Anchor nodes placement for effective passive localization

This paper discusses anchor nodes placement for effective passive localization. The authors show that, for effective passive localization, the optimal placement of the anchor nodes is at the center of the network in such a way that no three anchor nodes share linearity

Quasi-convergence of an implementation of optimal balance by backward-forward nudging

Optimal balance is a non-asymptotic numerical method to compute a point on the slow manifold for certain two-scale dynamical systems. It works by solving a modified version of the system as a boundary value problem in time, where the nonlinear terms are adiabatically ramped up from zero to the fully nonlinear dynamics. A dedicated boundary value solver, however, is often not directly available. The most natural alternative is a nudging solver, where the problem is repeatedly solved forward and backward in time and the respective boundary conditions are restored whenever one of the temporal end points is visited. In this paper, we show quasi-convergence of this scheme in the sense that the termination residual of the nudging iteration is as small as the asymptotic error of the method itself, i.e., under appropriate assumptions exponentially small. This confirms that optimal balance in its nudging formulation is an effective algorithm. Further, it shows that the boundary value problem formulation of optimal balance is well posed up at most a residual error as small as the asymptotic error of the method itself. The key step in our proof is a careful two-component Gronwall inequality

Uncovering protein interaction in abstracts and text using a novel linear model and word proximity networks

We participated in three of the protein-protein interaction subtasks of the Second BioCreative Challenge: classification of abstracts relevant for protein-protein interaction (IAS), discovery of protein pairs (IPS) and text passages characterizing protein interaction (ISS) in full text documents. We approached the abstract classification task with a novel, lightweight linear model inspired by spam-detection techniques, as well as an uncertainty-based integration scheme. We also used a Support Vector Machine and the Singular Value Decomposition on the same features for comparison purposes. Our approach to the full text subtasks (protein pair and passage identification) includes a feature expansion method based on word-proximity networks. Our approach to the abstract classification task (IAS) was among the top submissions for this task in terms of the measures of performance used in the challenge evaluation (accuracy, F-score and AUC). We also report on a web-tool we produced using our approach: the Protein Interaction Abstract Relevance Evaluator (PIARE). Our approach to the full text tasks resulted in one of the highest recall rates as well as mean reciprocal rank of correct passages. Our approach to abstract classification shows that a simple linear model, using relatively few features, is capable of generalizing and uncovering the conceptual nature of protein-protein interaction from the bibliome. Since the novel approach is based on a very lightweight linear model, it can be easily ported and applied to similar problems. In full text problems, the expansion of word features with word-proximity networks is shown to be useful, though the need for some improvements is discussed

Daily versus weekly iron supplementation and prevention of iron deficiency anaemia in lactating women

Objective: To demonstrate the effectiveness and social feasibility of weekly versus daily iron supplementation in preventing and treating iron deficiency anaemia among anaemic mothers. Design: A longitudinal in nature. Setting: Seven urban slum communities in Teklehaimanot Wereda, Addis Ababa, Ethiopia. Subjects: Two hundred seven eligible mothers were assigned to the daily supplementation, weekly supplementation or control groups following randomisation between March and May 2001. The daily supplemented groups (n=71) received 60 mg of elemental iron containing 300 mg ferrous sulphate and 400 µg folic acid from monday to friday. The weekly group (n=68) received one tablet once a week every monday supervised while the control group (n=68) was advised to take no medications without the knowledge of the investigators until the completion of the study. To eliminate a major source of variation, subjects participating in the study were de-wormed at the beginning of the study. Main outcome measures: Haemoglobin and serum ferritin concentrations were compared before and after the intervention among the groups. Results: The mean haemoglobin (Hgb), and serum ferritin concentration (SFC) at baseline were practically similar among the groups. Haemoglobin levels significantly increased at the end of the study in all the groups and the proportion of anaemia decreased from 6.9% to 1.6% in the daily, 6.7% to 1.7% in the weekly supplemented and 6.7% to 6.1% in the control groups. The difference noted between the daily and weekly supplemented groups was not significant. The improvement of SFC concentration was better in the daily than the weekly group but not statistically significant. Daily supplementation schedule caused more side effects and lower compliance level than the weekly supplementation schedule. Conclusion: Weekly supplementation is simple, comparable to daily supplementation and economically advantageous. Thus, it is recommended to adopt the strategy for controlling anaemia. Further because of higher compliance rate and lower side effects, it is deemed to be socially feasible. (East African Medical Journal: 2003 80(1): 11-16

