The impact of scatterometer wind data on global weather forecasting

The impact of SEASAT-A scatterometer (SASS) winds on coarse resolution atmospheric model forecasts was assessed. The scatterometer provides high resolution winds, but each wind can have up to four possible directions. One wind direction is correct; the remainder are ambiguous or "aliases'. In general, the effect of objectively dealiased-SASS data was found to be negligible in the Northern Hemisphere. In the Southern Hemisphere, the impact was larger and primarily beneficial when vertical temperature profile radiometer (VTPR) data was excluded. However, the inclusion of VTPR data eliminates the positive impact, indicating some redundancy between the two data sets

Small-scale piped water supply: end-user inclusive water research in arsenic affected areas in India and Bangladesh (DELTAP)

DELTAP is s multi-disciplinary research project, where geologists, water treatment scientists and industrial design engineers join forces to develop an integrated approach towards small-scale piped water supply (SPWS) systems in the arsenic-affected Ganges-Brahmaputra-Meghna Delta. The project has started in 2016 with a field study in Bihar (India) with a focus on water quality mapping with mobile crowd participation. The coming years the research will continue with 3 PhD candidates, both in India and Bangladesh, with the ultimate aim to develop blueprints for end-user inclusive SPWS systems

An open environment for development of manufacturing applications on vf-OS

Innovative methodologies for development promote strong involvement of the development community and the developers' engagement. This chapter describes a novel environment that was envisioned for this purpose, involved in the scope of the H2020 European Project virtual factory Open Operating System (vf‐OS). The purpose of the H2020 vf‐OS European Project is to provide manufacturing businesses with an open Operating System that will allow them to create, develop, build and load applications that span and cover the whole manufacturing operation and process. The vf‐OAK software development kit (SDK) is a centralized environment for the development of applications and, generically, for centralized access to the vf‐OS assets and functionalities. The SDK for vApps has a process interpreter which can transform the results from the Process Designer tool to JavaScript language. The vf‐OS System Dashboard is a runtime, central dashboard and task manager, aimed at monitoring, warning, configuring, and adapting system resources.info:eu-repo/semantics/acceptedVersio

Discovery of novel inhibitors of human 11β-hydroxysteroid dehydrogenase type 1

International audienc

Chemo- and Thermosensory Responsiveness of Grueneberg Ganglion Neurons Relies on Cyclic Guanosine Monophosphate Signaling Elements

Neurons of the Grueneberg ganglion (GG) in the anterior nasal region of mouse pups respond to cool temperatures and to a small set of odorants. While the thermosensory reactivity appears to be mediated by elements of a cyclic guanosine monophosphate (cGMP) cascade, the molecular mechanisms underlying the odor-induced responses are unclear. Since odor-responsive GG cells are endowed with elements of a cGMP pathway, specifically the transmembrane guanylyl cyclase subtype GC-G and the cyclic nucleotide-gated ion channel CNGA3, the possibility was explored whether these cGMP signaling elements may also be involved in chemosensory GG responses. Experiments with transgenic mice deficient for GC-G or CNGA3 revealed that GG responsiveness to given odorants was significantly diminished in these knockout animals. These findings suggest that a cGMP cascade may be important for both olfactory and thermosensory signaling in the GG. However, in contrast to the thermosensory reactivity, which did not decline over time, the chemosensory response underwent adaptation upon extended stimulation, suggesting that the two transduction processes only partially overlap. Copyright (C) 2011 S. Karger AG, Base

Decision-support for arsenic- and salt- mitigation in Bangladesh: the ASTRA approach

Bangladesh faces a growing water crisis. Limitations to safe water access arise from the widespread pathogenic contamination of its surface waters, the severe arsenic contamination of its aquifers and the growing salinity in the country’s coastal regions. Appropriate water supply methods are identified for some of these contexts, it is challenging to select resilient water supply solutions for the low-income, rural areas of Bangladesh. The ASTRA tool is developed to support the identification of potentially appropriate drinking water methods and to aid their implementation in this context. It can be seen as the combination of a multidisciplinary sourcebook and a decision-support instrument. This paper outlines the main mitigation routes as the (i) targeting of contamination-free groundwater, (ii) treatment of arsenic- and salt-contaminated aquifers and (iii) utilization of non-groundwater sources. The paper also describes the tool-inventory and the context factors applied to determine functional ranges of the included water supply methods

Ceramic Water Filter for Point-Of-Use Water Treatment in Developing Countries: Principles, Challenges and Opportunities

