Line reproduction in mapping utilizing the four color process model

The application of the four-color process to printing fine line work found on topographical maps was investigated. A description of the mapping process is included and the reason why the four-color process would be advantageous to cartographic printing was discussed. The chapter on fourcolor process theory was included for the benefit of the cartographic community - The experimental design for data transfer, color tolerance, target design to match spot and process color, as well as color space employed, were reviewed. The reasons for the use of a direct digital proofing system were explained. The results of data transfer were evaluated and solutions obtained for limitations in the transfer mechanisms. Color tolerances were established using the CIE LAB color space and two image maps. Using colorimetry, test targets matching the spot color to its equivalent process color were evaluated and found to fall within the established tolerances . Three topographical maps were produced totally in the digital domain. The Cartographic Community carefully evaluated these products and deemed them as the preferred method for generating topographic maps . The results of this study can be interpreted to show that the four-color process system is the most advantageous method for the generation of cartographic products

Evolution of a Fossil Subduction Zone: Insights from the Tauern Window, Eastern Alps

Subduction zones play a crucial role in the evolution of Earth's lithosphere. In many orogens, deeply subducted coherent high-pressure (HP) nappes were exhumed from deep to shallow parts of subduction channels. This process significantly affects the deformation pattern and internal structure of the orogen. Exhumation seems to occur preferentially during the transition from subduction to collision, when dense oceanic lithosphere has been consumed entirely and more buoyant continental lithosphere from a passive continental margin enters the subduction zone. Here, we present a detailed study on the structural, kinematic, and metamorphic evolution of a well-preserved paleo-subduction channel within the Tauern Window (Alps). First, we reevaluated the metamorphic history and regional tectono-stratigraphy of the tectonic units in the central Tauern Window. These units originate from the Alpine Tethys oceanic domain and the adjacent European passive continental margin. They experienced HP conditions during Alpine subduction, which was followed by exhumation to their current position in the Alpine nappe stack. By integrating new structural data and the well-preserved stratigraphy of the ocean-continent transition, we reconstructed the structure and kinematics of the nappes in great detail. Notably, we document a recumbent, tens-of-kilometers-scale sheath fold formed during pervasive top-to-the-foreland shear. This sheath fold comprises an isoclinally folded thrust that transported ophiolite relicts from the former Alpine Tethys onto a distal part of the European continental margin during early stages of subduction. It formed under HP conditions, immediately after the Europe-derived rocks in its core reached their maximum burial depth. The non-cylindrical shape of the sheath fold suggests its nucleation at a promontory of the former margin, inherited from Mesozoic rifting and subsequently amplified to a sheath geometry during top-to-the-foreland shear in the subduction zone. To gain insight into the temperature (T) structure of the sheath fold, we employed Raman spectroscopy on carbonaceous material (RSCM) thermometry on a large number of samples with high spatial resolution. The systematic spatial temperature trends reveal distinct domains related to the original subduction metamorphism and later T-dominated (Barrovian) metamorphic overprint. Integrating the peak-temperature pattern with the fold geometry unveils a two-stage process of nappe formation and sheath folding during exhumation. Our results highlight the existence of considerable along-strike heterogeneity within the deep portion of a fossil subduction zone, likely influenced by inherited rift structures and exhumation processes. Understanding such heterogeneities is crucial for interpreting seismic sections and numerical simulations of subduction zones, emphasizing the need to consider three-dimensional complexities beyond the idealized cylindrical models often used. By unraveling the structural and metamorphic evolution of exhumed HP nappes in the Tauern Window, this study contributes to a better understanding of the dynamic processes operating within subduction zones and their implications for mountain building

Evolving temperature field in a fossil subduction channel during the transition from subduction to collision (Tauern Window, Eastern Alps)