Vitamin A status in three woredas of Kambatta, Alaba, and Timbaro Zone, Southern Peoples’s Region

Abstract: As a part of comprehensive evaluative study on various strategies to control Vitamin A Deficiency (VAD), a baseline survey was conducted in three woredas of Kambatta, Alaba, and Timbaro Zone (KAT) in Southern Nations, Nationalities and People’s Region in 1996. A total of 4123 children from randomly selected peasant associations were clinically examined for signs of xerophthalmia while blood samples were collected from a systematically selected 197 children for serum retinol analysis. Results indicate that 1.2% (51) of the children had a history of night blindness and 0.2% (8) had bitot’s spots. Most cases of bitot’s spots (6 out of 8) were in the age range of 36-72 months. The prevalence of bitot’s spots was higher in male children compared to female children (5 and 3 respectively). Over a quarter of children (27.9%) had low serum retinol concentrations, while 4.6% had deficient serum retinol concentrations. Nearly equal numbers of male and female children (4 and 5 respectively) had deficient levels of serum retinol concentrations while more male children had low serum retinol levels compared to female children (28 and 17, respectively). The high prevalence of night blindness (WHO’s cut-off point of 1%) and serum retinol levels (WHO’s cut-off point of 20% less than or equal to 0.70 umole/1) indicates that VAD is emerging as a public health problem in an area previously considered free of VAD. These findings justify the need to strengthen the intervention strategies underway in the area. [Ethiop. J. Health Dev. 1998;12(3):225-229

Utility of Masson’s Trichrome Stain in the Quantification of Mean Vascular Density in Normal Oral Mucosa, Epithelial Dysplasia and Oral Squamous Cell Carcinoma

Indexación: Scopus; Scielo.El objetivo de este estudio fue valuar la utilidad del uso de la tinción de Tricrómico de Masson (TM) en la cuantificación de la densidad media vascular (DMV) en Mucosa Oral Normal (MON), Displasia Epitelial Oral (DEO) y Carcinoma Oral de Células Escamosas (COCE). Estudio descriptivo de serie de casos. Se analizaron 17 muestras de MON, 15 muestras de DEO y 16 de COCE, teñidas con TM. Para determinar su utilidad, se compararon con las mismas muestras analizadas con técnica de inmunohistoquímica contra CD31. La cuantificación de la DMV se realizó en las 3 áreas de mayor vascularización de cada muestra. Se determinó la DMV según diagnóstico mediante la tinción TM e inmunohistoquímica contra CD31, y se calculó la correlación entre ambos. La DMV cuantificada con TM y contra CD31 difiere según el diagnóstico, observándose un aumento de la DMV al malignizarse el diagnóstico. No se encontraron diferencias al comparar la DMV cuantificada con TM y contra CD31. La correlación de la DMV analizado por TM y contra CD31 es significativa y moderada. La cuantificación de vasos sanguíneos es posible mediante la tinción de TM en muestras de MON, DEO y COCE, con una correlación moderada con la inmunohistoquímica contra CD31.The objective of this study was to evaluate the utility of Masson's Trichrome (TM) staining in the quantification of the mean vascular density (DMV) in samples of normal oral mucosa (MON), oral epithelial dysplasia (ODE) and oral squamous cell carcinoma (COCE). The design - a descriptive study of case series. We analyzed 17 samples of MON, 15 samples of DEO and 16 samples of COCE, stained with TM. To determine usefulness, we compared and analyzed the same samples, either stained with TM or with immunohistochemical technique against CD31. Quantification of the DMV was performed in the 3 areas of greatest vascularization in each sample. DMV was determined according to diagnosis by TM staining and immunohistochemistry against CD31, and the correlation between the two was then calculated. DMV quantified with TM and against CD31 differs according to the diagnosis, with an increase in DMV upon malignant diagnosis. No differences were found when comparing DMV quantified with TM and against CD31. The correlation of the DMV analyzed by TM and against CD31 is significant and moderate. Quantification of blood vessels is possible by TM staining in samples of MON, DEO and COCE. TM staining is moderately correlated with immunohistochemistry against CD31.https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000401576&lng=en&nrm=iso&tlng=e

