Momentum transfer dependence of the proton's electric and magnetic polarizabilities

The Q^2-dependence of the sum of the electric and magnetic polarizabilities of the proton is calculated over the range 0 \leq Q^2 \leq 6 GeV^2 using the generalized Baldin sum rule. Employing a parametrization of the F_1 structure function valid down to Q^2 = 0.06 GeV^2, the polarizabilities at the real photon point are found by extrapolating the results of finite Q^2 to Q^2 = 0 GeV^2. We determine the evolution over four-momentum transfer to be consistent with the Baldin sum rule using photoproduction data, obtaining \alpha + \beta = 13.7 \pm 0.7 \times 10^{-4}\, \text{fm}^3.Comment: 4 pages, 3 figure

Quark-hadron duality constraints on \gamma Z box corrections to parity-violating elastic scattering

We examine the interference \gamma Z box corrections to parity-violating elastic electron--proton scattering in the light of the recent observation of quark-hadron duality in parity-violating deep-inelastic scattering from the deuteron, and the approximate isospin independence of duality in the electromagnetic nucleon structure functions down to Q^2 \approx 1 GeV^2. Assuming that a similar behavior also holds for the \gamma Z proton structure functions, we find that duality constrains the \gamma Z box correction to the proton's weak charge to be \Re e\, \square_{\gamma Z}^V = (5.4 \pm 0.4) \times 10^{-3} at the kinematics of the Q_{\text{weak}} experiment. Within the same model we also provide estimates of the \gamma Z corrections for future parity-violating experiments, such as MOLLER at Jefferson Lab and MESA at Mainz.Comment: 10 pages, 3 figures. Final version to be published in Phys. Lett.

Activating Mutations in TOR Are in Similar Structures As Oncogenic Mutations in PI3KCα

TOR (Target of Rapamycin) is a highly conserved Ser/Thr kinase and a central controller of cell growth. Using the crystal structure of the related lipid kinase PI3KCgamma, we built a model of the catalytic region of TOR, from the FAT domain to near the end of the FATC domain. The model reveals that activating mutations in TOR, identified in yeast in a genetic selection for Rheb-independence, correspond to hotspots for oncogenic mutations in PI3KCalpha. The activating mutations are in the catalytic domain (helices kalpha3, kalpha9, kalpha11) and the helical domain of TOR. Docking studies with small molecule inhibitors (PP242, NVP-BEZ235, and Ku-0063794) show that drugs currently in development utilize a novel pharmacophore space to achieve specificity. Thus, our model provides insight on the regulation of TOR and may be useful in the design of new anticancer drugs

The principle of equivalence and projective structure in space-times

This paper discusses the extent to which one can determine the space-time metric from a knowledge of a certain subset of the (unparametrised) geodesics of its Levi-Civita connection, that is, from the experimental evidence of the equivalence principle. It is shown that, if the space-time concerned is known to be vacuum, then the Levi-Civita connection is uniquely determined and its associated metric is uniquely determined up to a choice of units of measurement, by the specification of these geodesics. It is further demonstrated that if two space-times share the same unparametrised geodesics and only one is assumed vacuum then their Levi-Civita connections are again equal (and so the other metric is also a vacuum metric) and the first result above is recovered.Comment: 23 pages, submitted to Classical and Quantum Gravit

Student authoring, editing and electronic publishing

Millions of term papers have been written by college seniors who will be writing reports and publications as part of their professional responsibilities soon after graduation. While most term papers are graded and returned to student authors, a former student shared the observation that nothing less than an \u27A\u27 is acceptable on the job. Writing assignments can be made more meaningful by giving student authors responsibility for their writing similar to those professionals have; their work will be edited, read and used by others. Student papers were first published on the Department\u27s Cooperative Learning Center (CLC) local area network in 1991, after development of the Educators Software Package (ESP) for preparing hypertext information systems. Since then, over 2000 files have been published by CLC students in several courses. An immediate improvement in the quality of writing is observed when students know that the criterion for excellence is acceptable for publication, and their papers will be read by students for years to come. Editorial guidelines remind students that disciplined scientific writing is different from creative writing as a result of the comments of student editors. The student-authored information systems, complimented by professionally-authored files, are accessed through course, subject, and species menus. Search functions enable students to find information on our CLC network that others have written, and links to libraries and the World-Wide Web provide access to other publications. While the information on our CLC network is of significant value to the students, the greater long-term value lies in the development of professional responsibilities for writing and editing. Rather than writing a term paper and taking what they get for a grade, our students write and rewrite until their paper is accepted for publication. Student editors, graduate assistants, and course professors help the students reach that goal, and when it is reached, everyone benefits, including students in the future

The Crystal Structure of the Extracellular 11-heme Cytochrome UndA Reveals a Conserved 10-heme Motif and Defined Binding Site for Soluble Iron Chelates

Members of the genus Shewanella translocate deca- or undeca-heme cytochromes to the external cell surface thus enabling respiration using extracellular minerals and polynuclear Fe(III) chelates. The high resolution structure of the first undeca-heme outer membrane cytochrome, UndA, reveals a crossed heme chain with four potential electron ingress/egress sites arranged within four domains. Sequence and structural alignment of UndA and the deca-heme MtrF reveals the extra heme of UndA is inserted between MtrF hemes 6 and 7. The remaining UndA hemes can be superposed over the heme chain of the decaheme MtrF, suggesting that a ten heme core is conserved between outer membrane cytochromes. The UndA structure has also been crystallographically resolved in complex with substrates, an Fe(III)-nitrilotriacetate dimer or an Fe(III)-citrate trimer. The structural resolution of these UndA-Fe(III)-chelate complexes provides a rationale for previous kinetic measurements on UndA and other outer membrane cytochromes

Hadronic gamma-Z box corrections in M\oller scattering

The possibility of measuring the parity-violating asymmetry in M\oller scattering with sufficient accuracy to determine sin^2 theta_W to 0.1% offers a complementary path to the discovery of new physics to that followed at high energy colliders. We present a new calculation of the gamma-Z box contribution to parity-violating electron-proton scattering, which constitutes an important uncertainty in computing the background to this process. We show that while the gamma-Z correction grows rapidly with energy, it can be relatively well constrained by data from parity-violating inelastic scattering and parton distribution functions.Comment: 9 pages, 4 figures, to appear in Phys. Lett.

The regulation of cytokine networks in hippocampal CA1 differentiates extinction from those required for the maintenance of contextual fear memory after recall

We investigated the distinctiveness of gene regulatory networks in CA1 associated with the extinction of contextual fear memory (CFM) after recall using Affymetrix GeneChip Rat Genome 230 2.0 Arrays. These data were compared to previously published retrieval and reconsolidation-attributed, and consolidation datasets. A stringent dual normalization and pareto-scaled orthogonal partial least-square discriminant multivariate analysis together with a jack-knifing-based cross-validation approach was used on all datasets to reduce false positives. Consolidation, retrieval and extinction were correlated with distinct patterns of gene expression 2 hours later. Extinction-related gene expression was most distinct from the profile accompanying consolidation. A highly specific feature was the discrete regulation of neuroimmunological gene expression associated with retrieval and extinction. Immunity–associated genes of the tyrosine kinase receptor TGFβ and PDGF, and TNF families’ characterized extinction. Cytokines and proinflammatory interleukins of the IL-1 and IL-6 families were enriched with the no-extinction retrieval condition. We used comparative genomics to predict transcription factor binding sites in proximal promoter regions of the retrieval-regulated genes. Retrieval that does not lead to extinction was associated with NF-κB-mediated gene expression. We confirmed differential NF-κBp65 expression, and activity in all of a representative sample of our candidate genes in the no-extinction condition. The differential regulation of cytokine networks after the acquisition and retrieval of CFM identifies the important contribution that neuroimmune signalling plays in normal hippocampal function. Further, targeting cytokine signalling upon retrieval offers a therapeutic strategy to promote extinction mechanisms in human disorders characterised by dysregulation of associative memory