Faint Stars in the Ursa Minor Dwarf Spheroidal Galaxy: Implications for the Low-Mass Stellar Initial Mass Function at High Redshift

The stellar initial mass function at high redshift is an important defining property of the first stellar systems to form and may also play a role in various dark matter problems. We here determine the faint stellar luminosity function in an apparently dark-matter-dominated external galaxy in which the stars formed at high redshift. The Ursa Minor dwarf spheroidal galaxy is a system with a particularly simple stellar population - all of the stars being old and metal-poor - similar to that of a classical halo globular cluster. A direct comparison of the faint luminosity functions of the UMi Sph and of similar metallicity, old globular clusters is equivalent to a comparison of the initial mass functions and is presented here, based on deep HST WFPC2 and STIS imaging data. We find that these luminosity functions are indistinguishable, down to a luminosity corresponding to 0.3 solar masses. Our results show that the low-mass stellar IMF for stars that formed at very high redshift is apparently invariant across environments as diverse as those of an extremely low-surface-brightness, dark-matter-dominated dwarf galaxy and a dark-matter-free, high-density globular cluster within the Milky Way.Comment: Accepted by New Astronomy. 64 pages, including 9 embedded postscript tables and 20 embedded postscript figures, plus 14 separate jpeg figures. Postscript versions of the jpeg figures and a complete version of the paper with all figures embedded can be found at http://tarkus.pha.jhu.edu/~mlh

Herbaceous Legume Encroachment Reduces Grass Productivity and Density in Arid Rangelands

Worldwide savannas and arid grasslands are mainly used for livestock grazing, providing livelihood to over a billion people. While normally dominated by perennial C-4 grasses, these rangelands are increasingly affected by the massive spread of native, mainly woody legumes. The consequences are often a repression of grass cover and productivity, leading to a reduced carrying capacity. While such encroachment by woody plants has been extensively researched, studies on similar processes involving herbaceous species are rare. We studied the impact of a sustained and massive spread of the native herbaceous legume Crotalaria podocarpa in Namibia's escarpment region on the locally dominant fodder grasses Stipagrostis ciliata and Stipagrostis uniplumis. We measured tussock densities, biomass production of individual tussocks and tussock dormancy state of Stipagrostis on ten 10 m x 10 m plots affected and ten similarly-sized plots unaffected by C. podocarpa over eight consecutive years and under different seasonal rainfalls and estimated the potential relative productivity of the land. We found the percentage of active Stipagrostis tussocks and the biomass production of individual tussocks to increase asymptotically with higher seasonal rainfall reaching a maximum around 300 mm while the land's relative productivity under average local rainfall conditions reached only 40% of its potential. Crotalaria podocarpa encroachment had no effect on the proportion of productive grass tussocks, but reduced he productivity of individual Stipagrostis tussocks by a third. This effect of C. podocarpa on grass productivity was immediate and direct and was not compensated for by above-average rainfall. Besides this immediate effect, over time, the density of grass tussocks declined by more than 50% in areas encroached by C. podocarpa further and lastingly reducing the lands carrying capacity. The effects of C. podocarpa on grass productivity hereby resemble those of woody encroachers. Therefore, against the background of global change, the spread of herbaceous legumes and the underlying patterns needs to be further investigated to develop adequate counter measures for a sustainable land use.DF