Drinking water source contamination poses a great threat to human health in developing countries. Point-of-use (POU) water treatment techniques, which improve drinking water quality at the household level, offer an affordable and convenient way to obtain safe drinking water and thus can reduce the outbreaks of waterborne diseases. Ceramic water filters (CWFs), fabricated from locally sourced materials and manufactured by local labor, are one of the most socially acceptable POU water treatment technologies because of their effectiveness, low-cost and ease of use. This review concisely summarizes the critical factors that influence the performance of CWFs, including (1) CWF manufacturing process (raw material selection, firing process, silver impregnation), and (2) source water quality. Then, an in-depth discussion is presented with emphasis on key research efforts to address two major challenges of conventional CWFs, including (1) simultaneous increase of filter flow rate and bacterial removal efficiency, and (2) removal of various concerning pollutants, such as viruses and metal(loid)s. To promote the application of CWFs, future research directions can focus on: (1) investigation of pore size distribution and pore structure to achieve higher flow rates and effective pathogen removal by elucidating pathogen transport in porous ceramic and adjusting manufacture parameters; and (2) exploration of new surface modification approaches with enhanced interaction between a variety of contaminants and ceramic surfaces

Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism

Obesity and nutrient homeostasis are linked by mechanisms that are not fully elucidated. Here we describe a secreted protein, adropin, encoded by a gene, Energy Homeostasis Associated (Enho), expressed in liver and brain. Liver Enho expression is regulated by nutrition: lean C57BL/6J mice fed high-fat diet (HFD) exhibited a rapid increase, while fasting reduced expression compared to controls. However, liver Enho expression declines with diet-induced obesity (DIO) associated with 3 months of HFD or with genetically induced obesity, suggesting an association with metabolic disorders in the obese state. In DIO mice, transgenic overexpression or systemic adropin treatment attenuated hepatosteatosis and insulin resistance independently of effects on adiposity or food intake. Adropin regulated expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma, a major regulator of lipogenesis. Adropin may therefore be a factor governing glucose and lipid homeostasis, which protects against hepatosteatosis and hyperinsulinemia associated with obesity. © 2008 Elsevier Inc. All rights reserved

A Somatostatin Receptor Subtype-3 (SST3) Peptide Agonist Shows Antitumor Effects in Experimental Models of Nonfunctioning Pituitary Tumors

[Purpose] Somatostatin analogues (SSA) are efficacious and safe treatments for a variety of neuroendocrine tumors, especially pituitary neuroendocrine tumors (PitNET). Their therapeutic effects are mainly mediated by somatostatin receptors SST2 and SST5. Most SSAs, such as octreotide/lanreotide/pasireotide, are either nonselective or activate mainly SST2. However, nonfunctioning pituitary tumors (NFPTs), the most common PitNET type, mainly express SST3 and finding peptides that activate this particular somatostatin receptor has been very challenging. Therefore, the main objective of this study was to identify SST3-agonists and characterize their effects on experimental NFPT models.[Experimental Design] Binding to SSTs and cAMP level determinations were used to screen a peptide library and identify SST3-agonists. Key functional parameters (cell viability/caspase activity/chromogranin-A secretion/mRNA expression/intracellular signaling pathways) were assessed on NFPT primary cell cultures in response to SST3-agonists. Tumor growth was assessed in a preclinical PitNET mouse model treated with a SST3-agonist. [Results] We successfully identified the first SST3-agonist peptides. SST3-agonists lowered cell viability and chromogranin-A secretion, increased apoptosis in vitro, and reduced tumor growth in a preclinical PitNET model. As expected, inhibition of cell viability in response to SST3-agonists defined two NFPT populations: responsive and unresponsive, wherein responsive NFPTs expressed more SST3 than unresponsive NFPTs and exhibited a profound reduction of MAPK, PI3K-AKT/mTOR, and JAK/STAT signaling pathways upon SST3-agonist treatments. Concurrently, SSTR3 silencing increased cell viability in a subset of NFPTs. [Conclusions] This study demonstrates that SST3-agonists activate signaling mechanisms that reduce NFPT cell viability and inhibit pituitary tumor growth in experimental models that expresses SST3, suggesting that targeting this receptor could be an efficacious treatment for NFPTs.This work has been funded by the following grants: Junta de Andalucía [CTS-1406 (R.M. Luque), BIO-0139 (J.P. Castaño)]; Ministerio de Ciencia, Innovación y Universidades [BFU2016-80360-R (J.P. Castaño)] and Instituto de Salud Carlos III, co-funded by European Union [ERDF/ESF, “Investing in your future”: PI16/00264 (R.M. Luque), CP15/00156 (M.D. Gahete) and CIBERobn]. CIBER is an initiative of Instituto de Salud Carlos III