Parenting Enhancement, Interpersonal Psychotherapy to Reduce Depression in Low-Income Mothers of Infants and Toddlers: A Randomized Trial

Depressive symptoms and clinical depression are highly prevalent in low-income mothers and negatively affect their infants and toddlers

Speech Communication

Contains table of contents for Part IV, table of contents for Section 1, an introduction, reports on seven research projects and a list of publications.C.J. Lebel FellowshipDennis Klatt Memorial FundNational Institutes of Health Grant T32-DC00005National Institutes of Health Grant R01-DC00075National Institutes of Health Grant F32-DC00015National Institutes of Health Grant R01-DC00266National Institutes of Health Grant P01-DC00361National Institutes of Health Grant R01-DC00776National Science Foundation Grant IRI 89-10561National Science Foundation Grant IRI 88-05680National Science Foundation Grant INT 90-2471

Speech Communication

Contains table of contents for Part IV, table of contents for Section 1 and reports on five research projects.Apple Computer, Inc.C.J. Lebel FellowshipNational Institutes of Health (Grant T32-NS07040)National Institutes of Health (Grant R01-NS04332)National Institutes of Health (Grant R01-NS21183)National Institutes of Health (Grant P01-NS23734)U.S. Navy / Naval Electronic Systems Command (Contract N00039-85-C-0254)U.S. Navy - Office of Naval Research (Contract N00014-82-K-0727

Speech Communication

Contains table of contents for Part V, table of contents for Section 1, reports on six research projects and a list of publications.C.J. Lebel FellowshipDennis Klatt Memorial FundNational Institutes of Health Grant R01-DC00075National Institutes of Health Grant R01-DC01291National Institutes of Health Grant R01-DC01925National Institutes of Health Grant R01-DC02125National Institutes of Health Grant R01-DC02978National Institutes of Health Grant R01-DC03007National Institutes of Health Grant R29-DC02525National Institutes of Health Grant F32-DC00194National Institutes of Health Grant F32-DC00205National Institutes of Health Grant T32-DC00038National Science Foundation Grant IRI 89-05249National Science Foundation Grant IRI 93-14967National Science Foundation Grant INT 94-2114

An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map. We used this map to derive a quantitative sepsis response signature (SRSq) score reflective of immune dysfunction and predictive of clinical outcomes, which can be estimated using a 7- or 12-gene signature. Last, we built a machine learning framework, SepstratifieR, to deploy SRSq in adult and pediatric bacterial and viral sepsis, H1N1 influenza, and COVID-19, demonstrating clinically relevant stratification across diseases and revealing some of the physiological alterations linking immune dysregulation to mortality. Our method enables early identification of individuals with dysfunctional immune profiles, bringing us closer to precision medicine in infection.peer-reviewe

Evaluating the impact of a community-based cancer awareness roadshow on awareness, attitudes and behaviors

This study was funded by Cancer Research UK. Thanks to Ronan Keating and the Marie Keating Foundation who worked in partnership with Cancer Research UK to launch the Cancer Awareness Roadshow in 2006, and have continued to fund the Roadshow over the last nine years. Smith is the recipient of a Cancer Research UK Postdoctoral Fellowship (C42785/A17965)

Justifiable sensationalism

While prostitution had been a staple of sensational reporting for decades, the explosion of newspaper exposés about vice in London in the late 1940s and the early 1950s is difficult to miss. Taking this sexual sensationalism as its starting point, this article examines the relationship between the press, public opinion and policy change around the subject of prostitution, paying particular attention to the rise in media attention in the mid-twentieth century that is understood to have helped bring the Wolfenden Committee into being in 1954. It argues that while sexual sensationalism can be read as a kind of moral panic and as a tool of moral regulation, looking closely at the narratives and function of sensationalism, as well as its reception by the police, the State and the public, complicates this story. To understand the political impacts of sensational media, we need to look at the conflicts as much as the consensus within the ‘public sphere’, criminal justice and politics. In the formation of policies about commercial sex, public confusion was as important as public opinion and conflict was as central as consensus

Speech Communication

Contains table of contents for Part IV, table of contents for Section 1, an introduction and reports on nine research projects and a list of publications.C.J. Lebel FellowshipDennis Klatt Memorial FundDigital Equipment CorporationNational Institutes of Health Grant T32 DC00005National Institutes of Health Grant 5-R01 DC00075National Institutes of Health Grant F32 DC00015National Institutes of Health Grant S15 NS28048National Institutes of Health Grant R01 NS21183National Institutes of Health Grant P01 NS23734National Institutes of Health Grant 1-R01 DC00776National Science Foundation Grant IRI 88-05680National Science Foundation Grant IRI 89-1056

Speech Communication

Contains table of contents for Part IV, table of contents for Section 1, reports on six research projects, one report on the research laboratory and a list of publications.C.J Lebel FellowshipDennis Klatt Memorial FundNational Institutes of Health Grant R01-DC00075National Institutes of Health Grant R01-DC01291National Institutes of Health Grant R01-DC01925National Institutes of Health Grant R01-DC02125National Institutes of Health Grant R01-DC02978National Institutes of Health Grant R01-DC03007National Institutes of Health Grant R29-DC02525-01A1National Institutes of Health Grant F32-DC00194National Institutes of Health Grant F32-DC00205National Institutes of Health Grant T32-DC00038National Science Foundation Grant IRI 93-14967National Science Foundation Grant INT 94-2114

Speech Communication

Contains table of contents for Part V, table of contents for Section 1, reports on six research projects and a list of publications.C.J. Lebel FellowshipDennis Klatt Memorial FundNational Institutes of Health Grant F32-DC00194National Institutes of Health Grant F32-DC00205National Institutes of Health Grant P01-DC00361National Institutes of Health Grant R01-DC00075National Institutes of Health Grant R01-DC00261National Institutes of Health Grant R01-DC00266National Institutes of Health Grant R01-DC01291National Institutes of Health Grant R01-DC01925National Institutes of Health Grant R03-DC01721National Institutes of Health Grant R29 DC02525National Institutes of Health Grant T32-DC00038National Science Foundation Grant INT 94-21146National Science Foundation Grant IRI 89-0543