Aphonie bei multipler Sklerose = Aphonia Multiple Sclerosis

This is a report on a female patient suffering from slowly progressive multiple sclerosis. Soon after onset of the disease, hoarseness became manifest and lasted for six years, climaxing in aphonia. Treatment with L-dopa medication was successful. The patient regained her voice

EDITH - experimental in-torus maintenance system for fusion reactors. Final report

Experimentelles Handhabungssystem für Wartungsarbeiten im Torus eines Fusionsreaktors Wegen der besonderen Umgebungsbedingungen - erhöhte -Strahlung und Temperatur - können Reparaturarbeiten in der Plasmakammer eines Fusionsreaktors wie NET/ITER nur mittels eines fernbedienten Handhabungssystems durchgeführt werden. EDITH (Experimental Device for In-Torus Handling) ist der Prototyp eines solchen Systems. Es basiert auf einem Vielgelenkarm, der für die jeweiligen Aufgaben mit verschiedenen Endeffektoren bzw. Werkzeugen ausgerüstet ist. EDITH ist die zentrale Komponente eines Teststandes, mit dem in Originalgröße in einem nachgebildeten Ausschnitt einer Plasmakammer Fernhantierungsvorgänge experimentell untersucht werden. Exemplarisch für solche Aufgaben wurde der fernbediente Austausch von Schutzziegeln und Divertorplatten durchgeführt. Um den Operateuren eine schnelle und zuverlässige Durchführung der Arbeiten zu ermöglichen, wurde ein neuartiges Leit- und Steuersystem entwickelt. Das Leitsystem bildet in Form einer Fernhandhabungs-Arbeitsstation zusammen mit den Servomanipulatoren die Mensch-Maschine-Schnittstelle zur Steuerung und Überwachung aller Geräte. Die Arbeitsstation unterstützt die Operateure bei allen manuell zu steuernden Arbeiten, bei der Planung, Simulation und Programmierung automatisch durchzuführender Teilaufgaben und dient mit ihrem multimedialen Dokumentationssystem als ständig verfügbare Informationsquelle. Bei der Konzeption der Steuerung standen das dynamische Verhalten, die Betriebssicherheit und die Kopplung an das Leitsystem im Vordergrund. Qualifikationstests und erste Experimentiererfahrungen bestätigten, daß mit der bei FZK entwickelten Fernhantierungstechnik die gestellten Aufgaben sicher, zuverlässig und in vertretbarer Zeit ausgeführt werden können

The ecology and management of bluebunch wheatgrass (Agropyron spicatum) : a review

Agropyron spicatum, considered one of the most important native bunchgrasses in British Columbia, western Montana, the Columbia Basin and the area between the Cascades and Sierras and the Rockies, dominated millions of acres of pristine semiarid grass and sagebrush sites. It produced more herbage than all other associated species in these regions. A considerable amount of research has been done with this species since J. E. Weaver's work on roots in 1915. This review summarizes information from more than 300 articles relating to taxonomy, morphology, forage quality, ecology, physiology, and management of A. spicatum. It has been arranged so persons can easily locate articles relating A. spicatum to these various subject areas.Published July 1994. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalo

Tapping the nucleotide pool of the host: novel nucleotide carrier proteins of Protochlamydia amoebophila

Protochlamydia amoebophila UWE25 is related to the Chlamydiaceae comprising major pathogens of humans, but thrives as obligate intracellular symbiont in the protozoan host Acanthamoeba sp. The genome of P. amoebophila encodes five paralogous carrier proteins belonging to the nucleotide transporter (NTT) family. Here we report on three P. amoebophila NTT isoforms, PamNTT2, PamNTT3 and PamNTT5, which possess several conserved amino acid residues known to be critical for nucleotide transport. We demonstrated that these carrier proteins are able to transport nucleotides, although substrate specificities and mode of transport differ in an unexpected manner and are unique among known NTTs. PamNTT2 is a counter exchange transporter exhibiting submillimolar apparent affinities for all four RNA nucleotides, PamNTT3 catalyses an unidirectional proton-coupled transport confined to UTP, whereas PamNTT5 mediates a proton-energized GTP and ATP import. All NTT genes of P. amoebophila are transcribed during intracellular multiplication in acanthamoebae. The biochemical characterization of all five NTT proteins from P. amoebophila in this and previous studies uncovered that these metabolically impaired bacteria are intimately connected with their host cell’s metabolism in a surprisingly complex manner

Central Bank Communication in the Financial Crisis: Evidence from a Survey of Financial Market Participants

In this paper, we study whether central bank communication has a positive effect on market participants' perception of central banks' (i) credibility, (ii) unorthodox measures, and (iii) independence. We utilise a survey of more than 500 financial market participants from around the world who answered questions in reference to the Bank of England (BoE), the Bank of Japan (BoJ), the European Central Bank (ECB), and the Federal Reserve (Fed). We find that market participants believe that the Fed communicates best, followed by the BoE, ECB, and BoJ. Similar rankings are found on the issues of credibility, satisfaction with unconventional monetary policy, and possible deterioration in independence. Using ordered probit models, we show that central bank communication has a positive effect on how central banks are perceived and understood, as it enhances credibility, increases satisfaction with unorthodox measures, and fosters perceived independence of central banks

