Is your article EV-TRACKed?

The EV-TRACK knowledgebase is developed to cope with the need for transparency and rigour to increase reproducibility and facilitate standardization of extracellular vesicle (EV) research. The knowledgebase includes a checklist for authors and editors intended to improve the transparency of methodological aspects of EV experiments, allows queries and meta-analysis of EV experiments and keeps track of the current state of the art. Widespread implementation by the EV research community is key to its success

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

A checklist is associated with increased quality of reporting preclinical biomedical research: A systematic review

<div><p>Irreproducibility of preclinical biomedical research has gained recent attention. It is suggested that requiring authors to complete a checklist at the time of manuscript submission would improve the quality and transparency of scientific reporting, and ultimately enhance reproducibility. Whether a checklist enhances quality and transparency in reporting preclinical animal studies, however, has not been empirically studied. Here we searched two highly cited life science journals, one that requires a checklist at submission (<i>Nature</i>) and one that does not (<i>Cell</i>), to identify <i>in vivo</i> animal studies. After screening 943 articles, a total of 80 articles were identified in 2013 (pre-checklist) and 2015 (post-checklist), and included for the detailed evaluation of reporting methodological and analytical information. We compared the quality of reporting preclinical animal studies between the two journals, accounting for differences between journals and changes over time in reporting. We find that reporting of randomization, blinding, and sample-size estimation significantly improved when comparing <i>Nature</i> to <i>Cell</i> from 2013 to 2015, likely due to implementation of a checklist. Specifically, improvement in reporting of the three methodological information was at least three times greater when a mandatory checklist was implemented than when it was not. Reporting the sex of animals and the number of independent experiments performed also improved from 2013 to 2015, likely from factors not related to a checklist. Our study demonstrates that completing a checklist at manuscript submission is associated with improved reporting of key methodological information in preclinical animal studies.</p></div

Outline of the study.

<p>(A) Selection of articles: Twenty consecutive articles that met the inclusion criteria among those published beginning in January for both 2013 and 2015 in <i>Nature</i> (one that implemented a pre-submission checklist) and <i>Cell</i> (one that did not) journals. This represents articles from periods of time before and after the implementation of the checklist in May 2013. (B) Flow of the analysis: To examine whether quality of reporting has improved over time, the degree of key information reported in 2015 was compared to that in 2013 in both journals combined (Objective 1). To assess whether a checklist is associated with improved quality in reporting, we first compared the changes over time observed in <i>Nature</i> (④ vs. ③). If there was significant difference, we compared time “2015 vs. 2013” in <i>Cell</i> (② vs. ①) and <i>Nature</i> vs. <i>Ce</i>ll within 2013 (③ vs. ①) and 2015 (④ vs. ②) to adjust for differences between journals and changes over time in reporting (Objective 2).</p

Distribution of reporting study designs across time.

<p>The distributions of the reporting status are presented in stacked bar graphs. The numbers inside the stacks are the number of articles corresponding to each percentage. The data for 2013 and 2015 are the total numbers of articles assessed from <i>Cell</i> and <i>Nature</i> within a given year. Fisher exact test was performed to assess the difference in reporting each methodological across time. Significant <i>P</i> values (< 0.05) are provided.</p

Data abstraction form to assess the quality and transparency in reporting.

<p>Data abstraction form to assess the quality and transparency in reporting.</p

Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries: a 7-day cohort study of elective surgery

This was an investigator-initiated study funded by Nestle Health Sciences through an unrestricted research grant and by a National Institute for Health Research (UK) Professorship held by R.P. The study was sponsored by Queen Mary University of London

Kuluttajabarometri maakunnittain 2000, 2. neljännes

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