Sustainability As A Success Factor In Global Operations: A Survey Of Car Manufacturing Supply Chains

Since the 1990s, environmental issues have put companies under a growing pressure to reduce their environmental impact, especially in logistics operations. As a result, green supply chains have been gaining importance on the agendas of business executives seeking to create competitive distinction. Many companies have adopted a “green attitude,” seeking ways to integrate environmental dimensions into their business. Current research seeks to define green practices in each supply chain segment, to deepen the understanding of how companies formulate their green initiatives and to analyze the logistical bases and results connected with such decisions. The methodology used was a Survey with questions were based on patterns in green initiatives in the literature, this study’s sample was three large assembly companies in the automotive segment, with industrial plants located both in the southeast region of Brazil and globally. The results show that the wave of sustainability is a result of more than just the threat of negative publicity, and it is pushing enterprises into the green zone. At the same time, economic instability with oscillating growth is forcing enterprises to concentrate on improving efficiency to compensate for unstable demand and the price volatility of commodities, including water and energy

Cutaneous phototoxic reaction to intravenous micafungin in the outpatient setting: A case report

open access articleBackground Signal Transducer and Activator of Transcription 1 (STAT1) Gain of Function (GoF) mutations can predispose to chronic mucocutaneous candidiasis (CMC). Long term therapy with oral azole antifungals can result in resistance and the need to treat with alternatives such as echinocandins. Case Report A pan-azole-resistant Candida albicans was isolated from a mouth swab from a 39-year-old woman with lifelong CMC. Her condition warranted systemic treatment and this was achieved through daily infusions of micafungin, which the patient self-administered at home within the OPAT (Outpatient Parenteral Antimicrobial Therapy) service. The patient experienced a good and rapid clinical response. On day 18 of treatment the patient developed an itchy rash and presented back to our hospital on day 22. A diagnosis of phototoxic skin reaction, secondary to micafungin, was established through clinical history, signs, and investigations. Results Micafungin was withdrawn and the phototoxic reaction resolved without further intervention. The patient was maintained on amphotericin oral lozenges. Conclusion More research into the phototoxic potential of micafungin and its metabolites is needed but clinicians should remain aware of the potential of phototoxicity in individuals treated in outpatient and OPAT settings

Nitrogen fixation rates in the Guinea Dome and the equatorial upwelling regions in the Atlantic Ocean

Biological nitrogen fixation is a key process balancing the loss of combined nitrogen in the marine nitrogen cycle. Its relevance in upwelling or high nutrient regions is still unclear, with the few available studies in these regions of the ocean reporting rates that vary widely from below detection limit to > 100 nmol N L−1 d−1. In the eastern tropical Atlantic Ocean, two open ocean upwelling systems are active in boreal summer. One is the seasonal equatorial upwelling, where the residual phosphorus associated with aged upwelled waters is suggested to enhance nitrogen fixation in this season. The other is the Guinea Dome, a thermal upwelling dome. We conducted two surveys along 23° W across the Guinea Dome and the Equator from 15° N to 5° S in September 2015 and August–September 2016 with high latitudinal resolution (20–60 nm between stations). The abundance of Trichodesmium colonies was characterized by an Underwater Vision Profiler 5 and the total biological nitrogen fixation in the euphotic layer was measured using the 15N2 technique. The highest abundances of Trichodesmium colonies were found in the area of the Guinea Dome (9°–15° N) with a maximum of 3 colonies L−1 near the surface. By contrast, colonies were almost absent in the Equatorial band between 2° N and 5° S. The highest nitrogen fixation rate was measured at the northern edge of the Guinea Dome in 2016 (ca. 31 nmol N L−1 d−1). In this region, where diazotrophs thrived on a sufficient supply of both phosphorus and iron, a patchy distribution was unveiled by our increased spatial resolution scheme. In the Equatorial band, rates were considerably lower, ranging from below detection limit to ca. 4 nmol N L−1 d−1, with a clear difference in magnitude between 2015 (rates close to zero) and 2016 (average rates around 2 nmol N L−1 d−1). This difference seemed triggered by a contrasting supply of phosphorus between years. Our study stresses the importance of surveys with sampling at fine-scale spatial resolution, and shows unexpected high variability in the rates of nitrogen fixation in the Guinea Dome, a region where diazotrophy is a significant process supplying new nitrogen into the euphotic layer.publishedVersio

My Fair Trade: a introdução e algumas das notas de uma nova tradução do Pigmalião, de G. B. Shaw