The Star Clusters in the Starburst Irregular Galaxy NGC 1569

We examine star clusters in the irregular, starburst galaxy NGC 1569 from HST images. In addition to the two known super star clusters, we identify 45 other clusters that are compact but resolved. Integrated UVI colors of the clusters span a large range, and suggest that ages range from 3 Myrs to 1 Gyr. However, most of the clusters were formed at the tail end of the recent starburst. Numerous clusters in addition to the know super star clusters are similar in luminosity to a small globular cluster. We examined the radial surface brightness of four of the clusters. Their half-light radii and core radii are in the range observed in present-day globular clusters. Therefore, conditions that produced the recent starburst have also been those necessary for producing compact, bright star clusters. We examine resolved stars in the outer parts of the two super star clusters. Cluster A is dominated by bright blue stars with a small population of red supergiants. Sub-components A1 and A2 have similar colors and a two-dimensional color map does not offer evidence that one component is dominated by red supergiants and the other not. The contradiction of the presence of red super- giants with Wolf-Rayet stars may instead not be a contradiction at all since there coexistence in a coeval population is not inconsistent with the evolution of massive stars. Cluster B is dominated by red supergiants, and this is confirmed by the presence of the stellar CO absorption feature in an integrated spectrum. The various age indicators are consistent with a picture in which cluster B is of order 10--20 Myrs old, and cluster A is >4-5 Myrs old.Comment: To be published in AJ, November 200

Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation.

Genomic sequence interpretation can miss clinically relevant missense variants for several reasons. Rare missense variants are numerous in the exome and difficult to prioritise. Affected genes may also not have existing disease association. To improve variant prioritisation, we leverage population exome data to identify intragenic missense-depleted regions (MDRs) genome-wide that may be important in disease. We then use missense depletion analyses to help prioritise undiagnosed disease exome variants. We demonstrate application of this strategy to identify a novel gene association for human brain malformation. We identified de novo missense variants that affect the GDP/GTP-binding site of ARF1 in three unrelated patients. Corresponding functional analysis suggests ARF1 GDP/GTP-activation is affected by the specific missense mutations associated with heterotopia. These findings expand the genetic pathway underpinning neurologic disease that classically includes FLNA. ARF1 along with ARFGEF2 add further evidence implicating ARF/GEFs in the brain. Using functional ontology, top MDR-containing genes were highly enriched for nucleotide-binding function, suggesting these may be candidates for human disease. Routine consideration of MDR in the interpretation of exome data for rare diseases may help identify strong genetic factors for many severe conditions, infertility/reduction in reproductive capability, and embryonic conditions contributing to preterm loss

Buoyant Venus station mission feasibility study for 1972 and 1973 launch opportunities. Volume 3 - Configuration definition. Part 2 - Appendixes Final report

Buoyant Venus station mission study for 1972 - 1973 launch period - backup data including atmospheric models, heat shield requirements, etc

The relevance of outsourcing and leagile strategies in performance optimization of an integrated process planning and scheduling

Over the past few years growing global competition has forced the manufacturing industries to upgrade their old production strategies with the modern day approaches. As a result, recent interest has been developed towards finding an appropriate policy that could enable them to compete with others, and facilitate them to emerge as a market winner. Keeping in mind the abovementioned facts, in this paper the authors have proposed an integrated process planning and scheduling model inheriting the salient features of outsourcing, and leagile principles to compete in the existing market scenario. The paper also proposes a model based on leagile principles, where the integrated planning management has been practiced. In the present work a scheduling problem has been considered and overall minimization of makespan has been aimed. The paper shows the relevance of both the strategies in performance enhancement of the industries, in terms of their reduced makespan. The authors have also proposed a new hybrid Enhanced Swift Converging Simulated Annealing (ESCSA) algorithm, to solve the complex real-time scheduling problems. The proposed algorithm inherits the prominent features of the Genetic Algorithm (GA), Simulated Annealing (SA), and the Fuzzy Logic Controller (FLC). The ESCSA algorithm reduces the makespan significantly in less computational time and number of iterations. The efficacy of the proposed algorithm has been shown by comparing the results with GA, SA, Tabu, and hybrid Tabu-SA optimization methods

Improving the efficiency of genomic loci capture using oligonucleotide arrays for high throughput resequencing

