Designing Markets for Biodiversity Offsets: Lessons from Tradable Pollution Permits

Globally, governments and regulators face an ongoing trade‐off between meeting economic development needs and conserving biodiversity. Markets for biodiversity offsets are one tool which could secure biodiversity protection at lower costs to society whilst allowing some economic development to still take place. We provide a new perspective on biodiversity offset markets by focussing on what can be learnt from one of the best‐researched environmental markets: the market for tradable pollution permits. We argue there are four key design parameters in terms of how and what to trade. These design parameters likely determine the ecological effectiveness and economic efficiency of any market in biodiversity offsets. Applying lessons from tradable pollution permit markets will be important if the benefits of biodiversity offset markets are to be realized more fully in future. A well‐functioning market for biodiversity offsets dually minimizes the economic costs of preventing future losses in biodiversity due to development and provides an economic incentive for landowners to invest in biodiversity conservation. The most crucial aspect of the market is what to trade (the currency in the offset market), and this has significant implications on the other key aspects of market design; the trading ratio which governs the rate of exchange between offsets at different points in space and time; the scale of the market; and how the market is regulated. We argue that markets function best where the conservation priority is a well‐defined unit of biodiversity which can be readily measured and monitored. In situations where there are already strong regulations safeguarding biodiversity, the benefit of biodiversity offset markets is in reducing the aggregate costs of conservation. We believe biodiversity offset markets will offer the highest potential in developing countries with weaker environmental protection and a greater need to reconcile economic development needs with conservation under limited funding

The influence of particle surface roughness on elastic stiffness and dynamic response

Discrete-element method (DEM) simulations of planar wave propagation are used to examine the effect of particle surface roughness on the stiffness and dynamic response of granular materials. A new contact model that considers particle surface roughness is implemented in the DEM simulations. Face-centred cubic lattice packings and random configurations are used; uniform spheres are considered in both cases to isolate fabric and contact model effects from inertia effects. For the range of values considered here surface roughness caused a significant reduction in stiffness, particularly at lower confining stresses. The simulations confirm that surface roughness effects can at least partially explain the value of the exponent in the relationship between stiffness and mean confining stress for an assembly of spherical particles. Frequency domain analyses showed that the maximum frequency transmitted through the sample is reduced when surface roughness is considered. The assumption of homogeneity of stress and contacts in analytical micromechanical models is shown to lead to an overestimation of stiffness

Energy dissipation in soil samples during drained triaxial shearing

The discrete-element method was used to simulate drained triaxial compression of large-scale, polydisperse numerical samples at a range of void ratios while tracing all relevant energy components. The frictional dissipation and boundary work are almost equal regardless of sample density. The volumetric work reaches a steady value at large strain. However, the distortional work increases continually as sample deformation continues post-critical state. There is a preferential orientation for frictional dissipation at around 45° to the major principal stress direction. This matches the orientation at which there is the largest number of sliding contacts. The work equations, which are fundamental in most commonly used constitutive models, are linear when plotted against deviatoric strain. The modified Cam Clay work equation substantially over-predicts the frictional dissipation for dense samples. An alternative, thermodynamically consistent work equation gives a much better description of frictional dissipation and is therefore recommended to ensure accuracy in modelling

Carotid atherosclerosis and a reduced likelihood for lowered cognitive Performance in a Canadian first nations population

Background: We investigated the associations among cardiovascular risk factors, carotid atherosclerosis and cognitive function in a Canadian First Nations population. Methods: Individuals aged ≥18 years, without stroke, nonpreg- nant and with First Nations status were assessed by the Trail Making Test Parts A and B. Results were combined into a Trail Making Test executive function score (TMT-exec). Doppler ultrasonography assessed carotid stenosis and plaque volume. Anthropometric, vascular and metabolic risk factors were assessed by interview, clinical examinations and blood tests. Results: For 190 individuals with TMT-exec scores, the median age of the population was 39 years. Compared to the reference group, individuals with elevated levels of left carotid stenosis (LCS) and total carotid stenosis (TCS) were less likely to demonstrate lowered cognitive performance [LCS, odds ratio (OR): 0.47, 95% confidence interval (CI): 0.24-0.96; TCS, OR: 0.40, 95% CI: 0.20-0.80]. No effect was shown for plaque volume. In structural equation modeling, we found that for every 1-unit change in the anthropometric factor in kg/m2, there was a 0.86-fold decrease in the percent of TCS (p \u3c 0.05). Conclusions: Individuals with elevated levels of LCS and TCS were less likely to demonstrate lowered performance. There was some suggestion that TCS mediates the effect of anthropometric risk factors on cognitive function. Copyright © 2009 S. Karger AG, Basel

Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care: A Randomized Clinical Trial

