2,882 research outputs found
Development of a Detector Control System for the ATLAS Pixel Detector
The innermost part of the ATLAS experiment will be a pixel detector
containing around 1750 individual detector modules. A detector control system
(DCS) is required to handle thousands of I/O channels with varying
characteristics. The main building blocks of the pixel DCS are the cooling
system, the power supplies and the thermal interlock system, responsible for
the ultimate safety of the pixel sensors. The ATLAS Embedded Local Monitor
Board (ELMB), a multi purpose front end I/O system with a CAN interface, is
foreseen for several monitoring and control tasks. The Supervisory, Control And
Data Acquisition (SCADA) system will use PVSS, a commercial software product
chosen for the CERN LHC experiments. We report on the status of the different
building blocks of the ATLAS pixel DCS.Comment: 3 pages, 2 figures, ICALEPCS 200
Computational Indistinguishability between Quantum States and Its Cryptographic Application
We introduce a computational problem of distinguishing between two specific
quantum states as a new cryptographic problem to design a quantum cryptographic
scheme that is "secure" against any polynomial-time quantum adversary. Our
problem, QSCDff, is to distinguish between two types of random coset states
with a hidden permutation over the symmetric group of finite degree. This
naturally generalizes the commonly-used distinction problem between two
probability distributions in computational cryptography. As our major
contribution, we show that QSCDff has three properties of cryptographic
interest: (i) QSCDff has a trapdoor; (ii) the average-case hardness of QSCDff
coincides with its worst-case hardness; and (iii) QSCDff is computationally at
least as hard as the graph automorphism problem in the worst case. These
cryptographic properties enable us to construct a quantum public-key
cryptosystem, which is likely to withstand any chosen plaintext attack of a
polynomial-time quantum adversary. We further discuss a generalization of
QSCDff, called QSCDcyc, and introduce a multi-bit encryption scheme that relies
on similar cryptographic properties of QSCDcyc.Comment: 24 pages, 2 figures. We improved presentation, and added more detail
proofs and follow-up of recent wor
Diurnal salivary cortisol concentrations in Parkinsonâs disease: increased total secretion and morning cortisol concentrations
Background:Parkinsonâs disease (PD) is a chronic neurodegenerative disorder. There is limited knowledge about the function of the hypothalamic-pituitary-adrenal axis in PD. The primary aim of this prospective study was to analyze diurnal salivary cortisol concentrations in patients with PD and correlate these with age, gender, body mass index (BMI), duration of PD, and pain. The secondary aim was to compare the results with a healthy reference group. Methods:Fifty-nine PD patients, 35 women and 24 men, aged 50â79 years, were recruited. The reference group comprised healthy individuals matched for age, gender, BMI, and time point for sampling. Salivary cortisol was collected at 8 am, 1 pm, and 8 pm, and 8 am the next day using cotton-based Salivette Âźtubes and analyzed using SpectriaÂźCortisol I125. A visual analog scale was used for estimation of pain. Results:The median cortisol concentration was 16.0 (5.8â30.2) nmol/L at 8 am, 5.8 (3.0â16.4) at 1 pm, 2.8 (1.6â8.0) at 8 pm, and 14.0 (7.5â28.7) at 8 am the next day. Total secretion and rate of cortisol secretion during the day (8 amâ8 pm) and the concentration of cortisol on the next morning were lower (12.5 nmol/L) in the reference group. No significant correlations with age, gender, BMI, duration of PD, Hoehn and Yahr score, Unified Parkinsonâs Disease Rating Scale III score, gait, pain, or cortisol concentrations were found. Conclusion:The neurodegenerative changes in PD does not seem to interfere with the hypothalamic-pituitary-adrenal axis. Salivary cortisol concentrations in PD patients were increased in the morning compared with the reference group, and were not influenced by motor dysfunction, duration of disease, or coexistence of chronic or acute pain
Almost uniform sampling via quantum walks
Many classical randomized algorithms (e.g., approximation algorithms for
#P-complete problems) utilize the following random walk algorithm for {\em
almost uniform sampling} from a state space of cardinality : run a
symmetric ergodic Markov chain on for long enough to obtain a random
state from within total variation distance of the uniform
distribution over . The running time of this algorithm, the so-called {\em
mixing time} of , is , where
is the spectral gap of .
