Analisis Faktor yang Mempengaruhi Mental Wirausaha Menjadi Pengusaha (Studi Kasus: Mahasiswa Universitas Muhammadiyah Surakarta)

This research is observational analytical research with a cross-secional approach. The research was conducted on industrial engineering students of Muhammadiyah University of Surakarta with a sample of 250 respondents selected using purposive sampling. Independent or exogenous variables are predisposing factors (interests, talents, passions, hobbies, knowledge, attitudes and education levels); reinforcing factors (creativity, motivation, opportunity and model (success story); enabling factors (willingness of facilities and social networks). Intervening variables are internal factors (gender and age) and external factors (social and environmental support). Dependent or endogenous variables are mental entrepreneurship. The mental grain of entrepreneurship is judged from tenacious, diligent, capable, unyielding, independent, professional and confident indicators. The data was collected using questionnaires and analyzed with path analysis

Feature Extraction Algorithms of Retinal Microvasculature for Cost-Effective Medical Device

At present, chronic diseases such as stroke and diabetes mellitus continues to increase. In such medical conditions, if inappropriately treated, complications will easily occur such as visual morbidity, including blindness. According to the World Health Organization, as of 2010 worldwide, there are 39 million (13.6%) blind people due to visual morbidity related to chronic diseases. Therefore, this represent the magnitude of urgency needed to come up with technologies capable of preventing the unwanted complication (Mariotti, 2010). Digital image processing is one of the most remarkable advancing disciplines of computer visual image technology which is being widely employed in the modern biomedical imaging systems with increasing accuracy. This includes growing contributions of digital image processing in modern ophthalmic diagnostic systems. The human retina is the only location where blood vessels can be directly visualized non-invasively in vivo

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

Neuroblastoma is a childhood tumour of the peripheral sympathetic nervous system. The pathogenesis has for a long time been quite enigmatic, as only very few gene defects were identified in this often lethal tumour. Frequently detected gene alterations are limited to MYCN amplification (20%) and ALK activations (7%). Here we present a whole-genome sequence analysis of 87 neuroblastoma of all stages. Few recurrent amino-acid-changing mutations were found. In contrast, analysis of structural defects identified a local shredding of chromosomes, known as chromothripsis, in 18% of high-stage neuroblastoma. These tumours are associated with a poor outcome. Structural alterations recurrently affected ODZ3, PTPRD and CSMD1, which are involved in neuronal growth cone stabilization. In addition, ATRX, TIAM1 and a series of regulators of the Rac/Rho pathway were mutated, further implicating defects in neuritogenesis in neuroblastoma. Most tumours with defects in these genes were aggressive high-stage neuroblastomas, but did not carry MYCN amplifications. The genomic landscape of neuroblastoma therefore reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours

The Making of the NEAM Tsunami Hazard Model 2018 (NEAMTHM18)

The NEAM Tsunami Hazard Model 2018 (NEAMTHM18) is a probabilistic hazard model for tsunamis generated by earthquakes. It covers the coastlines of the North-eastern Atlantic, the Mediterranean, and connected seas (NEAM). NEAMTHM18 was designed as a three-phase project. The first two phases were dedicated to the model development and hazard calculations, following a formalized decision-making process based on a multiple-expert protocol. The third phase was dedicated to documentation and dissemination. The hazard assessment workflow was structured in Steps and Levels. There are four Steps: Step-1) probabilistic earthquake model; Step-2) tsunami generation and modeling in deep water; Step-3) shoaling and inundation; Step-4) hazard aggregation and uncertainty quantification. Each Step includes a different number of Levels. Level-0 always describes the input data; the other Levels describe the intermediate results needed to proceed from one Step to another. Alternative datasets and models were considered in the implementation. The epistemic hazard uncertainty was quantified through an ensemble modeling technique accounting for alternative models’ weights and yielding a distribution of hazard curves represented by the mean and various percentiles. Hazard curves were calculated at 2,343 Points of Interest (POI) distributed at an average spacing of ∼20 km. Precalculated probability maps for five maximum inundation heights (MIH) and hazard intensity maps for five average return periods (ARP) were produced from hazard curves. In the entire NEAM Region, MIHs of several meters are rare but not impossible. Considering a 2% probability of exceedance in 50 years (ARP≈2,475 years), the POIs with MIH >5 m are fewer than 1% and are all in the Mediterranean on Libya, Egypt, Cyprus, and Greece coasts. In the North-East Atlantic, POIs with MIH >3 m are on the coasts of Mauritania and Gulf of Cadiz. Overall, 30% of the POIs have MIH >1 m. NEAMTHM18 results and documentation are available through the TSUMAPS-NEAM project website (http://www.tsumaps-neam.eu/), featuring an interactive web mapper. Although the NEAMTHM18 cannot substitute in-depth analyses at local scales, it represents the first action to start local and more detailed hazard and risk assessments and contributes to designing evacuation maps for tsunami early warning.publishedVersio

Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. INTERPRETATION: International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems

Increasing the productivity of the wire-cut electrical discharge machine associated with sustainable production

Wire-cut electric discharge machining is a nontraditional technique by which the required profile is acquired using sparks energy. Concerning wire-cut electric discharge machining, high cutting rates and precision machining is necessary to improve productivity and achieve high quality of machined workpieces. In this research work, an experimental investigation was introduced to achieve higher productivity of the wire electrode associated with sustainable production in terms of product quality and less heat-affected zone. For this purpose, the effects of machining parameters including peak current, pulse on time and wire preloading were investigated using adaptive neuro-fuzzy inference system along with the Taguchi method. From this study, the optimal setting of machining parameters to achieve higher productivity and sustainability was identified. Moreover, Neuro-fuzzy modeling was successfully used to build an empirical model for the selection of machining parameters to achieve higher productivity at highest possible surface quality and minimum cost for sustainable production. (C) 2015 Elsevier Ltd. All rights reserved

Repetitive forging (RF) using inclined punches as a new bulk severe plastic deformation method

A new bulk severe plastic deformation method based on repetitive forging (RF) using inclined punches is proposed. This process consists of two half cycles. In the first half cycle, a square cross section deforms to parallelogram by forging with two inclined punches, and the parallelogram cross section is forged back to square using two flat punches in the second half cycle. This method was applied to commercially pure copper and significant grain refinement was achieved after four passes of RF. The results showed that significant improvement in the mechanical properties was obtained. Notable increase of yield and ultimate strengths corresponding to 358 MPa and 381 MPa after four passes of RF from the initial values of 121 MPa and 230.5 MPa is detectable. Microhardness increases to about 100 Hv after four passes of RF from the initial value of 53 Hv. Finite element (FE) results illustrate that RF is able to impose extremely high plastic strains to the materials. In the RF process, the processed samples have the same dimensions and geometry as those of the initial sample without any waste material and there is no need for back pressure. (C) 2012 Elsevier B.V. All rights reserved

Influence of substrate and annealing temperatures on optical properties of RF-sputtered TiO2 thin films

TiO2 thin films were deposited on unheated and heated glass substrates at an elevated sputtering pressure of 3 Pa by radio frequency (RF) reactive magnetron sputtering. TiO2 films deposited at room temperature were annealed in air for 1 h at various temperatures ranging from 300 to 600 °C. The structural and optical properties of the thin films were investigated using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and ultraviolet–visible–near infrared (UV–VIS–NIR) spectrophotometry. XRD results show that as-grown and post-annealed TiO2 films have anatase crystal structure. Higher substrate and annealing temperatures result in a slight increase of crystallinity. TiO2 films deposited at different substrate temperatures exhibit high visible transmittance and the transmittance decreases slightly with an increase in annealing temperature. The refractive indices (at λ = 550 nm) of the as-deposited and annealed films are found to be in the range of 2.31–2.37 and 2.31–2.35, respectively. Extinction coefficient decreases slightly with increasing substrate and annealing temperatures. The indirect and direct optical band gap of the as-grown films increases from 3.39 to 3.42 eV and 3.68 to 3.70 eV, respectively, with the increase of substrate temperatures. Annealed TiO2 films also exhibit an increase in the values of indirect and direct optical band gap

Morphological, structural, electrical, and piezoelectric analysis of hydrothermally grown ZnO nanowires on various substrates

International audienceIn this present work, we have successfully fabricated a piezoelectric structure based on ZnO nanowires (ZnO NWs) using a simple, low cost and environmentally friendly hydrothermal method. This structure forms the basis to fabricate vertically integrated nanogenerator device. This paper attempts to study the effect of several parameters such as the seed layer morphology, seed layer roughness, seed layer annealing temperature, growth temperature, and growth time on three different substrates, which are silicon substrate with a gold & platinum film as lower metal contact, and stainless steel. The structure and morphology of the seed layer and the as-obtained nanowires were characterized using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), and X-ray diffraction (XRD). SEM analysis shows that the non-aqueous seed solution must be stirred to avoid the formation of the two phases (milky and translucid) and thus the formation of ZnO particles with different sizes and morphologies. In addition, the annealing temperature influences the diameter of the ZnO seed layer and thus ZnO nanowires diameter. This work also shows that the length of the nanowires increases with the growth duration without affecting ZnO diameter (70 ± 30 nm). HR-TEM and XRD studies show the high crystalline quality of the one-dimensional nanomaterials deposited on stainless steel and confirm their high density along the c-axis direction. In this paper, we have also investigated the electrical and piezoelectric performances of the structure obtained. Indeed, the I-V curves exhibit nonlinear and asymmetric electrical characteristics, which confirms the formation of Schottky contacts between the metal and ZnO NWs. According to the piezo-response force microscope, an effective piezoelectric coefficient d33 between 5 and 7 pm/V as a function of the substrate was measured