We investigate the evolution of the three-dimensional thermal structure of a palaeo-subduction channel exposed in the Penninic units of the central Tauern Window (Eastern Alps). Structural and petrological observations reveal a sheath fold with an amplitude of some 20 km that formed under high-Pconditions (similar to 2 GPa). The fold is a composite structure that isoclinally folded the thrust of an ophiolitic nappe derived from Alpine Tethys Ocean onto a unit of the distal European continental margin, also affected by the high-Pconditions. This structural assemblage is preserved between two younger domes at either end of the Tauern Window. The domes deform isograds of theT-dominated Barrovian metamorphism that itself overprints the high-Pmetamorphism partly preserved in the sheath fold. Using Raman spectroscopy on carbonaceous material (RSCM), we are able to distinguish peak-temperature domains related to the original subduction metamorphism from domains associated with the later temperature-dominated (Barrovian) metamorphism. The distribution of RSCM temperatures in the Barrovian domain indicates a lateral and vertical decrease of peak temperature with increasing distance from the centres of the thermal domes. This represents a downward increase of palaeo-temperature, in line with previous studies. However, we observe the opposite palaeo-temperature trend in the lower limb of the sheath fold, namely an upward increase. We interpret this inverted palaeo-temperature domain as the relic of a subduction-related temperature field. Towards the central part of the sheath fold's upper limb, RSCM temperatures increase to a maximum of similar to 520 degrees C. Further upsection in the hangingwall of the sheath fold, palaeo-peak temperatures decrease to where they are indistinguishable from the peak temperatures of the overprinting Barrovian metamorphism. Peak-temperature contours of the subduction-related metamorphism are oriented roughly parallel to the folded nappe contacts and lithological layering. The contours close towards the northern, western and eastern parts of the fold, resulting in an eye-shaped, concentric pattern in cross-section. The temperature contour geometry therefore mimics the fold geometry itself, indicating that these contours were also folded in a sheath-like manner. We propose that this sheath-like pattern is the result of a two-stage process that reflects a change of the mode of nappe formation in the subduction zone from thrusting to fold nappe formation. First, thrusting of a hot oceanic nappe onto a colder continental nappe created an inverted peak-thermal gradient. Second, sheath folding of this composite nappe structure together with the previously established peak-temperature pattern during exhumation. This pattern was preserved because temperatures decreased during retrograde exhumation metamorphism and remained less than the subduction-related peak temperatures during the later Barrovian overprint. The fold ascended with diapir-like kinematics in the subduction channel

Results of Lung Cancer Screening in the Community.

PURPOSE: To address doubts regarding National Lung Screening Trial (NLST) generalizability, we analyzed over 6,000 lung cancer screenings (LCSs) within a community health system. METHODS: Our LCS program included 10 sites, 7 hospitals (2 non-university tertiary care, 5 community) and 3 free-standing imaging centers. Primary care clinicians referred patients. Standard criteria determined eligibility. Dedicated radiologists interpreted all LCSs, assigning Lung Imaging Reporting and Data System (Lung-RADS) categories. All category 4 Lung-RADS scans underwent multidisciplinary review and management recommendations. Data was prospectively collected from November 2013 through December 2018 and retrospectively analyzed. RESULTS: Of 4,666 referrals, 1,264 individuals were excluded or declined, and 3,402 individuals underwent initial LCS. Second through eighth LCSs were performed on 2,758 patients, for a total of 6,161 LCSs. Intervention rate after LCS was 14.6% (500 individuals) and was most often additional imaging. Invasive interventions (n = 226) were performed, including 141 diagnostic procedures and 85 surgeries in 176 individuals (procedure rate 6.6%). Ninety-five lung cancers were diagnosed: 84 non-small cell (stage 1: 60; stage 2: 7; stage 3: 9; stage 4: 8), and 11 small cell lung cancers. The procedural adverse event rate was 23/226 (10.1%) in 21 patients (0.6% of all screened individuals). Pneumothorax (n = 10) was the most frequent, 6 requiring pleural drainage. There were 2 deaths among 85 surgeries or 2.3% surgical mortality. CONCLUSIONS: Our LCS experience in a community setting demonstrated lung cancer diagnosis, stage shift, intervention frequency, and adverse event rate similar to the NLST. This study confirms that LCS can be performed successfully, safely, and with equivalence to the NLST in a community health care setting

Stakeholder Theory and Marketing: Moving from a Firm-Centric to a Societal Perspective

This essay is inspired by the ideas and research examined in the special section on “Stakeholder Marketing” of the Journal of Public Policy & Marketing in 2010. The authors argue that stakeholder marketing is slowly coalescing with the broader thinking that has occurred in the stakeholder management and ethics literature streams during the past quarter century. However, the predominant view of stakeholders that many marketers advocate is still primarily pragmatic and company centric. The position advanced herein is that stronger forms of stakeholder marketing that reflect more normative, macro/societal, and network-focused orientations are necessary. The authors briefly explain and justify these characteristics in the context of the growing “prosociety” and “proenvironment” perspectives—orientations that are also in keeping with the public policy focus of this journal. Under the “hard form” of stakeholder theory, which the authors endorse, marketing managers must realize that serving stakeholders sometimes requires sacrificing maximum profits to mitigate outcomes that would inflict major damage on other stakeholders, especially society

Electronic Medical Record Inaccuracies: Multicenter Analysis of Challenges with Modified Lung Cancer Screening Criteria.

