Mass flow through solid 4He induced by the fountain effect

Using an apparatus that allows superfluid liquid 4He to be in contact with hcp solid \4he at pressures greater than the bulk melting pressure of the solid, we have performed experiments that show evidence for 4He mass flux through the solid and the likely presence of superfluid inside the solid. We present results that show that a thermomechanical equilibrium in quantitative agreement with the fountain effect exists between two liquid reservoirs connected to each other through two superfluid-filled Vycor rods in series with a chamber filled with solid 4He. We use the thermomechanical effect to induce flow through the solid and measure the flow rate. On cooling, mass flux appears near T = 600 mK and rises smoothly as the temperature is lowered. Near T = 75 mK a sharp drop in the flux is present. The flux increases as the temperature is reduced below 75 mK. We comment on possible causes of this flux minimum.Comment: 20 pages, 22 figures, 7 table

Bound states of 3He at the edge of a 4He drop on a cesium surface

We show that small amounts of 3He atoms, added to a 4He drop deposited on a flat cesium surface at zero temperature, populate bound states localized at the contact line. These edge states show up for drops large enough to develop well defined surface and bulk regions together with a contact line, and they are structurally different from the well-known Andreev states that appear at the free surface and at the liquid-solid interface of films. We illustrate the one-body density of 3He in a drop with 1000 4He atoms, and show that for sufficiently large number of impurities, the density profiles spread beyond the edge, coating both the curved drop surface and its flat base and eventually isolating it from the substrate.Comment: 10 pages and 7 figures. Submitted to PR

Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain

<p>Abstract</p> <p>Background</p> <p>Sporadic late-onset Alzheimer's disease (AD) appears to evolve from an interplay between genetic and environmental factors. One environmental factor that continues to be of great interest is that of <it>Chlamydia pneumoniae </it>infection and its association with late-onset disease. Detection of this organism in clinical and autopsy samples has proved challenging using a variety of molecular and histological techniques. Our current investigation utilized immunohistochemistry with a battery of commercially available anti-<it>C. pneumoniae </it>antibodies to determine whether <it>C. pneumoniae </it>was present in areas typically associated with AD neuropathology from 5 AD and 5 non-AD control brains.</p> <p>Results</p> <p>Immunoreactivity for <it>C. pneumoniae </it>antigens was observed both intracellularly in neurons, neuroglia, endothelial cells, and peri-endothelial cells, and extracellularly in the frontal and temporal cortices of the AD brain with multiple <it>C. pneumoniae</it>-specific antibodies. This immunoreactivity was seen in regions of amyloid deposition as revealed by immunolabeling with two different anti-beta amyloid antibodies. Thioflavin S staining, overlaid with <it>C. pneumoniae </it>immunolabeling, demonstrated no direct co-localization of the organism and amyloid plaques. Further, the specificity of <it>C. pneumoniae </it>labeling of AD brain sections was demonstrated using <it>C. pneumoniae </it>antibodies pre-absorbed against amyloid β 1-40 and 1-42 peptides.</p> <p>Conclusions</p> <p>Anti-<it>C. pneumoniae </it>antibodies, obtained commercially, identified both typical intracellular and atypical extracellular <it>C. pneumoniae </it>antigens in frontal and temporal cortices of the AD brain. <it>C. pneumoniae</it>, amyloid deposits, and neurofibrillary tangles were present in the same regions of the brain in apposition to one another. Although additional studies are required to conclusively characterize the nature of Chlamydial immunoreactivity in the AD brain, these results further implicate <it>C. pneumoniae </it>infection with the pathogenesis of Alzheimer's disease.</p

Rockhopper: a True HPC System with Cloud Concepts

Presented at IEEE Cluster 2013 in Indianapolis, INA number of services for scientific computing based on cloud resources have recently drawn significant attention in both research and infrastructure provider communities. Most cloud resources currently available lack true high performance characteristics, such as high-speed interconnects or storage. Researchers studying cloud systems have pointed out that many cloud services do not provide service level agreements that may meet the needs of the research community. Furthermore, the lack of location information provided to the user and the shared nature of the systems use may create risk for users of the system, in the instance that their data is moved to an unknown location with an unknown level of security. Indiana University and Penguin Computing have partnered to create a system, Rockhopper, which addresses many of these issues. This system is a true high performance resource, with on-demand allocations and control and tracking of jobs, situated at Indiana University's high-security datacenter facility. Rockhopper allows researchers to flexibly conduct their work under a number of use cases while also serving as an extension of cyberinfrastructure that scales from the researcher's local environment all the way up through large national resources. We describe the architecture and ideas behind the creation of the system, present a use case for campus bridging, and provide a typical example of system usage. In a comparison of Rockhopper to a cloud-based system, we run the Trinity RNA-seq software against a number of datasets on both the Rockhopper system and on Amazon's EC2 service

In-flight scale/distortion calibration of the Hubble Space Telescope fixed-head star trackers

