Globalising assessment: an ethnography of literacy assessment, camels and fast food in the Mongolian Gobi

What happens when standardised literacy assessments travel globally? The paper presents an ethnographic account of adult literacy assessment events in rural Mongolia. It examines the dynamics of literacy assessment in terms of the movement and re-contextualisation of test items as they travel globally and are received locally by Mongolian respondents. The analysis of literacy assessment events is informed by Goodwin’s ‘participation framework’ on language as embodied and situated interactive phenomena and by Actor Network Theory. Actor Network Theory (ANT) is applied to examine literacy assessment events as processes of translation shaped by an ‘assemblage’ of human and non-human actors (including the assessment texts)

Impact of Rubin Observatory LSST Template Acquisition Strategies on Early Science from the Transients and Variable Stars Science Collaboration: Non-time-critical Science Cases

Vera C. Rubin Observatory Legacy Survey of Space and Time, LSST, will revolutionize modern astronomy by producing an extremely deep (coadded depth ~27 mag) depth-limited survey of the entire southern sky (LSST Science Collaboration et al. 2009). The 8.4 m large-aperture, wide-field telescope, which is based in Cerro Pachón, will image the entire Southern sky every three nights in multiple bands (SDSS-u, g, r, i, z, y) and produce a fire-hose of data, 20 Tb each night, concluding in a 60 petabyte data set as the legacy of the 10 yr survey. Extracting meaningful light curves from variable objects requires difference imaging to both identify variability and calibrate light curve data products. Templates, co-added groups of visits that act as an image of the "static" sky, are a key component of Difference Imaging Analysis (DIA) and as such are of paramount importance for all science that involves variable objects. As the "non-time-critical" science cases discussed here are mostly periodic, they generally do not depend upon the survey alert stream; however, templates are still crucial for performing science and calibrations during the first year. We provide recommendations for observing strategies for template acquisition starting from commissioning and through Year 1 of the survey

Using Cognitive Interviewing for the Semantic Enhancement of Multi-Lingual Versions of Personality Questionnaires

We discuss the use of cognitive interviewing with bilinguals as an integral part of cross-cultural adaptation of personality questionnaires. The aim is to maximize semantic equivalence to increase the likelihood of items maintaining the intended structure and meaning in the target language. We refer to this part of adaptation as semantic enhancement, and integrate cognitive interviewing within it as a tool for scrutinizing translations, the connotative meaning, and the psychological impact of items across languages. During the adaptation of a work-based personality questionnaire from English to Arabic, Chinese (Mandarin), and Spanish, we cognitively interviewed 12 bilingual participants about 136 items in different languages (17% of all items), of which 67 were changed. A content analysis categorizing the reasons for amending items elicited eleven errors that affect two identified forms of semantic equivalence. We provide the resultant coding scheme as a framework for designing cognitive interviewing protocols and propose a procedure for implementing them. We discuss implications for theory and practic

The K-theoretic Farrell-Jones Conjecture for hyperbolic groups

We prove the K-theoretic Farrell-Jones Conjecture for hyperbolic groups with (twisted) coefficients in any associative ring with unit.Comment: 33 pages; final version; to appear in Invent. Mat

Impact of Rubin Observatory LSST Template Acquisition Strategies on Early Science from the Transients and Variable Stars Science Collaboration: Non-time-critical Science Cases

Vera C. Rubin Observatory Legacy Survey of Space and Time, LSST, will revolutionize modern astronomy by producing an extremely deep (coadded depth ~27 mag) depth-limited survey of the entire southern sky (LSST Science Collaboration et al. 2009). The 8.4 m large-aperture, wide-field telescope, which is based in Cerro Pachón, will image the entire Southern sky every three nights in multiple bands (SDSS-u, g, r, i, z, y) and produce a fire-hose of data, 20 Tb each night, concluding in a 60 petabyte data set as the legacy of the 10 yr survey. Extracting meaningful light curves from variable objects requires difference imaging to both identify variability and calibrate light curve data products. Templates, co-added groups of visits that act as an image of the "static" sky, are a key component of Difference Imaging Analysis (DIA) and as such are of paramount importance for all science that involves variable objects. As the "non-time-critical" science cases discussed here are mostly periodic, they generally do not depend upon the survey alert stream; however, templates are still crucial for performing science and calibrations during the first year. We provide recommendations for observing strategies for template acquisition starting from commissioning and through Year 1 of the survey

