Crystal structure of a mixed-ligand silver(I) complex of the non-steroidal anti-inflammatory drug diclofenac and pyrimidine

In the title mixed-ligand silver(I) coordination polymeric complex with the non-steroidal anti-inflammatory drug diclofenac (C14H11Cl2NO2) (diclH) and pyrimidine (pym), namely poly[{μ2-2-[2-(2,6-dichloroanilino)phenyl]acetato-κ2O:O′}(μ2-pyrimidine-κ2N1:N3)silver(I)], [Ag(C14H10Cl2NO2)(C4H4N2)]n or [Ag(μ-dicl)(μ-pym)]n, the very distorted tetrahedral AgN2O2 coordination centres comprise two N-atom donors from bridging pym ligands [Ag—N = 2.381 (3) and 2.412 (3) Å] and two carboxylate O-atom donors from dicl ligands [Ag—O = 2.279 (2) and 2.280 (2) Å], which bridge Ag atoms, giving a centrosymmetric dinuclear units with a short Ag...Ag separation [2.8931 (5) Å]. Within the units are short intraligand C—Cl...π(pym) interactions [3.6409 (15) Å]. The units are linked through the bridging N atoms of the pym ligand into a two-dimensional sheet–polymer structure lying parallel to (100) and stabilized by inter-ring π–π interactions between the pym ligands [Cg...Cg = 3.4199 (17) Å]. Additional inter-unit C—H...O and C—H...Cg hydrogen-bonding interactions between the sheets give an overall three-dimensional structure

A New Photoluminescent and Antibacterial Polymeric Silver(I) Complex Generated from Pyridine-2,3-dicarboxylic Acid

Ondokuz Mayis University [PYO.MUH.1904.11.015]A new two-dimensional polymeric [Ag-2(mu-Hpydc)(2)(mu-pyz)](n) (1) (H (2) pydc = pyridine-2,3-dicarboxylic acid, pyz = pyrazine), has been synthesized and characterized by elemental analysis, IR spectroscopy, thermal analysis and single crystal X-ray diffraction. X-ray diffraction analyses show that Hpydc exhibits novel coordination mode in 1, acts as a bridging ligand between two Ag(I) centers via deprotonated carboxylate mu-O1 atoms, forming binuclear [Ag-2(mu-Hpydc)(2)] units (Ag center dot center dot center dot Ag separation is 2.9482(4) ). These units are connected to each other through pyz and Hpydc ligands, leading to two-dimensional polymeric structure. The coordination geometry around the silver(I) ions in the complex is a highly distorted square-pyramidal (tau = 0.229) with an AgN2O3 chromospheres. The solid state photoluminescence properties of 1 and H (2) pydc have been studied at room temperature. Furthermore, the complex has been tested for its in vitro antibacterial activity and is determined to be highly effective for antibacterial activity against Gram-positive and Gram-negative pathogenic bacteria cells. A new polymeric 2D silver(I) complex [Ag-2(mu-Hpydc)(2)(mu-pyz)](n) (1) (H (2) pydc = pyridine-2,3-dicarboxylic acid, pyz = pyrazine) has been synthesized and characterized by elemental analysis, IR spectroscopy, thermal analysis and single crystal X-ray diffraction. The solid state photoluminescence properties of 1 and H (2) pydc have been studied at room temperature and also it has been tested for its in vitro antibacterial activity

New copper(II) complexes including pyridine-2,5-dicarboxylic acid: synthesis, spectroscopic, thermal properties, crystal structure and how these complexes interact with purified PON 1 enzyme

<p>We report the synthesis of two square-pyramidal copper(II) complexes, [Cu(2,5-pydc)(2-aepy)(H₂O)]·H₂O, <b>1</b>, and [Cu(2,5-pydc)(2-ampy)(H₂O)]·H₂O, <b>2</b> (2-aepy = 2-(aminoethyl)pyridine, 2-ampy = 2-(aminomethyl)pyridine, 2,5-pydc = pyridine-2,5-dicarboxylic acid or isocinchomeronic acid). The synthesized complexes have been characterized by X-ray diffraction, FT-IR, elemental, and thermal analysis techniques. The crystal structure of <b>1</b> was established by X-ray analysis. Powder X-ray diffraction analysis showed that the complexes are pure. The inhibition of human serum paraoxonase 1 (PON 1, EC 3.1.8.1) enzyme with these complexes were investigated. We used diethyl 4-nitrophenyl phosphate as a substrate to measure the paraoxonase activity of PON 1 enzyme spectrophotometrically. Complexes <b>1</b> and <b>2</b> decreased the <i>in vitro</i> PON 1 activity with different inhibition mechanisms. Complexes <b>1</b> and <b>2</b> inhibited paraoxonase activity of this enzyme as competitively and noncompetitively, respectively.</p

A highly fluorescent dinuclear silver(I) complex of pyrazine derivatives: Combined experimental and DFT/TD-DFT investigations

Research Fund of Ondokuz Mayis University [PYO.MUH.1901.11.011]A dinuclear neutral silver(l) complex, [Ag-2(Hpyzdc)(2)(mu-dmpyz)] (1) (H(2)pydc = pyrazine-2,3-dicarboxylic acid, dmpyz = 2,3-dimethylpyrazine), has been synthesized and characterized by elemental analysis, IR spectroscopy, thermal analysis and single crystal X-ray diffraction. X-ray diffraction data have shown that the Hpydc ligands in 1 act as bidentate ligands via the pyrazine nitrogen and carboxylate oxygen atoms, and the further carboxylic group remains unbonded in the protonated form. Uncommon intermolecular interactions have been observed in the crystal structure, such as dihapto aromatic and intramolecular agostic interactions. DFT calculations have also supported the latterly mentioned agostic interaction. Complex 1 exhibits, in the solid state, strong fluorescence with two emission maxima in the visible region. TD-DFT calculations performed on the optimized structure in acetonitrile medium, modeled within PCM approach, have significantly quantified the experimental absorption profile and suggested that LLCT and MLLCT transitions are mainly responsible for the higher and lower energy fluorescences respectively. (C). 2013 Elsevier Ltd. All rights reserved