are more skewed towards reward. Spike cross-correlations between the hippocampus and LS are greatest for cells that have reward-proximate place fields, suggesting a role for the LS in relaying task-relevant hippocampal spatial information to downstream areas, such as the VTA

Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution.

Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists.</p

Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution.

Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists