367 research outputs found
Transabdominal ultrasonographic measurement of caudal vena cava to aorta derived ratios in clinically healthy neonatal foals
Background: Ultrasonographic measurement of the vena cava and aorta (Ao) diameters and their ratios have been suggested to be a reliable way of quantifying hypovolemia. Objective: To evaluate the feasibility and reliability of an ultrasonographic technique for measurement of Ao and caudal vena cava (CVC) and derived ratios using three different acoustic windows in a population of healthy neonatal foals. Correlation between Ao and CVC measurements and ratios and foals' age or bodyweight were also investigated. Methods: In 14 healthy foals aged less than 7 days, the diameters of the Ao and of the CVC in long and short axis were measured by two observers from images obtained using three different ultrasonographic imaging planes (left dorsal, left ventral and right views). The Ao and CVC cross-sectional area and the CVC/Ao diameter and area ratios were calculated. Image quality was subjectively assessed. Intraobserver and interobserver reliabilities for image quality scores and measurements were evaluated between the two observers. Simple linear regression models were used to identify correlations between the CVC/Ao measurements and ratios and the age and bodyweight of the foals. Results: The left ventral view showed the highest reliability. A correlation between bodyweight and the short axis measurement of the CVC was found (R2 = 0.385; p = 0.018). Age was positively correlated with the long axis of measurement of the CVC (R2 = 0.426; p = 0.011) and CVC/Ao diameter ratio (R2 = 0.625; p = 0.001). Conclusions: The left ventral view allows the Ao and CVC cross sections to be easily visualized and measured in neonatal foals in right lateral recumbency
Higher spin interactions with scalar matter on constant curvature spacetimes: conserved current and cubic coupling generating functions
Cubic couplings between a complex scalar field and a tower of symmetric
tensor gauge fields of all ranks are investigated on any constant curvature
spacetime of dimension d>2. Following Noether's method, the gauge fields
interact with the scalar field via minimal coupling to the conserved currents.
A symmetric conserved current, bilinear in the scalar field and containing up
to r derivatives, is obtained for any rank r from its flat spacetime
counterpart in dimension d+1, via a radial dimensional reduction valid
precisely for the mass-square domain of unitarity in (anti) de Sitter spacetime
of dimension d. The infinite collection of conserved currents and cubic
vertices are summarized in a compact form by making use of generating functions
and of the Weyl/Wigner quantization on constant curvature spaces.Comment: 35+1 pages, v2: two references added, typos corrected, enlarged
discussions in Subsection 5.2 and in Conclusion, to appear in JHE
Maxwell-like Lagrangians for higher spins
We show how implementing invariance under divergence-free gauge
transformations leads to a remarkably simple Lagrangian description of massless
bosons of any spin. Our construction covers both flat and (A)dS backgrounds and
extends to tensors of arbitrary mixed-symmetry type. Irreducible and traceless
fields produce single-particle actions, while whenever trace constraints can be
dispensed with the resulting Lagrangians display the same reducible,
multi-particle spectra as those emerging from the tensionless limit of free
open-string field theory. For all explored options the corresponding kinetic
operators take essentially the same form as in the spin-one, Maxwell case.Comment: 77 pages, revised version. Erroneous interpretation and proof of the
gauge-fixing procedure for mixed-symmetry fields corrected. As a consequence,
the mixed-symmetry, one-particle Lagrangians are to be complemented with
conditions on the divergences of the fields; all other conclusions unchanged.
Additional minor changes including references added. To appear in JHE
On the cubic interactions of massive and partially-massless higher spins in (A)dS
Cubic interactions of massive and partially-massless totally-symmetric
higher-spin fields in any constant-curvature background of dimension greater
than three are investigated. Making use of the ambient-space formalism, the
consistency condition for the traceless and transverse parts of the
parity-invariant interactions is recast into a system of partial differential
equations. The latter can be explicitly solved for given s_1-s_2-s_3 couplings
and the 2-2-2 and 3-3-2 examples are provided in detail for general choices of
the masses. On the other hand, the general solutions for the interactions
involving massive and massless fields are expressed in a compact form as
generating functions of all the consistent couplings. The St\"uckelberg
formulation of the cubic interactions as well as their massless limits are also
analyzed.Comment: 42 pages, 2 tables, LaTex. Comments on two-derivative couplings
involving partially-massless spin-2 fields added, typos corrected, references
added. v2: final version to appear in JHEP. v3: formulae (3.4) and (3.9)
correcte
Half-integer Higher Spin Fields in (A)dS from Spinning Particle Models
We make use of O(2r+1) spinning particle models to construct linearized
higher-spin curvatures in (A)dS spaces for fields of arbitrary half-integer
spin propagating in a space of arbitrary (even) dimension: the field
potentials, whose curvatures are computed with the present models, are
spinor-tensors of mixed symmetry corresponding to Young tableaux with D/2 - 1
rows and r columns, thus reducing to totally symmetric spinor-tensors in four
dimensions. The paper generalizes similar results obtained in the context of
integer spins in (A)dS.Comment: 1+18 pages; minor changes in the notation, references updated.
Published versio
Patients’ Perceptions and Experiences of Familial Hypercholesterolemia, Cascade Genetic Screening and Treatment
Background: Familial hypercholesterolemia (FH) is a serious genetic disorder affecting approximately 1 in every 300 to 500 individuals and is characterised by excessively high low-density lipoprotein (LDL) cholesterol levels, substantially increased risk of early-onset coronary heart disease (CHD) and premature mortality. If FH is untreated, it leads to a greater than 50 % risk of CHD in men by the age of 50 and at least 30 % in women by the age of 60. FH can be diagnosed through genetic screening and effectively managed through pharmacological treatment and lifestyle changes. Purpose: Familial hypercholesterolemia (FH) is a genetic health condition that increases the risk of cardiovascular disease. Although FH can be effectively managed with appropriate pharmacological and dietary interventions, FH detection rate through genetic screening remains low. The present study explored perceptions and experiences of FH patients (N = 18) involved in a genetic cascade screening programme. Methods: Face-to-face interviews were conducted to assess patients’ knowledge and understanding of FH, explore factors linked to adherence to health-protective behaviours and examine perceptions of genetic screening. Results: Thematic analysis of interviews revealed four themes: disease knowledge, severity of FH, lifestyle behavioural change and barriers to cascade screening and treatment. Participants recognised FH as a permanent, genetic condition that increased their risk of CHD and premature mortality. Many participants dismissed the seriousness of FH and the importance of lifestyle changes because they perceived it to be effectively managed through medication. Despite positive attitudes toward screening, many participants reported that relatives were reluctant to attend screening due to their relatives’ ‘fatalistic’ outlook or low motivation. Participants believed that they had insufficient authority or control to persuade family members to attend screening and welcomed greater hospital assistance for contact with relatives. Conclusions: Findings support the adoption of direct methods of recruitment to cascade screening led by medical professionals, who were perceived as having greater authority. Other implications included the need for clinicians to provide clear information, particularly to those who are asymptomatic, related to the seriousness of FH and the necessity for adherence to medication and lifestyle changes
Ordinary-derivative formulation of conformal totally symmetric arbitrary spin bosonic fields
Conformal totally symmetric arbitrary spin bosonic fields in flat space-time
of even dimension greater than or equal to four are studied. Second-derivative
(ordinary-derivative) formulation for such fields is developed. We obtain gauge
invariant Lagrangian and the corresponding gauge transformations. Gauge
symmetries are realized by involving the Stueckelberg and auxiliary fields.
Realization of global conformal boost symmetries on conformal gauge fields is
obtained. Modified de Donder gauge condition and de Donder-Stueckelberg gauge
condition are introduced. Using the de Donder-Stueckelberg gauge frame,
equivalence of the ordinary-derivative and higher-derivative approaches is
demonstrated. On-shell degrees of freedom of the arbitrary spin conformal field
are analyzed. Ordinary-derivative light-cone gauge Lagrangian of conformal
fields is also presented. Interrelations between the ordinary-derivative gauge
invariant formulation of conformal fields and the gauge invariant formulation
of massive fields are discussed.Comment: 51 pages, v2: Results and conclusions of v1 unchanged. In Sec.3,
brief review of higher-derivative approaches added. In Sec.4, new
representations for Lagrangian, modified de Donder gauge, and de
Donder-Stueckelberg gauge added. In Sec.5, discussion of interrelations
between the ordinary-derivative and higher-derivative approaches added.
Appendices A,B,C,D and references adde
Adult women and ADHD: on the temporal dimensions of ADHD identities
This paper uses conceptual resources drawn psychosocial process thinking (Stenner, 2017, Brown and Reavey, 2015, Brown and Stenner, 2009) and from G.H. Mead in particular, to contribute to an emerging body of work on the experiences of adult women with ADHD (Singh, 2002, Waite and Ivey, 2009, Quinn and Madhoo, 2014, Horton-Salway and Davies, 2018). It has a particular focus on how ADHD features in the construction of women’s identities and life-stories and it draws upon findings from a qualitative investigation of adult women diagnosed or self-diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). A theoretically informed ‘thematic decomposition’ of 16 depth interviews reveals how complex processes of identity transformation are mediated by the social category of ADHD. Through this process, pasts are reconstructed from the perspective of an ‘emergent’ identity that offers participants the potential for a more enabling and positive future
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