<p>Abstract</p> <p>Background</p> <p>The emergence of next-generation sequencing technology presents tremendous opportunities to accelerate the discovery of rare variants or mutations that underlie human genetic disorders. Although the complete sequencing of the affected individuals' genomes would be the most powerful approach to finding such variants, the cost of such efforts make it impractical for routine use in disease gene research. In cases where candidate genes or loci can be defined by linkage, association, or phenotypic studies, the practical sequencing target can be made much smaller than the whole genome, and it becomes critical to have capture methods that can be used to purify the desired portion of the genome for shotgun short-read sequencing without biasing allelic representation or coverage. One major approach is array-based capture which relies on the ability to create a custom in-situ synthesized oligonucleotide microarray for use as a collection of hybridization capture probes. This approach is being used by our group and others routinely and we are continuing to improve its performance.</p> <p>Results</p> <p>Here, we provide a complete protocol optimized for large aggregate sequence intervals and demonstrate its utility with the capture of all predicted amino acid coding sequence from 3,038 human genes using 241,700 60-mer oligonucleotides. Further, we demonstrate two techniques by which the efficiency of the capture can be increased: by introducing a step to block cross hybridization mediated by common adapter sequences used in sequencing library construction, and by repeating the hybridization capture step. These improvements can boost the targeting efficiency to the point where over 85% of the mapped sequence reads fall within 100 bases of the targeted regions.</p> <p>Conclusions</p> <p>The complete protocol introduced in this paper enables researchers to perform practical capture experiments, and includes two novel methods for increasing the targeting efficiency. Coupled with the new massively parallel sequencing technologies, this provides a powerful approach to identifying disease-causing genetic variants that can be localized within the genome by traditional methods.</p

Detailed Chemical Evolution of Carina and Sagittarius Dwarf Spheroidal Galaxies

In order to verify the effects of the most recent data on the evolution of Carina and Sagittarius Dwarf Spheroidal Galaxies (dSph) and to set tight constraints on the main parameters of chemical evolution models, we study in detail the chemical evolution of these galaxies through comparisons between the new data and the predictions of a model, already tested to reproduce the main observational constraints in dSphs. Several abundance ratios, such as [$\alpha$/Fe], [Ba/Fe] and [Eu/Fe], and the metallicity distribution of stars are compared to the predictions of our models adopting the observationally derived star formation histories in these galaxies. These new comparisons confirm our previously suggested scenario for the evolution of these galaxies, and allow us to better fix the star formation and wind parameters. In particular, for Carina the comparisons indicate that the best efficiency of star formation is $\nu = 0.15 Gyr^{-1}$, that the best wind efficiency parameter is $w_i$ = 5 (the wind rate is five times stronger than the star formation rate), and that the star formation history, which produces the best fit to the observed metallicity distribution of stars is characterized by several episodes of activity. In the case of Sagittarius our results suggest that $\nu=3 Gyr^{-1}$ and $w_i=9$, again in agreement with our previous work. Finally, we show new predictions for [N/Fe] and [C/Fe] ratios for the two galaxies suggesting a scenario for Sagittarius very similar to the one of the solar vicinity in the Milky Way, except for a slight decrease of [N/Fe] ratio at high metallicities due to the galactic wind. For Carina we predict a larger [N/Fe] ratio at low metallicities, reflecting the lower star formation efficiency of this galaxy relative to Sagittarius and the Milky Way.Comment: 11 pages, 7 figures, accepted for publication in Asttronomy & Astrophysic

The Ital-FLAMES survey of the Sagittarius dwarf Spheroidal galaxy. I. Chemical abundances of bright RGB stars

We present iron and $\alpha$ element (Mg, Ca, Ti) abundances for a sample of 15 Red Giant Branch stars belonging to the main body of the Sagittarius dwarf Spheroidal galaxy. Abundances have been obtained from spectra collected using the high resolution spectrograph FLAMES-UVES mounted at the VLT. Stars of our sample have a mean metallicity of [Fe/H]=-0.41$\pm$0.20 with a metal poor tail extending to [Fe/H]=-1.52. The $\alpha$ element abundance ratios are slightly subsolar for metallicities higher than [Fe/H]\gtsima-1, suggesting a slow star formation rate. The [$\alpha$/Fe] of stars having [Fe/H]$<$-1 are compatible to what observed in Milky Way stars of comparable metallicity.Comment: 16 pages, 10 figures, 6 tables. Accepted for publication in A&A. Minor changes in the tex