This paper describes an in-flight scale and distortion calibration procedure that has been developed for the Ball Aerospace Systems Division Fixed-Head Star Trackers (FHST's) used on the Hubble Space Telescope (HST). The FHST is a magnetically focused and deflected imaging sensor that is designed to track stars as faint as m(sub v) = 5.7 over an 8 degree by 8 degree field of view. Raw FHST position measurements are accurate to approximately 200 arcseconds, but this can be improved to 10-15 arcseconds by processing the raw measurements through calibration polynomials that correct for flat field, temperature intensity, and magnetic field effects. The coefficients for these polynomials were initially determined using ground test data. On HST the use of three FHST's is an integral part of the preliminary attitude update procedures required before the acquisition of guide stars for science observations. To this end, FHST-based attitude determination having single-axis errors no worse than 22 arcseconds (1 sigma) is required. In early 1991 it became evident that one of the HST FHST's was experiencing a significant change in its optical scale. By mid-1993 the size of this error had grown to a point that, if not corrected, it would correspond to a maximum position error on the order of 100 arcseconds. Subsequent investigations demonstrated that substantial, uncompensated cubic distortion effects had also developed, the maximum contribution to position errors from the cubic terms being on the order of 30 arcseconds. To ensure accurate FHST-based attitude updates, procedures have been developed to redetermine the FHST scale and distortion calibration coefficients based on in-flight data gathered during normal HST operations. These scale and distortion calibrations have proven very effective operationally, and procedures are in place to monitor FHST calibration changes on a continuing basis

Additive Pressures of Elevated Sea Surface Temperatures and Herbicides on Symbiont-Bearing Foraminifera

Elevated ocean temperatures and agrochemical pollution individually threaten inshore coral reefs, but these pressures are likely to occur simultaneously. Experiments were conducted to evaluate the combined effects of elevated temperature and the photosystem II (PSII) inhibiting herbicide diuron on several types of symbiotic algae (diatom, dinoflagellate or rhodophyte) of benthic foraminifera in hospite. Diuron was shown to evoke a direct effect on photosynthetic efficiency (reduced effective PSII quantum yield ΔF/F′m), while elevated temperatures (>30°C, only 2°C above current average summer temperatures) were observed to impact photosynthesis more indirectly by causing reductions in maximum PSII quantum yield (Fv/Fm), interpreted as photodamage. Additionally, elevated temperatures were shown to cause bleaching through loss of chlorophyll a in foraminifera hosting either diatoms or dinoflagellates. A significant linear correlation was found between reduced Fv/Fm and loss of chlorophyll a. In most cases, symbionts within foraminifera proved more sensitive to thermal stress in the presence of diuron (≥1 µg L−1). The mixture toxicity model of Independent Action (IA) described the combined effects of temperature and diuron on the photosystem of species hosting diatoms or dinoflagellates convincingly and in agreement with probabilistic statistics, so a response additive joint action can be assumed. We thus demonstrate that improving water quality can improve resilience of symbiotic phototrophs to projected increases in ocean temperatures. As IA described the observed combined effects from elevated temperature and diuron stress it may therefore be employed for prediction of untested mixtures and for assessing the efficacy of management measures

Three-dimensional cephalometric evaluation of maxillary growth following in utero repair of cleft lip and alveolar-like defects in the mid-gestational sheep model

Objective: To evaluate maxillary growth following in utero repair of surgically created cleft lip and alveolar (CLA)-like defects by means of three-dimensional (3D) computer tomographic (CT) cephalometric analysis in the mid-gestational sheep model. Methods: In 12 sheep fetuses a unilateral CLA-like defect was created in utero (untreated control group: 4 fetuses). Four different bone grafts were used for the alveolar defect closure. After euthanasia, CT scans of the skulls of the fetuses, 3D re-constructions, and a 3D-CT cephalometric analysis were performed. Results: The comparisons between the operated and nonoperated skull sides as well as of the maxillary asymmetry among the experimental groups revealed no statistically significant differences of the 12 variables used. Conclusions: None of the surgical approaches used for the in utero correction of CLA-like defects seem to affect significantly postsurgical maxillary growth; however, when bone graft healing takes place, a tendency for almost normal maxillary growth can be observed. Copyright (c) 2006 S. Karger AG, Basel

Hidden spin-current conservation in 2d Fermi liquids

We report the existence of regimes of the two dimensional Fermi liquid that show unusual conservation of the spin current and may be tuned by varying some parameter like the density of fermions. We show that for reasonable models of the effective interaction the spin current may be conserved in general in 2d, not only for a particular regime. Low temperature spin waves propagate distinctively in these regimes and entirely new ``spin-acoustic'' modes are predicted for scattering-dominated temperature ranges. These new high-temperature propagating spin waves provide a clear signature for the experimental search of such regimes.Comment: 4 pages, no figures, revised version, accepted for pub. in the PR