Importance: Successful treatment of opioid misuse among people with chronic pain has proven elusive. Guidelines recommend nonopioid therapies, but the efficacy of mindfulness-based interventions for opioid misuse is uncertain. Objective: To evaluate the efficacy of Mindfulness-Oriented Recovery Enhancement (MORE) for the reduction of opioid misuse and chronic pain. Design, Setting, and Participants: This interviewer-blinded randomized clinical trial enrolled patients from primary care clinics in Utah between January 4, 2016, and January 16, 2020. The study included 250 adults with chronic pain receiving long-term opioid therapy who were misusing opioid medications. Interventions: Treatment with MORE (comprising training in mindfulness, reappraisal, and savoring positive experiences) or supportive group psychotherapy (control condition) across 8 weekly 2-hour group sessions. Main Outcomes and Measures: Primary outcomes were (1) opioid misuse assessed by the Drug Misuse Index (self-report, interview, and urine screen) and (2) pain severity and pain-related functional interference, assessed by subscale scores on the Brief Pain Inventory through 9 months of follow-up. Secondary outcomes were opioid dose, emotional distress, and ecological momentary assessments of opioid craving. The minimum intervention dose was defined as 4 or more completed sessions of MORE or supportive group psychotherapy. Results: Among 250 participants (159 women [63.6%]; mean [SD] age, 51.8 [11.9] years), 129 were randomized to the MORE group and 121 to the supportive psychotherapy group. Overall, 17 participants (6.8%) were Hispanic or Latino, 218 (87.2%) were White, and 15 (6.0%) were of other races and/or ethnicities (2 American Indian, 3 Asian, 1 Black, 2 Pacific Islander, and 7 did not specify). At baseline, the mean duration of pain was 14.7 years (range, 1-60 years), and the mean (SD) morphine-equivalent opioid dose was 101.0 (266.3) mg (IQR, 16.0-90.0 mg). A total of 203 participants (81.2%) received the minimum intervention dose (mean [SD], 5.7 [2.2] sessions); at 9 months, 92 of 250 participants (36.8%) discontinued the study. The overall odds ratio for reduction in opioid misuse through the 9-month follow-up period in the MORE group compared with the supportive psychotherapy group was 2.06 (95% CI, 1.17-3.61; P = .01). At 9 months, 36 of 80 participants (45.0%) in the MORE group were no longer misusing opioids compared with 19 of 78 participants (24.4%) in the supportive psychotherapy group. Mixed models demonstrated that MORE was superior to supportive psychotherapy through 9 months of follow-up for pain severity (between-group effect: 0.49; 95% CI, 0.17-0.81; P = .003) and pain-related functional interference (between-group effect: 1.07; 95% CI, 0.64-1.50; P < .001). Participants in the MORE group reduced their opioid dose to a greater extent than those in the supportive psychotherapy group. The MORE group also had lower emotional distress and opioid craving. Conclusions and Relevance: In this randomized clinical trial, among adult participants in a primary care setting, the MORE intervention led to sustained improvements in opioid misuse and chronic pain symptoms and reductions in opioid dosing, emotional distress, and opioid craving compared with supportive group psychotherapy. Despite attrition caused by the COVID-19 pandemic and the vulnerability of the sample, MORE appeared to be efficacious for reducing opioid misuse among adults with chronic pain. Trial Registration: ClinicalTrials.gov Identifier: NCT0260253

An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs

Background: Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs is a crucial problem in computational biology and includes the subtask of predicting the location of known TFBS motifs in a given DNA sequence. It has previously been shown that, when scoring matches to known TFBS motifs, interdependencies between positions within a motif should be taken into account. However, this remains a challenging task owing to the fact that sequences similar to those of known TFBSs can occur by chance with a relatively high frequency. Here we present a new method for matching sequences to TFBS motifs based on intuitionistic fuzzy sets (IFS) theory, an approach that has been shown to be particularly appropriate for tackling problems that embody a high degree of uncertainty. Results: We propose SCintuit, a new scoring method for measuring sequence-motif affinity based on IFS theory. Unlike existing methods that consider dependencies between positions, SCintuit is designed to prevent overestimation of less conserved positions of TFBSs. For a given pair of bases, SCintuit is computed not only as a function of their combined probability of occurrence, but also taking into account the individual importance of each single base at its corresponding position. We used SCintuit to identify known TFBSs in DNA sequences. Our method provides excellent results when dealing with both synthetic and real data, outperforming the sensitivity and the specificity of two existing methods in all the experiments we performed. Conclusions: The results show that SCintuit improves the prediction quality for TFs of the existing approaches without compromising sensitivity. In addition, we show how SCintuit can be successfully applied to real research problems. In this study the reliability of the IFS theory for motif discovery tasks is proven

On Combining Stated Preferences and Revealed Preferences Approaches to Evaluate Environmental Resources Having a Recreational Use

This work aims at analysing the value of recreational water uses for the Idro Lake (Lombardy, Northern Italy), which has been experiencing dramatic fluctuations in its levels in recent years, due to excessive productive withdrawal that affected recreational uses. It estimates the economic benefits deriving from recreational uses, by considering the current recreational demand and the hypothetical one obtained by considering an “improved quality” scenario. Through an on-site survey, we built a panel dataset. Following Whitehead et al. (2000) and Hanley et al. (2003) we get welfare estimates by combining SP and RP responses. The present CS is estimated in €134 per individual, whilst the increase in CS is estimated in €173 per individual. These figures can be confronted with the economic value of competitive uses and with the clean up costs, respectively, to infer some policy indications

Turning round the telescope. Centre-right parties and immigration and integration policy in Europe

This is an Author's Original Manuscript of 'Turning round the telescope. Centre-right parties and immigration and integration policy in Europe', whose final and definitive form, the Version of Record, has been published in the Journal of European Public Policy 15(3):315-330, 2008 [copyright Taylor & Francis], available online at: http://www.tandfonline.com/doi.org/10.1080/13501760701847341