The National Comprehensive Cancer Network expanded their lung cancer screening (LCS) criteria to comprise one additional clinical risk factor, including chronic obstructive pulmonary disease (COPD). The electronic medical record (EMR) is a source of clinical information that could identify high-risk populations for LCS, including a diagnosis of COPD; however, an unsubstantiated COPD diagnosis in the EMR may lead to inappropriate LCS referrals. We aimed to detect the prevalence of unsubstantiated COPD diagnosis in the EMR for LCS referrals, to determine the efficacy of utilizing the EMR as an accurate population-based eligibility screening trigger using modified clinical criteria. We performed a multicenter review of all individuals referred to three LCS programs from 2012 to 2015. Each individual\u27s EMR was searched for COPD diagnostic terms and the presence of a diagnostic pulmonary functionality test (PFT). An unsubstantiated COPD diagnosis was defined by an individual\u27s EMR containing a COPD term with no PFTs present, or the presence of PFTs without evidence of obstruction. A total of 2834 referred individuals were identified, of which 30% (840/2834) had a COPD term present in their EMR. Of these, 68% (571/840) were considered unsubstantiated diagnoses: 86% (489/571) due to absent PFTs and 14% (82/571) due to PFTs demonstrating no evidence of postbronchodilation obstruction. A large proportion of individuals referred for LCS may have an unsubstantiated COPD diagnosis within their EMR. Thus, utilizing the EMR as a population-based eligibility screening tool, employing expanded criteria, may lead to individuals being referred, potentially, inappropriately for LCS

Selenoprotein gene nomenclature

The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4 and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine-R-sulfoxide reductase 1) and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15 kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV) and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates

Models and metaphors: complexity theory and through-life management in the built environment

Complexity thinking may have both modelling and metaphorical applications in the through-life management of the built environment. These two distinct approaches are examined and compared. In the first instance, some of the sources of complexity in the design, construction and maintenance of the built environment are identified. The metaphorical use of complexity in management thinking and its application in the built environment are briefly examined. This is followed by an exploration of modelling techniques relevant to built environment concerns. Non-linear and complex mathematical techniques such as fuzzy logic, cellular automata and attractors, may be applicable to their analysis. Existing software tools are identified and examples of successful built environment applications of complexity modelling are given. Some issues that arise include the definition of phenomena in a mathematically usable way, the functionality of available software and the possibility of going beyond representational modelling. Further questions arising from the application of complexity thinking are discussed, including the possibilities for confusion that arise from the use of metaphor. The metaphor of a 'commentary machine' is suggested as a possible way forward and it is suggested that an appropriate linguistic analysis can in certain situations reduce perceived complexity

The Impact of Aerobic Exercise on Fronto-Parietal Network Connectivity and Its Relation to Mobility: An Exploratory Analysis of a 6-Month Randomized Controlled Trial

Impaired mobility is a major concern for older adults and has significant consequences. While the widely accepted belief is that improved physical function underlies the effectiveness of targeted exercise training in improving mobility and reducing falls, recent evidence suggests cognitive and neural benefits gained through exercise may also play an important role in promoting mobility. However, the underlying neural mechanisms of this relationship are currently unclear. Thus, we hypothesize that 6 months of progressive aerobic exercise training would alter frontoparietal network (FPN) connectivity during a motor task among older adults with mild subcortical ischemic vascular cognitive impairment (SIVCI)—and exercise-induced changes in FPN connectivity would correlate with changes in mobility. We focused on the FPN as it is involved in top-down attentional control as well as motor planning and motor execution. Participants were randomized either to usual-care (CON), which included monthly educational materials about VCI and healthy diet; or thrice-weekly aerobic training (AT), which was walking outdoors with progressive intensity. Functional magnetic resonance imaging was acquired at baseline and trial completion, where the participants were instructed to perform bilateral finger tapping task. At trial completion, compared with AT, CON showed significantly increased FPN connectivity strength during right finger tapping (p < 0.05). Across the participants, reduced FPN connectivity was associated with greater cardiovascular capacity (p = 0.05). In the AT group, reduced FPN connectivity was significantly associated with improved mobility performance, as measured by the Timed-Up-and-Go test (r = 0.67, p = 0.02). These results suggest progressive AT may improve mobility in older adults with SIVCI via maintaining intra-network connectivity of the FPN