STAT2 deficiency and susceptibility to viral illness in humans

Severe infectious disease in children may be a manifestation of primary immunodeficiency. These genetic disorders represent important experiments of nature with the capacity to elucidate nonredundant mechanisms of human immunity. We hypothesized that a primary defect of innate antiviral immunity was responsible for unusually severe viral illness in two siblings; the proband developed disseminated vaccine strain measles following routine immunization, whereas an infant brother died after a 2-d febrile illness from an unknown viral infection. Patient fibroblasts were indeed abnormally permissive for viral replication in vitro, associated with profound failure of type I IFN signaling and absence of STAT2 protein. Sequencing of genomic DNA and RNA revealed a homozygous mutation in intron 4 of STAT2 that prevented correct splicing in patient cells. Subsequently, other family members were identified with the same genetic lesion. Despite documented infection by known viral pathogens, some of which have been more severe than normal, surviving STAT2-deficient individuals have remained generally healthy, with no obvious defects in their adaptive immunity or developmental abnormalities. These findings imply that type I IFN signaling [through interferon-stimulated gene factor 3 (ISGF3)] is surprisingly not essential for host defense against the majority of common childhood viral infections

Kepler eclipsing binary stars. VII. the catalogue of eclipsing binaries found in the entire Kepler data set

The primary Kepler Mission provided nearly continuous monitoring of ~200,000 objects with unprecedented photometric precision. We present the final catalog of eclipsing binary systems within the 105 deg2 Kepler field of view. This release incorporates the full extent of the data from the primary mission (Q0-Q17 Data Release). As a result, new systems have been added, additional false positives have been removed, ephemerides and principal parameters have been recomputed, classifications have been revised to rely on analytical models, and eclipse timing variations have been computed for each system. We identify several classes of systems including those that exhibit tertiary eclipse events, systems that show clear evidence of additional bodies, heartbeat systems, systems with changing eclipse depths, and systems exhibiting only one eclipse event over the duration of the mission. We have updated the period and galactic latitude distribution diagrams and included a catalog completeness evaluation. The total number of identified eclipsing and ellipsoidal binary systems in the Kepler field of view has increased to 2878, 1.3% of all observed Kepler targets

Allogeneic hematopoietic stem cell transplantation for severe, refractory juvenile idiopathic arthritis.

Patients with juvenile idiopathic arthritis (JIA) can experience a severe disease course, with progressive destructive polyarthritis refractory to conventional therapy with disease-modifying antirheumatic drugs including biologics, as well as life-threatening complications including macrophage activation syndrome (MAS). Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative immunomodulatory strategy for patients with such refractory disease. We treated 16 patients in 5 transplant centers between 2007 and 2016: 11 children with systemic JIA and 5 with rheumatoid factor-negative polyarticular JIA; all were either refractory to standard therapy, had developed secondary hemophagocytic lymphohistiocytosis/MAS poorly responsive to treatment, or had failed autologous HSCT. All children received reduced toxicity fludarabine-based conditioning regimens and serotherapy with alemtuzumab. Fourteen of 16 patients are alive with a median follow-up of 29 months (range, 2.8-96 months). All patients had hematological recovery. Three patients had grade II-IV acute graft-versus-host disease. The incidence of viral infections after HSCT was high, likely due to the use of alemtuzumab in already heavily immunosuppressed patients. All patients had significant improvement of arthritis, resolution of MAS, and improved quality of life early following allo-HSCT; most importantly, 11 children achieved complete drug-free remission at the last follow-up. Allo-HSCT using alemtuzumab and reduced toxicity conditioning is a promising therapeutic option for patients with JIA refractory to conventional therapy and/or complicated by MAS. Long-term follow-up is required to ascertain whether disease control following HSCT continues indefinitely

Psychometric evaluation of the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) in Italy

Two studies were conducted to adapt the Basic Psychological Need Satisfaction and Frustration Scale (BPNSFS) to the Italian context. Results suggest that the BPNSFS can be considered a promising instrument in the context of SDT-based research for investigating satisfaction and frustration of the three basic needs in Italy