Vitamin A deficiency status in Tigray Region, Ethiopia, 1996

Abstract: A survey was conducted to determine the prevalence of xerophthalmia in Alaje and Samre weredas of Tigray Region, Northern Ethiopia, where EPI-plus and Wereda Integrated Basic Service (WIBS) approaches are being launched to prevent and control vitamin A deficiency. A total of 5,253 preschool children (PSC) were clinically examined between October and November, 1996 for ocular signs of xerophthalmia. Blood samples were drawn from 248 PSC for serum retinol levels(SRL). The overall prevalence rates of night blindness (XN) and Bitot's spot (X B) for both weredas were 1 0.9% and 1.5%, respectively, with a higher prevalence rate in males than females (53 vs 26). Alaje wereda(EPI-plus) had XN=21(0.8%) and X B=38(1.4%), and Samre wereda (WIBS) had 1 XN=25(1.0%) and X B=41(1.7%). No sex difference was seen in the prevalence rate of corneal 1 xerosis and keratomalacia (0.4%). The most affected age groups were children between five and six years of age. Both weredas showed the distribution of serum retinol levels to be deficient in 21(16.7%) in Samre and 19(15.5%) in Alaje, and low in 60(47.6%) in Samre and 57(46.7%) in Alaje. Low SRL is found to be highest among children between five and six years of age in males and between two to three years of age in females in both weredas. The high prevalence rate of X B 1 (three times higher than the WHO cut-off point), and the low level of serum retinol value found in this study indicates the need and urgency for the continuation of the aforementioned strategies of vitamin A deficiency control program launched in the Region until their impact is further evaluated. [Ethiop. J. Health Dev. 1999;13(2):87-91

Performance of upstream interaction region detectors for the FIRST experiment at GSI

The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at GSI has been designed to study carbon fragmentation, measuring 12C double differential cross sections (∂2σ/ ∂θ∂E) for different beam energies between 100 and 1000 MeV/u. The experimental setup integrates newly designed detectors in the, so called, Interaction Region around the graphite target. The Interaction Region upstream detectors are a 250 μm thick scintillator and a drift chamber optimized for a precise measurement of the ions interaction time and position on the target. In this article we review the design of the upstream detectors along with the preliminary results of the data taking performed on August 2011 with 400 MeV/u fully stripped carbon ion beam at GSI. Detectors performances will be reviewed and compared to those obtained during preliminary tests, performed with 500 MeV electrons (at the BTF facility in the INFN Frascati Laboratories) and 80 MeV/u protons and carbon ions (at the INFN LNS Laboratories in Catania)

FIRST experiment: Fragmentation of Ions Relevant for Space and Therapy

Nuclear fragmentation processes are relevant in different fields of basic research and applied physics and are of particular interest for tumor therapy and for space radiation protection applications. The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at SIS accelerator of GSI laboratory in Darmstadt, has been designed for the measurement of different ions fragmentation cross sections at different energies between 100 and 1000 MeV/nucleon. The experiment is performed by an international collaboration made of institutions from Germany, France, Italy and Spain. The experimental apparatus is partly based on an already existing setup made of the ALADIN magnet, the MUSIC IV TPC, the LAND2 neutron detector and the TOFWALL scintillator TOF system, integrated with newly designed detectors in the interaction Region (IR) around the carbon removable target: a scintillator Start Counter, a Beam Monitor drift chamber, a silicon Vertex Detector and a Proton Tagger for detection of light fragments emitted at large angles (KENTROS). The scientific program of the FIRST experiment started on summer 2011 with the study of the 400 MeV/nucleon 12C beam fragmentation on thin (8mm) carbon targe

Non-uniform grid-based routing in sensor networks

This paper discusses non-uniform grid-based routing in sensor networks