We present a natural quantum version of this algorithm based on repeated
measurements of the {\em quantum walk} . We show that it
samples almost uniformly from with logarithmic dependence on
just as the classical walk does; previously, no such
quantum walk algorithm was known. We then outline a framework for analyzing its
running time and formulate two plausible conjectures which together would imply
that it runs in time when is
the standard transition matrix of a constant-degree graph. We prove each
conjecture for a subclass of Cayley graphs.Comment: 13 pages; v2 added NSF grant info; v3 incorporated feedbac
Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue
The transcription factor T-bet was identified in CD4+ T cells, and it controls interferon Îł production and T helper type 1 cell differentiation. T-bet is expressed in certain other leukocytes, and we recently showed (Lord, G.M., R.M. Rao, H. Choe, B.M. Sullivan, A.H. Lichtman, F.W. Luscinskas, and L.H. Glimcher. 2005. Blood. 106:3432â3439) that it regulates T cell trafficking. We examined whether T-bet influences homing of mast cell progenitors (MCp) to peripheral tissues. Surprisingly, we found that MCp homing to the lung or small intestine in T-betâ/â mice is reduced. This is reproduced in adhesion studies using bone marrowâderived MCs (BMMCs) from T-betâ/â mice, which showed diminished adhesion to mucosal addresin cellular adhesion moleculeâ1 (MAdCAM-1) and vascular cell adhesion moleculeâ1 (VCAM-1), endothelial ligands required for MCp intestinal homing. MCp, their precursors, and BMMCs do not express T-bet, suggesting that T-bet plays an indirect role in homing. However, adoptive transfer experiments revealed that T-bet expression by BM cells is required for MCp homing to the intestine. Furthermore, transfer of WT BM-derived dendritic cells (DCs) to T-betâ/â mice restores normal MCp intestinal homing in vivo and MCp adhesion to MAdCAM-1 and VCAM-1 in vitro. Nonetheless, T-betâ/â mice respond vigorously to intestinal infection with Trichinella spiralis, eliminating a role for T-bet in MC recruitment to sites of infection and their activation and function. Therefore, remarkably, T-bet expression by DCs indirectly controls MCp homing to mucosal tissues
Exploring out-of-equilibrium quantum magnetism and thermalization in a spin-3 many-body dipolar lattice system
Understanding quantum thermalization through entanglement build-up in
isolated quantum systems addresses fundamental questions on how unitary
dynamics connects to statistical physics. Here, we study the spin dynamics and
approach towards local thermal equilibrium of a macroscopic ensemble of S = 3
spins prepared in a pure coherent spin state, tilted compared to the magnetic
field, under the effect of magnetic dipole-dipole interactions. The experiment
uses a unit filled array of 104 chromium atoms in a three dimensional optical
lattice, realizing the spin-3 XXZ Heisenberg model. The buildup of quantum
correlation during the dynamics, especially as the angle approaches pi/2, is
supported by comparison with an improved numerical quantum phase-space method
and further confirmed by the observation that our isolated system thermalizes
under its own dynamics, reaching a steady state consistent with the one
extracted from a thermal ensemble with a temperature dictated from the system's
energy. This indicates a scenario of quantum thermalization which is tied to
the growth of entanglement entropy. Although direct experimental measurements
of the Renyi entropy in our macroscopic system are unfeasible, the excellent
agreement with the theory, which can compute this entropy, does indicate
entanglement build-up.Comment: 12 figure
A First Search for Cosmogenic Neutrinos with the ARIANNA Hexagonal Radio Array
The ARIANNA experiment seeks to observe the diffuse flux of neutrinos in the
10^8 - 10^10 GeV energy range using a grid of radio detectors at the surface of
the Ross Ice Shelf of Antarctica. The detector measures the coherent Cherenkov
radiation produced at radio frequencies, from about 100 MHz to 1 GHz, by
charged particle showers generated by neutrino interactions in the ice. The
ARIANNA Hexagonal Radio Array (HRA) is being constructed as a prototype for the
full array. During the 2013-14 austral summer, three HRA stations collected
radio data which was wirelessly transmitted off site in nearly real-time. The
performance of these stations is described and a simple analysis to search for
neutrino signals is presented. The analysis employs a set of three cuts that
reject background triggers while preserving 90% of simulated cosmogenic
neutrino triggers. No neutrino candidates are found in the data and a
model-independent 90% confidence level Neyman upper limit is placed on the all
flavor neutrino+antineutrino flux in a sliding decade-wide energy bin. The
limit reaches a minimum of 1.9x10^-23 GeV^-1 cm^-2 s^-1 sr^-1 in the 10^8.5 -
10^9.5 GeV energy bin. Simulations of the performance of the full detector are
also described. The sensitivity of the full ARIANNA experiment is presented and
compared with current neutrino flux models.Comment: 22 pages, 22 figures. Published in Astroparticle Physic
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