2,923 research outputs found
Influence of Sediment Nutrients on Growth of Emergent Hygrophila
Hygrophila (
Hygrophila
polysperma
(Roxb.) T. Anderson) is
a plants which forms serious aquatic weed problems. Both
submerged and emergent growth forms occur. Nutritional
studies with a controlled release fertilizer and sediments collected
from hygrophila-infested areas were conducted with
the emergent growth habit to provide insights into growth of
this introduced plant. Plant dry weights for experimental 16-
week culture periods with low average temperatures were associated
with low amounts of hygrophila biomass as compared
to culture periods with high average temperatures.
Hygrophila cultured in sand rooting media with the controlled
release fertilizer produced as much as 20 times more
dry weight than plants cultured in sediments only. First-degree
linear regression statistics showed hygrophila dry
weights were highly related to ammonia nitrogen, magnesium,
sodium, and pH values in the sediments. These findings
show the close relationship of the emergent growth
habit of hygrophila to sediment nutrients. Analyses for certain
sediment characteristics may provide an indication of
the potential growth that may be expected for weed infestations
of this plant. Hygrophila grows year round in south
Florida; however, visual observations of canals and other bodies
of water indicate that lower amounts of hygrophila plants
occur during the cooler months of year than during the summer
season. These findings show the seasonal growth of
emergent hygrophila occurs with biomass dependent on
both sediment nutrients and temperature
SEI power source alternatives for rovers and other multi-kWe distributed surface applications
To support the Space Exploration Initiative (SEI), a study was performed to investigate power system alternatives for the rover vehicles and servicers that were subsequently generated for each of these rovers and servicers, candidate power sources incorporating various power generation and energy storage technologies were identified. The technologies were those believed most appropriate to the SEI missions, and included solar, electrochemical, and isotope systems. The candidates were characterized with respect to system mass, deployed area, and volume. For each of the missions a preliminary selection was made. Results of this study depict the available power sources in light of mission requirements as they are currently defined
BATSE Observations of Gamma-Ray Burst Spectra. IV. Time-Resolved High-Energy Spectroscopy
We report on the temporal behavior of the high-energy power law continuum
component of gamma-ray burst spectra with data obtained by the Burst and
Transient Source Experiment. We have selected 126 high fluence and high flux
bursts from the beginning of the mission up until the present. Much of the data
were obtained with the Large Area Detectors, which have nearly all-sky
coverage, excellent sensitivity over two decades of energy and moderate energy
resolution, ideal for continuum spectra studies of a large sample of bursts at
high time resolution. At least 8 spectra from each burst were fitted with a
spectral form that consisted of a low-energy power law, a spectral break at
middle energies and a high-energy continuum. In most bursts (122), the
high-energy continuum was consistent with a power law. The evolution of the
fitted high-energy power-law index over the selected spectra for each burst is
inconsistent with a constant for 34% of the total sample. The sample
distribution of the average value for the index from each burst is fairly
narrow, centered on -2.12. A linear trend in time is ruled out for only 20% of
the bursts, with hard-to-soft evolution dominating the sample (100 events). The
distribution for the total change in the power-law index over the duration of a
burst peaks at the value -0.37, and is characterized by a median absolute
deviation of 0.39, arguing that a single physical process is involved. We
present analyses of the correlation of the power-law index with time, burst
intensity and low-energy time evolution. In general, we confirm the general
hard-to-soft spectral evolution observed in the low-energy component of the
continuum, while presenting evidence that this evolution is different in nature
from that of the rest of the continuum.Comment: 30 pages, with 2 tables and 9 figures To appear in The Astrophysical
Journal, April 1, 199
Public Health Surveillance for Australian bat lyssavirus in Queensland, Australia, 2000–2001
From February 1, 2000, to December 4, 2001, a total of 119 bats (85 Megachiroptera and 34 Microchiroptera) were tested for Australian bat lyssavirus (ABLV) infection. Eight Megachiroptera were positive by immunofluorescence assay that used cross-reactive antibodies to rabies nucleocapsid protein. A case study of cross-species transmission of ABLV supports the conclusion that a bat reservoir exists for ABLV in which the virus circulates across Megachiroptera species within mixed communities
Recommendations for selecting drug-drug interactions for clinical decision support
To recommend principles for including drug-drug interactions (DDIs) in clinical decision support
Canagliflozin impairs TÂ cell effector function via metabolic suppression in autoimmunity