This article presents the introduction, translation notes and general notes of  a new Portuguese translation of George Bernard Shaw’s Pygmalion. Besides the usual presentation and discussion of translation problems and their solutions, historical data on the play and its role in Shaw´s life and within his work is briefly considered. We further point to the practical application in this translation work of some concepts developed by theorists of the translation of theatre texts, such as Bassnett (1985) and Betti (2003). We also point out that Pygmalion’s unique condition — a play where language figures with the prominence of a main character, with lines that frequently require for their construction an effort akin to the drawing of an illustration — allows one to recognize in the translation work situations “between the verbal and the visual” as noted, in a different translation condition, by Oittinen (1995). Also, Pygmalion highlights the “cooperative strategy” of  Bassnett (1985) as, by far, the most convenient strategy for the translation of theatre texts.O artigo apresenta a introdução e as notas para uma nova tradução do Pigmalião, de George Bernard Shaw. Além da usual apresentação e discussão de dificuldades e soluções de tradução, o texto busca apresentar um breve histórico da peça e algumas considerações acerca de sua inserção na vida e na obra de Shaw. Ademais, a aplicação prática, no trabalho em pauta, de alguns conceitos de teóricos da tradução teatral,  como em Bassnett (1985) e Betti (2003), é apontada e explicitada. Buscamos também fazer ver que a condição específica de Pigmalião — o tratar-se de uma peça em que a própria língua tem o destaque de um personagem principal, com falas que precisam ser freqüentemente “desenhadas” — permite que se reconheçam nessa peça teatral situações tradutórias que ficam “entre o verbal e o visual”, como o apontado, em outra situação tradutória, por Oittinen (1995). Pigmalião faz também ressaltar a “estratégia cooperativa” de Bassnett (1985) como, de longe, a mais conveniente para a tradução teatral

Brazilian guidelines for diagnosis, treatment and follow-up of primary cutaneous melanoma - part II

The last Brazilian guidelines on melanoma were published in 2002. Development in diagnosis and treatment made updating necessary. The coordinators elaborated ten clinical questions, based on PICO system. A Medline search, according to specific MeSH terms for each of the 10 questions was performed and articles selected were classified from A to D according to level of scientific evidence. Based on the results, recommendations were defined and classified according to scientific strength. The present Guidelines were divided in two parts for editorial and publication reasons. In this second part, the following clinical questions were answered: 1) which patients with primary cutaneous melanoma benefit from sentinel lymph node biopsy? 2) Follow-up with body mapping is indicated for which patients? 3) Is preventive excision of acral nevi beneficious to patients? 4) Is preventive excision of giant congenital nevi beneficious to patients? 5) How should stages 0 and I primary cutaneous melanoma patients be followed

Nitrogen fixation rates in the Guinea Dome and the equatorial upwelling regions in the Atlantic Ocean

Biological nitrogen fixation is a key process balancing the loss of combined nitrogen in the marine nitrogen cycle. Its relevance in upwelling or high nutrient regions is still unclear, with the few available studies in these regions of the ocean reporting rates that vary widely from below detection limit to > 100 nmol N L−1 d−1. In the eastern tropical Atlantic Ocean, two open ocean upwelling systems are active in boreal summer. One is the seasonal equatorial upwelling, where the residual phosphorus associated with aged upwelled waters is suggested to enhance nitrogen fixation in this season. The other is the Guinea Dome, a thermal upwelling dome. We conducted two surveys along 23° W across the Guinea Dome and the Equator from 15° N to 5° S in September 2015 and August–September 2016 with high latitudinal resolution (20–60 nm between stations). The abundance of Trichodesmium colonies was characterized by an Underwater Vision Profiler 5 and the total biological nitrogen fixation in the euphotic layer was measured using the 15N2 technique. The highest abundances of Trichodesmium colonies were found in the area of the Guinea Dome (9°–15° N) with a maximum of 3 colonies L−1 near the surface. By contrast, colonies were almost absent in the Equatorial band between 2° N and 5° S. The highest nitrogen fixation rate was measured at the northern edge of the Guinea Dome in 2016 (ca. 31 nmol N L−1 d−1). In this region, where diazotrophs thrived on a sufficient supply of both phosphorus and iron, a patchy distribution was unveiled by our increased spatial resolution scheme. In the Equatorial band, rates were considerably lower, ranging from below detection limit to ca. 4 nmol N L−1 d−1, with a clear difference in magnitude between 2015 (rates close to zero) and 2016 (average rates around 2 nmol N L−1 d−1). This difference seemed triggered by a contrasting supply of phosphorus between years. Our study stresses the importance of surveys with sampling at fine-scale spatial resolution, and shows unexpected high variability in the rates of nitrogen fixation in the Guinea Dome, a region where diazotrophy is a significant process supplying new nitrogen into the euphotic layer. Keywords: Biological nitrogen fixation, Equatorial Atlantic, Guinea Dome, Thermal domes, Upwelling systems, Nutrients, Diazotroph

