Simulations of the Population of Centaurs I: The Bulk Statistics

Large-scale simulations of the Centaur population are carried out. The evolution of 23328 particles based on the orbits of 32 well-known Centaurs is followed for up to 3 Myr in the forward and backward direction under the influence of the 4 massive planets. The objects exhibit a rich variety of dynamical behaviour with half-lives ranging from 540 kyr (1996 AR20) to 32 Myr (2000 FZ53). The mean half-life of the entire sample of Centaurs is 2.7 Myr. The data are analyzed using a classification scheme based on the controlling planets at perihelion and aphelion, previously given in Horner et al (2003). Transfer probabilities are computed and show the main dynamical pathways of the Centaur population. The total number of Centaurs with diameters larger than 1 km is estimated as roughly 44300, assuming an inward flux of one new short-period comet every 200 yrs. The flux into the Centaur region from the Edgeworth-Kuiper belt is estimated to be 1 new object every 125 yrs. Finally, the flux from the Centaur region to Earth-crossing orbits is 1 new Earth-crosser every 880 yrsComment: 15 pages, 2 figures, MNRAS in pres

Lightcurves of 20--100 kilometer Kuiper Belt Objects using the Hubble Space Telescope

We report high precision photometry of three small and one larger Kuiper Belt Objects (KBOs) obtained with the Advanced Camera for Surveys onboard the Hubble Space Telescope (ACS/HST). The three small bodies are the smallest KBOs for which lightcurve measurements are available. 2003 BF91 has a diameter of 20 kilometers (assuming 10% albedo) and a 1.09 magnitude, 9.1-hour lightcurve that is feasibly explained by the rotation of an elongated, coherent body that is supported by material strength and best imagined as an icy outer Solar System analog to asteroid (243) Ida. Two other small KBOs, 2003 BG91 and 2003 BH91 (diameters 31 and 18 km, with albedo 10%), exhibit an unremarkable lightcurve and no detectable photometric variation, respectively. For the larger KBO 2000 FV53 (116 km diameter, assuming 10% albedo) we strongly detect a non-sinusoidal periodic (7.5 hours) brightness variation with a very small amplitude (0.07 mag). This KBO may be nearly spherical, a result that might not be unusual in the Kuiper Belt but would be remarkable among outer Solar System satellites of similar size. We carry out a study of possible physical states and bulk densities under the assumptions of both fluid equilibrium and finite, non-zero internal friction. The densities for the these KBOs are likely to be in the range 1--2 g/cm3, and a plausible solution for 2000 FV53 is a rubble pile of this density that is held slightly out of the minimum-energy shape by internal friction among constituent blocks that are relatively small. Our interpretation of 2000 FV53 as a pulverized but essentially primordial object and 2003 BF91 as a collisional fragment is consistent with models of collisional timescales in the outer Solar System. We compile all published KBO lightcurve data and compare our results to the larger population. [abridged]Comment: AJ, in press. Tables 1-4 will be electronic only in published version but appear here in full. Figures 1,3,5 in colo

Base damage, local sequence context andTP53mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability

The mutational pattern for the TP53 tumour suppressor gene in lung tumours differs to other cancer types by having a higher frequency of G:C>T:A transversions. The aetiology of this differing mutation pattern is still unknown. Benzo[a]pyrene,diol epoxide (BPDE) is a potent cigarette smoke carcinogen that forms guanine adducts at TP53 CpG mutation hotspot sites including codons 157, 158, 245, 248 and 273. We performed molecular modelling of BPDE-adducted TP53 duplex sequences to determine the degree of local distortion caused by adducts which could influence the ability of nucleotide excision repair. We show that BPDE adducted codon 157 has greater structural distortion than other TP53 G:C>T:A hotspot sites and that sequence context more distal to adjacent bases must influence local distortion. Using TP53 trinucleotide mutation signatures for lung cancer in smokers and non-smokers we further show that codons 157 and 273 have the highest mutation probability in smokers. Combining this information with adduct structural data we predict that G:C>T:A mutations at codon 157 in lung tumours of smokers are predominantly caused by BPDE. Our results provide insight into how different DNA sequence contexts show variability in DNA distortion at mutagen adduct sites that could compromise DNA repair at well characterized cancer related mutation hotspots