Augmented TÂ cell function leading to host damage in autoimmunity is supported by metabolic dysregulation, making targeting immunometabolism an attractive therapeutic avenue. Canagliflozin, a type 2 diabetes drug, is a sodium glucose co-transporter 2 (SGLT2) inhibitor with known off-target effects on glutamate dehydrogenase and complex I. However, the effects of SGLT2 inhibitors on human TÂ cell function have not been extensively explored. Here, we show that canagliflozin-treated TÂ cells are compromised in their ability to activate, proliferate, and initiate effector functions. Canagliflozin inhibits TÂ cell receptor signaling, impacting on ERK and mTORC1 activity, concomitantly associated with reduced c-Myc. Compromised c-Myc levels were encapsulated by a failure to engage translational machinery resulting in impaired metabolic protein and solute carrier production among others. Importantly, canagliflozin-treated TÂ cells derived from patients with autoimmune disorders impaired their effector function. Taken together, our work highlights a potential therapeutic avenue for repurposing canagliflozin as an intervention for TÂ cell-mediated autoimmunity
GRIPS - Gamma-Ray Imaging, Polarimetry and Spectroscopy
We propose to perform a continuously scanning all-sky survey from 200 keV to
80 MeV achieving a sensitivity which is better by a factor of 40 or more
compared to the previous missions in this energy range. The Gamma-Ray Imaging,
Polarimetry and Spectroscopy (GRIPS) mission addresses fundamental questions in
ESA's Cosmic Vision plan. Among the major themes of the strategic plan, GRIPS
has its focus on the evolving, violent Universe, exploring a unique energy
window. We propose to investigate -ray bursts and blazars, the
mechanisms behind supernova explosions, nucleosynthesis and spallation, the
enigmatic origin of positrons in our Galaxy, and the nature of radiation
processes and particle acceleration in extreme cosmic sources including pulsars
and magnetars. The natural energy scale for these non-thermal processes is of
the order of MeV. Although they can be partially and indirectly studied using
other methods, only the proposed GRIPS measurements will provide direct access
to their primary photons. GRIPS will be a driver for the study of transient
sources in the era of neutrino and gravitational wave observatories such as
IceCUBE and LISA, establishing a new type of diagnostics in relativistic and
nuclear astrophysics. This will support extrapolations to investigate star
formation, galaxy evolution, and black hole formation at high redshifts.Comment: to appear in Exp. Astron., special vol. on M3-Call of ESA's Cosmic
Vision 2010; 25 p., 25 figs; see also www.grips-mission.e
Calibrating a network meta-analysis of diabetes trials of sodium glucose co-transporter 2 inhibitors, glucagon-like peptide-1 receptor analogues and dipeptidyl peptidase-4 inhibitors to a representative routine population : a systematic review protocol
Introduction: Participants in randomised controlled trials (trials) are generally younger and healthier than many individuals encountered in clinical practice. Consequently, the applicability of trial findings is often uncertain. To address this, results from trials can be calibrated to more representative data sources. In a network meta-analysis, using a novel approach which allows the inclusion of trials whether or not individual-level participant data (IPD) is available, we will calibrate trials for three drug classes (sodium glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP1) receptor analogues and dipeptidyl peptidase-4 (DPP4) inhibitors) to the Scottish diabetes register.
Methods and analysis: Medline and EMBASE databases, the US clinical trials registry (clinicaltrials.gov) and the Chinese Clinical Trial Registry (chictr.org.cn) will be searched from 1 January 2002. Two independent reviewers will apply eligibility criteria to identify trials for inclusion. Included trials will be phase 3 or 4 trials of SGLT2 inhibitors, GLP1 receptor analogues or DPP4 inhibitors, with placebo or active comparators, in participants with type 2 diabetes, with at least one of glycaemic control, change in body weight or major adverse cardiovascular event as outcomes. Unregistered trials will be excluded.
We have identified a target population from the population-based Scottish diabetes register. The chosen cohort comprises people in Scotland with type 2 diabetes who either (1) require further treatment due to poor glycaemic control where any of the three drug classes may be suitable, or (2) who have adequate glycaemic control but are already on one of the three drug classes of interest or insulin.
Ethics and dissemination: Ethical approval for IPD use was obtained from the University of Glasgow MVLS College Ethics Committee (Project: 200160070). The Scottish diabetes register has approval from the Scottish A Research Ethics Committee (11/AL/0225) and operates with Public Benefit and Privacy Panel for Health and Social Care approval (1617-0147).
PROSPERO registration number: CRD42020184174
BurstCube: A CubeSat for gravitational wave counterparts
BurstCube aims to expand sky coverage in order to detect, localize, and rapidly disseminate information about gamma-ray bursts (GRBs). BurstCube is a\u276U\u27 CubeSat with an instrument comprised of 4 Cesium Iodide (CsI) scintillators coupled to arrays of Silicon photo-multipliers (SiPMs) and will be sensitive to gamma-rays between 50 keV and 1 MeV. BurstCube will assist current observatories, such as Swift and Fermi, in the detection of GRBs as well as provide astronomical context to gravitational wave (GW) events detected by LIGO, Virgo, and KAGRA. BurstCube is currently in its development phase with a launch readiness date in early 2022
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