Connecting OKI and SQI: one small piece of code, a giant leap for reusing learning objects

Learning object repositories are infrastructures for storing learning resources. If they offer a critical mass of materials, they have the potential to facilitate teaching and learning by offering means to reuse and integrate existing materials. This paper discusses search interoperability efforts. By bridging the OKI Open Service Interface Definition (OSIDs) for repositories and Simple Query Interface (SQI), a CEN/ISSS standard for interconnecting search engines, two worlds of repositories are consolidated. The results of this work have already been implemented in two systems: ARIADNE and the LionShare Peer-to-Peer (P2P) environmentstatus: publishe

Design of shading‐ and hotspot‐resistant shingled modules

10.1002/pip.3507Progress in Photovoltaics: Research and Application

Critical Physiotherapy: Introducing the German-speaking Section of the Critical Physiotherapy Network (DCPN)

Hintergrund Zu den Veränderungen in der Welt, die für Gesundheitsberufe von Bedeutung sind, gehören der tiefgreifende soziale und demografische Wandel, zunehmende Technologisierung, Digitalisierung, Umweltzerstörung sowie die Ökonomisierung des Gesundheitswesens. Diese komplexen, neuen Herausforderungen verlangen Anpassungen von Berufsrollen und Aufgaben aller Fachkräfte im Gesundheitssystem. Ziel Zeitgemäßer Fortschritt in der Physiotherapie ist nur auf Basis einer grundsätzlichen kritischen Analyse und Weiterentwicklung möglich. 2014 gründete sich das Critical Physiotherapy Network (CPN), das diese kritische Arbeit weltweit durch Forschung, Veröffentlichungen, Kurse und Konferenzbeiträge vorantreibt. Mit einer wachsenden Zahl von Mitgliedern aus dem deutschsprachigen Raum war es Zeit, eine deutschsprachige CPN-Sektion (DCPN) ins Leben zu rufen, um die Vernetzung und Zusammenarbeit zu erleichtern und die im deutschsprachigen Raum noch junge Kritische Physiotherapie zu fördern. Methode Beantwortung erster Fragen hinsichtlich Notwendigkeit, Ziele, Arbeitsweise, Handlungsfelder und Perspektiven der Kritischen Physiotherapie. Methodologisch eng mit der qualitativen Forschung verwandt, ermöglicht die Kritische Physiotherapie eine professionelle Weiterentwicklung, die sich an den Bedürfnissen von Individuum und Gesellschaft in ihrer ökologischen Eingebundenheit orientiert. Schlussfolgerung Durch das Hinterfragen von Selbstverständlichkeiten und Grundfesten der physiotherapeutischen Handlungspraxis und Wissenschaft eröffnet die Kritische Physiotherapie ein neues Selbstverständnis und neue Handlungsräume.Background Amongst the dramatic changes in the world that are of particular importance to the health professions are profound social and demographic changes, increasing technologization, digitalization, environmental degradation and changing healthcare economics. These complex, new challenges require adjustments to the roles and tasks of all professionals in the health system. Objective Contemporary progress in physiotherapy can only happen on the basis of fundamental critical analysis and further development of the profession. The Critical Physiotherapy Network (CPN) was founded in 2014 and advanced these critical work internationally, through research, publications, courses and conference contributions. With a growing number of German-speaking members, it was time to set up a German-speaking CPN section (DCPN) to facilitate networking and cooperation, and promote critical physiotherapy. Method Answering first questions regarding the necessity, goals, approaches, field and perspectives of critical physiotherapy. Methodologically closely related to qualitative research, critical physiotherapy enables professional development based on the needs of individuals and society within their ecological context. Conclusion By questioning taken-for-granted assumptions and foundations of physiotherapy practice and science, critical physiotherapy opens toward new professional understandings and scopes of practice

Subfunctionalization of POMC paralogues in Senegalese sole (Solea senegalensis)

The precursor protein proopiomelanocortin (POMC) gives rise to a variety of biologically active peptides through cell-specific posttranslational processing. Two transcripts of pomc were found in the flatfish Solea senegalensis (ssePOMC-A and ssePOMC-B), that most likely represent subfunctionalized paralogues: ssePOMC-A lacks the N-terminal cleavage site for β-MSH, whereas ssePOMC-B cannot yield ACTH and completely lacks the opioid consensus sequence in the β-END region. An analysis of nucleotide substitution rates shows that the POMC-derived peptides possess well-conserved regions under purifying selection, except the β-END derived from POMC-B, which has undergone positive selection. The calculated Ks values for ssePOMC-A versus ssePOMC-B and zebrafish POMCα versus zebrafish POMCβ are 0.40 and 0.72, respectively, indicating that the zebrafish POMC paralogues started to evolve almost twice as early in evolution, and that the Solea POMC paralogues arose independently from the whole genome duplication event that gave rise to the zebrafish paralogues. This makes ssePOMC-B the first identified POMCα orthologue that lacks the opioid consensus. Furthermore, pomc-a expression is down-regulated in chronic stressed S. senegalensis juveniles, whereas pomc-b expression levels remain unaffected, indicating different physiological roles for both POMC paralogues. The distribution of functional POMC-derived peptide hormones over two pomc genes in S. senegalensis suggests subfunctionalization of the paralogues, a relevant notion when studying POMC function in endocrine responses.This work was partially funded by grants AGL2007-61211/ACU (Ministerio Educación y Ciencia of Spain) and Proyecto de Excelencia PO7-RNM-02843 (Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía) to J.M.M. The authors are grateful to “Planta de Cultivos Marinos” (CASEM, Puerto Real, Spain) for the donation of S. senegalensis. Y.W. is funded by Ministerio de Educación y Ciencia (Spain) through the program “Formación de Profesorado Universitario” (Ref: AP2006-03932). E.V. is funded by the SmartMix Program of the Netherlands Ministry of Economic Affairs and the Ministry of Education, Culture and Science.Peer reviewe

Operation compared with watchful waiting in elderly male inguinal hernia patients: a review and data analysis.

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