Dust observations of Comet 9P/Tempel 1 at the time of the Deep Impact

On 4 July 2005 at 05:52 UT, the impactor of NASA's Deep Impact (DI) mission crashed into comet 9P/Tempel 1 with a velocity of about 10 km/s. The material ejected by the impact expanded into the normal coma, produced by ordinary cometary activity. The characteristics of the non-impact coma and cloud produced by the impact were studied by observations in the visible wavelengths and in the near-IR. The scattering characteristics of the "normal" coma of solid particles were studied by comparing images in various spectral regions, from the UV to the near-IR. For the non-impact coma, a proxy of the dust production has been measured in various spectral regions. The presence of sublimating grains has been detected. Their lifetime was found to be about 11 hours. Regarding the cloud produced by the impact, the total geometric cross section multiplied by the albedo was measured as a function of the color and time. The projected velocity appeared to obey a Gaussian distribution with the average velocity of the order of 115 m/s. By comparing the observations taken about 3 hours after the impact, we have found a strong decrease in the cross section in J filter, while that in Ks remained almost constant. This is interpreted as the result of sublimation of grains dominated by particles of sizes of the order of some microns.Comment: Accepted by A&

Assessment of Transformed Properties In Vitro and of Tumorigenicity In Vivo in Primary Keratinocytes Cultured for Epidermal Sheet Transplantation

Epidermal keratinocytes are used as a cell source for autologous and allogenic cell transplant therapy for skin burns. The question addressed here is to determine whether the culture process may induce cellular, molecular, or genetic alterations that might increase the risk of cellular transformation. Keratinocytes from four different human donors were investigated for molecular and cellular parameters indicative of transformation status, including (i) karyotype, (ii) telomere length, (iii) proliferation rate, (iv) epithelial-mesenchymal transition, (v) anchorage-independent growth potential, and (vi) tumorigenicity in nude mice. Results show that, despite increased cell survival in one keratinocyte strain, none of the cultures displayed characteristics of cell transformations, implying that the culture protocol does not generate artefacts leading to the selection of transformed cells. We conclude that the current protocol does not result in an increased risk of tumorigenicity of transplanted cells

Discovery of the peculiar supernova 1998bw in the error box of GRB980425

The discovery of X-ray, optical and radio afterglows of gamma-ray bursts (GRBs) and the measurements of the distances to some of them have established that these events come from Gpc distances and are the most powerful photon emitters known in the Universe, with peak luminosities up to 10^52 erg/s. We here report the discovery of an optical transient, in the BeppoSAX Wide Field Camera error box of GRB980425, which occurred within about a day of the gamma-ray burst. Its optical light curve, spectrum and location in a spiral arm of the galaxy ESO 184-G82, at a redshift z = 0.0085, show that the transient is a very luminous type Ic supernova, SN1998bw. The peculiar nature of SN1998bw is emphasized by its extraordinary radio properties which require that the radio emitter expand at relativistical speed. Since SN1998bw is very different from all previously observed afterglows of GRBs, our discovery raises the possibility that very different mechanisms may give rise to GRBs, which differ little in their gamma-ray properties.Comment: Under press embargo at Nature (submitted June 10, 1998

The similarity of the interstellar comet 2I/Borisov to solar system comets from high resolution optical spectroscopy

Aims: 2I/Borisov (hereafter 2I) is the first visibly active interstellar comet observed in the Solar System, allowing us for the first time to sample the composition of a building block from another system. We report on the monitoring of 2I with the Ultraviolet-Visual Echelle Spectrograph, the high-resolution optical spectrograph of the ESO Very Large Telescope at Paranal, for four months from November 15, 2019 to March 16, 2020. Our goal is to characterise the activity and composition of 2I with respect to Solar System comets. Methods: We collected high-resolution spectra at 12 different epochs from 2.1 au pre-perihelion to 2.6 au post-perihelion. Results: On December 24 and 26, 2019, close to perihelion, we detected several OH lines of the 309 nm (0-0) band and derived a water production rate of 2.2 ± 0.2 × 10^26 molecules s^−1. The three [OI] forbidden oxygen lines were detected at different epochs and we derived a green-to-red doublet intensity ratio (G/R) of 0.31 ± 0.05 close to perihelion. The NH_2 ortho and para lines from various bands were measured and allowed us to derive an ortho-to-para abundance ratio (OPR) of 3.21 ± 0.15, corresponding to an OPR and spin temperature of ammonia of 1.11 ± 0.08 and 31 −5/+10 K, respectively. These values are consistent with the values usually measured for Solar System comets. Emission lines of the radicals NH (336 nm), CN (388 nm), CH (431 nm), and C2 (517 nm) were also detected. Several FeI and NiI lines were identified and their intensities were measured to provide a ratio of log (NiI/FeI) = 0.21 ± 0.18, which is in agreement with the value recently found in Solar System comets. Conclusions: Our high spectral resolution observations of 2I/Borisov and the associated measurements of the NH2 OPR and the Ni/Fe abundance ratio are remarkably similar to Solar System comets. Only the G/R ratio is unusually high, but it is consistent with the high abundance ratio of CO/H2O found by other investigators