Reemergence of Oropouche Fever, Northern Brazil

Oropouche fever has reemerged in Parauapebas and Porto de Moz municipalities, Pará State, Brazil. Serologic analysis (immunoglobulin M–ELISA) and virus isolation confirmed Oropouche virus (OROV) in both municipalities. Nucleotide sequencing of 2 OROV isolates from each location indicated genotypes I (Parauapebas) and II (Porto de Moz) in Brazil

The role of phosphodiesterase 12 (PDE12) as a negative regulator of the innate immune response and the discovery of antiviral inhibitors

2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-L constitute a major effector arm of interferon (IFN)-mediated antiviral defense. OAS produces a unique oligonucleotide second messenger, 2',5'-oligoadenylate (2-5A), that binds and activates RNase-L. This pathway is down-regulated by virus- and host-encoded enzymes that degrade 2-5A. Phosphodiesterase 12 (PDE12) was the first cellular 2-5A- degrading enzyme to be purified and described at a molecular level. Inhibition of PDE12 may up-regulate the OAS/RNase-L pathway in response to viral infection resulting in increased resistance to a variety of viral pathogens. We generated a PDE12-null cell line, HeLaΔPDE12, using transcription activator-like effector nuclease-mediated gene inactivation. This cell line has increased 2-5A levels in response to IFN and poly(I-C), a double-stranded RNA mimic compared with the parental cell line. Moreover, HeLaΔPDE12 cells were resistant to viral pathogens, including encephalomyocarditis virus, human rhinovirus, and respiratory syncytial virus. Based on these results, we used DNA-encoded chemical library screening to identify starting points for inhibitor lead optimization. Compounds derived from this effort raise 2-5A levels and exhibit antiviral activity comparable with the effects observed with PDE12 gene inactivation. The crystal structure of PDE12 complexed with an inhibitor was solved providing insights into the structure-activity relationships of inhibitor potency and selectivity

Curricularização da extensão: uma experiência no curso superior de Tecnologia em Gestão da Tecnologia da Informação

Resolution CNE/CES nº 7, of 2018, establishes the Guidelines for Extension in Brazilian Higher Education and regulates the provisions of Target 12.7 of Law nº 13.005/201, which deals with the inclusion of 10% of the workload in extension courses in the curriculum superiors, consolidating the inseparability between teaching, research, and extension. In order to comply with this regulation, this work presents an experience developed in the Superior Technology course in Information Technology Management, in order to contribute to other courses, presenting a practical example of proposals for curricularization of the extension already implemented. This is research with a qualitative and descriptive approach, which seeks to describe actions of a curriculum project that aimed to maintain the computers of a state school, in addition to making students aware of the recycling of electronic waste and the importance of recycling. sustainability. The results of the work and the students' actions point to the importance of the teaching, research, and extension tripod in the students' professional and citizenship training.  A Resolução CNE/CES nº 7 de 2018 estabelece as Diretrizes para a Extensão na Educação Superior Brasileira e regulamenta o disposto na Meta 12.7 da Lei nº 13.005/201 que trata da inclusão de 10% da carga horária em extensão nos currículos dos cursos superiores, consolidando a indissociabilidade entre ensino, pesquisa e extensão. Para atender essa normativa, este trabalho apresenta uma experiência desenvolvida no Curso Superior de Tecnologia em Gestão da Tecnologia da Informação, de forma a contribuir com outros cursos, apresentando um exemplo prático de propostas de curricularização da extensão já implementadas. Trata-se de uma pesquisa de abordagem qualitativa e descritiva, que busca descrever ações de um projeto da curricularização que teve como objetivo dar manutenção nos computadores de uma escola estadual, além de conscientizar os discentes a respeito da reciclagem do lixo eletrônico e da importância da sustentabilidade. Os resultados do trabalho e das ações dos alunos sinalizam para a importância do tripé ensino, pesquisa e extensão na formação profissional e cidadã dos estudantes