Assessment of a novel smartglass-based point-of-care fusion approach for mixed reality-assisted targeted prostate biopsy: A pilot proof-of-concept study

PurposeWhile several biopsy techniques and platforms for magnetic resonance imaging (MRI)-guided targeted biopsy of the prostate have been established, none of them has proven definite superiority. Augmented and virtual reality (mixed reality) smartglasses have emerged as an innovative technology to support image-guidance and optimize accuracy during medical interventions. We aimed to investigate the benefits of smartglasses for MRI-guided mixed reality-assisted cognitive targeted biopsy of the prostate.MethodsFor prospectively collected patients with suspect prostate PIRADS lesions, multiparametric MRI was uploaded to a smartglass (Microsoft® Hololens I), and smartglass-assisted targeted biopsy (SMART TB) of the prostate was executed by generation of a cognitive fusion technology at the point-of-care. Detection rates of prostate cancer (PCA) were compared between SMART TB and 12-core systematic biopsy. Assessment of SMART-TB was executed by the two performing surgeons based on 10 domains on a 10-point scale ranging from bad (1) to excellent (10).ResultsSMART TB and systematic biopsy of the prostate were performed for 10 patients with a total of 17 suspect PIRADS lesions (PIRADS 3, n = 6; PIRADS 4, n = 6; PIRADS 5, n = 5). PCA detection rate per core was significant (p < 0.05) higher for SMART TB (47%) than for systematic biopsy (19%). Likelihood for PCA according to each core of a PIRADS lesion (17%, PIRADS 3; 58%, PIRADS 4; 67%, PIRADS 5) demonstrated convenient accuracy. Feasibility scores for SMART TB were high for practicality (10), multitasking (10), execution speed (9), comfort (8), improvement of surgery (8) and image quality (8), medium for physical stress (6) and device handling (6) and low for device weight (5) and battery autonomy (4).ConclusionSMART TB has the potential to increase accuracy for PCA detection and might enhance cognitive MRI-guided targeted prostate biopsy in the future

Microsporidia::Why Make Nucleotides if You Can Steal Them?

Microsporidia are strict obligate intracellular parasites that infect a wide range of eukaryotes including humans and economically important fish and insects. Surviving and flourishing inside another eukaryotic cell is a very specialised lifestyle that requires evolutionary innovation. Genome sequence analyses show that microsporidia have lost most of the genes needed for making primary metabolites, such as amino acids and nucleotides, and also that they have only a limited capacity for making adenosine triphosphate (ATP). Since microsporidia cannot grow and replicate without the enormous amounts of energy and nucleotide building blocks needed for protein, DNA, and RNA biosynthesis, they must have evolved ways of stealing these substrates from the infected host cell. Providing they can do this, genome analyses suggest that microsporidia have the enzyme repertoire needed to use and regenerate the imported nucleotides efficiently. Recent functional studies suggest that a critical innovation for adapting to intracellular life was the acquisition by lateral gene transfer of nucleotide transport (NTT) proteins that are now present in multiple copies in all microsporidian genomes. These proteins are expressed on the parasite surface and allow microsporidia to steal ATP and other purine nucleotides for energy and biosynthesis from their host. However, it remains unclear how other essential metabolites, such as pyrimidine nucleotides, are acquired. Transcriptomic and experimental studies suggest that microsporidia might manipulate host cell metabolism and cell biological processes to promote nucleotide synthesis and to maximise the potential for ATP and nucleotide import. In this review, we summarise recent genomic and functional data relating to how microsporidia exploit their hosts for energy and building blocks needed for growth and nucleic acid metabolism and we identify some remaining outstanding questions

The Waddlia Genome: A Window into Chlamydial Biology

Growing evidence suggests that a novel member of the Chlamydiales order, Waddlia chondrophila, is a potential agent of miscarriage in humans and abortion in ruminants. Due to the lack of genetic tools to manipulate chlamydia, genomic analysis is proving to be the most incisive tool in stimulating investigations into the biology of these obligate intracellular bacteria. 454/Roche and Solexa/Illumina technologies were thus used to sequence and assemble de novo the full genome of the first representative of the Waddliaceae family, W. chondrophila. The bacteria possesses a 2′116′312bp chromosome and a 15′593 bp low-copy number plasmid that might integrate into the bacterial chromosome. The Waddlia genome displays numerous repeated sequences indicating different genome dynamics from classical chlamydia which almost completely lack repetitive elements. Moreover, W. chondrophila exhibits many virulence factors also present in classical chlamydia, including a functional type III secretion system, but also a large complement of specific factors for resistance to host or environmental stresses. Large families of outer membrane proteins were identified indicating that these highly immunogenic proteins are not Chlamydiaceae specific and might have been present in their last common ancestor. Enhanced metabolic capability for the synthesis of nucleotides, amino acids, lipids and other co-factors suggests that the common ancestor of the modern Chlamydiales may have been less dependent on their eukaryotic host. The fine-detailed analysis of biosynthetic pathways brings us closer to possibly developing a synthetic medium to grow W. chondrophila, a critical step in the development of genetic tools. As a whole, the availability of the W. chondrophila genome opens new possibilities in Chlamydiales research, providing new insights into the evolution of members of the order Chlamydiales and the biology of the Waddliaceae